• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.24-30
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• 2018

Various investigations of vegetable oil extracted from natural resources are underway because of their low cost and environmental value. On the other hand, the double bonds in vegetable oil should be substituted to other high reactive functional groups due to their low reactivity for synthesizing bio-polymeric materials. ${\alpha}$-eleostearic acid, which consists of a conjugated triene, is the main component of tung oil, and the conjugated triene allows tung oil to have higher reactivity than other vegetable oils. In this study, tung oil was copolymerized with styrene and divinylbenzene to make a thermoset resin without any substitution of functional groups. The thermal and mechanical properties were measured to examine the effects of the composition of each monomer on the synthesized thermoset resin. The results showed that the products have only one Tg, which means the synthesized thermoset resins are homogeneous at the molecular level. The mechanical properties show that tung oil acts as a soft segment in the copolymer and makes a more elastic product. On the other hand, divinylbenzene acts as a hard segment and makes a more brittle product.

• Tuberculosis and Respiratory Diseases
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• v.59 no.2
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• pp.142-150
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• 2005

Background : Continuous growth stimulation by various factors, as well as chronic oxidative stress, may co-exist in many solid tumors, such as lung cancer. A new family of antioxidant proteins, the peroxiredoxins (Prxs), have been implicated in the regulation of many cellular processes, including cell proliferation, differentiation and apoptosis. However, a real pathophysiological significance of Prx proteins, especially in lung disease, has not been sufficiently defined. Therefore, this study was conducted to investigate the distribution and expression of various Prx isoforms in lung cancer and other pulmonary conditions. Method : Patients diagnosed with lung cancer, and who underwent surgery at the Ajou Medical Center, were enrolled. The expressions of Prxs, Thioredoxin (Trx) and Thioredoxin reductase (TR) were analyzed using proteomic techniques and the subcellular localization of Prx proteins was studied using immunohistochemistry on normal mouse lung tissue. Result : Immunohistochemical staining has shown the isoforms of Prx I, II, III and V are predominantly expressed in bronchial and alveolar lining epithelia, as well as in the alveolar macrophages of the normal mouse lung. The isoforms of Prx I and III, and thioredoxin were also found to be over-expressed in the lung cancer tissues compared to their paired normal lung controls. There was also an increased amount of the oxidized form of Prx I, as well as a putative truncated form of Prx III, in the lung cancer samples when analyzed using 2-dimensional electrophoresis. In addition, a 43 kDa intermediate molecular weight protein band, and other high molecular weight bands of over 20 kDa, recognized by the anti-Prx I antibody, were present in the tissue extracts of lung cancer patients on 1-Dimensional electrophoresis, which require further investigation. Conclusion : The over-expressions of Prx I and III, and Trx in human lung cancer tissue, as well as their possible chaperoning function, may represent an attempt by tumor cells to adjust to their microenvironment in a manner advantageous to their survival and proliferation, while maintaining their malignant potential.