• Journal of Applied Biological Chemistry
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• 제64권2호
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• pp.177-184
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• 2021

축산용 항생제는 투여된 양의 일부만이 체내에서 사용되며 나머지는 분뇨로 배출되며 이를 활용한 퇴비를 농경지에 살포함으로써 농업환경에 유입되어 2차 오염 등을 초래하고 있다. 따라서, 농업환경 중 항생제 관리기준 설정 등 사후 관리 기술이 필요하다. 본 연구는 국내 사용빈도가 높은 것으로 알려진 tetracycline 및 sulfonamide 계열 등의 항생제를 대상으로 매체별 잔류량을 비교하고 퇴비 시용 전·후 농경지 토양 중 잔류항생제의 위해성을 평가하기 위하여 수행되었다. Buffer 및 SPE를 사용한 전처리 방법은 ppb 수준에서 70% 이상의 회수율을 나타냈으며, 검출한계(LOD)의 범위는 퇴비와 토양에서 각각 0.13-0.46 ㎍/kg과 0.05-0.25 ㎍/kg이었다. 잔류 항생제 분석결과 퇴비 중 tetracycline 계열 항생제의 잔류 농도는 5.38-196.0 ㎍/kg, sulfonamide 계열은 below the detection of limit (BDL)-259.0 ㎍/kg 수준으로 검출되었다. 농경지 토양의 경우 각각 0.30-53.3 ㎍/kg, BDL-4.16 ㎍/kg의 잔류 수준을 나타냈으며 토양분배계수(Kd) 값이 높은 tetracycline 계열 항생제의 잔류 농도가 sulfonamide 계열보다 높았다. 퇴비 시용 전후의 농경지 토양의 항생제에 대한 인체위해도는 항생제 종류에 따른 차이가 있었으나, 전체 HQ가 1 이하에서 안전하다는 기준에 의하면 조사된 항생제 5종 모두 인체 위해성이 매우 낮았으며 시용 전·후의 영향이 전체 위해도에 미치는 비율을 고려하면, 퇴비시용이 토양의 항생제에 대한 인체위해성에 미치는 영향은 미비한 것으로 판단되었다.

• 대한후두음성언어의학회지
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• 제32권2호
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• pp.81-86
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• 2021

Background and Objectives Therapies have been reported to treat the glottal gap previously. However, these voice therapies showed the limits because many techniques focused only on one among breathing, resonance and phonation. In addition patients often have difficulties visiting hospital frequently. 'Gliding and humming' is vocal training technique that readjusts total vocal patterns such as breathing, resonance and phonation. This technique can be easily applied during short term sessions. The purpose of this study is to evaluate the efficiency of voice therapy with 'gliding and humming' for patients with glottic gap during short-term treatment sessions. Materials and Method Twenty-three patients with glottal gap were selected. Of all patients, 14 patients had sulcus vocalis and 12 patients had muscle tension dysphonia (MTD). Voice therapies were performed 1.9 sessions in average. GRBAS, jitter, shimmer, noise to harmonic ratio, semitone range, closed quotient_vowel and maximum phonation time were compared before and after the therapies. In addition, changes of glottal gap and MTD severity were evaluated. Results Statistically significant improvement was observed. MTD improvement was observed only among the patients with glottal gap improvement. Also sulcus vocalis group showed the statistically significant improvement. Conclusion 'Gliding and humming' was effective to the patients with glottic gap and sulcus vocalis. Also, among patients who have both glottic gap and MTD, the data suggests that voice therapy for glottic gap also makes improvement in MTD.

• 한국지하수토양환경학회지:지하수토양환경
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• 제26권3호
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• pp.37-49
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• 2021

There is domestic Soil Contamination Warning Standard (SCWS) as remediation standard concentration of contaminated soils. No risk should be observed at soil concentration less than SCWS. Therefore, SCWS was evaluated to confirm the risk assessment. Background Concentration of Soil (BGC) and target remediation concentration were also assessed. The results show that Excess Cancer Risk (ECR) of SCWS was the highest in the groundwater intake pathway (Adult: 6.27E-04, Child: 2.81E-04). Total Cancer Risk (TCR) was 7.76E-04 and 4.30E-04 for adult and child, exceeding reference value (10^-6). Hazard Quotient (Non-Carcinogenic Risk, HQ) was the highest in the indoor air inhalation pathway (Adult: 3.64E+03, Child: 8.74E+02). Hazard Index (Total Non-Carcinogenic Risk, HI) exceeded reference value 1. ECR of the BGC was the highest in the groundwater intake pathway (Adult: 1.71E-04, Child: 7.67E-05). TCR was 2.12E-04 for adults and 1.17E-04 for children, exceeding the reference value (10^-6). HQ was the highest in groundwater intake pathway (Adult: 4.10E-01, Child: 1.84E-01). HI was lower than reference value 1 (Adult: 4.78E-01, Child: 2.50E-01). The heavy metal affecting ECR was Arsenic (As). The remediation-concentration of As was 7.14 mg/kg which is higher than BGC (6.83 mg/kg). TCR of As should be less than reference value (10^-6), but it was higher for all of SCWS, BGC and target remediation concentration. Therefore, it is suggested that risk assessment factors should be re-evaluated to fit domestic environmental settings and SCWS should be induced to satisfy the risk assessment.

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.87-94
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• 2022

본 논문은 501 다트게임의 최소 다트 촉 투척 횟수인 9회에 대한 획득점수 조합을 찾는 연구를 수행하였다. 다트게임에서 한 번 투척으로 획득할 수 있는 최대 점수는 60점으로 60×8+21×1=501에 의거 60점을 8회, 21점을 1회 획득하면 9회 투척으로 퍼펙트 다트게임을 종료할 수 있다. 이를 9-다트 종료라 한다. 이와 같이 9회 투척으로 501점을 획득 가능한 점수의 조합에 관한 연구는 18개와 14개만 알려져 있으며, 전수탐색 알고리즘을 적용한 연구는 수행되지 않고 있다. 본 논문은 전형적인 전수탐색법인 분기한정법의 O(2ⁿ) 지수시간 수행 복잡도를 다항시간 복잡도로 단순화 시키는 방법으로 나눗셈 분기한정 알고리즘을 제안하였다. 제안된 방법은 레벨을 8로 한정시키고, 501/60의 몫 레벨로 점프하고 역추적으로 이전 단계에서의 가능한 점수 조합만을 탐색하는 방법을 적용하였다. 제안된 알고리즘으로 찾은 9회의 퍼펙트게임의 가능한 점수 조합은 90개(101개 경우)를 얻었다.

• 한국도서관정보학회지
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• 제53권2호
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• pp.215-239
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• 2022

모든 공공도서관은 공비운영, 무료공개, 만인제공을 이념적 지주로 삼는 지방공공재이며 문화기반시설이다. 이러한 정체성은 공공도서관이 서비스 권역 내의 지역주민에게 각종 지식정보, 다양한 프로그램, 커뮤니티 공간 등을 제공하는 동시에 궁극적으로 국가 및 사회의 문화발전에 이바지할 때 정당화된다. 이를 위해서는 국가와 지방자치단체가 법적 기준에 부합하는 개체수를 확충하고, 유능한 전문인력을 배치하며, 접근·이용이 편리한 시설과 공간을 제공해야 한다. 그런데 지역별 공공도서관 상호간에 인프라와 서비스에 격차가 존재하면 주민의 접근·이용에 불평등을 초래하고 이는 정보격차 및 문화복지 격차로 귀결될 수밖에 없다. 이에 본 연구는 충남지역 공공도서관이 생활밀착형 지식정보서비스 기관, 문화향유 및 평생학습 공간으로 자리매김하려면 공공도서관의 균형발전 및 역량강화가 선행되어야 한다는 입장에서 시도별 및 충남지역 시군별 입지계수, 핵심 인프라 및 서비스 지표를 이용하여 상대적 격차를 분석하였다. 그 결과를 바탕으로 충남지역의 취약한 시군을 중심으로 공공도서관 격차 요소를 접근성, 핵심 인프라, 서비스로 나누어 격차 해소 방안을 제시하였다.

• Animal Bioscience
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• 제35권5호
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• pp.690-697
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• 2022

Objective: This study aimed to evaluate the effect of the ad libitum and restricted feeding regimen on fasting heat production (FHP) and body composition. Methods: Twelve Hubbard broilers breeders were selected with the same body weight and submitted in two feeding regimes: Restricted (T1) with feed intake of 150 g/bird/d and ad libitum (T2). The birds were randomly distributed on the treatments in two runs with three replications per treatment (per run). The birds were adapted to the feed regimens for ten days. After that, they were allocated in the open-circuit chambers and kept for three days for adaptation. On the last day, oxygen consumption (VO₂) and carbon dioxide production (VCO₂) were measured by 30 h under fasting. The respiratory quotient (RQ) was calculated as the VCO₂/VO₂ ratio, and the heat production (HP) was obtained using the Brower equation (1985). The FHP was estimated throughout the plateau of HP 12 hours after the feed deprivation. The body composition was analyzed by dual-energy X-ray absorptiometry scanning at the end of each period. Data were analyzed for one-way analysis of variance using the Minitab software. Results: The daily feed intake was 30 g higher to T2 (p<0.01) than the T1. Also, the birds of the T2 had significatively (p<0.05) more oxygen consumption (+3.1 L/kg^0.75/d) and CO₂ production (+2.2 L/kg^0.75/d). That resulted in a higher FHP 359±14 kJ/kg^0.75/d for T2 than T1 296±17.23 kJ/kg^0.75/d. In contrast, the RQ was not different between treatments, with an average of 0.77 for the fasting condition. In addition, protein and fat composition were not affected by the treatment, while a tendency (p<0.1) was shown to higher bone mineral content on the T1. Conclusion: The birds under ad libitum feeding had a higher maintenance energy requirement but their body composition was not affected compared to restricted feeding.

• 보건행정학회지
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• 제4권1호
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• pp.49-76
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• 1994

Small area variations in health care utilization have long been studied as an important issue related to boto cost containment and quality assurance. This study was conducted to investigate if variations in hospital services across small geographic areas in Korea existed. The claims data of the fiscal year 1992 obtained from the regional health insurance societies were used for the study. Main findings of the research can be summarized as follows : 1. Extremal Quotients(EQ) of hospital expenditure per capita and hospital days per capita varied among diagnosis types. The EQ ranged from 2.05(cataract) to 41.67(pneumonia) in hospital expenditure per capita and from 1.86(cataract) to 45.89(pneumonia) in hospital days per capita. The diagnosis groups which showed high variation were pneumonia, cephalo-pelvic disproportion, gastritis and duodenitis, fracture of rib, and acute bronchitis. Those which showed low variation were acute appendicitis and cataract. 2. The EQ level of admission rate was different in terms of diagnosis types, ranging from 2.57(catarct) to 44.45(pneumonia). The variations were high in medical disorders such as pneumonia, oephalo-pelvic disproportion, gastritis and duodenitis and acute bronchitis, while relatively low in surgical conditions such as acute appendicitis and cataract. 3. As an indicator of service intensity, the EQ of expenditure per admission ranged from 1.67(acute appendicitis) to 31.27(essential hypertension). The diagnoses which had high variation were essential hypertension, gastric ulcer, whereas those which had low variation were cephalopelvic disproportion and acute appendicitis. With regard to hospital days per admission, the EQ ranged from 1.55(acute appendicitis) to 28.13(gastric ulcer) by diagnosis types. The diagnosis groups with showed high variation were gastric ulcer, essential hypertension, and acute bronchitis, whereas those with low variation were cephalo-pelvic disproportion, intervertebral disc disorders, and acute appendicitis. Both the expenditure and hospital days per admission showed lewwer variations than the expenditure per capita, hospital days per capita and admission rate. 4. Comparing patterns of variation in utilization indices, diagnoses such as essential hypertension, gastric ulcer, fracture of rib showed higher variations in expenditure per admission than in admission rates, whereas diagnoses such as pneumonia, cephalo-pelvic disproportion and gastric ulcer showed higher variations in admission rate than expenditure per admission. These findings suggest that wide variations existed in several diagnoses groups across small areas in Korea. Further research should be performed to investigate factors related to small area variations including provider behavior.

• 한국환경보건학회지
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• 제49권2호
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• pp.108-117
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• 2023

Background: When particles are absorbed into the human body, they penetrate deep into the lungs and interact with the tissues of the body. Heavy metals in PM_2.5 can cause various diseases. The main source of PM_2.5 emissions in South Korea's atmosphere has been surveyed to be places of business. Objectives: The concentration of heavy metals in PM_2.5 near the Ulsan Industrial Complex was measured and a health risk assessment was performed for residents near the industrial complex for exposure to heavy metals in PM_2.5. Methods: Concentrations of heavy metals in PM_2.5 were measured at four measurement sites (Ulsan, Mipo, Onsan, Maegok) near the industrial complexes. Heavy metals were analyzed according to the Air Pollution Monitoring Network Installation and Operation Guidelines presented by the National Institute of Environmental Research. Among them, only five substances (Mn, Ni, As, Cd, Cr⁶⁺) were targeted. The risk assessment was conducted on inhalation exposure for five age groups, and the excess cancer risk and hazard quotient were calculated. Results: In the risk assessment of exposure to heavy metals in PM_2.5, As, Cd, and Cr⁶⁺ exceeded the risk tolerance standard of 10^-6 for carcinogenic hazards. The highest hazard levels were observed in Onsan and Mipo industrial complexes. In the case of non-carcinogenic hazards, Mn was identified as exceeding the hazard tolerance of 1, and it showed the highest hazard in the Ulsan Industrial Complex. Conclusions: This study presented a detailed health risk from exposure to heavy metals in PM_2.5 by industrial complexes located in Ulsan among five age groups. It is expected to be utilized as the basis for preparing damage control and industrial emission reduction measures against PM_2.5 exposure at the Ulsan Industrial Complex.

• Nutrition Research and Practice
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• 제17권4호
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• pp.717-734
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• 2023

BACKGROUND/OBJECTIVES: This study aimed to identify preschool children's eating behaviors associated with early childhood obesity and its multi-level, socio-ecological determinants. SUBJECTS/METHODS: In a cross-sectional study of 364 mothers of preschool children aged 3-5 years, these children's healthy eating behaviors were assessed using a validated preschool nutrition quotient (NQ-P) questionnaire. The children's overweight or obesity statuses were determined based on body mass index percentiles from the 2017 Korean National Growth Chart. The associations between the NQ-P score and risk of overweight or obesity were examined using multivariable logistic regression. The associations of individual, maternal, physical, and media environmental factors with the NQ-P score were also examined using multivariable linear regression. RESULTS: Preschool children with greater NQ-P scores were at a significantly lower risk of overweight or obesity (P < 0.01). The NQ-P score had a significantly positive association with maternal body mass index and an inverse association with household income (all P < 0.05). Maternal parenting and feeding practices exhibited associations with the NQ-P score. Positive associations were observed with "warm," "structured," and "autonomy-supportive" parenting as well as monitoring feeding practices (all P < 0.05). In addition, the NQ-P score had a significantly positive association with the childcare center's anti-obesogenic environment, such as the provision of nutritional and physical-activity support and vicinity of the built food environment to the home, including access to good-quality food, fruits and vegetables, and low-fat foods (all P < 0.05). Regarding media environments, the NQ-P score demonstrated more significant associations with viewing and eating and/or cooking content displayed on online video platforms (all P < 0.05) than with that on television. CONCLUSIONS: Our findings confirm the significance of healthy eating behaviors in early-childhood-obesity prevention and underscore the importance of multilevel maternal, physical, and media environmental interventions that effectively guide eating behaviors in preschool children.

• Journal of Nutrition and Health
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• 제56권3호
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• pp.277-287
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• 2023

본 연구는 광주 지역 대학생을 대상으로 섭식 행동과 영양 상태를 조사하고, 섭식 행동 유형별 영양 상태를 비교하여 이들 요인의 관련성을 분석하고자 수행되었다. 주요 결과는 첫째, 대상자의 성별에 따라 섭식 행동 수준과 유형의 분포는 유의한 차이를 보였다. 여학생이 남학생보다 감정적 섭식과 외부적 섭식 행동 수준이 높았고, 섭식 행동 유형에서 감정적, 절제적, 복합 섭식 유형이 많았다. 둘째, 대상자의 섭식 행동 유형에 따라 영양 상태는 차이가 있었다. 감정적 섭식 유형의 대상자가 절제적 섭식 유형보다 영양 지수가 낮았고, 다양과 식행동 영역에서 유의한 차이를 보였으며, 세부적으로 감정적 섭식 유형이 건강한 식생활에 대한 노력과 주관적 건강 상태, 영양 표시 확인, 식사 전 손 씻기, 물 섭취량에서 절제적 및 복합 유형보다 낮은 수준으로 나타났다. 외부적 섭식 유형의 대상자는 절제적 섭식 유형보다 절제 수준이 유의하게 낮았으며, 라면과 가당 음료에 대한 절제력이 절제적 및 복합 섭식 유형보다 낮은 수준으로 나타났다. 이와 같이 본 연구에서는 대학생의 섭식 행동 유형별로 잠재된 주요 영양 문제를 파악하였고, 유형별 문제 개선을 위한 맞춤 전략을 세우는 데 기여할 것으로 기대한다.