• Journal of Ginseng Research
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• 제34권4호
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• pp.336-341
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• 2010

One mechanism of inner ear damage by noise-induced hearing loss (NIHL) is the production of reactive oxygen species (ROS). Because Korean red ginseng (KRG) has an anti-ROS effect in various tissues, KRG may have a role in preventing NIHL. A window period exists in which ROS formations continue after noise exposure, and further damage can be prevented by antioxidants. In this study, we aimed to investigate the effects of KRG after exposure to noise. KRG (200 mg/kg) was fed to mice for 3 days after noise exposure. The change in hearing level was analyzed by measuring the auditory brainstem response. To induce a temporary threshold shift (TTS) of hearing, mice were exposed to 110 dB white noise for 3 hours. Fast recovery of hearing was observed in mice fed KRG 1 hour and 1 day after noise exposure for 3 days. The expression of 8-oxoguanine was not observed in the inner ears of mice fed KRG 1 hour after noise exposure, but was evident in the stria vascularis of mice in the control group (noise exposure only). From this study, we conclude that KRG acted as an effective inhibitor of NIHL in TTS cases.

• Journal of Audiology & Otology
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• 제23권1호
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• pp.33-38
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• 2019

Background and Objectives: Determination of the lesion side based on the direction of the nystagmus could result in confusions to the clinicians due to mismatch between the vestibular function tests and also between vestibular and audiologic features. To minimize these mistakes, we elucidated the clinical manifestation and vestibular function test results in cases with recovery spontaneous nystagmus (rSN). Subjects and Methods: Patients who visited ENT clinic of tertiary referral hospital for acute onset continuous vertigo from January 2008 to December 2011 were enrolled. In these patients, we assessed onset time of vertigo, time point of paralytic spontaneous nystagmus (SN) and time point of rSN. At each time point of SN, vestibular function tests and hearing function tests were performed. Results: We confirmed the rSN among patients with unilateral vestibulopathy and demonstrated that high gain of the rotatory chair test (slow harmonic acceleration) and/or mismatch of the SN direction and contralateral caloric weakness could indicate the recovery state of patients and nystagmus observed in this stage is recovery phase nystagmus. Conclusions: In acute vestibulopathy patients, recovery phase nystagmus was observed and on this stage of disease vestibular function tests shows several features that could predict recovery state.

• 대한청각학회지
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• 제23권1호
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• pp.33-38
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• 2019

Background and Objectives: Determination of the lesion side based on the direction of the nystagmus could result in confusions to the clinicians due to mismatch between the vestibular function tests and also between vestibular and audiologic features. To minimize these mistakes, we elucidated the clinical manifestation and vestibular function test results in cases with recovery spontaneous nystagmus (rSN). Subjects and Methods: Patients who visited ENT clinic of tertiary referral hospital for acute onset continuous vertigo from January 2008 to December 2011 were enrolled. In these patients, we assessed onset time of vertigo, time point of paralytic spontaneous nystagmus (SN) and time point of rSN. At each time point of SN, vestibular function tests and hearing function tests were performed. Results: We confirmed the rSN among patients with unilateral vestibulopathy and demonstrated that high gain of the rotatory chair test (slow harmonic acceleration) and/or mismatch of the SN direction and contralateral caloric weakness could indicate the recovery state of patients and nystagmus observed in this stage is recovery phase nystagmus. Conclusions: In acute vestibulopathy patients, recovery phase nystagmus was observed and on this stage of disease vestibular function tests shows several features that could predict recovery state.

• Journal of Ginseng Research
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• 제33권2호
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• pp.104-110
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• 2009

고려 홍삼이 소음성 난청에서 청력 보호 및 회복에 관여하는 지를 밝히기 위하여 마우스에서 홍삼을 투여 후 소음에 노출시켜 청력 역치의 변화 및 와우의 활성 산소 유리기에 대한 노출 정도를 보았다. 영구적 청력 역치 이동의 경우에 홍삼은 청력 보호 및 회복에 관여하지 못했다. 하지만 일과성 청력 역치 이동의 경우에는 홍삼이 어느 정도의 농도 이상으로 투여 된다면 청력 회복에 효과적으로 작용하는 것으로 밝혀졌다. 향후 홍삼의 난청 억제 효과에 대해 적정 농도 및 투여 방법 등에 대한 후속연구가 뒤따라야 하겠고 인간에서 발생하는 소음성 난청에의 적합성 판정을 위해 보다 장깆거인 소음 노출 기간과 장기적인 홍삼 복용에 대한 연구가 필요하겠다. 또한 홍삼내의 여러 활성물질에 관한 연구를 통하여 보다 효과적인 화합물을 찾기 위한 노력도 동반되어야 할 것이다.

• Journal of Audiology & Otology
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• 제23권2호
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• pp.96-102
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• 2019

Background and Objectives: Temporal bone fracture (TBF) is a common occurrence in cases of head trauma. Although the incidence of temporal bone concussion (TBC) has increased in cases of head trauma, it has not been extensively studied. We assessed the characteristics of TBF and TBC in patients with head trauma. Subjects and Methods: We conducted a retrospective review of 432 patients with head injury who visited our hospital between January 2011 and April 2016. Of these patients, 211 who met the inclusion criteria were included in the study. Their clinical characteristics, causes of injury, and hearing function were analyzed. Results: Among the 211 patients, 157 had TBFs and 54 had TBCs. Ear symptoms were more common among patients with TBF than among those with TBC. Car accidents were the most common cause of both TBF and TBC, but assault and sports injuries were more common among patients with TBC than among those with TBF. The occurrence of facial palsy in both cases of TBF and TBC. Hearing loss was observed among 35 patients with TBF and 11 patients with TBC. However, patients with TBF showed conductive hearing loss with an air-bone gap. Hearing function of these patients with TBF recovered with a reduced air-bone gap, but the patients with TBC showed little recovery. Conclusions: Emergency physicians should focus more on temporal bone injury in patients with head trauma. Therefore, an early complete diagnostic battery, which includes high-resolution computed tomography, audiometric tests, neurologic examination, and vestibular tests, be performed in patients with head trauma.

• 대한청각학회지
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• 제23권2호
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• pp.96-102
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• 2019

Background and Objectives: Temporal bone fracture (TBF) is a common occurrence in cases of head trauma. Although the incidence of temporal bone concussion (TBC) has increased in cases of head trauma, it has not been extensively studied. We assessed the characteristics of TBF and TBC in patients with head trauma. Subjects and Methods: We conducted a retrospective review of 432 patients with head injury who visited our hospital between January 2011 and April 2016. Of these patients, 211 who met the inclusion criteria were included in the study. Their clinical characteristics, causes of injury, and hearing function were analyzed. Results: Among the 211 patients, 157 had TBFs and 54 had TBCs. Ear symptoms were more common among patients with TBF than among those with TBC. Car accidents were the most common cause of both TBF and TBC, but assault and sports injuries were more common among patients with TBC than among those with TBF. The occurrence of facial palsy in both cases of TBF and TBC. Hearing loss was observed among 35 patients with TBF and 11 patients with TBC. However, patients with TBF showed conductive hearing loss with an air-bone gap. Hearing function of these patients with TBF recovered with a reduced air-bone gap, but the patients with TBC showed little recovery. Conclusions: Emergency physicians should focus more on temporal bone injury in patients with head trauma. Therefore, an early complete diagnostic battery, which includes high-resolution computed tomography, audiometric tests, neurologic examination, and vestibular tests, be performed in patients with head trauma.

• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.539-548
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• 2007

In the paper, a wireless charger with the function of auto-shutdown for fully implantale middle ear hearing devices (F-IMEHD) has been designed. The wireless charger can communicate with an implant module to be turned off automatically shutdown after an internal rechargeable battery has been fully-charged by electromagnetic coupling using two coils. For the communication with an implant module, the wireless charger uses the load shift keying (LSK) method. But, the variation of the mutual inductance due to the different distance between two coils can cause the communication error in receiving the fully-charged signal from an implant module. To solve the problem, the implemented wireless charger has a variable reference generator for LSK communication. The wireless charger generates proper level of the reference voltage for a comparator using an ADC (analog-to-digital converter) and a DAC (digital-to-analog converter). Through the result of experiment, it has been confirmed that the presented wireless charger can detect signals from implantable module. And wireless charger can stop generating electromagnetic flux after an implanted battery has been fully charged in spite of variable coil distance according to different skin thickness.

• 대한의용생체공학회:의공학회지
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• 제28권5호
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• pp.618-627
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• 2007

As our society progresses rapidly toward an aged society, there is a stiff increase in the population of the aged persons who have difficulties in adjusting themselves to environments due to declines of their physical functions. Therefore, there is a great need for the concept of 'Universal Design' that demands the design of overall social structure to care for the elderly. Due to this reason, the physical function of the aged persons should thoroughly be studied for the development of rehabilitation and training equipments to help the recovery of physical functions of the elderly. Among the variety of physical functions of the elderly, visual functions, motion characteristics, hearing functions, and somatosensory functions have significant influence toward everyday lives and are physical functions to study for the construction of urgently needed physical function databases of the elderly. This study concentrates on visual functions among the variety of physical functions of the elderly. To measure various visual functions of the elderly, a measurement room for the elderly has been developed, which can mimic everyday lives and perform measurements of visual functions with subjects in seated position. The measurement items for the construction of the database were capabilities in everyday vision according to changes in arrangement of colors and light intensity and capabilities in everyday vision, color distinction, dark adaptation, and light glare against changes in contrast.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권3호
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• pp.313-317
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• 2000

Return of facial nerve function is important in patients with facial nerve paralysis by trauma. Sometimes, delay in diagnosis of facial nerve paralysis make recovery of facial nerve function difficult. Traumatic facial palsy mostly occur after temporal bone fracture in unilateral. Temporal bone fracture after head trauma are divided into the three group; longitudinal fracture, transverse fracture and mixed fracture. The most common symptoms are hearing impairment, bloody otorrhea, loss of consciousness and facial nerve paralysis. The early care of temporal bone fracture involves facial nerve paralysis. And there has been many discussion and study in the treatment of the immediate or delayed facial palsy ; examply, surgical approach, time and methods. We have managed a patient with unilateral facial nerve paralysis after longitudinal temporal bone fracture in mastoid process and conservative facial nerve decompression was performed. We have obtained good result and report this case with review of literatures.

• 한국산학기술학회논문지
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• 제18권9호
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• pp.123-126
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• 2017

볼거리(mumps)는 유행선 이하선염(epidemic parotitis)으로 불리며, 볼거리 바이러스에 의해 유발되는 바이러스성 감염질환이다. 볼거리는 췌장염, 고환염, 청력장애, 난소염, 이하선염 및 뇌수막염과 같은 합병증을 일으킬 수 있다. 볼거리로 인한 중추신경계의 침범은 볼거리로 진단된 환자의 65%에 달한다는 보고가 있으며, 그 중 대부분은 볼거리 뇌막염(mumps meningitis)이다. 이에 반해 볼거리 뇌염(mumps meningoencephalitis)은 볼거리 환자 6000명당 1명의 경우로 매우 드물다고 알려져 있다. 뇌염은 볼거리바이러스의 흔하지 않은 중추신경계의 합병증으로 홍역-볼거리-풍진 예방접종은 볼거리바이러스로 인한 치명적인 합병증을 예방해주고 경과를 가볍게 해준다고 알려져 있다. 저자들은 24세의 젊은 여자가 이하선염을 동반하지 않은 볼거리 바이러스로 인한 급성 뇌염을 경험하여 이에 대한 사례 연구를 하였다. 환자는 예방접종 시기에 맞춰 볼거리 예방접종을 받았다. 본 병원을 내원 시 환자는 인지능력의 저하를 보였으며 치료 후 빠른 회복을 보였고 합병증은 보이지 않았다. 이 연구는 볼거리 바이러스에 대한 2차 접종을 시기에 맞춰 받은 환자에서 이하선염의 동반 없이 뇌염증상이 발생한 환자에 대한 사례 연구이다.