• The Korean Journal of Pain
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• v.22 no.1
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• pp.21-27
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• 2009

Background: The neuropathic pain arising from nerve injury is difficult to treat and the therapeutic effects of opioid drugs remain debatable. Agonists acting at the ${\alpha}_2$ adrenergic and opioid receptors have analgesic properties and they act synergistically when co-administered in the spinal cord. The lack of subtype-selective pharmacological agents has previously impeded the synergistic effects that are mediated by the adrenergic receptor subtypes. Methods: We created neuropathic pain model by ligating the L5 spinal nerve in Sprague-Dawley rats (n = 18). We divided the rats into three groups (n = 6 for each group), and we administered intraperitoneal morphine (1 mg/kg, 3 mg/kg, 5 mg/kg) and then we measured the mechanical allodynia with using von-Frey filaments for 8 hours. We then injected morphine (5 mg/kg) intraperitoneally, twice a day for 2 weeks. We measured the tactile and cold allodynia in the morphine group (n = 9) and the saline group (n = 9). After 2 weeks, we decapitated the rats and harvested the spinal cords at the level of lumbar enlargement. We compared the ${\alpha}_2$ subtype mRNA expression with that of control group (n = 6) by performing real time polymerase chain reaction (RTPCR). Results: Intraperitoneal morphine reduced the neuropathic pain behavior in the dose-dependent manner. Chronic morphine administration showed an antiallodynic effect on the neuropathic pain rat model. The rats did not display tolerance or hyperalgesia. The expression of the mRNAs of the ${\alpha}_{2A}$, ${\alpha}_{2B}$, ${\alpha}_{2C}$ subtypes decreased, and morphine attenuated this effect. But we could not get statistically proven results. Conclusions: Systemic administration of morphine can attenuate allodynia during both the short-term and long-term time course. Morphine has an influence on the expression of ${\alpha}_2$ receptor subtype mRNA. Yet we need more research to determine the precise effect of morphine on the ${\alpha}_2$ subtype gene expression.

• Journal of KIISE:Computing Practices and Letters
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• v.5 no.4
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• pp.467-478
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• 1999

실시간 태스크의 최악 실행시간을 예측할 때 과예측이 발생하는 원인은, 첫째 프로그램의 동적인 최악 실행 행태를 정적으로 분석하는 것이 근본적으로 어렵기 때문이며, 둘째 최근의 RISC 형태 프로세서에 포함되어 있는 파이프라인 실행 구조와 캐쉬 등이 그러한 정적 분석을 더욱 어렵게 만들기 때문이다. 그런데 기존의 연구에서는 각각의 과예측 원인을 해결하기 위한 방법에 대해서만 언급하고 있을 뿐 분석의 정확도에서 각 원인이 차지하는 비중에 대해서는 언급하고 있지 않다. 이에 본 연구에서는 최악 실행시간 예측시 과예측을 유발하는 원인들, 즉 분석 요소들의 영향을 정량적으로 조사함으로써 기존의 최악 실행시간 분석 기법들이 보완해야 할 방향을 제시하고자 한다. 본 연구에서는 실험이 특정 분석 기법에 의존하지 않도록 하기 위하여 시뮬레이션 방법에 기반한다. 이를 위해 분석 요소별 스위치가 포함된 MIPS R3000 프로세서를 위한 시뮬레이터를 구현하였는데, 각 스위치는 해당 분석 요소에 대한 분석의 정확도 수준을 결정한다. 모든 스위치 조합에 대해서 시뮬레이션을 반복 수행한 다음 분산 분석을 수행하여 어떤 분석 요소가 가장 큰 영향을 끼치는지 고찰한다.Abstract Existing analysis techniques for estimating the worst case execution time (WCET) of real-time tasks still suffer from significant overestimation due to two types of overestimation sources. First, it is unavoidably difficult to predict dynamic behavior of programs statically. Second, pipelined execution and caching found in recent RISC-style processors even more complicate such a prediction. Although these overestimation sources have been attacked in many existing analysis techniques, we cannot find in the literature any description about questions like which one is most important. Thus, in this paper, we quantitatively analyze the impacts of overestimation sources on the accuracy of the worst case timing analysis. Using the results, we can identify dominant overestimation sources that should be analyzed more accurately to get tighter WCET estimations. To make our method independent of any existing analysis techniques, we use simulation based methodology. We have implemented a MIPS R3000 simulator equipped with several switches, each of which determines the accuracy level of the timing analysis for the corresponding overestimation source. After repeating simulation for all of the switch combinations, we perform the variance analysis and study which factor has the largest impact on the accuracy of the predicted WCETs.

• Journal of Korean Society for Geospatial Information Science
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• v.12 no.4 s.31
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• pp.35-43
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• 2004

Multibeam Echosounder system is the latest technology of a hydrographic survey utilized in producing an electronic nautical chart, obtaining a DEM with high precision, making a moving image by Swath surveying a wide area. As a fundamental study for improving the precision of MBES, we compared and analyzed measurements of DGPS and Motion sensor, and studied for the dynamic characteristics of vessel's movements. DGPS was installed in front and in the rear and on both side or the vessel and surveyed. The receiving precision of surveyed GPS results was obtained to the satisfactory extent that was possible to valuate the accuracy of Motion sensor as 0.0016$^{\circ}$ of the roll value and 0.0009$^{\circ}$ of the pitch value. The relationship between the values of heading, pitch, and roll in Motion sensor and the data of DGPS was proportional correlation. In addition, it is considered that deviations by elements like rapid turning and vibration of the vessel will be occurred, although the correlation of each deviation according to each amount or change is proportional. It is suitable that GPS installs in the central line of the vessel that is less affected than other places by waving because the amount of change in the tide level obtained from GPS survey and the value of heave are similar with the values taken by Motion sensor, and the velocity of GPS is different from installed places. The accuracy of the final result from MBES could be affected by the values of gyro and Motion sensor inputted to MBES processor because there were intervals of 15s and 13s of receiving time in gyro and Motion sensor respectively compared with the real-time measurements of DGPS.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.559-563
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• 2015

Monitor of All-sky X-ray Image (MAXI) is a Japanese X-ray all-sky surveyer mounted on the International Space Station (ISS). It has been scanning the whole sky since 2009 during every 92-minute ISS rotation. X-ray transients are quickly found by the real-time nova-search program. As a result, MAXI has issued 133 Astronomer's Telegrams and 44 Gamma-ray burst Coordinated Networks so far. MAXI has discovered six new black holes (BH) in 4.5 years. Long-term behaviors of the MAXI BHs can be classified into two types by their outbursts; a fast-rise exponential-decay type and a fast-rise flat-top one. The slit camera is suitable for accumulating data over a long time. MAXI issued a 37-month catalog containing 500 sources above a ~0.6 mCrab detection limit at 4-10 keV in the region ${\mid}{b}{\mid}$ > $10^{\circ}$. The SSC instrument utilizing an X-ray CCD has detected diffuse soft X-rays extending over a large solid angle, such as the Cygnus super bubble. MAXI/SSC has also detcted a Ne emission line from the rapid soft X-ray nova MAXI J0158-744. The overall shapes of outbursts in Be X-ray binaries (BeXRB) are precisely observed with MAXI/GSC. BeXRB have two kinds of outbursts, a normal outburst and a giant one. The peak dates of the subsequent giant outbursts of A0535+26 repeated with a different period than the orbital one. The Be stellar disk is considered to either have a precession motion or a distorted shape. The long-term behaviors of low-mass X-ray binaries (LMXB) containing weakly magnetized neutron stars are investigated. Transient LMXBs (Aql X-1 and 4U 1608-52) repeated outbursts every 200-1000 days, which is understood by the limit-cycle of hydrogen ionization states in the outer accretion disk. A third state (very dim state) in Aql X-1 and 4U 1608-52 was interpreted as the propeller effect in the unified picture of LMXB. Cir X-1 is a peculiar source in the sense that its long-term behavior is not like typical LMXBs. The luminosity sometimes decreases suddenly at periastron. It might be explained by the stripping of the outer accretion disk by a clumpy stellar wind. MAXI observed 64 large flares from 22 active stars (RS CVns, dMe stars, Argol types, young stellar objects) over 4 years. The total energies are $10^{34}-10^{36}$ erg $s^{-1}$. Since MAXI can measure the spectrum (temperature and emission measure), we can estimate the size of the plasma and the magnetic fields. The size sometimes exceeds the size of the star. The magnetic field is in the range of 10-100 gauss, which is a typical value for solar flares.

• Journal of the Korea Computer Graphics Society
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• v.17 no.3
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• pp.43-50
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• 2011

We present a trade-off technique for fast but qualitative planar shape deformation using a layered mesh. We construct a layered mesh that is embedding a planar input shape; the upper-layer is denoted as a control mesh and the other lower-layer as a shape mesh that is defined by mean value coordinates relative to the control mesh. First, we try to preserve some shape properties including user constraints for the control mesh by means of a known existing nonlinear least square optimization technique, which produces deformed positions of the control mesh vertices. Then, we compute the deformed positions of the shape mesh vertices indirectly from the deformed control mesh by means of simple coordinates computation. The control mesh consists of a small number of vertices while the shape layer contains relatively a large number of vertices in order to embed the input shape as tightly as possible. Since the time-consuming optimization technique is applied only to the control mesh, the overall execution is extremely fast; however, the quality of deformation is sacrificed due to the sacrificed quality of the control mesh and its relativity to the shape mesh. In order to change the deformation behavior and consequently to compensate the quality sacrifice, we present a method to control the deformation stiffness by incorporating the orientation into the user constraints. According to our experiments, the proposed technique produces a planar shape deformation fast enough for real-time applications on limited embedded systems such as cell phones and tablet PCs.

• The Journal of the Korea Contents Association
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• v.21 no.1
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• pp.531-540
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• 2021

As cyber attacks and crimes increase exponentially and hacking attacks become more intelligent and advanced, hacking attack methods and routes are evolving unpredictably and in real time. In order to reinforce the enemy's responsiveness, this study aims to propose a method for developing an artificial intelligence-based security control platform by building a next-generation security system using artificial intelligence to respond by self-learning, monitoring abnormal signs and blocking attacks.The artificial intelligence-based security control platform should be developed as the basis for data collection, data analysis, next-generation security system operation, and security system management. Big data base and control system, data collection step through external threat information, data analysis step of pre-processing and formalizing the collected data to perform positive/false detection and abnormal behavior analysis through deep learning-based algorithm, and analyzed data Through the operation of a security system of prevention, control, response, analysis, and organic circulation structure, the next generation security system to increase the scope and speed of handling new threats and to reinforce the identification of normal and abnormal behaviors, and management of the security threat response system, Harmful IP management, detection policy management, security business legal system management. Through this, we are trying to find a way to comprehensively analyze vast amounts of data and to respond preemptively in a short time.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.23 no.1
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• pp.82-96
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• 2024

While analyzing traffic flow, speed, traffic volume, and density are important macroscopic indicators, and acceleration and spacing are the important microscopic indicators. The speed and traffic volume can be collected with the currently installed traffic information collection devices. However, acceleration and spacing data are necessary for safety and autonomous driving but cannot be collected using the current traffic information collection devices. 'You Look Only Once'(YOLO), an object recognition technique, has excellent accuracy and real-time performance and is used in various fields, including the transportation field. In this study, to measure acceleration and spacing using YOLO, we developed a model that measures acceleration and spacing through changes in vehicle speed at each interval and the differences in the travel time between vehicles by setting the measurement intervals closely. It was confirmed that the range of acceleration and spacing is different depending on the traffic characteristics of each point, and a comparative analysis was performed according to the reference distance and screen angle to secure the measurement rate. The measurement interval was 20m, and the closer the angle was to a right angle, the higher the measurement rate. These results will contribute to the analysis of safety by intersection and the domestic vehicle behavior model.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.3
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• pp.150-161
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• 2022

Purpose: To determine the effects of the microgroove-fibronectin complex surface on the expression of various genes related to cellular activity in human gingival fibroblasts. Materials and Methods: Smooth titanium specimens (NE0), acid-treated titanium specimens (E0), microgroove and acid-treated titanium specimens (E60/10), fibronectin-fixed smooth titanium specimens (NE0FN), acid-treated and fibronectin-immobilized titanium specimens (E0FN), and microgroove and acid-treated titanium specimens immobilized with fibronectin (E60/10FN) were prepared. Real-time polymerase chain reaction experiments were conducted on 44 genes related to cell behavior of human gingival fibroblasts. Results: Adhesion and proliferation of human gingival fibroblast on microgroove-fibronectin complex titanium were activated through four types of signaling pathway. Integrin α5, Integrin β1, Integrin β3, Talin-2, which belong to the focal adhesion pathway, AKT1, AKT2, NF-κB, which belong to the PI3K-AKT signaling pathway, MEK2, ERK1, ERK2, which belong to the MAPK signaling pathway, and Cyclin D1, CDK4, CDK6 genes belonging to the cell cycle signaling pathway were upregulated on the microgroove-fibronectin complex titanium surface (E60/10FN). Conclusion: The microgroove-fibronectin complex titanium surface can up-regulate various genes involved in cell behavior.

• The Korean Journal of Financial Management
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• v.6 no.1
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• pp.31-62
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• 1989

By using deterministic dynamic models, we observe the behavior of the foreign exchange rate of a small open economy with rational expectation formation and different restrictions on the international economic integrations. First, an economy connected to the world by purchasing power parity and uncovered interest parity is studied in the next section. In both sections, financial assets available in the economy are domestic money and bonds. Stocks are added as a financial instrument in the next section, and real capital accumulation is also taken into account. Furthermore, the economy concerned there is fairly autonomous, and not directly governed by either purchasing power parity or uncovered interest parity. The expectation formation used throughout the whole paper is complete perfect foresight, which is the certainty version of rational expectation and free from any forecast errors. It is found that upon monetary expansion the short run depreciation of the foreign exchange rate is a fairly robust result regardless of the degree of the international economic integration, while it is not true for fiscal expansion. The expectation on the long run state significantly affects the short run response of the exchange rate. All of our models postulate that the current account should be balanced eventually. As the result, the short run behavior of the exchange rate is affected by the expectation on the long run balance and may well be a blend of the traditional flow view and modem asset view. The initial overshooting of the exchange rate is easily observed even in the fairly autonomous economy Furthermore, the initial overshooting is not reduced over time, but augmented for some time before it is eventually eliminated. As long as we maintain rational expectaion, introducing time delay in the adjustment of the foreign goods price to the foreign exchange rate does not make much difference.

• Journal of Korean Society of Transportation
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• v.20 no.3
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• pp.149-158
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• 2002

For the purpose of preciously describing real time traffic pattern in urban road network, dynamic network loading(DNL) models able to simulate traffic behavior are required. A number of different methods are available, including macroscopic, microscopic dynamic network models, as well as analytical model. Equivalency minimization problem and Variation inequality problem are the analytical models, which include explicit mathematical travel cost function for describing traffic behaviors on the network. While microscopic simulation models move vehicles according to behavioral car-following and cell-transmission. However, DNL models embedding such travel time function have some limitations ; analytical model has lacking of describing traffic characteristics such as relations between flow and speed, between speed and density Microscopic simulation models are the most detailed and realistic, but they are difficult to calibrate and may not be the most practical tools for large-scale networks. To cope with such problems, this paper develops a new DNL model appropriate for dynamic traffic assignment(DTA), The model is combined with vertical queue model representing vehicles as vertical queues at the end of links. In order to compare and to assess the model, we use a contrived example network. From the numerical results, we found that the DNL model presented in the paper were able to describe traffic characteristics with reasonable amount of computing time. The model also showed good relationship between travel time and traffic flow and expressed the feature of backward turn at near capacity.