• Journal of Astronomy and Space Sciences
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• v.22 no.3
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• pp.283-292
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• 2005

Ionosphere is deeply coupled to the space environment and introduces the perturbations to radio signal because of its electromagnetic characteristics. Therefore, the status of ionosphere can be estimated by analyzing the GPS signal errors which are penetrating the ionosphere and it can be the key to understand the global circulation and change in the upper atmosphere, and the characteristics of space weather. We used 9 GPS Continuously Operating Reference Stations (CORS), which have been operated by Korea Astronomy and Space Science Institute (KASI) , to determine the high precision of Total Electron Content (TEC) and the pseudorange data which is phase-leveled by a linear combination with carrier phase to reduce the inherent noise. We developed the method to model a regional ionosphere with grid form and its results over South Korea with $0.25^{\circ}\;by\;0.25^{\circ}$ spatial resolution. To improve the precision of ionosphere's TEC value, we applied IDW (Inverse Distance Weight) and Kalman Filtering method. The regional ionospheric model developed by this research was compared with GIMs (Global Ionosphere Maps) preduced by Ionosphere Working Group for 8 days and the results show $3\~4$ TECU difference in RMS values.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.3
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• pp.613-622
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• 2015

The convergence of IT technology and marine facilities monitoring system is needed for effective monitoring systems to marine facilities. Especially the spread of smart device such as smart phone, smart pad, smart TV provide an environment that can check the status of the marine facility for marin facilities manager. However, smart phones and smart pads are used in a variety of OS used. Thus the monitoring system of the various service environments is difficult. In addition, There is inconvenience that must individually developed monitoring system for each device. In order to solve this problem NMMS (N-Screen Marine-facility Monitoring System) is proposed. NMMS is consist of Real-time monitoring system, Fault diagnosis system, Data storage system. To improve variety of smart devices accessibility, we use HTML 5. Through NMMS, marine facilities manager can use smart device such as PC, Notebook, smart phone, smart pad for marine facilities monitoring.

• Environmental Analysis Health and Toxicology
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• v.19 no.4
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• pp.359-366
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• 2004

Iron (Fe) is an essential metal in biological processes, which maintains a homeostasis in the human body. Divalent metal transporter 1 (DMT1) has been known as an iron transporting membrane protein, which is involved in the uptake Fe at the apical portion of intestinal epithelium, and may transport Fe across the membrane of acidified endosome in peripheral tissues. In this study, we studied the tissue distribution of DMT1 in the Fe supplemented (FeS) diet fed rats, and the regulation of DMT1 expression by depleting body Fe. Sprague-Dawley rats were divided into two groups, and fed FeS (120 mg Fe/kg) diet or Fe deficient (FeD, 2∼6 mg Fe/kg) diet for 4 weeks. The evaluation of body Fe status was monitored by measuring sFe, UIBC and tissue Fe concentration. Additionally, DMT1 mRNA levels were analyzed in the peripheral tissues by using the quantitative real time RT-PCR method. In the FeS diet fed rats, the tissue Fe was maintained at a relatively high level, and DMT1 was eventually expressed in all tissues studied. DMT1 was highly expressed in the testis, kidney and spleen, while a moderate levels of DMT1 expression was detected in the brain, liver and heart. In the digestive system, the highest level of DMT1 was found in the duodenum. Feeding the FeD diet caused a reduced body weight gain and depletion of body Fe with finding of decreased sFe, increased UIBC and decreased tissue Fe concentration. The depletion of body Fe upregulated DMT1 expression in the peripheral tissue. The expression of DMT1 was very sensitive to the body Fe depletion in the small intestine, especially in the duodenum, showing dramatically higher levels in the FeD rats than those of the FeS group. In the FeD diet fed animals, the expression of DMT1 was low significantly in other tissues compared with the duodenum. The expression of DMT1, however, was 60∼120% higher in the testis, kidney and spleen, and 30∼50% higher in the lung, liver and heart, compared to the FeS diet fed rats. In summary, DMT1 expression was ubiquitous in mammalian tissue, and the level of expression was the organ-dependent. The expression of DMT1 in peripheral tissues was upregulated by depletion of body Fe. Duodenum was the most sensitive tissue among organs studied during Fe depletion, and expressed the greatest level of DMT1, while other tissues were less higher than in duodenum. This study supports that DMT1 plays a role in maintaining the body Fe level through intestinal uptake as well as homeostasis of Fe in the peripheral tissue.

• Journal of the Korea Convergence Society
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• v.9 no.1
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• pp.51-58
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• 2018

The late 20th century saw the industrial period end only to transform into the digital era where people have begun to pay attention to craft because it a field that respects emotion as the essential value, an alternative to overcome the side effect that people have created. Today a new world - where the virtual and the real co-exist through artificial intelligence (AI) - has suddenly approached us and the future of craft is faced with a new situation as it needs to present a new creative solution as a tool that is necessary for human way of life - a tool that has been a necessity throughout history and the evolution of life. As a result for a continued development, craft attempts to establish a new paradigm through current trends represented by our modern society, which is the emergence of creative development through convergence. This study presents creative experiments attempted through the convergence of craft with other heterogeneous tendencies connected to the field. The objective of the study is to enable makers to acquire a more creative way of thinking at the same time as inspiring them and suggesting new creative possibilities in order to develop their work through creative convergence. In Chapter 2, the study investigates on the current status of craft in general, and compares it with what is taking place in Korea; in Chapter 3 the significance of convergence in craft and the process of creating is addressed through case studies. Lastly in Chapter 4, with the basis on analytical case studies, the attribute and the potential of convergence in the field of craft is observed. By analyzing different phenomena presented through attempts to converge in contemporary craft, it has been possible to view the future of the 21st century craft through assessments on what is active and what is as yet hidden potential.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7575-7581
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• 2014

MicroRNAs (miRNAs) play an essential role in the development and progression of nasopharyngeal carcinomas (NPC). Despite advances in the field of cancer molecular biology and biomarker discovery, the development of clinically validated biomarkers for primary NPC has remained elusive. In this study, we investigated the expression and clinical significance of miRNAs as novel primary NPC diagnostic biomarkers. We used an array containing 2, 500 miRNAs to identify 22 significant miRNAs, and these candidate miRNAs were validated using 67 fresh NPC and 25 normal control tissues via quantitative real-time PCR (qRT-PCR). Expression and correlation analyses were performed with various statistical approaches, in addition to logistic regression and receiver operating characteristic curve analyses to evaluate diagnostic efficacy. qRT-PCR revealed five differentially expressed miRNAs (miR-93-5p, miR-135b-5p, miR-205-5p and miR-183-5p) in NPC tissue samples relative to control samples (p<0.05), with miR-135b-5p and miR-205-5p being of significant diagnostic value (p<0.01). Moreover, comparison of NPC patient clinicopathologic data revealed a negative correlation between miR-93-5p and miR-183-5p expression levels and lymph node status (p<0.05). These findings display an altered expression of many miRNAs in NPC tissues, thus providing information pertinent to pathophysiological and diagnostic research. Ultimately, miR-135b-5p and miR-205-5p may be implicated as novel NPC candidate biomarkers, while miR-93-5p, miR-650 and miR-183-5p may find application as relevant clinical pathology and diagnostic candidate biomarkers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.179-183
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• 2016

Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2002.11a
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• pp.147-153
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• 2002

Due to the growth of population and industrial development at the coastal cities, there has been much increase in necessity to effective control of the wastes into the coastal water and river. The amount of disposal at those waters has been increased rapidly and it is necessary for us to track of it in order to keep the water clean. The investigation and research related to the water quality in this region have been conducted continuously but the systematic survey of the disposed wastes at the bottom was neglected and/or minor. In this study we surveyed the status of disposed waste distribution at the bottom coastal water and river from the scanned images. The intensity of sound received by the side scan sonar tow vehicle from the sea floor provides information as to the general distribution and characteristics of the superficial wastes. The port and starboard side scanned images produced from a transducer borne on a tow fish connected by tow cable to a tug boat have the area with width of 22m∼112m, and band of 44m∼224m. All data are displayed in real-time on a high-resolution color display (1280 ${\times}$ 1024 pixels) together with position information by DGPS. From the field measurement and analysis of the recorded images, we could draw the location and distribution of bottom disposals. Furthermore, we made a database system which might be fundamental for planning the waste reception and process control system.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.3
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• pp.103-110
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• 2016

Recently, structural health monitoring system(SHMS) has been appled cable bridges as the effective maintenance tool and the management threshold is considered to assess the status of the bridge in SHMS. The threshold is generally determined by the allowable limit based on design specification because there is no method and standard for threshold calculation. In case of the conventional thresholds, it is difficult to recognize the event, abnormal behavior and gradual damage within the threshold. Therefore, this study reviewed the problem of previous methods and proposed the advanced methodologies based on probabilistic approach for threshold calculation which can be applied to practice work. Gumbel distribution is adopted in order to calculate the threshold for caution and warning states considering the expectations for return periods of 50 and 100 years. The thresholds were individually determined for measurement data and data variation to detect the various abnormal behaviors within allowable range. Finally, it has confirmed that the thresholds by the proposed method is detectable the abnormal behavior of real-time measuring data from SHMS.

• Fire Science and Engineering
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• v.29 no.6
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• pp.51-56
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• 2015

In Korea, measures to maintain sustainable fire safety performance for apartment buildings are insufficient in terms of fire-fighting products, skilled personnel, and maintenance status. Also, because of the particular features of a fire compartment, it has structural problems that are very likely to cause damage to human life when a fire occurs. Currently, problems with the fire supervisory system installed in an apartment building cannot be checked in real time, so it is difficult to identify the location of a fire accurately. Protected areas are also not assigned to each household, and residents cannot be clearly informed of the occurrence of a fire. As a consequence, safety evacuation cannot be secured. In addition, it is impossible to test the operation performance for water detectors in sprinkler fire extinguishing systems outside of the household. Therefore, an experiment was conducted to evaluate the performance of a remote fire supervisory system. The results show that the system satisfies all performance requirements. Also, an household alarm system was installed in each household to alert of any occurrence of a fire accurately, and the performance of the alarm system was improved to ensure that residents were quickly evacuated.

• Journal of Korean Society of Rural Planning
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• v.23 no.3
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• pp.163-174
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• 2017

This study developed the prototype of the system and implemented its main functions, which is the intelligent integrated agricultural water management information system and service (IaWAMISS). The developed system was designed to be able to collect, process and analyze the agricultural water information of spatially dispersed reservoirs in whole country and spatial geographic information distributed in various systems of other organizations. The system, IaWAMISS, is also possible to provide the reproduced information services in each reservoir and space units, such as agricultural water demand and supply analysis and drought prediction, to the people, experts, and policy makers. This study defined the 6 step modules to develop the system, which are to design the components of intelligent integrated information system, to derive the utilization contents of existing systems, to design the new development elements for IaWAMISS, to design the reservoir information system can be used by managers of city and county, to designate the monitoring reservoirs managed by city and county, and finally to prepare the sharing system between organizations with the existing information systems. In order to implement the prototype of the system, this study shows the results for three important functions of the system: spatial integration of reservoirs' information, data link integration between the existing systems, and intelligent analysis program development to assist decision support for agricultural water management. For the spatial integration with the reservoir water information of the Korea Rural Community Corporation, this study get IaWAMISS to receive the real-time reservoir storage information from the measurement facility installed in the municipal management reservoir. The data link integration connecting databases of the existing systems, was implemented by integrating the meteorological information of the Korea Meteorological Administration with IaWAMISS, so that the rainfall forecast data could be derived and used. For the implementation of the intelligent analysis program, this study also showed the results of analysis and prediction of agricultural water demand and supply amount, estimation of Palmer drought index, analysis of flood risk area in typhoon course region, and analysis of the storage status of reservoirs related to each storm. This study confirmed the possibility and efficiency of an useful system development through the prototype design and implementation of IaWAMISS. By solving the preliminary 6 step modules presented in this study, it is possible not only to efficiently manage water by spatial unit, but also to provide the service of information and to enhance the relevant policy and national understanding to the people.