• 환경영향평가
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• 제27권6호
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• pp.521-547
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• 2018

본 연구는 식물자원 및 생태계에 대한 정보가 부족한 지기산 일대를 대상으로 관속식물상을 조사하여 자연환경 평가 및 기초자료 구축을 위해 수행되었다. 현지조사 결과, 낙엽활엽수 및 침활혼효림을 이루는 지역으로서 관속식물은 96과 286속 391종 7아종 40변종 3품종 2교잡종 등443분류군이 확인되었다. 한반도 고유종은 은사시나무, 개나리, 만리화, 넓은잎각시붓꽃 4분류군이 확인되었다. IUCN 평가기준에 따른 적색목록은 6분류군으로 취약종(VU)에 만리화, 관심대상종(LC)에 이팝나무, 물잔디, 보춘화, 미평가종(NE)에 인삼, 푸른하늘지기가 확인되었다. 식물구계학적 특정식물은 27분류군으로, V등급에 2분류군, IV등급에 3분류군, III등급에 6분류군, II등급에 4분류군, I등급에 12분류군이 조사되었다. 특이분포식물은 27분류군으로 북방계식물이 4분류군, 남방계식물이 12분류군, 격리분포식물이 10분류군이었으며, 최근 학계에 보고된 흰들제비꽃 1분류군이 확인되었다. 외래식물은 67분류군으로 귀화율(NI) 15.12%, 도시화지수(UI) 20.9%로 나타났다.

• 대한한방내과학회지
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• 제29권4호
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• pp.1037-1047
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• 2008

Background : A traditional Oriental medicine, GongJjn-dan (GJD), is one of the most well-known tonic agents in Korea. Among 6 types of GJD components, antler, red ginseng, and Cornus fructus have shown antioxidant effects, while EtOH-induced tissue damage may be a consequence of oxidative stress. Objectives & Methods : The hepatoprotective effects of GJD were evaluated on EtOH-mediated experimental liver damaged rats at 50, 100, 250 and 500mg/kg comparing with 100mg/kg of silymarin as a reference drug in the present study. Test substances were dosed once a day for 60 days with oral administration of 20% ethanol 2.5ml/100g body weight twice a day (equivalent to 7.9g ethanol/kg/day). Each of 8 rats per group was selected using body weight at 10 days after acclimatization. Experimental animals were sacrificed after 60 days of continuous oral treatment of test substances with 20% ethanol treatment, and changes on the body weight, liver weight, and serum AST and ALT were observed. Results : There were dramatic decreases of body weight and increases of liver weight and serum AST and ALT. Similar inhibition effects on the EtOH-induced hepatic damages were detected between equal dosages of GJD and silymarin. Conclusion : Based on these results. it is concluded that GJD showed clear hepatoprotective effects on EtOH-induced hepatic damage.

• 한국식품저장유통학회지
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• 제17권3호
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• pp.430-434
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• 2010

왕겨초액은 최근 목초액을 대신할 수 있는 소재로 많은 연구가 이루어지고 있다. 본 연구는 왕겨초액과 목초액의 항산화 활성을 비교하고, 왕겨초액과 홍삼 및 로즈마리 농축액과의 발효를 통한 시료의 항산화 활성을 비교하여 보았다. DPPH와 FRAP 활성 실험을 통해 항산화 활성을 알아본 결과, 왕겨초액의 항산화 활성은 목초액 보다는 다고 미흡하나, 로즈마리와의 동시 발효를 통해 왕겨초액의 항산화 활성을 높일 수 있으므로, 이취 제거로 인한 기능성 소재로서의 가능성을 확인하였다.

• 한국자원식물학회지
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• 제26권3호
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• pp.374-382
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• 2013

The objective of this study was determined to evaluate ${\alpha}$-amylase, ${\alpha}$-glucosidase, pancreatic lipase inhibition in vitro and DPPH radical scavenging activity of the several Korean resources plants. The ${\alpha}$-amylase inhibitory activity of Salicornia herbacea, Erythronium japonicum (flower) and Phragmites communis (root) in water extract showed relatively high 62.8%, 66.5% and 69.3%, respectively. The ${\alpha}$-amylase inhibitory activity of Citrus junos (pericarp) and Cornus officinalis in methanol extract was found to have an effect with 32.8% in Citrus junos (pericarp) and 60.9% in Cornus officinalis. Corylopsis coreana in both water and methanol extract had the highest ${\alpha}$-glucosidase inhibitory activity of 81.7% and 89.5%, while the extract of Portulaca oleracea, Ficus carica and Citrus junos was not measured ${\alpha}$-glucosidase inhibitory activity at given experiment concentration. Depending on the extraction solvent and the plant species, it was observed that there was a significant difference in ${\alpha}$-glucosidase inhibitory activity. The pancreatic lipase inhibitory activity showed relatively higher in the methanol extract than water extract except pericarp of Citrus junos. The DPPH radical scavenging activity of selected plants was much difference between measured plant species, and showed that the increase was proportional to the concentration. These results suggested that selected plants had the potent biological activity on carbohydrate, lipid Inhibitory activity and antioxidant activity, therefore these plant resources could be a good materials to develop medicinal preparations, nutraceuticals or health functional foods for diabetes or obesity.

• 한국산학기술학회논문지
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• 제13권10호
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• pp.4604-4611
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• 2012

본 연구는 경남지역 산업체 근로자를 대상으로 구강건강영향지수에 미치는 요인을 알아보고자 272명을 대상으로 설문지를 자기기입식으로 작성하도록 하였으며 다음과 같은 결론을 얻을 수 있었다. 구강건강영향지수에 영향을 미치는 변인은 전신건강지수, 연령, 식생활 행동, 구강건조증의 4변인인 것으로 나타났다. 변인중 전신건강지수와 식생활 행동은 구강건강영향지수에 정적 영향을 미쳤으며, 연령과 구강건조증은 부적 영향을 미쳐, 전신건강지수가 높고, 좋은 식생활 행동을 가질수록 구강건강영향지수가 높으며, 연령이 낮고, 구강건조증이 없을수록 구강건강영향지수가 높다는 것을 알 수 있었다. 이상의 결과 근로자의 구강건강영향지수에 미치는 요인을 분석하여 구강건강증진을 위한 프로그램 개발에 힘을 써 구강질환이 발생되기 전에 예방하고 나아가 근로자의 건강과 구강건강영향지수를 향상 시켜야 할 것이다.

• Journal of Microbiology and Biotechnology
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• 제30권3호
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• pp.439-447
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• 2020

We investigated the immune restoration activity of Undaria pinnatifida fucoidan-rich extract in cyclophosphamide-induced immunosuppressed mice. C57BL/6 mice were intraperitoneally injected with 80 mg/kg of cyclophosphamide (CP) and orally administered with either drinking water (DW), red ginseng extract (RG), or one of three different doses of Undaria pinnatifida fucoidan-rich extract (DSU02 50, 100, and 150 mg/kg). After 14 days, liver, spleen, and whole blood were isolated from each animal. The frequencies of NK and CD³⁺, CD⁴⁺, and CD⁸⁺ T cells were significantly increased in splenocytes isolated from the DSU02 100 mg/kg and DSU02 150 mg/kg groups (NK1.1+, 5.4% or 4.9% vs 3.8%; CD³⁺, 39.3% or 37.9% vs 32.3%; CD4+, 22% or 20.2% vs 17.4%; CD8+, 12.7% or 11.6% vs 10.1%). NK cytotoxicity was enhanced in the DSU02-fed groups at all doses (CP-treated DW, 93.4%; RG, 107.2%; DSU02 50, 107.3%; DSU02 100, 107.3%; DSU02 150, 107.1%), and the proliferation of T cells (CD³⁺, CD⁴⁺, and CD⁸⁺) was also greater in the DSU02 100 mg/kg and DSU02 150 mg/kg administered groups compared with the unfed group. Plasma concentrations of TNF-α, IgM, and total IgG from the DSU02 150 mg/kg group were also significantly higher compared with the other groups (TNF-α: CP-treated DW - 21.5 pg/ml, DSU02 150 - 47.1 pg/ml; IgM: CP-treated DW - 82.9 ng/ml, DSU02 150 - 110.8 ng/ml; total IgG: CP-treated DW - 114.4 ng/ml, DSU02 150 - 162.7 ng/ml). We suggest that Undaria pinnatifida fucoidan-rich extract could be a promising candidate for a marine natural immune stimulator.

• BMB Reports
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• 제44권10호
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• pp.659-664
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• 2011

As part of the search for biologically active anti-osteoporotic agents that enhance differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rh2(S), which is an active component in ginseng. Rh2(S) stimulates osteoblastic differentiation and mineralization, as manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic genes) and Alizarin Red staining, respectively. Rh2(S) activates p38 mitogen-activated protein kinase (MAPK) in time- and concentration-dependent manners, and Rh2(S)-induced differentiation and mineralization of osteoblastic cells were totally inhibited in the presence of the p38 MAPK inhibitor, SB203580. In addition, pretreatment with Go6976, a protein kinase D (PKD) inhibitor, significantly reversed the Rh2(S)-induced p38 MAPK activation, indicating that PKD might be an upstream kinase for p38 MAPK in MC3T3-E1 cells. Taken together, these results suggest that Rh2(S) induces the differentiation and mineralization of MC3T3-E1 cells through activation of PKD/p38 MAPK signaling pathways, and these findings provide a molecular basis for the osteogenic effect of Rh2(S).

• 생명과학회지
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• 제24권5호
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• pp.573-587
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• 2014

혈관신생은 모든 조직의 성장과 발달, 그리고 상처회복 등에 매우 중요하다. 지방조직은 우리 몸에서 가장 혈관이 발달된 조직으로서 각 지방세포들은 모세혈관에 둘러싸여 있으며 신생혈관들은 지방세포에 영양분과 산소를 공급한다. 혈관의 내피세포들은 파라크린 신호경로, 세포외 성분, 세포들 간의 직접적인 작용을 통해 지방세포와 교류한다. 활성화된 지방세포들은 VEGF, FGF-2, leptin, HGF와 같은 혈관신생인자들을 생성하며, 이들은 단독으로 혹은 협력하여 혈관신생을 증가시키고 지방조직의 성장과 대사를 촉진한다. 따라서 혈관신생 억제제들은 비만과 비만관련 질환을 치료하는데 유용할 것으로 생각된다.

• Journal of Preventive Medicine and Public Health
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• 제26권4호
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• pp.551-564
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• 1993

Since the widespread application of hyperbaric oxygenation in clinical medicine, the problems of oxygen toxicity have been attracting a deep interest from the researchers on hyperbaric medicine as a practical issue. Among extensive research trials, the study on the protective agents oxygen toxicity occupied one of the most challenging field. As the mechanisms of oxygen toxicity, the role of the oxygen free radicals produced by peroxidation process are strongly accepted by the leading researchers on oxygen toxicity, the probable protective effects of antioxidant against oxygen toxicity are sustaining a sufficient rational. Maltol ($2-methyl-3-hydroxy-{\gamma}-pyrone$) which is known to be a component of Korean red ginseng has been reporting to have an antioxidant action. But, further study is needed to provide definite evidence for this compound to be an antioxidant, since the action was based on the results which were obtained under in vitro experiment. In this study, the author attempted to evaluate the effect of maltol as protective agent against oxygen toxicity through the observation of death rate, convulsion rate, time to convulsion and microscopic pathological changes in some organs of experimental rats exposed to various conditions. The findings observed are as follows : 1) The death rate, convulsion rate, time to convulsion, lung/weight ratio and microscopic pathological finding of lung were identified as reliable objective and quantitative indices for oxygen toxicity. 2) Maltol showed excellent protective effect against pulmonary oxygen toxicity as an antioxidant.

• 한국환경과학회지
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• 제23권5호
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• pp.911-942
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• 2014

This study was carried out to investigate the flora of indigenous habitat of Donghae-si and Samcheok-si in Gangwon-do, Korea. The vascular plants were collected 18 times (from March to October 2011), and were identified as 804 taxa; 127 families, 445 genera, 720 species, 8 subspecies, 69 varieties, 5 forms and 2 hybrids. In the flora of this area, the calcicolous plants were 55 taxa; Cheilanthes argentea, Clematis serratifoliam, Quercus variabilis. Epipactis papillosa, etc. The endangered plants designated and protected by the wildlife protection law, the Ministry of Environment, Korean were counted to one taxon; Cymbidium macrorhizum. The red list of vascular plants according to IUCN valuation basis were examined, endangered species (EN); Prunus yedoensis and Cymbidium macrorhizum, Vulnerable species (VU); Juniperus chinensis, Pulsatilla tongkangensis, Diarthron linifolium and Swertia wilfordii, Near Threatened species (NT); Paeonia japonica, Allium senescens, Epipactis papillosa and Pogonia minor, Least Concern species (LC); Asplenium ruta-muraria, Platycladus orientalis, Monotropa hypopithys and Eleutherococcus divaricatus var. chiisanensis, etc., Data Deficient species (DD); Paeonia lactiflora var. trichocarpa, and Not Evaluate species (NE); Prunus choreiana, Panax ginseng and Polygonatum infundiflorum etc. Korean endemic plants of this area were 26 taxa; Aconitum pseudolaeve, Corydalis hirtipes, Vicia chosenensis, Salvia chanroenica and Hemerocallis hakuunensis, etc. The floristic regional indicator plants found in this area were 130 taxa comprising 11 taxa of grade V, 15 taxa of grade IV, 33 taxa of grade III, 15 taxa of grade II, 56 taxa of grade I. The naturalized plants were identified as 67 taxa and the percent of naturalized index (NI) was 8.3% of total 804 taxa vascular plants.