• Archives of Pharmacal Research
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• 제18권3호
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• pp.183-188
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• 1995

Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.

• 노동경제논집
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• 제43권4호
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• pp.143-177
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• 2020

본 연구는 영유아 보육료 지원정책이 보육시설공급률에 따라 노동공급과 출산율에 상이한 영향을 미쳤음을 분석하였다. 구체적으로 보육시설공급률이 높을수록 보육료 지원에 의해 보육시설 입소에 유리한 다자녀모의 경력유지 확률이 증가했을 뿐 아니라 첫째 자녀의 출산율이 높아졌고, 국공립 어린이집의 공급률이 높은 경우에는 보육비 지원 이후 둘째 자녀 출산율도 유의하게 높아졌음을 보여준다. 이는 보육료 지원정책의 효과가 출생순위에 따른 보육시설 입소 우선순위, 거주지역 보육시설의 양적, 질적 공급 정도에 따라 달라짐을 보여준다.

• 환경생물
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• 제38권4호
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• pp.625-633
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• 2020

The effects of temperature and salinity on egg development and settlement of the ascidian Herdmania momus were investigated. Adult specimens were collected from the Dodu Yacht facility in Jeju Island, Korea(33°30'30.54"N, 126°27'55.46"E) in August 2018. Egg development and larval settlement were observed and recorded at 8 h intervals using a stereomicroscope, under nine temperature (10, 13, 16, 19, 22, 25, 28, 31, and 34℃), and four salinity regimens (28, 30, 32, and 34 psu). The highest hatching rate (82.8±7%) was observed at 32 psu and 25℃ and the lowest hatching rate (1.0±2%) was at 34 psu and 13℃. The developmental rate (0.222±0.0994) was highest at 28 psu and 28℃, and lowest (0.016±0.008) at 30 psu and 13℃. The highest settlement success rate (77.1±5%) was at 32psu and 25℃ and the lowest(0.1±1.0%) was at 30psu, and 13℃. The rate of settlement(0.080±0.000) was highest at 28psu and 28℃, and lowest(0.013±0.000) at 30psu and 13℃. Both hatching and settlement success rates increased as temperature increased and tended to decrease beyond an optimal temperature range. Herdmania momus preferred 30-34 psu salinity and 22-25℃ temperature. This study provides baseline information about the life history of H. momus, and important data to control the damage caused by the increase in number and distribution of this invasive ascidian.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.243-248
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• 1999

There is substantial evidence that anatomical connections and functional interactions exist between vestibular and autonomic systems. Heart rate variability (HRV) including mean, standard deviation, coefficient of variation (CV), power spectrum was analyzed for evaluation of the physiological role of the vestibular system on control of heart rate in rabbits. In anesthetized rabbits, electrical stimulation of the vagus nerve decreased heart rate and decreased LF/HF by increasing HF. On the cervical sympathetic nerve increased heart rate and increased LF/HF by increasing LF. Atropine, cholinergic blocker, increased heart rate and increased LF/HF by reducing HF, and propranolol, ${\beta}$-adrenergic blocker, decreased heart rate and decreased LF/HF by reducing LF> In unanesthetized rabbits, stimulation of the vestibular system induced by rotation or caloric increased heart rate and increased LF/HF by increasing LF> Also electrical stimulation of the vestibular nerve produced the same of effects as rotation or caloric in anesthetized rabbits. These results suggest that Stimulation of the vestibular system increased heart rate not by inhibiting the parasympathetic nerve but by activating the sympathetic nerve.

• 한국임상수의학회지
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• 제20권1호
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• pp.121-130
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• 2003

The purpose of this study was to investigate the effect of breeding conditions on reproductive efficiency of thoroughbred broodmares by ultrasonography. The mean age and breeding career of 120 mares used in this study were 11 years old and 6 years, respectively. The average pregnancy rate and embryonic loss rate were 87.5%, 11.8%. The groups that were 8-10 years old, 4-6 years, maiden and mated on May showed the highest pregnancy rate. While mares mated on 1st estrus post partus had the highest ovulation rate but showed the highest embryonic loss rate and he lowest pregnancy rate. And broodmares that had more intrauterine foreign bodies such as cyst and fluid with age and breeding career had represented lower pregnancy rate and higher embryonic loss rate than those having normal uterine condition. These results suggest that the breeding condition and uterine environment of mares had a significant influence on reproductive efficiency.

• Asian-Australasian Journal of Animal Sciences
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• 제4권3호
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• pp.293-298
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• 1991

A study was conducted to determine the effect of environmental temperature and level of food intake on plasma concentration of thyroid hormones. Three dairy heifers were used in an experiment which consisted of three levels of chamber temperature (10, 20 and $30^{\circ}C$) and three levels of food intake (100, 75 and 50% of recommended requirements). The analysis showed significant effects of environmental temperature on plasma triiodothyronine concentration, rectal temperature, respiration rate and heart rate but not on heat production. The range of plasma triiodothyronine was 2.51~1.79 ng/ml when the environmental temperature varied from 10 to $30^{\circ}C$. Effects of feed intake level were significant for heart rate and heal production. Heat production decreased from 25.9 to $20.0kJ/kg^{0.75}{\cdot}h$ when the TDN intake decreased from 66.3 to $35.1g/kg^{0.75}{\cdot}d$. There was no interactive effect of environmental temperature and feed intake level. Plasma triiodothyronine concentration decreased under high environmental temperature without any changes in heat production. The effects of environmental temperature and feed intake level on the physiological function of thyroid gland, as indicated by the relative circulating rate of thyroid hormones, were found to be clear.

• 한국작물학회지
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• 제31권4호
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• pp.408-415
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• 1986

본 연구는 해가림의 투광율이 인삼잎의 광합성능력 및 호흡에 미치는 영향을 구명하고 이들의 계절적 변리를 추적하기 위하여 진행하였던 바 그 결과를 요약하면 다음과 같다. 1. 각 공시 투광율의 해가림하에서 생육된 인삼잎은 온도 및 연생의 차이에 관계없이 모두 10,000 lux하에서 최대광합성을 나타내었고 계절적 차이는 인정되지 않았다. 2. 10∼15％ 투광율의 해가림하에서 생육된 인삼잎의 광합성량이 각 온도 및 광도에서 가장 높았으며, 2년생 인삼에서는 이의 계절적 차이가 현저하지 않았으나 4년생에서는 생육성기에 비해 후기의 최적투광율이 약간 낮아지는 경향이었다. 3. 인삼잎의 광합성능력은 생육성기에 비해 후기에 현저한 감소를 나타내었는데 그 정도는 후열 재식인삼에서 현저히 높았다. 4. 암호흡양은 생육성기에는 10∼15％ 투광율하에서 생육된 인삼잎에서 많았으나 생육후기에는 20∼25％의 투광율하의 잎에서 현저히 많았고 각 투광율에 관계없이 온도가 높을 수록 암호흡양은 현저히 증가되었다. 5. 인삼잎의 엽록소함량은 해가림의 투광율이 증가될 수록 현저한 감소를 나타내었으며 이러한 경향의 계절적 차이는 인정되지 않았다.

• Asian-Australasian Journal of Animal Sciences
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• 제16권8호
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• pp.1218-1223
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• 2003

The effects of type (high and low voltages) and time (3, 40 and 60 min postmortem) of stimulation on drip loss and meat color at 24 h post-mortem were determined on M. longissimus dorsi of 38 crossbred steers and heifers. In addition, the effect of pH early postmortem (70 min postmortem) on the rate and extend of meat tenderization was examined. Either high or low voltage stimulation at 3 min showed a tendency for faster pH decline (p=0.052) and higher drip loss (p=0.08), and improved the color dimensions of L*, a* and b* (p<0.01), compared to stimulation at 40 min. This was equivalent to approximately one unit of an AUSMEAT color chip. On the other hand, although there were significant differences in pH decline between high voltage stimulation at 40 and 60 min, and between low voltage stimulation at 40 min and control sides, drip loss and meat color did not differ significantly (p>0.05). The results suggested that early application of stimulation, regardless of type of stimulation, improved overall meat color at 24 h postmortem through its effect on faster glycolysing rate. However, if the pH decline was moderate, the benefit of electrical stimulation on meat color was not apparent. An intermediate pH decline resulted in the lowest shear force. Due to differential ageing rates the optimum pH at 70 min postmortem increased with ageing time from 5.96, 6.07, 6.12 and 6.14 for 1, 3, 7 and 14 days postmortem, respectively. This implied that a small difference in the rate of pH decline was important, especially carcasses stimulated for very early postmortem, and the optimum rate of pH decline varied with intended ageing period. The study suggests that the beneficial or adverse effects of electrical stimulation on drip loss, meat color and tenderness is determined by the rate of pH decline, rather than by stimulation treatment and time of application per se.

• The Korean Journal of Physiology
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• 제3권1호
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• pp.45-49
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• 1969

The effects of water extracts and powder of Korean ginseng on the division of Saccharomyces cerevisiae were studied. 1. The addition of several doses of water extracts and powder of ginseng to the yeast medium of Moyer and Coghill showed various promoted division of Saccharomyces. 2. The optimal dose of ginseng on tile division of Saccharomyces (0.08% dry ginseng medium solution per $10\;cells/mm^3$) could be recognized. 3. On the culture for 24 hours at $18^{\circ}C$, the cell number of control group was $13.25{\times}10^3\;cells/mm^3$ and that of the optimal dose group of water extracts of ginseng was $23.20{\times}10^3\;cells/mm^3$. On the culture, for 24 hours at $25^{\circ}C$, the cell number of control group was $16.85{\times}10^3\;cells/mm^3$ and that of the optimal dose group was $30.20{\times}10^3\;cells/mm^3$. The increasing rate of cell divison by the ginseng was about twice than that of control group. The optimal dose treatment of ginseng at $18^{\circ}C$ was more effective than control group at $25^{\circ}C$. 4. On the culture for 24 hours at $18^{\circ}C$, the increasing rate of water extracts of ginseng was 75.1%, and the rate of ginseng powder was 7.6%. On the culture for 24 hours at $25^{\circ}C$, the rate of water extracts of ginseng was 79.8%, and the rate of ginseng powder was 57.2%. Therefore water extracts of ginseng was more effective than ginseng powder of same dry weight, and the promoted effect of ginseng powder at $25^{\circ}C$ was more effective than at $18^{\circ}C$.

• 한국잠사곤충학회지
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• 제13권1호
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• pp.17-22
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• 1971

1968년부터 1970년까지 뽕나무위축병에 관하여 접목전염 및 곤충매개전염시험을 한바 결과를 요약하면 다음과 같다. 1. 병근에 건전수목을 절접하므로서 활착주수중 30%의 전염율을 나타냈다. 건전근에 병수목을 절접함에 있어서는 병수목을 월동전에 채취 저장하였다가 익춘 공시한 것은 활착주수중 14%가 전염되였는데 반하여 월동후에 채취한 병수목에 있어서는 전혀 발병되지 않았다. 건전대목에 병수목을 절접하여 불활착된 것 중 대아가 발조한 것은 전혀 발병되지 않았다. 2. 뽕나무위축병의 무병지대에서 채집한 마름무늬매 미충을 중증위축병주에서 7일, 14일, 21일 간식 각각흡즙시킨 성충을 무병실생묘에 방사접종한 결과 7일구는 전염되지 않았으며 14일구는 22％, 21일구는 61％ 전염율을 나타냈다. 흡즙시간과 접종시간은 길수록 전염율이 높았다.