• Journal of Chest Surgery
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• 제57권2호
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• pp.128-135
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• 2024

Background: This retrospective study aimed to determine the treatment patterns and the surgical and oncologic outcomes after completion lobectomy (CL) in patients with locoregionally recurrent stage I non-small cell lung cancer (NSCLC) who previously underwent sublobar resection. Methods: Data from 36 patients who initially underwent sublobar resection for clinical, pathological stage IA NSCLC and experienced locoregional recurrence between 2008 and 2016 were analyzed. Results: Thirty-six (3.6%) of 1,003 patients who underwent sublobar resection for NSCLC experienced locoregional recurrence. The patients' median age was 66.5 (range, 44-77) years at the initial operation, and 28 (77.8%) patients were men. Six (16.7%) patients underwent segmentectomy and 30 (83.3%) underwent wedge resection as the initial operation. The median follow-up from the initial operation was 56 (range, 9-150) months. Ten (27.8%) patients underwent CL, 22 (61.1%) underwent non-surgical treatments (chemotherapy, radiation, concurrent chemoradiation therapy), and 4 (11.1%) did not receive treatment or were lost to follow-up after recurrence. Patients who underwent CL experienced no significant complications or deaths. The median follow-up time after CL was 64.5 (range, 19-93) months. The 5-year overall survival (OS) and post-recurrence survival (PRS) were higher in the surgical group than in the non-surgical (p<0.001) and no-treatment groups (p<0.001). Conclusion: CL is a technically demanding but safe procedure for locoregionally recurrent stage I NSCLC after sublobar resection. Patients who underwent CL had better OS and PRS than patients who underwent non-surgical treatments or no treatments; however, a larger cohort study and long-term surveillance are necessary.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3973-3976
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• 2015

Objectives: To explore the expression of aquaporin 1 ($AQP_1$) in bladder uroepithelium cell carcinoma (BUCC) and its relevance to recurrence. Materials and Methods: Tissue samples from 45 BUCC patients who underwent total cystectomy or transurethral resection of bladder tumor (TURBT) and from 40 patients with non-bladder cancers who underwent special detection or treatments were collected. The level of expression of $AQP_1$ in BUCC tissues and normal bladder tissues was assessed by immunohistochemistry so as to analyze the relevance to pathological patterns and time of recurrence in BUCC patients. Results: The expression levels of $AQP_1$ normal bladder tissues and BUCC tissues were $2.175{\pm}0.693$ and $3.689{\pm}0.701$, respectively, and the difference was significant (t=9.99, P<0.0001). Marked increase was noted with BUCC histological grade and pathological stage (P<0.01). Moreover, the expression of $AQP_1$ was evidently higher in cancerous tissues with lymph node metastasis than in those without (P<0.01). With short-term recurrence, the positive cell expression rate of $AQP_1$ was higher in primary tissues, which increased obviously after recurrence. Additionally, the recurrent time of BUCC was negatively associated with the positive cell expression rate of $AQP_1$ and the difference between the expression of $AQP_1$ before and after recurrence (r=-0.843, F=39.302, P=0.000; r=-0.829, F=35.191, P=0.000). Conclusions: $AQP_1$, which reflects the grade, stage, lymph node metastasis and recurrence of BUCC, has potential guiding significance in the diagnosis and treatment of bladder cancarcinoma.

• Journal of Chest Surgery
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• 제26권1호
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• pp.32-35
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• 1993

During the period from September 1989 through December 1992, 118 cases of coronary arterial bypass graft were performed at Department of Cardiothoracic Surgery, Asan Medical Center. Twenty-one of these had history of recent or remote percutaneous transluminal coronary angioplasty. They consisted of 13 males[age,58.7 + 5.4 years] and 8 females[age, 63.6 + 2.8years] with the mean age of 60.6. History of old myocardial infarction was noted in 24%[5/21] of the patients and congestive heart failure in 2 cases. The angina by type of presentation is unstable in all of the patients. The patterns of involvement of coronary arterial disease were left main disease[1], single vessel disease[5], double vessel involvement[10], and triple vessel involvement[5]. We performed 4 cases of single bypasses, 7 cases of double, 8 cases of triple, and 2 cases of quadruple bypasses. Total of 51 grafts[LIMA:12, RSVG:39] were inserted in 21 cases with average of 2.4 grafts per patient. The methods of myocardial protection were cold blood cardioplegia[8 cases], intermittent aortic occlusion[11], and continuous coronary perfusion with local coronary sharing[2]. There were no operative or late death. The only cardiac complication was 1 case of low cardiac output required IABP. The other complications were 1 case of sternal wound infection and 1 case of postoperative bleeding required reoperation. And there was no case of perioperative myocardial infarction. Postoperatively, 3 cases of recurrent angina were detected at 5, 7, and 18months after surgery. One of them was managed successfully with repeat PTCA[who was recurred 18 months postoperatively], and the other two with medication. I conclude that we can approach the patients more aggressively with PTCA, because of our acceptable operative risks.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.158-158
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• 2018

Drought is a recurrent natural hazard in Bangladesh. It has significant impacts on agriculture, environment, and society. Well-timed information on the onset, extent, intensity, duration, and impacts of drought can mitigate the potential drought-related losses. Thus, drought characteristics need to be explained in terms of frequency, severity, and duration. This paper aims to characterize the spatial and temporal pattern of meteorological drought using EDI and illustrated drought severity over Bangladesh. Twenty-seven (27) station-based daily rainfall data for the study period of 1981-2015 were used to calculate the EDI values over Bangladesh. The evaluation of EDI is conducted for 4 sub-regions over the country to confirm the historical drought record-developed at the regional scale. The finding shows that on average, the frequency of severe to extreme drought is approximately 0.7 events per year. As a result of the regional analysis, most of the recorded historical drought events were successfully detected during the study period. Additionally, the seasonal analysis showed that the extreme droughts were frequently hit in northwestern, middle portion of the eastern and small portion of central parts of Bangladesh during the Kharif(wet) and Rabi(dry) seasons. The severe drought was affected recurrently in the central and northern regions of the country during all cropping seasons. The study also points out that the northern, south-western and central regions in Bangladesh are comparatively vulnerable to both extreme and severe drought event. The study showed that EDI would be a useful tool to identify the drought-prone area and time and potentially applicable to the climate change-induced drought evolution monitoring at regional to the national level in Bangladesh. The outcome of the present study can be used in taking anticipatory strategies to mitigate the drought damages on agricultural production as well as human sufferings in drought-prone areas of Bangladesh.

• The Korean Journal of Physiology and Pharmacology
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• 제23권4호
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• pp.281-289
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• 2019

Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and VEGFR-3 was significantly upregulated in the human brains affected with temporal lobe epilepsy. Moreover, pharmacologic inhibition of VEGF receptors after acute seizures could suppress the generation of spontaneous recurrent seizures, suggesting a critical role of VEGF-related signaling in epilepsy. Therefore, in the present study, the spatiotemporal expression of VEGF-C and VEGFR-3 against pilocarpine-induced status epilepticus (SE) was investigated in C57BL/6N mice using immunohistochemistry. At 1 day after SE, hippocampal astrocytes and microglia were activated. Pyramidal neuronal death was observed at 4 days after SE. In the subpyramidal zone, VEGF-C expression gradually increased and peaked at 7 days after SE, while VEGFR-3 was significantly upregulated at 4 days after SE and began to decrease at 7 days after SE. Most VEGF-C/VEGFR-3-expressing cells were pyramidal neurons, but VEGF-C was also observed in some astrocytes in sham-manipulated animals. However, at 4 days and 7 days after SE, both VEGFR-3 and VEGF-C immunoreactivities were observed mainly in astrocytes and in some microglia of the stratum radiatum and lacunosum-moleculare of the hippocampus, respectively. These data indicate that VEGF-C and VEGFR-3 can be upregulated in hippocampal astrocytes and microglia after pilocarpine-induced SE, providing basic information about VEGF-C and VEGFR-3 expression patterns following acute seizures.

• 산업경영시스템학회지
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• 제44권2호
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• pp.115-123
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• 2021

A lot of sensor and control signals is generated by an industrial controller and related internet-of-things in discrete manufacturing system. The acquired signals are such records indicating whether several process operations have been correctly conducted or not in the system, therefore they are usually composed of binary numbers. For example, once a certain sensor turns on, the corresponding value is changed from 0 to 1, and it means the process is finished the previous operation and ready to conduct next operation. If an actuator starts to move, the corresponding value is changed from 0 to 1 and it indicates the corresponding operation is been conducting. Because traditional fault detection approaches are generally conducted with analog sensor signals and the signals show stationary during normal operation states, it is not simple to identify whether the manufacturing process works properly via conventional fault detection methods. However, digital control signals collected from a programmable logic controller continuously vary during normal process operation in order to show inherent sequence information which indicates the conducting operation tasks. Therefore, in this research, it is proposed to a recurrent neural network-based fault detection approach for considering sequential patterns in normal states of the manufacturing process. Using the constructed long short-term memory based fault detection, it is possible to predict the next control signals and detect faulty states by compared the predicted and real control signals in real-time. We validated and verified the proposed fault detection methods using digital control signals which are collected from a laser marking process, and the method provide good detection performance only using binary values.

• 인터넷정보학회논문지
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• 제24권6호
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• pp.99-105
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• 2023

4차 산업혁명 시대의 흐름에 발맞춰 형사사법 분야에서는 효율적인 법률서비스 제공을 위해 인공지능을 활용한 리걸테크(Legaltech)에 주목하고 있다. 본 논문은 국내 형사사법 분야의 리걸테크 활용 가능성을 증대시키기 위해 순환신경망(RNN)을 적용할 수 있는 범죄 예측 모델을 제시한다. 이를 위하여 판결문상 기술된 범죄사실에 기반하여 스크립트 분석기법 활용을 통해 범행 과정을 전·중·후 단계로 구분하였다. 또한, 각 시점에 따라 범죄의 수법과 증거 등을 수사 8하원칙이 가지는 문장 구성 요소와 한국어 품사 구성에 기반하여 객체·행위·환경으로 분류하였다. 이 연구에서 도출된 사건 요약 분석 틀은 특정 범죄 수법의 전형적인 패턴을 파악하기에 용이하며 상황적 범죄예방 전략을 수립하는데 기여할 수 있다. 나아가 이 연구의 결과는 향후 후속연구에서의 RNN모델 기반 범죄 상황 예측 데이터 생성 연구에 유용한 참고자료로 활용될 수 있을 것이다.

• 인터넷정보학회논문지
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• 제25권2호
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• pp.49-55
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• 2024

본 논문은 물고기 양식 전문가의 먹이 배급을 모방하는 신경망 모델인 PredFeed Net을 제안한다. PredFeed Net은 기존의 먹이 배급 자동화 시스템과 달리, 전문가의 먹이 배급 패턴을 학습하는 방식으로 먹이 배급량을 예측한다. 이는 실제 수조에서 환경에 따른 먹이 배급 변수를 바꾸며 실험할 필요 없이, 기존의 환경 데이터와 먹이 배급 전문가의 먹이 배급 기록만으로 학습이 가능하다는 이점이 있다. 학습이 완료된 PredFeed Net은 현재 환경이나 어류의 상태를 통해 다음 먹이 배급량을 예측한다. 먹이 배급량 예측은 먹이 배급 자동화에 필요한 요소이며, 먹이 배급 자동화는 스마트 양식업이나 아쿠아포닉스 시스템 같은 최신 양식어업에 발전에 기여한다.

• 스마트미디어저널
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• 제12권11호
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• pp.18-26
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• 2023

빌딩에너지관리시스템(BEMS: Building Energy Management System)은 생산 및 소비되는 에너지를 효율적으로 관리하는 시스템이다. 그러나 건물 내 전력소비는 물리적인 특성상으로 인해 생산 및 소비가 일정하지 않아 안정적인 전력 공급이 필수적이다. 이에 따라 건물의 안정적인 전력 공급을 위해서는 정확한 건물 내 전력 소비 예측이 중요하다. 최근에는 시계열분석, 통계분석, 인공지능 등 다양한 방법을 이용하여 전력소비예측에 관한 연구가 진행되고 있다. 본 논문은 Prophet 모델의 장점과 단점을 분석하여 장점인 growth, seasonality, holidays를 선택하였고, Prophet 모델의 단점인 데이터의 복잡성과 외부변수(기후 데이터)의 제한성을 해결하기 위하여 GRU을 조합하여 단기(2일) 및 중기(7일, 15일, 30일) 전력소비량 예측 알고리즘을 제안한다. 실험결과, 제안한 방법은 기존 GRU 및 Prophet 모델보다 성능이 우수하였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제2권1호
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• pp.21-29
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• 1999

목 적: 학동기 소아들의 반복성 복통의 발생빈도, 임상증상, 의료기관 이용양상, 선택기준 및 관련된 요인을 조사하여 반복성 복통 환아의 특징, 증상의 발현 및 유지에 영향을 줄 수 있는 요인을 알아보고, 반복성 복통 환아의 의료기관 이용양상과 문제점을 파악하여 향후 치료를 위한 기초 자료를 제공하고자 실시하였다. 방 법: 1998년 6월 광주시내 초등학교 학부모 1417명을 대상으로 반복성 복통의 발생빈도, 임상증상, 의료기관 이용양상을 알아보기 위하여 설문조사를 실시하였다. 결 과: 1) 총응답자는 1417명, 남자 715명, 여자 702명이었고, 남녀비 1.02:1 평균나이는 10.3세였다. 2) 반복성 복통증의 발생 빈도는 18.9%이었다. 남자는 18.4%, 여자는 19.2%였다. 복통의 지속시간은 10분 이내가 68.5%였다. 3) 정확한 진단을 받지 못한 경우가 62.5%였고, 66.3%가 치료를 받았고, 67.5%가 치료시 증상 호전을 보였다. 민간요법을 실시한 경우도 66%를 차지하였다. 4) 치료 의료기관은 소아과 35.2%로 많았으나, 약국 및 내과의 이용률도 30%정도를 차지하였다. 연령이 증가함에 따라 소아과 이용률이 감소하고 내과의 이용율이증가하였다. 의료기관의 선택기준은 거리의 근접성이 36.3%로 가장 많았고, 의료인의 친절도, 치료의 질 순이었다. 5) 동반증상은 55.5%에서 있었고, 두통이 30.9%로 가장 많았고, 흉통, 현기증, 구토 순이었고, 동반 증상이 없는 경우도 44.5%였다. 6) 반복성 복통의 발생시기는 하루 중 식후가 35.3%로 가장 많았고, 식사전, 수업중 순이었다. 주내 변동은 월요일이 21.4%로 가장 많았으며, 점차 감소하여 토요일이 가장 낮았다. 7) 복통의 발생부위는 배꼽주위가 38%로 가장 많았고, 심와부 등 중앙부에 위치하였으며, 통증의 성격은 작열통이 36.9%로 가장 많았다. 결 론: 반복성 복통 환아는 대부분 정확한 진단을 받지 못하고, 전문적인 치료없이 대증적인 치료 및 민간요법이 많이 시행되고 있었다. 연령이 증가함에 따라 소아과 이외의 타과의 이용률이 증가하였다. 반복성 복통에 대한 올바른 이해와 함께 정확한 진단 및 전문적인 의료기관의 선택이 필요하고 이에 대한 홍보 및 대응책이 필요하다.