• Journal of Preventive Medicine and Public Health
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• 제20권2호
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• pp.280-286
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• 1987

For evaluating the boosting (anamnestic) effects of the most recent commercially produced plasma derived heat-inactivated hepatitis B vaccine (A. Co.), 117 adults with naturally acquired antibody to hepatitis B surface antigen (anti-HBs) were selected at random. In addition, out of case immunized at zero and 1 month, and boosted at 6 months (primary boosting) by conventional vaccine (B. Co), inactivated by pepsin digestion and formalin treatment, 11 cases who showed elevated titer after primary boosting were also submitted to the study. The results were as follows: 1) Out of the 117 subjects with naturally acquired anti-HBs, 6(5.1%) showed isolated anti-HBs and the titers were below 10 ratio units (RU). Negative seroconversion was seen in 4(3.4%) of the 117 cases at 12 months after the screening and, of these cases, 3 showed isolated anti-HBs and the titers were below 10 RU. 2) Eighty-three percent of the cases with naturally acquired isolated anti-HBs below 10 RU did not respond to a booster injection with 3 us dose of A. Co. vaccine at all, but 90% of the other subjects responded. 3) The anti-HBs titers of all the 11 cases who showed a rise of more than 10 RU (increased GMT, 28.04) at one month after primary booster injection by $20{\mu}g$ dose of B. Co. vaccine decreased at 19 months after the primary booster. And 3 subjects (27.3%) of the 11 reached negative seroconversion. All of the 11 cases, who had secondary booster injection with $3{\mu}g$ dose of A. Co. vaccine at 19 months after primary boosting, showed increased anti-HBs titer at least 20 RU or more (increased GMT, 57. 72) at one month after the boosting. According to the above results in the anti-HBs screening survey for the purpose of immunization with hepatitis B vaccine, subjects with isolated anti-HBs below 10 RU should be regarded as being in an unimmunized state. In cases who are in risk circumstances, immunized primarily with a $20{\mu}g$ dose of B. Co. vaccine, a secondary booster injection should be given within 2 years after initiation of primary immunization and a $3{\mu}g$ booster dose of A. Co. vaccine can be reliably used.

• 한국강구조학회 논문집
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• 제22권4호
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• pp.389-398
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• 2010

교량용 HSB 고성능 강재를 적용한 정모멘트부 강합성거더의 휨저항강도를 모멘트-곡률 해석법으로 산정하고 일반 강재에 적용되는 AASHTO LRFD 조밀단면 휨저항강도 설계식에 의한 휨저항강도와 비교하여 기존 설계식의 적용성을 검토하였다. 다양한 연성특성을 갖는 2,391개 단면을 임의추출법으로 선정하고 재료 비선형 모멘트-곡률 해석 프로그램을 이용하여 이들 단면에 대한 휨저항강도를 구하였다. 합성단면을 구성하는 콘크리트 재료는 CEB-FIP 모델로, HSB600 및 HSB800 강재는 탄소성-변형경화 재료로 모델링하였다. HSB 강재를 적용한 강합성거더 단면의 연성비와 콘크리트 바닥판의 압축강도에 따른 휨저항강도 특성을 분석하고 SM520-TMC 일반 강재를 적용한 경우와 휨저항강도를 비교하였다. 2,391개의 HSB600 강합성거더 단면의 휨저항강도를 분석한 결과, 기존 LRFD 휨저항강도 설계식을 적용할 수 있는 것으로 분석되었다. 반면에, HSB800 강재를 적용한 강합성거더의 경우에는 기존 LRFD 조밀단면 휨저항강도 설계식은 비안전측으로 평가되었으며, HSB800 강합성거더의 모멘트-곡률해석 결과에 근거한 새로운 정모멘트부 휨저항강도 산정식을 제안하였다.

• 대한전자공학회논문지SD
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• 제42권6호
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• pp.31-38
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• 2005

본 논문에서는 exclusive-OR 연산을 기반으로 암호화된 그레이 영상에 위상 랩핑(phase-wrapping)과 다중 위상 분할(multi-phase separation)방법을 적용하여 광학적 복호화가 용이하도록 한 광 암호화 시스템을 제안하였다. 암호화시 그레이 영상을 이진 영상들의 합으로 분리한 후 각각의 이진영상을 이진 무작위 영상과 변형된 XOR(modified XOR) 연산을 수행하고, 연산된 이진 영상들과 이진 무작위 영상들을 따로 결합한 후 이를 위상 부호화하여 암호화 영상과 키 영상을 만든다. 복호화시 암호화 영상과 키 영상의 위상 정보를 광소자로 구현할 경우 제어 가능한 위상 범위의 현실적 한계로 인해 그레이 정보 복원에 제약이 따른다. 따라서 위상 랩핑(phase-wrapping) 방법으로 암호화 영상과 키 영상의 위상 범위를 줄이고, 다중 위상분할(multi-phase separation)로 이 영상들을 낮은 레벨의 위상영상들로 분할함으로써, 위상범위가 제한된 광소자로도 그레이영상의 복호화가 가능하도록 하였다. 복호화는 암호화 영상과 키 영상의 곱을 기준파와 간섭시켜 간단히 구현하며, 컴퓨터 모의 실험을 이용해 제안한 방법의 타당성과 복호화시 위상 범위의 제한에 따른 영향을 분석하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권10호
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• pp.1599-1609
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• 2020

Objective: This study was designed to determine how feeding diets differing in crude protein (CP) and undegraded intake protein (UIP) levels affected productivity, blood metabolites, carcass characteristics, and the production economics of Hanwoo steers. Methods: Thirty-six Hanwoo steers (age = 8.2±0.5 mo; body weight = 254±16.1 kg) were assigned at random to one of three treatments (4 steers/pen; 3 pens/treatment): i) a low-CP diet (LP; control) containing 12.1% CP with 35.1% UIP, 12.0% CP with 36.8% UIP, and 12.9% CP with 48.8% UIP, in the growing, fattening, and finishing periods, respectively; ii) a high-CP, low-UIP diet (HPLU) containing 15.0% CP with 33.7% UIP, 14.0% CP with 35.7% UIP, and 13.1% CP with 46.7% UIP, respectively; and iii) a high-CP, high-UIP diet (HPHU) containing 15.0% CP with 45.8% UIP, 14.0% CP with 44.6% UIP, and 13.0% CP with 51.1% UIP, respectively. Results: The treatments did not affect feed intake and growth performance, except for average daily gain during the fattening period that tended to be the lowest (p = 0.08) in the HPLU-fed steers. The feed CP conversion ratio over the entire feeding period was higher with high-CP diets. The treatments did not affect most blood metabolites; however, blood cholesterol and low-density lipoprotein concentrations during the fattening and finishing periods were the lowest in steers fed a HPLU diet. The treatments had negligible effects on cold carcass weight, yield traits including longissimus muscle area, backfat thickness, yield index, and yield grade, plus quality traits including meat color, fat color, texture, and maturity. However, marbling score and frequency of carcass quality grade 1⁺⁺ were greater in HPHU-fed steers. Conclusion: Feeding diets with higher CP and UIP levels did not affect growth performance but tended to improve the carcass quality of Hanwoo steers, resulting in greater economic return.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5075-5079
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• 2015

Background: Adverse effects of treatment prolongation beyond 8 weeks with radiotherapy for cervical cancer have been established. Clinical data also show that cisplatin increases the biologically effective dose of radiotherapy. However, there are no data on the effect of overall treatment time in patients with locally advanced cervical cancer treated with concomitant chemo-radiotherapy (CCRT) in an Indian population. The present study concerned the feasibility of concurrent chemotherapy and interspacing brachytherapy during the course of external radiotherapy to reduce the overall treatment time and compare the normal tissue toxicity and loco-regional control with a conventional schedule. Materials and Methods: Between January 2009 and March 2012 fifty patients registered in the Gynaecologic Oncology Clinic of Institute Rotary Cancer Hospital with locally advanced cervical cancer (FIGO stage IIB-IIIB) were enrolled. The patients were randomly allocated to treatment arms based on a computer generated random number. Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin $40mg/m^2$. High dose rate intra-cavitary brachytherapy (HDR-ICBT) was performed after one week of completion of external beam radiotherapy (EBRT). The prescribed dose for each session was 7Gy to point A for three insertions at one week intervals. Arm II (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions. Mention HDR-ICBT ICRT was performed after 40Gy and 7Gy was delivered to point A for three insertions (days 23, 30, 37) at one week intervals. Cisplatin $20mg/m^2/day$ was administered from D1-5 and D24-28. Overall treatment time was taken from first day of EBRT to last day of HDR brachytherapy. The overall loco-regional response rate (ORR) was determined at 3 and 6 months. Results: A total of 46 patients completed the planned treatment. The overall treatment times in arm I and arm II were $65{\pm}12$ and $48{\pm}4$ days, respectively (p=0.001). At three and six months of follow-up the ORR for arm I was 96% while that for arm II was 88%. No statistically significant difference was apparent between the two arms. The overall rate of grade ${\geq}3$ toxicity was numerically higher in arm I (n=7) than in arm II (n=4) though statistical significance was not reached. None of the predefined prognostic factors like age, performance status, baseline haemoglobin level, tumour size, lymph node involvement, stage or histopathological subtype showed any impact on outcome. Conclusions: In the setting of concurrent chemoradiotherapy a shorter treatment schedule of 48 days may be feasible by interspacing brachytherapy during external irradiation. The response rates and toxicities were comparable.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6131-6136
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• 2014

Objective: Epidemiology studies have reported conflicting results between glutathione S-transferase Mu-1 (GSTM1), glutathione S-transferase theta-1 (GSTT1) and glutathione S-transferase pi-1 (GSTP1) and ovarian cancer (OC) susceptibility. In this study, an updated meta-analysis was applied to determine whether the deletion of GSTM1, GSTT1 and GSTP1 has an influence on OC susceptibility. Methods: A published literature search was performed through PubMed, Embase, Cochrane Library, and Science Citation Index Expanded database for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity between studies was assessed using the Cochrane Q test and $I^2$ statistics. Sub-group analysis was conducted to explore the sources of heterogeneity. Sensitivity analysis was employed to evaluate the respective influence of each study on the overall estimate. Results: In total, 10 published studies were included in the final analysis. The combined analysis revealed that there was no significant association between GSTM1 null genotype and OC risk (OR=1.01, 95%CI: 0.91-1.12). Additionally, there was no significant association between GSTT1 genetic polymorphisms and OC risk (OR=0.98, 95% CI: 0.85-1.13). Similalry, no significant associations were found concerning the GSTP1 rs1695 locus and OC risk. Meanwhile, subgroup analysis did not show a significant increase in eligible studies with low heterogeneity. However, sensitivity analysis, publication bias and cumulative analysis demonstrated the reliability and stability of the current meta-analysis. Conclusions: These findings suggest that GSTs genetic polymorphisms may not contribute to OC susceptibility. Large epidemiological studies with the combination of GSTM1 null, GSTT1 null and GSTP1 Ile105Val polymorphisms and more specific histological subtypes of OC are needed to prove our findings.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5177-5182
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• 2012

Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2731-2737
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• 2013

Background: This study evaluated the validity and reliability of applying the Katz's Activities of Daily Living (ADL) scale in an Iranian sample of elderly oncologic patients following initial cancer treatment. Materials and Methods: The scale was translated with the forward-backward procedure to give an Iranian version. The ADL scale was then applied in a random sample of 400 oncologic patients aged 60 and older following initial cancer treatment. Assessment of the scale stability was twice, with a 14-days (two weeks) interval, to 30 (of the 400) eligible elderly cancer patients in March 2012. To measure treatment effects, the index was run with 150 patients in a three month recall, following oncology processing. Exploratory and confirmatory factor analysis was performed for assessment of construct validity of the Katz's ADL. Reliability was measured with internal consistency (Cronbach's alpha co-efficient), and test/retest (Spearman's r value) of the instrument. Criterion validity was evaluated by comparing the Katz with Physical Function (PF) subscale of SF 36. Known-group validity was approved by comparing of Katz' ADL between quartile groups of PF subscale of SF 36. Results: In our study the ADL demonstrated a high degree of internal homogeneity (Cronbach's alpha 0.923). There was a high correlation between scores of two time measurement of Katz's ADL (p value of two- related- samples test was 0.3). Construct validity showed a correlation coefficient of 0.572 between the ADL and PF scores. In factor analysis, 2 factors were extracted. Evidence for the reliability of the questionnaire was good and known group validity was approved by significant differences of ADL score between quartiles of the PF subscale of SF36. Conclusions: The results suggest that the Iranian version of ADL applied for oncologic older adult patients following initial cancer treatment is a reliable and a valid clinical instrument and comparable to those reported in other studies.

• Journal of Nutrition and Health
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• 제47권4호
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• pp.236-246
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• 2014

호두의 혈중 지질 수준 및 혈관 건강 개선 기능성을 평가하기 위하여 메타 분석을 실시하였다. 2014년 7월 9일 기준으로 DB 검색을 통해 426건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 19건 (n = 1,040)의 연구가 분석에 포함되었다. 호두를 일상 식사에서 일부 지방 급원 또는 열량을 대체하여 섭취하였을 때, 총 콜레스테롤, 저밀도 콜레스테롤, 중성지방 수준 및 혈류 매개 혈관 확장능을 각각 -0.124 mmol/l, -0.085 mmol/l, -0.080 mmol/l, +1.313 % 수준으로 대조군 대비 유의하게 개선시키는 것으로 분석되었다.

• 지식경영연구
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• 제21권3호
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• pp.177-195
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• 2020

소비자 구전은 정보통신기술의 발전과 모바일 기기의 보급 가속화로 그 영향력 또한 급속도로 커지고 있다. 그러나 과도한 마케팅 경쟁은 가짜리뷰와 같은 거짓 온라인 구전을 확산시켰고, 이로 인해 소비자들은 온라인 구전에 대한 피로감과 함께 온라인을 통해 얻게 되는 정보를 불신하는 결과를 초래하고 있으며, 이는 소비자의 합리적 구매 결정 행위에 부정적인 영향을 미치기도 한다. 이에 대한 문제 인식의 확산으로 가짜리뷰의 형태적 특성에 대한 연구를 비롯해 가짜리뷰를 효과적으로 분류하기 위한 다양한 탐지 방법에 대한 연구가 증가하고 있다. 이에 본 연구에서는 네이버 블로그에 작성된 포스트를 대상으로 데이터를 수집하고, 사용자의 무의식에 기반한 습관적 패턴을 머신러닝 모형을 통해 분석해 보았다. 게시물이 작성된 블로그와 그 게시물에서 추출한 변수를 분석하여 향후 가짜리뷰 예측에 활용하고자 하였다. 연구 결과, 광고성 리뷰 예측에 있어 해당 글 작성자의 블로그에 등록된 전체 포스트의 개수와 포스트의 등록 날짜는 매우 높은 상관관계를 보였으며, 해당 포스트가 속한 분류에 등록된 포스트의 개수, 포스트 본문에 사용된 이미지의 개수, 블로그에 포함된 메뉴 개수, 포스트 제목 및 본문의 길이, 포스트가 획득한 '좋아요'의 개수 또한 높은 상관관계를 보였다. 또한 광고성 리뷰 여부를 판단하기 위한 머신러닝 모형에 있어서 랜덤포레스트를 활용한 모형이 가장 우수한 모형으로 확인되었다. 본 연구에서는 블로그에 작성된 리뷰 내용에 대한 형태소 분석을 시행하는 대신 리뷰를 작성한 사람의 행위를 분석하기 위한 시도를 하였다. 이를 위해 블로그와 포스트의 특성 데이터를 수작업이 아닌 웹 크롤링 기법으로 수집하고 머신러닝 모형을 통해 광고성 리뷰 여부를 판별할 가능성을 확인한 점은 향후 가짜리뷰의 빠른 탐지를 위한 효율성 및 효과성 향상에 기여할 수 있을 것이다.