• 한국임상수의학회지
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• 제20권3호
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• pp.357-363
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• 2003

These studies were carried out to develop non-contact thermometer to take easily the body temperature of domestic animals instead of taking rectal temperature. For the studies, 86 cattle, 57 horses, 72 pigs, 43 goats, and 42 dogs were used and body parts as neck, flank, axilla, lateral abdomen, gluteus, inguinal region, or jugular groove were chosen for taking temperature according to different species. Two types of commercial non-contact thermometers were used to take the temperature of certain body part and at the same time the rectal temperature using digital thermo-meter was taken to compare the difference of temperature between rectum and certain body part. The difference of mean temperature in cattle between rectum and axilla and flank were 0.52 and $2.41^{\circ}C$, respectively, using non-contact thermometer I, whereas $3.02^{\circ}C$ between rectum and flank using thermometer II. The difference of mean temperature in horses between rectum and axilla, gluteus, and jugular groove were 0.52, 1.49, and $0.26^{\circ}C$, respectively, using thermometer I, whereas 2.28 ane $0.92^{\circ}C$ between rectum and gluteus or jugular groove using thermometer II. The difference of mean temperature in swine between rectum and flank, inguinal region, and neck were 1.23, 0.21, and $0.8^{\circ}C$, respectively, using thermometer I, whereas 1.42, 0.711, and $1.25^{\circ}C$ using thermometer II The difference of mean temperature in goats between rectum and lateral abdomen and inguinal region were 1.02 and $0.12^{\circ}C$, respectively, using thermometer I, whereas 1.96 and $1.01^{\circ}C$ using thermometer II. The difference of mean temperature in dogs between rectum and lateral abdomen, inguinal region, and neck were 3.26, 0.24, and $2.37^{\circ}C$, respectively, using thermometer I, whereas 3.45, 0.56, and $2.61^{\circ}C$ using thermometer II.

• 한국임상수의학회지
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• 제19권1호
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• pp.28-36
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• 2002

These studies were carried out to develop some easy-checking thermometers instead of taking temperature of ectum for the farmers to detect easily a diseased animal with fever. Thermometers such as pincher-type, hood-type, raser-type, stick-type, and wrap-type were devised for the experiments. The experimental animals were cattle, horse, swine, aprine, and canine. Temperature-taking parts of the body were ear, shoulder, axilla, gluteal part, and coccygeal part according o the devised thermometer. Rectal temperature was taken at the same time for the comparison of temperature between rectum nd the certain part. The difference of temperature between rectum and shoulder part using eraser-type thermometer for the domestic animals were $3.37^{\circ}C$ for cattle, $1.94^{\circ}C$ for horses, $2.04^{\circ}C$ for swine, $1.27^{\circ}C$ for caprine, $0.9^{\circ}C$ for canine. The difference of temperature between rectum and gluteal part using eraser-type thermometer for domestic animals were $3.46^{\circ}C$ for cattle, $1.98^{\circ}C$ for horses, $2.22^{\circ}C$ for swine, and $1.1^{\circ}C$ for canine. The difference of intra-individual temperature taken by eraser-type thermometer of shoulder and gluteal part were 0.3 and $0.8^{\circ}C$ for cattle, 0.7 and $1.1^{\circ}C$ for horses, 0.6 and $0.7^{\circ}C$ for swine, 0.9 and $1.1^{\circ}C$ for canine. The difference of temperature between rectum and shoulder part taken by hood-type thermometer for cattle was $3.93^{\circ}C$ and the difference of intra-individual temperature was $0.8^{\circ}C$. The difference of temperature between rectum and gluteal part taken by stick-type thermometer for cattle was $3.7^{\circ}C$ and the difference of intra-individual temperature was $0.8^{\circ}C$. The other types of thermometers than the above three were not proved to be reliable to detect temperature of domestic animals. It was concluded that hood-type, stick-type and eraser-type thermometers are recommendable devices of thermometer to detect easily the status of body temperature and that the eraser-type was proved to be a practical one of the thermometers used in this study.

• 한국식품영양학회지
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• 제26권3호
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• pp.339-344
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• 2013

신선한 암퇘지 막창부위의 지방을 제거하고, 분쇄기로 잘게 파쇄하여 가열하지 않은 것과 $100^{\circ}C$의 autoclave에서 10분간 가열한 것으로 나누어 polyethylene film으로 1차 포장한 후 알루미늄 호일로 2차 포장한 다음, 각각 $1^{\circ}C$, $5^{\circ}C$ 및 $10^{\circ}C$에서 보관하면서 품질 변화를 관찰하였다. 저장 온도를 달리한 파쇄막창의 pH는 6.5~7.0의 범위를 나타내었으며 생막창에 비해 가열막창에서 다소 높게 나타났다. 저장 중 TBA가는 가열막창이 생막창보다 높은 값을 나타내었으며, $10^{\circ}C$ 저장에서는 4일 이후 급격히 증가하였다. $5^{\circ}C$ 저장에서는 생막창의 경우 8일 이후, 가열막창은 6일 이후에 급격한 상승을 보인 것으로 확인되었다. VBN값을 기준으로 볼 때 생막창의 경우 $10^{\circ}C$에서 저장할 경우 8일, $5^{\circ}C$에서 저장할 경우 12일, $1^{\circ}C$에서 저장할 경우 16일까지는 저장이 가능한 것으로 나타났으며, 가열한 막창의 경우 $10^{\circ}C$에서 8일, $5^{\circ}C$에서 14일, $1^{\circ}C$에서 16일까지 저장이 가능한 것으로 나타났다. 위의 결과를 바탕으로 막창을 $10^{\circ}C$에서 냉장 유통할 경우 6일 이내의 유통기간 설정이 바람직할 것으로 판단된다. 또한, 대장균군의 사멸과 중온균과 호냉성 균의 효율적인 억제를 위해서는 막창을 $100^{\circ}C$에서 20분 동안 가열하는 것이 바람직할 것으로 판단된다.

• Journal of Pharmaceutical Investigation
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• 제34권2호
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• pp.91-94
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• 2004

To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting points of various formulations composed of P 124 and P 188 were investigated. To investigate the effect of poloxamer to the dissolution ad dissolution mechanism of diclofenac sodium from the suppository the dissolution of diclofenac sodium delivered by the poloxamer-based suppository was performed. Furthermore, to investigate the mucoadhesive property of the poloxamer-based sold suppository, the identification test in the rectum was carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous. Ver small amounts of P 188 affected the melting points of poloxamer mixtures. In particular, the poloxamer mixture [P 124/P 188 (97/3%)] with the melting point of about $32^{\circ}C$ was a sold for at room temperature and instantly melted at physiological temperature. Furthermore, very small amounts of P 188 in the poloxamer-based suppository hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. At 4 h after administration, the blue colo of poloxamer-based suppository [diclofenac sodium/poloxamer mixture (2.5/97.5%)] with the P 124/ P 188 ratio of (97/3%) and blue lake in the rectum was faded. However, the position of suppository in the rectum did not significantly change with time. Thus, it retained in thε rectum for at least 4 h. Our results indicated that the poloxamer-based sold suppository with P 124 and P 188 would be a candidate of rectal dosage form for diclofenac sodium.

• Radiation Oncology Journal
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• 제4권2호
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• pp.115-128
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• 1986

온열요법은 암치료에 있어서 방사선과 병용하였을 때 상호보완 작용을 하여 방사선에 저항성이 높은 세포주기의 S-기에 민감하게 작용하며 세포의 준치사손상의 회복을 저지시킴으로써 방사선의 효과를 상승시킬 수 있다. 저자는 100Watt, 2450MHz의 마이크로파 온열기구를 제작하고 조직등가인 판톰을 이용하여 예비측정과 방열조사 조건 및 방법을 계획한 후 생물학적 반응을 관찰하기 위하여 흰쥐 102마리를 이용하여 온열요법, X-선조사 (6Gy-15Gy) 및 선 조사와 온열요법을 병행하여 직장과 방광의 조직학적 소견을 관찰하여 다음과 같은 결론을 얻었다. 1) 100Watt, 2450MHz의 소형마이코로파 온열발생장치로서 조직을 $40{\sim}50^{\circ}C$로 유지하여 1시간 이상 가열할 수 있었다. 2) 조직온열분포는 깊이 3cm, 직명 2-10cm의 넓이에 $40{\sim}44^{\circ}C$의 온도분포를 계속 유지할 수 있었다. 3) 온열요법 단독으로는 직장의 점막하층의 부종을 볼 수 있었으나 방광의 조직학적 변화는 볼 수 없었다. 4) 점막상피괴사는 직장에 X-선조사 6Gy의 15일군에서, 방광에 8Gy의 15일군에서 각각 나타나기 시작하였으며, 근층괴사는 직장에 X-선조사 8Gy의 15일군에서, 방광에 10Gy의 60일군에서 각각 나타났다. 5) X-선조사와 온열요법병행군에서 직장과 방광의 조직학적변화 (점막과 근층의 괴사)를 관찰하여 열증강율은 1.0으로 증가되지 않음으로서 직장과 방광의 내용선량의 변화가 없음을 시사하였다.

• 생명과학회지
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• 제18권2호
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• pp.187-192
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• 2008

본 연구는 수분 및 글리세를 섭취가 renin activity, 직장온도, 혈중 전해질 농도에 미치는 효과에 대하여 알아보기 위해 수분 섭취 그룹과 글리세롤 섭취 그룹으로 나누어 측정한 결과는 다음과 같다. renin activity의 경우, 안정시와 비교하여 운동 후 40분에 수분 섭취 그룹과 글리세를 섭취 그룹에서 유의한 증가를 보였다(p<0.01). Osmolality의 경우, 수분 섭취 그룹에서 차이를 보이지 않았으나, 글리세를 섭취그룹에서는 안정 시와 비교하여 운동 후 40분에 차이를 보였다(p<0.05). 직장온도의 경우, 수분 섭취 그룹과 글리세를 섭취 그룹 모두 운동 시간에 따라 점진적으로 증가하는 것을 볼 수 있었다. Na과 K의 경우, 수분 섭취 그룹에서 차이를 보이지 않았으나 글리세를 섭취 그룹에서 차이를 보였다(p<0.05). Ca과 Mg의 경우, 두 그룹 모두 그룹과 운동시기 간에 유의한 차이를 보이지 않았다.

• Asian-Australasian Journal of Animal Sciences
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• 제12권6호
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• pp.886-890
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• 1999

From previous studies, there is a strong possibility in buffaloes that the marked increase in blood volume (BV) under hot conditions contributes to heat transportation from the rectum to the skin. The present study was done to clarify changes with environmental temperature on water-shift between blood and extracellular fluid (ECF), heat distribution between the rectum and the skin, and blood flow rates (BFR) at the hind legs (reflecting the skin surface). Four buffaloes and four Friesian cows were successively exposed to three different temperatures of $20^{\circ}C$, $30^{\circ}C$ and $35^{\circ}C$. BV and ECF volume were measured with Evans' blue and sodium-thiocyanate dilution methods, respectively. Rectal and subcutaneous (as the skin) temperatures were measured by copper-constantan thermocouples. BFR were measured by a supersonic blood flow meter. With an increase in environmental temperature, skin temperature in buffaloes increased significantly than cows, but rectal temperature was not significantly different between two species. BV, especially plasma compartment, increased significantly in only buffaloes, while ECF volume did not change in both species. BFR increased significantly in buffaloes, but not in cows. From these results, the increased of BV may be caused by water flowing from ECF compartment. The water-shift may induce the increase of BFR and skin temperature. It is suggested in the present study that internal changes of blood compartment in buffaloes contribute to transfer of heat to the skin surface.

• Asian-Australasian Journal of Animal Sciences
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• 제29권6호
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• pp.814-822
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• 2016

This study was conducted to determine and compare the effects of yeast yeast culture (YC) and vitamin E (VE) supplementation on endotoxin absorption and antioxidant status in lactating dairy goats suffering from heat stress (HS). Three first lactation Saanen dairy goats (body weight $30{\pm}1.5kg$) were surgically fitted with indwelling catheters in the portal vein, mesenteric vein and carotid artery, and were randomly assigned to a $3{\times}3$ Latin square design. Dietary treatments were the basal diet, and the basal diet supplemented with either 100 IU VE or 30 g YC. Goats were kept in temperature and humidity-controlled room at $35^{\circ}C$ from 8:00 to 20:00 and at $24^{\circ}C$ from 20:00 till the next morning at 8:00. The relative humidity was kept at 55%. HS increased dairy goats' rectum temperature and respiration frequency (p<0.01). HS reduced plasma flux rate of milk goats (p<0.01), but the plasma flux rate increased when the animal was under the conditions of the thermo-neutral period (p<0.01). The VE supplementation lowered dairy goats' rectum temperature during thermo-neutral period (p<0.01). Meanwhile, no significant differences were observed between the control and YC treatment in rectum temperature and respiration frequency (p>0.05). Dietary supplementation of VE and YC reduced heat stressed dairy goats' endotoxin concentration of the carotid artery and portal vein (p<0.01). However, the endotoxin concentration of the YC treatment was higher than that of the VE treatment (p<0.01). Both VE and YC supplementation decreased heat stressed dairy goats' absorption of endotoxin in portal vein (p<0.01). The endotoxin absorption of YC treatment was higher than the VE treatment (p<0.01). The addition of VE and YC decreased dairy goats' superoxide dismutase (SOD) concentration during HS and the whole experiment period (p<0.01). The addition of VE lowered SOD concentration during thermo-neutral period (p<0.01). Likewise, the addition of VE and YC lowered dairy goats' malonaldehyde (MDA) concentration during HS and the whole experimental period, and the MDA concentration in the VE treatment was lower than the YC treatment (p<0.05). The addition of VE decreased MDA concentration during thermo-neutral period. On the contrast, the addition of VE increased dairy goats total antioxidant potential (TAP) concentration during HS, thermo-neutral and the whole experimental period (p<0.01). The addition of YC increased TAP concentration only during HS period (p<0.01). It is concluded that both VE and YC are useful in alleviating HS of dairy goats by weakening endotoxin absorption and promoting antioxidant capacity. Compared with YC, VE is much more powerful in easing dairy goats HS.

• Journal of Ginseng Research
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• 제41권3호
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• pp.347-352
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• 2017

Background: Panax ginseng (PG) has a long history of use in Asian medicine because of its multiple pharmacological activities. It has been considered that PG in a type of white ginseng may induce undesirable thermogenic effects, but not in a type of red ginseng. However, there is a lack of evidence about the correlation between ginsenoside and thermogenesis. Methods: We investigated the effects of PG with different ginsenoside compositions on body temperature, blood pressure, and thermogenesis-related factors in rats. Results: With increasing steaming time (0 h, 3 h, 6 h, and 9 h), the production of protopanaxadiol ginsenosides increased, whereas protopanaxatriol ginsenosides decreased in white ginseng. In both short- and long-term studies, administration of four ginseng extracts prepared at different steaming times did not induce significant changes in body temperature (skin, tail, and rectum) and blood pressure of rats compared to saline control. In addition, there were no significant differences in the molecular markers related to thermogenesis (p > 0.05), mRNA expressions of peroxisome proliferator-activated receptor-gamma coactivator-$1{\alpha}$ and uncoupling protein 1 in brown adipose tissue, as well as the serum levels of interleukin-6, inducible nitric oxide synthase, and nitrite among the treatment groups. Conclusion: These observations indicate that the potential undesirable effects of PG on body temperature could not be explained by the difference in ginsenoside composition.

• 한국의류산업학회지
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• 제12권6호
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• pp.830-836
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• 2010

The purpose of this research was to investigate the effects of skin pressure by wearing all-in-one on the rhythm of body temperature such as skin and rectal temperature which play a crucial role in the nocturnal rhythm. Five healthy female were participated in the study as subjects. The experimental clothing was an all-in-one, one of the foundation, which is worn for shaping the body. The total experimental periods were 5 days. On the 1st day, subjects did not wear the all-in-one (None), and they wore it for about 12 hours per day from 2nd to 5th day (Wearing1~4). Skin and rectal temperature were measured during the entire experimental days to figure out the rhythm of body temperature during sleep. When subjects wore the all-in-one, the gradients of the forearm and calf skin temperature at the sleep onset were significantly smaller than "None". It indicated that the rise of extremities' skin temperature was low on the "Wearing1~4". The decline of rectal temperature in "Wearing 1~4" was smaller than "None". Therefore, the skin pressure by all-in-one may cause the temperature of extremities' skin and rectum to change, resulting the fluctuation of the circadian rhythm, finally it could have effects on the rhythm of sleep.