• BMB Reports
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• 제56권3호
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• pp.178-183
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• 2023

Huntington's disease (HD) is a neurodegenerative disorder, of which pathogenesis is caused by a polyglutamine expansion in the amino-terminus of huntingtin gene that resulted in the aggregation of mutant HTT proteins. HD is characterized by progressive motor dysfunction, cognitive impairment and neuropsychiatric disturbances. Histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase, has been shown to induce transport- and release-defect phenotypes in HD models, whilst treatment with HDAC6 inhibitors ameliorates the phenotypic effects of HD by increasing the levels of α-tubulin acetylation, as well as decreasing the accumulation of mutant huntingtin (mHTT) aggregates, suggesting HDAC6 inhibitor as a HD therapeutics. In this study, we employed in vitro neural stem cell (NSC) model and in vivo YAC128 transgenic (TG) mouse model of HD to test the effect of a novel HDAC6 selective inhibitor, CKD-504, developed by Chong Kun Dang (CKD Pharmaceutical Corp., Korea). We found that treatment of CKD-504 increased tubulin acetylation, microtubule stabilization, axonal transport, and the decrease of mutant huntingtin protein in vitro. From in vivo study, we observed CKD-504 improved the pathology of Huntington's disease: alleviated behavioral deficits, increased axonal transport and number of neurons, restored synaptic function in corticostriatal (CS) circuit, reduced mHTT accumulation, inflammation and tau hyperphosphorylation in YAC128 TG mouse model. These novel results highlight CKD-504 as a potential therapeutic strategy in HD.

• Journal of Radiation Protection and Research
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• 제48권2호
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• pp.68-76
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• 2023

Background: In the process of discussion on the possibility of using radionuclide-contaminated soil and debris generated by radiation disasters, a strategy for the proper management of radiation exposure protection while considering the source of the contaminated materials is necessary. Materials and Methods: The radiological protection criteria that are likely to be applied to the source-related approach based on the International Commission on Radiological Protection recommendations and the International Atomic Energy Agency safety standards are summarized. We proposed five interpretations of radiation protection to contribute to the promotion of discussion on the possibility of using a part of low-level-radionuclide-contaminated soil and debris in the post-accident rehabilitation. Interpretations I to III are based on the idea of "using a reference level to protect the public in post-accident rehabilitation," whereas IV and V are based on the idea of "using the dose constraint to protect the public in the post-accident rehabilitation when the sources are handled in a planned activity." The former idea is subdivided into three based on the definition of the source, which is managed by the reference level, and the latter idea is divided into two depending on whether or not additional dose from using contaminated materials is deemed acceptable. Results and Discussion: To confirm the applicability of the five interpretations presented, we suggested the concrete values of protection criteria via two feasible cases. In this case study, we proposed radiation protection by the dose constraint based on the Interpretation IV and chose 1 mSv/yr for the public and 20 mSv/yr for workers dealing with radionuclide-contaminated materials. Conclusion: We concretely and systematically demonstrated how the concept of radiation protection can be applied to the process of discussion on the possibility of using radionuclide-contaminated materials within the framework of an international system of protection. This study's findings can provide necessary information to discuss the possibility of using radionuclide-contaminated materials as an alternative option for recovery and reconstruction after a radiation disaster from the viewpoint of radiation protection.

• 대한물리치료과학회지
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• 제30권4호
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• pp.29-43
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• 2023

Background: In the rehabilitation of stroke patients, regular physical activity is very important not only as a treatment for maximal functional recovery but also as a strategy to prevent the recurrence of stroke. The purpose of this study was to objectively measure the amount of physical activity in people with stroke, and to examine the differences in motor and cognitive function according to a level of physical activity. Design: A cross-sectional study. Methods: Physical activity (GENEActiv), motor function (Fugl-Meyer Assessment), cognitive function (Montreal Cognitive Assessment-Korean version), and the Korean version of Modified Barthel Index were evaluated in adult stroke patients with hemiplegia. Results: There was no statistically significant difference in the level of physical activity according to the motor and cognitive function. There was no statistically significant difference in motor and cognitive function according to the level of physical activity, but there was a statistically significant difference in the MBI (p<.01). Conclusion: As a result of the difference in the MBI according to the level of physical activity, it was found that the more moderate to vigorous physical activities are performed, the higher the independence in daily living. These results can be interpreted as that the more often you participate in physical activities such as physical therapy (gait training), the better your independence in ADL. Since regular physical activity participation of adult stroke patients can improve daily living performance, it is considered necessary to participate in physical activities such as continuous physical therapy.

• 융합보안논문지
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• 제23권5호
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• pp.21-27
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• 2023

클라우드 컴퓨팅 환경에서 서버나 애플리케이션들이 수 분 사이에 구축되고 장애 발생 시 복구 또한 쉬워졌다. 특히, 잠시 서비스하기 위해서 물리적인 서버를 구축하는 것 보다 클라우드에서 가상 서버를 이용하면 편리함과 동시에 비용도 저렴하다. 하지만 그러한 서버나 애플리케이션들의 기반이 되는 네트워크나 보안시스템은 대부분 하드웨어 기반으로 구성되어 있어 클라우드 가상화 적용에 어려움이 많다. 클라우드 내에서도 네트워크나 보안설비 등에 대한 가상화를 통한 보호가 필요하게 되었다. 본 논문은 네트워크 가상화 기술을 활용하여 클라우드 네트워크의 보안을 강화하는 방법에 대한 연구를 다루고 있다. 가상 서버 및 가상 네트워크를 생성해 다양한 보안 이점을 제공하는 가상화 기술을 활용해 링크 가상화와 라우터 가상화를 적용하여 보안이 강화된 네트워크를 구성하였다. 구성된 네트워크에 가상 방화벽 기능을 적용해 네트워크를 격리할 수 있었으며, 이 결과를 토대로 가상화 환경에서 보안 취약점을 극복하고 안전한 네트워크 구성을 위한 관리 전략을 제안하는데 기여할 것으로 기대된다.

• 한국전문물리치료학회지
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• 제31권2호
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• pp.142-150
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• 2024

Background: Scapular dyskinesis (SD) is closely related to imbalance of the rotator cuff (RC) muscles. However, previous studies have only focused on isometric strength. To our knowledge, there has been no study examining potential differences in concentric and eccentric strength and functional strength ratio (FSR) of the RC muscles based on functional parameters related to throwing in with or without SD. Objects: This study aimed to determine whether there was a difference in the RC muscle strength and FSR between the dominant shoulder with SD and the non-dominant shoulder without SD in adolescent baseball players. Methods: Forty adolescent baseball players participated and classified types of SD based on movement patterns using the SD test by two examiners. The isokinetic concentric and eccentric peak torque of the internal rotation (IR) and external rotation (ER) were measured and quantified as peak torque to body weight (PT/BW). Also, the FSR was obtained by calculating the strength ratios of eccentric IR to concentric ER (IRecc/ERcon) and eccentric ER to concentric IR (ERecc/IRcon), respectively. Results: There was a significant decrease in the IR and ER PT/BW in the dominant shoulder with SD compared to the non-dominant shoulder without SD (p < 0.05), regardless of contraction types. However, no significant difference was observed in the FSR in both IRecc/ERcon and ERecc/IRcon ratios. Conclusion: The findings indicate that the isokinetic concentric and eccentric PT/BW of the IR and ER muscles were significantly lower in the dominant shoulder with SD than in the nonthrowing shoulder without SD. Therefore, when establishing a strategy for addressing RC muscle weakness in adolescent baseball players with SD, it is essential to consider an approach that accounts for scapular kinematic recovery.

• 대한간호학회지
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• 제30권5호
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• pp.1279-1291
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• 2000

The main objectives of this study were to analyze the concept of hope, so to provide basic data to develop a valid instrument to measure hope, and to develop hope enhancing nursing intervention a program for cancer patients. The hybrid model approach was applied in three phases, the theoretical phase, the empirical phase, and the analytic phase. The study was developed on universal attributes explaining generalized hope and specific hope, which were revealed in a comprehensive review of the literature. In the empirical phase, eight cancer patients undergoing chemotherapy were interviewed to reveal causes, motivation, and their resource of hope according to The Hope Assessment Guide (Farren, Herth, & Popovich, 1995). In the analytical phase, the results of the two previous stages of the study were compared. The results were as follows : In the theoretical phase, six dimensions of hope emerged; affective, cognitive, behavioral, affiliative, temporal and contextual dimension. The antecedent of hope was loss, crisis, uncertainity, and stress. The consequences were renewal, development of new methods, safety, peace and transcendental competence. In the empirical phase, these six dimensions emerged as theoretical phases were verified and specified as these descriptive terms: feeling, intention, expectation, activity, relation, future- orientation, reality and goal-setting. The antecedent factor of hope was occurrence or recurrence of cancer. The consequence of hope was ability to cope with real condition, feeling of safety and comfort, peace, development of new strategy and recovery of disease. The major content of hope in this phase was related to specific hope, but it was also influenced on by general hope. In the analytic phase, general and specific hope was renamed as trait and state hope. All attributes emerged at the empirical phases, and also emerged at the theoretical phase. However, cognitive and contextual dimensions were revised and specified. In conclusion, the concept of hope is divided into trait hope and state hope, and state hope is an anticipatory expectation that occurs at the time of a stressful stimulus, such as being diagnosed with cancer. Hope is a multidimensional dynamic energized mental state which has the dimensions of affective, cognitive, behavioral, affiliative, temporal and contextual. There should be further studies to develope the state and trait hope scale according to definition and attributes of hope investigated in this study. In addition, considering results of the empirical phase, the family is very a important factor as a resource of hope, so it is necessary to consider family in implementing a nursing intervention program to enhance hope.

• 한국어류학회지
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• 제27권2호
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• pp.86-94
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• 2015

멸종위기어류 여울마자의 생물학적 특성 및 복원을 위한 기초자료를 확보하기 위해 2013년 남강에서 채집하여 난 발생과정과 초기생활사를 연구하였다. 성숙란은 암컷에 Ovaprim을 주사 (0.5 mL/kg)하여 얻었으며 건식법으로 인공 수정시켰다. 성숙란은 약한 점착성을 가지며 밝은 청록색을 띤 분리침 성란이었으며, 난경은 $0.63{\pm}0.02mm$ (n=20), 포란수 (n=5)는 평균 $3,827{\pm}1,225$ (2,850~5,916)개였다. 수온은 $21{\pm}1^{\circ}C$에서 72시간 뒤에 부화하였으며, 부화 직후 전기 자어 크기는 전장 $2.79{\pm}0.04mm$ (n=10)였다. 부화 후 5일에는 전장 $4.10{\pm}0.07mm$ (n=10)로 난황을 모두 흡수하여 후기자어로 이행하였고 부화 30일째에는 전장 $9.74{\pm}0.24mm$ (n=10)로 모든 지느러미의 기조가 정수가 되어 치어기로 이행하였다. 부화 후 100일 후에는 전장 $27.00{\pm}1.94mm$ (n=10)로 체측반문과 외부형태가 성어와 유사한 모습을 보였다.

• 벤처창업연구
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• 제14권6호
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• pp.11-27
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• 2019

최근 국내 창업지원 정책은 스타트업 중심에서, 스케일업 중심으로 전환기를 맞고 있다. 제2벤처 '붐' 확산 전략(2019.3.6.)은 신규 벤처 투자 연 5조원 달성, 유니콘 기업 20개 창출, M&A 활성화와 역동적 회수 시장 조성을 발표하는 등 국내 스케일업 정책이 투자/금융 등 자금지원에만 집중되어 있는 것으로 확인되고 있다. 물론, 기업 성장을 위해서는 자금지원이 정책적으로 매우 중요한 것은 기존 연구를 통해 확인되고 있으나, 스케일업을 효과적으로 달성하기 위해서는 다양한 정책적 지원이 필요할 것으로 보인다. 이러한 한계를 극복하고자 본 연구는 미국, 영국 등 이미 스케일업 정책을 도입하여 운영 중인, 해외 선진국의 스케일업 지원정책을 문헌 등 자료를 분석하고, 이를 바탕으로 국내 스케일업 정책을 분석하여 효과적인 스케일업 정책을 수립할 수 있도록 시사점을 도출하고자 한다. 이를 통해 국정목표인 일자리 창출과 국가경제 성장에 효과적으로 기여할 수 있는 스케일업 지원 정책 수립에 시사점을 제공할 것으로 기대한다. 또한, 학술적으로는 국내외 스케일업에 대한 연구가 매우 부족한 실정으로, 이번 정책사례 비교연구를 통해서 시사점을 제안하여 향후 스케일업 관련 연구주제의 확장성 측면과 관련된 다양한 연구가 활성화 되는데 기여하고자 한다. 본 연구에서는 글로벌 정책사례로는 미국은 'ScaleUp America Initiative', EU는 'the Start-up and Scale-up Initiative' 정책, 영국은 'Scale Up Institute', 독일은 'German Accelerator', 프랑스는 '프렌치 테크(La French Tech)' 정책, 중국은 중관촌 등 스타트업의 핵심거점의 정책을 중심으로 문헌 등 자료조사를 통해 본 연구를 진행하였다.

• Journal of Korean Neurosurgical Society
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• 제29권8호
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• pp.1126-1135
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• 2000

Objectives : The goal of surgical management of cerebral arteriovenous malformation(AVM) is elimination of the lesion without development of new neurological deficits. To improve the management results of cerebral AVMs in the future, this article discusses about surgical complications of the AVM and their management. Material and Methods : During the past 18 years, 116 patients with cerebral AVMs were managed by surgery. Among these cases, 7 cases died, 7 cases developed new neurological deficits, 11 cases residual AVM and 5 cases intracerebral hematoma(ICH) after surgery. The author analyzes the causes of those complications and investigates the methods to minimized those complications based on the review of the literatures. Results : One stage removal of AVM and ICH in the poor neurological state were performed in 5 of 7 death cases. Subtotal removal of ICH followed by delayed AVM surgery after recovery is regard as one method to improve the outcome of patient with large ICH. Postoperative new neurological deficits developed owing to normal perfusion pressure breakthrough(NPPB) in 3, judgement error in 2, preoperative embolization in 1 and cortical injury in 1 case(s). Proper management of NPPB, accurate anatomical knowledge and physiological monitoring during operation, and well trained skill for embolization are regard as methods to minimize those complications. Residual AVMs after surgery were noticed in 11 cases, in which unintended 6 cases due to inaccurate dissection of peripheral margin of AVM, and intended 3 cases due to massive brain swelling during operation, 1 cases due to diffuse type and 1 case due to multiple type of AVM. Accurate dissection of peripheral margin of AVM and mild hypotension during operation may help to avoid this complication. Postoperative hemorrhage occurred in 3 cases due to rupture of the residual AVM and in 2 cases due to oozing from the AVM bed. Complete resection of AVM, complete control of bleeding points at AVM bed and mild hypotension during early postoperative period are the methods to avoid this complication. Conclusion : A precise but flexible therapeutic strategy and refined skill for endovascular, radiosurgical and microsurgical techniques are required to successful treatment of cerebral AVM. Adequate timing of AVM resection, accurate anatomical knowledge, proper management of NPPB and accurate dissection of peripheral margin of AVM are the key points for avoiding complications of the AVM surgery.

• 한국콘텐츠학회논문지
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• 제18권2호
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• pp.158-168
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• 2018

본 연구는 가정폭력 피해여성을 대상으로, 춤을 통한 치유적 신체표현 프로그램을 적용하여, 이들의 외상후 성장에 미치는 효과를 검증하였다. 본 연구의 대상은 서울지역의 가정폭력 피해여성을 위한 쉼터(7개 시설)에 거주하는 가정폭력 피해여성으로서, 실험집단 23명, 통제집단 23명으로 구성하였다. 실험집단에게 적용한 춤 치유 신체표현 프로그램은 총 18회기로 구성하였고, 주 3회, 6주에 걸쳐 진행되며, 각 회기는 90분 동안 실시하도록 하였다. 본 연구의 춤 치유 신체표현 프로그램은 신체표현과 동작 경험을 중심으로 한 춤을 기반으로 삼되, 내면의 표출을 위한 즉흥적 비형식적이고 창조적인 표현에 초점을 두고 있다. 이에 다수의 춤 치유 및 무용치료 선행연구들의 활동과 원리를 참조하고, 가정폭력과 외상 관련 심리 상담 선행연구에서의 상담기법 및 상호작용, 치유적 원리의 특성을 회기 구조 단계마다 적용하였다. 연구 결과, 춤 치유 신체표현 프로그램은 실험집단의 외상 후 성장 전체 및 하위차원인 대인관계깊이, 자기지각, 가능성발견, 영적관심 차원에 향상 효과가 있는 것으로 나타났으며, 실험집단과 통제집단의 사후점수 및 향상정도에서 유의한 차이가 나타났다. 결국 본 연구는 춤의 근원적이고 치유적인 속성을 이해하고, 사회적 차원에서 가정폭력 피해여성과 같이 심리적 고통을 경험하는 대상들에게 스스로 회복할 수 있는 기회를 제공하는 선순환적 치유방식 및 춤의 활용성에 관한 기초자료를 제공하였다는데 의의가 있다.