• Annals of Clinical Neurophysiology
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• 제5권1호
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• pp.1-10
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• 2003

Small-fiber neuropathy (SFN) is a common clinical problems. The disorder is a generalized peripheral polyneuropathy that selectively involves small-diameter myelinated and unmyelinated nerve fibers. It is often idiopathic and typically presents with painful feet in patients over the age of 60. And autoimmune mechanisms are often suspected, but rarely identified. The clinical features consisted of painful dysesthesias and postganglionic sympathetic dysfunction, as well as reduced pinprick and temperature sensation. Although affected patients complain of neuropathic pain, this condition is often difficult to diagnose because of the few objective physical signs and normal nerve conduction studies. Diagnosis of SFN is made on the basis of the clinical features, normal nerve conduction studies, and abnormal specialized tests of small fiber function. These specialized studies include assessment of epidermal nerve fiber density as well as sudomotor, quantitative sensory, and cardiovagal testing. Unless an underlying disease is identified, treatment is usually directed toward alleviation of neuropathic pain.

• International Journal of Advanced Culture Technology
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• 제7권1호
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• pp.162-173
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• 2019

This study proposed 'Body Food,' an interactive tactile mat that provides interactive visual responses and induces physical activity in young children at the time of developing tactile and five senses, along with the touch of various stimuli. The product combines fiber materials and digital content to achieve a variety of visual and auditory responses in real time when children touch the fabric. User tests were conducted for 4-year-olds and the result was positive in terms of physical exercise and artistic experience, but quantitative testing is required to generalize it. In the future, we will complement physical and digital contents to realize more complete product.

• 한국식품조리과학회지
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• 제21권2호
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• pp.180-189
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• 2005

The purpose of this study is to determine the optimal mix ratio of Maneul-Sulgi and thereby, review its availability as health cake. For this purpose, the ratios of garlic juice and powder were varied with sugar added. As a result of quantitative descriptive analysis, it was found that the more the garlic juice and powder were added to non-glutinous rice, the Garlic taste was stronger. On the other hand, the less garlic powder was added, the cake would taste softer, and the less garlic juice was added, the cake was more chewy and moist. The feeling after swallowing was best when the ratio of garlic juice was $7\%$. As a consequence of surveying the tastes of Maneul-Sulgi, it was found that the less garlic powder was added to non-glutinous rice, the cake was more preferred. It was perceived that the ratio of garlic juice should be $7\%$ for flavor and desirable taste. As a result of testing the mechanic characteristics, it was found that the less garlic juice was used, the cake was more hard, elastic, cohesive, viscose and chewy. The more garlic powder was used, the Adhesiveness was higher. The Overall acceptability of sensory examination for Garlic taste had positive correlation Hardness of sensory examination and mechanical examination for adhesiveness.

• The Korean Journal of Pain
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• 제24권1호
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• pp.22-30
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• 2011

Background: Pregabalin has been shown to have analgesic effect in acute pain models. The primary objective was to examine the efficacy a single dose of pregabalin, would have on morphine consumption following lumbar discectomy. Methods: With ethical approval a randomized, placebo-controlled prospective trial was undertaken in 32 patients (ASA I-II, 18-65 years) with radicular low back pain for > 3 months undergoing elective lumbar discectomy. Patients received either oral pregabalin 300 mg (PG Group) or placebo (C Group) one hour before surgery. Pain intensity, the accumulative morphine consumption and adverse effects were recorded for 24 hours following surgery. Functional, psychological and quantitative sensory testing were also assessed. Results: Fourteen patients out of the 32 recruited were randomized to receive pregabalin. Morphine consumption was reduced (absolute difference of 42.3%) between groups with medium effect size. (Mann-Whitney; U =52.5, z-score= 2.84, P = 0.004, r = 0.14). This was not associated with a significant difference in the incidence of adverse effects between the two groups. The median pain intensity (VAS) on movement was not significantly different between groups. Conclusions: A single pre-operative dose of pregabalin (300 mg) did not result in a reduction in pain intensity compared to placebo in this patient cohort but the significant reduction in morphine consumption suggests that a fixed peri-operative dosing regime warrants investigation.

• The Korean Journal of Pain
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• 제21권2호
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• pp.126-130
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• 2008

Background: Females generally have a lower pain and temporal summation threshold than men. However, the results of studies designed to evaluate gender differences in the thresholds of heat pain and the temporal summation have been inconsistent. Newly developed device, CHEPS (Contact Heat Evoked Potential Stimulation) model of PATHWAY, have superiority on its fast rise and return time in temperature. Therefore we investigated gender differences in heat pain and temporal summation threshold. Methods: Forty healthy volunteers (20 males and 20 females) were enrolled in this study. A thermode was applied to the volar side of each volunteer's left forearm and heat pain and the temporal summation threshold was then measured. The heat pain threshold was estimated using the staircase method by starting from $36^{\circ}C$ and then increasing the temperature in $0.5^{\circ}C$ increments. The temporal summation threshold was estimated by applying five successive stimulation of the same temperature starting at $2^{\circ}C$ lower than the heat pain threshold and then increasing the temperature in $0.5^{\circ}C$ increments. Results: The mean heat pain thresholds was found to be $41.63{\pm}1.63^{\circ}C$ for males and $41.60{\pm}1.84^{\circ}C$ for females and the temporal summation thresholds were found to be $40.83{\pm}1.64^{\circ}C$ for males and $40.77{\pm}1.93^{\circ}C$ for females. The differences between males and females were not statistically significant. Conclusions: The result of this study suggested that there are no gender differences in heat pain and temporal summation threshold.

• Journal of Oral Medicine and Pain
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• 제32권4호
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• pp.413-419
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• 2007

다양한 종류의 정량적 통각검사들의 연관성을 알아보기 위하여 56 명의 측두하악장애 환자를 대상으로 측두근, 교근, 측두하악관절 부위, 그리고 경골근의 냉통각역치 (Cold Pain Threshold, CPT), 열통각역치 (Heat Pain Threshold, HPT), 열통증인내역치 (Heat Pain Tolerance Threshold, PTT), 압력통각역치 (Pressure Pain Threshold, PPT)를 측정하였으며, 각기 다른 통각 역치 간의 상관관계와 측정 부위 별 통각 역치 간의 상관 관계를 분석하였다. CPT, HPT, PTT를 포함한 온도통각역치의 성별간 차이는 나타나지 않았다. 그러나 PPT는 여성이 남성에 비하여 모든 부위에서 유의하게 낮은 역치를 나타내었다. CPT, HPT, PTT를 포함한 세 가지의 온도통각역치들은 모든 측정 부위에서 약정도에서 강정도 (mild to high)의 상관관계를 나타내었다 (r= 0.324-0.754, p<0.05). PPT 값은 각각의 온도통각역치와 통계적으로 유의한 상관관계를 나타내지 않았다. 모든 측정 부위의 통각역치값들은 서로간에 약정도에서 강정도 (mild to high)의 상관관계를 나타내었다 (r= 0.284-0.878, p<0.05). 측두하악장애 환자의 온도통각역치와 열통각인내역치 사이에는 유의한 상관관계가 존재하나 온도통각역치와 압력통각역치 간에는 상관관계가 나타나지 않는 것이 관찰되었으며, 각기 다른 부위에서 측정된 통각역치 간에는 비교적 높은 상관관계가 나타났다.