• Applied Chemistry for Engineering
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• v.7 no.4
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• pp.735-742
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• 1996

Polymeric matrices were prepared with dextran and silver sulfadiazine by adding glycerine as a plasticiser. Namely, the release rate of the drug from the polymeric matrix formulations in dissolved phases was determined in a phosphate buffer solution. The results were as follows : The drug release time was delayed as drug loading contents increased, whereas it decreased as the glycerine concentration increased. The drug release time was not changed with varying the molecular weight of the dextran. The apparent release rate constant (k) increased as the composition of silver sulfadiazine and glycerine was increased. But the apparent release rate constant (k) was not changed with increasing molecular weight of the dextran.

• Fire Science and Engineering
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• v.28 no.5
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• pp.1-7
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• 2014

The present study has been conducted to analyse the effects of various pool diameters on the measurement of heat release rate (HRR) of heptane fire using large scale cone calorimeter (LSC). The burning rate which is the major parameter for HRR compared with the previous model suggested by A. Hamins. The combustion efficiency for heptane by oxygen consumption method is about 91%, which is almost same with the previous results of 92% suggested by J. Gore. The convective HRR by enthalpy consumption method was 54% lower than HRR by oxygen consumption method. This results are practical use for establishing the reliability of heat release rate for fire experiment.

• Journal of the Korean Institute of Gas
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• v.11 no.2 s.35
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• pp.10-14
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• 2007

Flash point is one of the major physical properties used to evaluate fire hazards of the combustible liquids. Properties showing relative fire hazards of the combustible liquids are heat release rate(HRR), peak heat release rate(PHRR), time to ignition(TTI), mass loss rate, and yield of $CO/CO_2$. The relationships between flash points and fire properties of the combustible liquids were examined in this study. For this study, mass loss rate and time to ignition were measured to calculate fire properties of the combustible liquids. The results showed that good correlations could be found between flash point and time to ignition, time to peak heat release rate, and the propensity to flashover. From a presented results, the parameters can be used to evaluate relative hazards of the combustible liquids on fire.

• YAKHAK HOEJI
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• v.43 no.4
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• pp.447-457
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• 1999

The purpose of this study is to prepare the adhesive type patch containing flurbiprofen, and to demonstrate the feasibility of flurbiprofen administration through the intact skin using adhesive type patch preparation. For this purpose, two pressure sensitive adhesives, Polyisobutylene(PIB) and $Gelva^{\circledR}737$, were selected from the chemical grade of polymers, and the adhesive type patches of flurbiprofen were prepared. The release rate of flurbiprofen from the PIB-based adhesive patch was higher than that from $Gelva^{\circledR}737$ based adhesive patch. The release rate of flurbiprofen from the PIB-based A-type patch with 1.0mm, 1.5mm or 2.0mm thicknesses followed the first order kinetics. In the skin permeation study, using male hairless mouse skin, a monophasic skin permeation profile was observed with 1% flurbiprofen loading dose. The inclusion of palmitic acid or SLS(0.25~0.5%) as an enhancer produced a remarkable enhancement in the skin permeation rate of flurbiprofen, and the percentile ratio of drug and enhancer appeared to be important for the effective enhancement. In the in vivo percutaneous absorption study, the plasma concentration of the optimal formulation was significantly (p<0.01) higher than that of the conventional cataplasma ($Bifen^{\circledR}$). These studies demonstrate a good feasibility of flurbiprofen administration through the intact skin using a transdermal patch, and show a possibility of the development of flurbiprofen patches.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.493-501
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• 2005

Effect of solvents on physical characteristics and release characteristics of monolithic acetaminophen (APAP) hydroxypropylmethylcellulose (HPMC) matrix granules and tablets were examined. Various types and amounts of solvents were employed for granulation and coating. APAP and other excipients were mixed and were then wet-granulated in a high-speed mixer. The dried granules were then directly compressed and film-coated with low viscosity grade HPMC. As the amount of water increased, the size of granules also increased, showing more spherical and regular shape. However, manufacturing problems such as capping and lamination in tableting occurred when water was used alone as a granulating solvent. The physical properties of HPMC matrix granules were not affected by the batch size. The initial release rate as well as the amount of APAP dissolved had a tendency to decrease as the water level increased. Addition of nonaqueous solvent like ethanol to water resulted in good physical properties of granules. When compared to water/ethanol as a coating solvent, the release rate of film-coated HPMC matrix tablets was more sensitive to the conditions of coating and drying in methylene chloride/ethanol. Most of all, monolithic HPMC matrix tablet when granulated in ethanol/water showed dual release with about $50\%$ drug release immediately within few minutes followed by extended release. It was evident that the type and amount of solvents (mainly water and ethanol) were very important for wet granulation and film-coating of monolithic HPMC matrix tablet, because the plastic deforming and fragmenting properties of material were changed by the different strengths of the different solvents.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.2
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• pp.184-191
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• 1999

Th effects of exhaust gas recirculation(EGR) on the characteristics of combustion exhaust emissions and specific fuel consumption(SFC) are experimentally investigated by four-cylin-der four-cycle and direct injection marine diesel engine. In order to reduce soot contents in the recirculated exhaust gas to intake system of the engines a novel diesel soot removal system with a cylinder-type scrubber which has water injector(4 nozzles in 1.0mm diameter)is specially designed and manufactured for the experi-mental system. The obtained results are as follows; The combustion pressure in cylinder is decreased and ignition is delayed with increasing EGR rate. The accumulated quantity of heat release is slightly decreased and the tendency of heat release rate is not constant. NOx and Soot emissions are decreased by maximum 7% and 540% with scrubber tan without scrubber in the range of experimental conditions. Those are increased at the lean burn area with increasing equivalence ration in the constant value of engine speed and EGR rate. Also those are decreased with increasing EGR rate in the constant value of engine speed and equivalence ratio.

• Journal of Korean Society on Water Environment
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• v.25 no.5
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• pp.742-749
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• 2009

To examine the characteristics of the nutrient release from the sediments in two reservoirs, Lake Paldang and Lake Cheungpyeung, we analyzed physical and chemical properties of the sediments and calculated the nutrient release rates from the sediments. The particle properties of sediments in Lake Paldang changed from silt to sand after summer rainy season, especially in the water area of the Kyeungan River where the water depth was shallow and the width of river was narrow. The sediments in Lake Cheungpyeung had higher contents of silt and clay than in Lake Paldang, and the particle size was not much different before and after rainfall. The release rates of nutrients in two lakes varied with the kind of nutrients and the season. The release rates of DTN and ${NH_4}^+-N$ in Lake Paldang were faster in spring than autumn. But the Lake Cheungpyeung showed similar values of release rates before and after summer rainy season. ${NO_3}^--N$ and phosphorous were not released from sediments or were absorbed into sediments all the time in two lakes. Compared with other lakes, the sediments of two lakes consisted of bigger particles and had a lower organic matters content than other lake-type reservoirs. Due to the short hydraulic retention time and no stratification throughout the year in Lake Paldang and Lake Cheungpyeung, the release rates of nutrients from sediment in these reservoirs were lower than other lakes and this seems to be a typical characteristic of river-type reservoirs.

• Journal of Radiation Protection and Research
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• v.26 no.3
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• pp.291-298
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• 2001

The designed release rate of liquid effluents from radwaste treatment system should be calculated and evaluated during normal operation, including anticipated operational occurrence and be assured that the release concentration and off-site dose at unrestricted area do not exceed the limits of regulation. The expected annual release rate and off-site dose for the currently operating nuclear power plants in Korea had been calculated and evaluated using PWR-GALE and LADTAP-II which was based on USNRC Regulatory Guide 1.109. Recently, the MOST Notice 2001-2 related to release concentration and off-site dose at unrestricted area was revised to reflect the concept of ICRP-60. It is necessary for KORI 3&4 to re-calculate the release concentration and off-site dose and to compare these results with the limits of regulation. As the results of assessment, we confirmed that the release concentrations were less than its limits of MOST Notice 2001-2 and the off-site dose at unrestricted area using K-DOSE60 was 3.61E-03 mSv/yr to the age of five for the effective dose, and 4.10E-2 mSv/yr to thyroid of the age of five for the organ equivalent dose. We also confirmed the off-site dose was within the limits of MOST Notice 2001-2. Therefore, the release concentration and off-site dose re-evaluated at unrestricted area in KORI 3&4 were well below the regulation limits of MOST Notice 2001-2.

• Journal of Pharmaceutical Investigation
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• v.22 no.3
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• pp.205-210
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• 1992

In order to develop a controlled-release oral drug delivery system (DDS) of theophylline (TP), microporous membrane-coated tablets were prepared and evaluated in vitro and in vivo. Rapidly water-soluble core tablets of TP (300 mg) were prepared by wet granulation and compression technique, Then the core tablets were spray-coated with polyvinylchloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of coating suspensions on the pharmaceutical characteristics such as membrane strength and dissolution was investigated in vitro. The membranes remained unbroken in pH 1.2 buffer at $37^{\circ}C$ at least for 2 hours after the disintergration test. TP was released from the coated-released tablets at a zero-order rate over 8 hours. The release at pH 1.2 and 4.0 was similar in rate but a little more rapid than that at pH 6.8. The coated tablets were administered to three healthy male volunteers and their saliva profiles of TP were compared with those from the commercial sustained release TP tablets such as Slobid and Asconthin. Saliva TP concentrations from the coated tablets were successfully sustained over 48 hours after the dosing and were comparable to those of the commercial sustained-release tablets. The membrane-coating technique is very simple and does not need any sophisticated equipments. In this respect, the membrane-coated tablets may be superior to the commercial sustained-release tablets and this technique is worth adopting by the pharmaceutical industries.

• Journal of The Korean Society of Agricultural Engineers
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• v.58 no.2
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• pp.1-9
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• 2016

This study aims to assess the effectiveness of activated carbon (AC) and crushed concrete (CC) as capping material to block the release of nitrogen, phosphorus, and organic substance from reservoir sediments. The efficiency of AC and CC as capping material was evaluated in a reactor in which a 1 or 3 cm thick layer of capping materials was placed on the sediments collected from Mansu reservoir in Anseong-city. Dissolved oxygen (DO) concentration, total nitrogen (T-N), total phosphorus (T-P), and chemical oxygen demand (COD) concentration in reservoir water above the uncapped sediments and capping material were monitored for 45 days. The release rate of T-N was in the following increasing order: AC 3 cm ($1.18mg/m^2{\cdot}d$) < CC 1 cm ($2.66mg/m^2{\cdot}d$) < AC 1 cm ($2.94mg/m^2{\cdot}d$) < CC 3 cm ($3.42mg/m^2{\cdot}d$) < uncapped ($4.59mg/m^2{\cdot}d$). The release rate of T-P was in the following increasing order: AC 3 cm ($0mg/m^2{\cdot}d$) $${\approx_-}$$ CC 3 cm ($0mg/m^2{\cdot}d$) < CC 1 cm ($0.03mg/m^2{\cdot}d$) < AC 1 cm capped ($0.07mg/m^2{\cdot}d$) < uncapped ($0.24mg/m^2{\cdot}d$). The release of nitrogen and phosphorus were effectively blocked by AC capping of 3 cm thickness, and CC capping of 3 cm thickness effectively controlled the release of phosphorus. The order of increasing COD release rate was as follows: AC 3 cm ($0mg/m^2{\cdot}d$) $${\approx_-}$$ CC 3 cm ($0mg/m^2{\cdot}d$) < CC 1 cm ($5.03mg/m^2{\cdot}d$) < AC 1 cm ($7.28mg/m^2{\cdot}d$) < uncapped ($10.05mg/m^2{\cdot}d$), indicating that AC and CC capping effectively interrupted the release of organic contaminants from the sediments. It was concluded that AC and CC could effectively block the release of T-N, T-P and COD release from contaminated reservoir sediments.