• 한국미생물·생명공학회지
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• 제36권4호
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• pp.360-365
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• 2008

식품 내의 잔류 항생물질의 검사는 주로 미생물의 생육 억제 여부를 통한 생물학적인 분석을 이용한다. 이러한 방법은 여러 가지 계열의 항생제들에 대한 미생물의 민감성을 토대로 이용되고 있다. 그러나 현재 사용하고 있는 미생물들로는 동물용의약품으로 허가되어 식용동물에 사용되고 있는 점점 다양해지는 항생제 및 합성항균제를 식품에서 모두 검출할 수는 없다는 한계가 있다. 그러므로 본 연구는 검출 가능한 항생제 및 합성항균제 계열의 범위를 확대하고, 각 약품별 감도를 증진시키기 위한 새로운 방법들을 조사하였다. B. megaterium ATCC 9885, B. subtilis ATCC 6633, B. cereus ATCC l1778 and Geobacillus stearothermophilus (B. stearothermophilus) ATCC 10149를 사용한 검사의 민감성은 macrolides, quinolones와 monensin, chloramphenicol에 대한 검출 감도가 낮았다. 반면에 M. luteus(K. rhizophila) ATCC 9341는 macrolides에 대한 높은 검출 감도를 나타냈고, E. coli ATCC l1303는 quinolones와 aminoglycosides에 대한 높은 민감성을 나타냈다. 결론적으로, 두 균주의 추가로 검출가능한 항생제 및 합성항균제의 범위를 확대하였으며, 검출감도를 높일 수 있게 되었다.

• 한국자기공명학회논문지
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• 제3권1호
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• pp.52-59
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• 1999

Authors synthesized common intermediates which are applicable for potential antibiotics. Their complete 13C and 1H NMR chemical shift data as well as carbon-and proton-fluorine coupling constants are reported. The knowledge of proton and carbon-fluorine coupling constants may help one assign the NMR data of the fluorinated quinolone derivatives. These results agree with the data published previously.

• Clinical and Experimental Pediatrics
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• 제51권10호
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• pp.1042-1046
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• 2008

The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has been limited because of their potential to induce arthropathy in juvenile animals. Despite class label warnings against use in children, prescriptions for quinolone antibiotics to treat infections in children have become increasingly prevalent. The main use of fluoroquinolones in pediatrics should be, understandably, in serious life-threatening infections for which other antibiotics therapies are not effective or available. While most of the published studies failed to detect an increased rate of articular adverse effects in children treated with fluoroquinolones, an increase in the use of these compounds, particularly in community-acquired lower respiratory infections, could accelerate the emergence of multidrug-resistant (including fluoroquinolone) pneumococcal strains. This review will discus the main issues related to the use of fluoroquinolones in children, the major problems of resistance developing among these compounds, with special emphasis on the potential side effects and skilled use of these alternative potent drugs in pediatric infection.

• 혜화의학회지
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• 제26권1호
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• pp.68-72
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• 2017

Objectives: The purpose of this case study is to report the clinical effects of acupuncture and Korean medicine on antibiotics-induced functional dyspepsia. Methods: The patient, 79-year-old, who complained about nausea and vomiting after taking antibiotics was treated by acupuncture and Korean medicine. We measured the amount of meals eaten by patient and quantified the degree of nausea she felt. Results: After the treatment, the symptoms were decreased. Conclusion: Acupuncture and herb medicine may be effective therapy on antibiotic's side effects such as nausea and vomit.

• 약학회지
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• 제45권4호
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• pp.334-338
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• 2001

A series of (-)-9-fluoro-2,3-dihydro-3(S)-methyl-10-(4-substituted-1-piperazinyl)-7-oxo-7H-pyrido [1,2,3-de] [1,4]-benzoxazine-6-carboxylic acid (5-8) was synthesized and evaluated for antibacterial activity against gram(+) and gram(-) bacteria. These synthesized compounds showed a lower activity than levofloxacin.

• 한국염색가공학회:학술대회논문집
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• 한국염색가공학회 2008년도 제38차 학술발표대회
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• pp.19-21
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• 2008

The quinolone antibiotics Ciprofloxacin shows broad antimicrobial spectrum, heat stability, limited water solubility, and similar structure and size to disperse dyes. The object of this study is to develop the infection-resistant medical extile material by applying Ciprofloxacin to a series of polyester materials such as PET, PDO, PLA, and PGA. All the Ciprofloxacin compound polyester materials demonstrated the superior antimicrobial activity to the organisms S. aureus and E. coli.

• 한국미생물·생명공학회지
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• 제51권4호
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• pp.555-558
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• 2023

Staphylococcus aureus is a prominent multidrug-resistant pathogen known for its resistance to a variety of antibiotics. To combat this, a wide range of antibiotics, including quinolones, is utilized. While the efficacy of quinolones against S. aureus has been established, the rise in quinolone-resistant strains, particularly in methicillin-resistant S. aureus (MRSA), has necessitated a shift in their usage patterns. Genomic sequencing plays a crucial role as it offers insights into the genetic mechanisms of resistance. Thus, we report the complete genome sequence of an oxolinic acid-resistant strain of S. aureus isolated from sweet potato leaves, a crop commonly cultivated in Korea.

• Fisheries and Aquatic Sciences
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• 제19권10호
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• pp.45.1-45.5
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• 2016

As a novel strategy to remove ${\beta}$-lactam antibiotic residues from fish tissues, utilization of ${\beta}$-lactamase, enzyme that normally degrades ${\beta}$-lactam structure-containing drugs, was explored. The enzyme (TEM-52) selectively degraded ${\beta}$-lactam antibiotics but was completely inactive against tetracycline-, quinolone-, macrolide-, or aminoglycoside-structured antibacterials. After simultaneous administration of the enzyme with cefazolin (a ${\beta}$-lactam antibiotic) to the carp, significantly lowered tissue cefazolin levels were observed. It was confirmed that the enzyme successfully reached the general circulation after intraperitoneal administration, as the carp serum obtained after enzyme injection could also degrade cefazolin ex vivo. These results suggest that antibiotics-degrading enzymes can be good candidates for antibiotic residue depuration.

• 약학회지
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• 제40권3호
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• pp.347-350
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• 1996

The post-antibiotic effect (PAE), which is defined as the period of time lag that the target organisms resume normal growth rate after complete removal of the antibiotics, of LB 20304 and ciprofloxacin was evaluated against Staphylococcus aureus 6538p and Escherichia coli 3190Y, respectively. The PAE was estimated by adding each antibiotic to a log phase of growth and incubating at $37^{\circ}$C for 1 h.Antibiotic was removed by centrifugation, and total viable cell counts were determined hourly for a further 10 h. The PAEs of LB20304 against S. aureus at concentrations of $1{\times}MIC\;and\;2{\mu}g/ml$ were 10 min and 93min, respectively. LB20304 showed a comparable PAE to ciprofloxacin. Against E. coli, the PAE of LB20304 was also similar to that of ciprofloxacin at concentration of $4{\times}MIC$ but it was much longer than that of ciprofloxacin at concentration of 2${\mu}g/ml$. LB20304 showed higher lethality than ciprofloxacin against both S. aureus and E. coli strains.

• 약학회지
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• 제38권5호
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• pp.586-594
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• 1994

The general pharmacological effects of DWQ-013, a new synthetic quinolone antibacterial agent, were examined on the central nervous system in experimentral animals and the following results were obtained. Drug interaction of DWQ-013 with theophylline, fenbufen and nonsteroidal antiinflammatory drugs was also examined. DWQ-013 decreased touch escape effect on the general behavior and decreased body temperature at a concentration of 1000 mg/kg in mice. But DWQ 013 had no effect on the locomotor activity, rotarod perfomance and traction test in mice. Furthermore, DWQ-013 increased pentobarbital-induced sleeping time and affected the onset time in acetic acid-induced writhing test in mice. DWQ-013 reduced onset time and death time on strychnine-induced convulsions and death time on pentylenetetrazole-induced convulsions at a concentration of 1000 mg/kg in mice. But, the drug had no effect on the electroshock. DWQ-013 did not interact with fenbufen and any other NSAIDs but it did interact with theophylline. From these results, it could be suggested that DWQ-013 had less pharmacological effect than other quinolones on the central nervous system.