• Toxicological Research
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• v.34 no.1
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• pp.7-12
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• 2018

Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge. Molecular mechanism on the DNCB-mediated AD was further evaluated. Skin tissues were collected from mice treated with DNCB, and each tissue was equally divided into two sections; one for protein and the other for mRNA analysis. Expression of filaggrin, an important protein for keratinocyte integrity, was evaluated through SDS-PAGE. Level of mRNA expression for cytokines was determined through semi-quantitative reverse transcriptase polymerase chain reaction. Expression of filaggrin protein was significantly enhanced in the mice treated with DNCB compared with the vehicle (acetone : olive oil = 4 : 1 mixture) treatment group or the normal group without any treatment. Level of tumor necrosis factor-alpha and interleukin-18 mRNA expression, cytokines involved in activity of type-1 helper T ($T_H1$) cell, was significantly downregulated in the AD group compared with other control groups. These results suggest that suppression of $T_H1$ cell-mediated immune response could be reflected into the skin tissue of mice treated with DNCB for AD induction, and disturbance of keratinocyte integrity might evoke a compensatory mechanism.

• Journal of Preventive Medicine and Public Health
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• v.32 no.4
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• pp.491-498
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• 1999

Objectives : To determine the relations between seven blood lipids such as total cholesterol(TC), triglyceride(TG), HDL-cholesterol(HDL), LDL-cholesterol(LDL), apolipoprotein A-1(Apo A1), apolipoprotein B(Apo B) and lipoprotein(a)(Lp(A)) and the coronary heart diseases(CHD), the quantitative techniques of meta-analysis were applied to studios of blood lipids and CHD in Koreans. Methods : We searched the Korean and the English literature published from 1980 to August, 1997 by manual search and bibliography review. Information on sample size, study design, participant characteristics(gender, age) and blood lipid levels were abstracted by reviewers using inclusion criteria. Estimates of the effect sizes of blood lipid levels on CHD in Koreans and corresponding 95% confidence intervals were calculated using random-effect models. Results : We identified 16 case-control studies to apply meta-analysis. The overall effect sizes for CHD were 20.3(95% CI: 14.23-20.22) in TC, 24.8(95% CI: 12.6-36.86) in TG, 15.16(95% CI: 3.99-26.33) in LDL, -3.48(95% CI: -5.79 - -1.17) in HDL, -9.78(95% CI: -16.98 - -2.58) in Apo-a1, 17.88(95% CI: 9.72-26.05) in Apo B and 18.95(95% CI: 17.88-20.02) in Lp(a). Conclusions : Our results suggested that seven blood lipids were significantly associated with CHD in Koreans. Well-designed and prospective studies between blood lipids and CMD in Koreans should be peformed.

• Journal of Environmental Impact Assessment
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• v.19 no.3
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• pp.347-356
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• 2010

Forests are being seriously fragmented as a result of land development. Land development with disregard to its subsequent environmental impacts is a primary threat to biodiversity by incurring massive habitat losses and changes in structure and composition of forests. The purpose of this study was to develop the impact assessment model for quantitative distance or degree of disturbance by land developments. This study conducted a survey about structure and composition of forest species to determine degree of impact from land development. The edge effect of forest fragmentation on the number of bird species, population size, and bird diversity was obvious. In particular, the bird diversity sharply declines around the forest edge where intensive land development projects take place. To assess the disturbance of forest species, the factors selected were the bird diversity and the rate of edge species. The impact assessment model about bird diversity was explained by type of forest fragmentation and type of vegetation ($R^2$=0.23, p<0.005). The other model about edge species explained by a distance, type of forest fragmentation, type of vegetation, and width of road ($R^2$=0.34, p<0.001). In order to test the applicability of the model developed in this study, the models was applied to the Samsong housing development in Goyang-si, Gyunggi-do. The impacts of land development on the bird species were reasonably quantified to suggest effective mitigation measure. The impact assessment model developed in this study is useful to assess the magnitude of disturbance of bird species. Particularly, the model could be applied to the current Environmental Impact Assessment practices to predict and quantify the impacts of land developments projects on forest bird species.

• Journal of Power Electronics
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• v.18 no.5
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• pp.1336-1346
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• 2018

Wide band gap semiconductor devices such as SiC MOSFETs are becoming the preferred devices for high frequency and high power density converters due to their excellent performances. However, the proportion of the switching loss that accounts for the whole inverter loss is growing along with an increase of the switching frequency. In view of the third quadrant working characteristics of a SiC MOSFET, synchronous rectification discontinuous pulse-width modulation is proposed (SRDPWM) to further reduce system losses. The SRDPWM has been analyzed in detail. Based on a frequency domain mathematical model, a quantitative mathematical analysis of the harmonic characteristic is conducted by double Fourier transform. Meanwhile, a switching loss model and a conduction loss model of inverter for SRDPWM have been built. Simulation and experimental results verify the result of the harmonic analysis of the double Fourier analysis and the accuracy of the loss models. The efficiencies of the SRDPWM and the SVPWM are compared. The result indicates that the SRDPWM has fewer losses and a higher efficiency than the SVPWM under high switching frequency and light load conditions as a result of the reduced number of switching transitions. In addition, the SRDPWM is more suitable for SiC MOSFET converters.

• Atmosphere
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• v.26 no.4
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• pp.495-508
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• 2016

In order to determine the prediction possibility of heavy rainfall, a variety of analyses was conducted by using three-dimensional data obtained from Korea Local Analysis and Prediction System (KLAPS) re-analysis data. Strong moisture convergence occurring around the time of the heavy rainfall is consistent with the results of previous studies on such continuous production. Heavy rainfall occurred in the cloud system with a thick convective clouds. The moisture convergence, temperature and potential temperature advection showed increase into the heavy rainfall occurrence area. The distribution of integrated liquid water content tended to decrease as rainfall increased and was characterized by accelerated convective instability along with increased buoyant energy. In addition, changes were noted in the various characteristics of instability indices such as K-index (KI), Showalter Stability Index (SSI), and lifted index (LI). The meteorological variables used in the analysis showed clear increases or decreases according to the changes in rainfall amount. These rapid changes as well as the meteorological variables changes are attributed to the surrounding and meteorological conditions. Thus, we verified that heavy rainfall can be predicted according to such increase, decrease, or changes. This study focused on quantitative values and change characteristics of diagnostic variables calculated by using numerical models rather than by focusing on synoptic analysis at the time of the heavy rainfall occurrence, thereby utilizing them as prognostic variables in the study of the predictability of heavy rainfall. These results can contribute to the identification of production and development mechanisms of heavy rainfall and can be used in applied research for prediction of such precipitation. In the analysis of various case studies of heavy rainfall in the future, our study result can be utilized to show the development of the prediction of severe weather.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.2
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• pp.107-114
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• 1989

Model pile pull-out tests have been executed to investigate the characteristics of the critical relative displacement at which the critical pile skin resistance is mobilized. Test result shows that the critical relative displacement is neither constant nor pile size dependent, but it is the most closely related with the magnitude of the critical skin resistance. The empirical relationship between the two quantities has been established. Behavior of centrifuge physical models of skin-resistance-related problems has been investigated on a quantitative basis by a computational method. A pile downdrag problem has been employed as an example of the skin-resistance-related problems. A simple transfer function type method has been developed for the analysis of the downdrag. It is concluded from the analysis that centrifuge physical modeling of skin-resistance-related problems may lead to an erroneous result on an unconservative side, as may have been expected due to the violation of the similarity rule by the quantity of the critical relative displacement.

• Korean Journal of Community Nutrition
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• v.18 no.4
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• pp.312-323
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• 2013

Variables affecting bone heath of growing children were analyzed among forty nine 10-12 year old elementary students in three rural regions of north west Chungnam area. Information on age of the parents, duration of breast feeding and birth weight were collected from the guardians of the participants and nutrient intake and diet quality were assessed by average of three-day food records of participants with the help of dietitians. Bone health status was measured by calceneal broadband ultrasound attenuation (BUA) using quantitative ultrasound (QUS). Results showed that anthropometic indexes and nutrient intake levels were not different between boys and girls. However, iron intake was significantly lower in girls than in boys. Girls after menarche showed lower intake levels for thiamin, riboflavin, pyridoxine and niacin than girls before menarche. z-scores of BMI were lower than -1 and higher than +1 showed shorter breast feeding period than others but the difference was statistically non-significant. Overall, the subjects did not consume enough s of calcium, vitamin C and folic acid. Zinc intake and BMI were the most significant factors affecting BUA by the results of backward elimination in multiple regression models. Phosphorous and beta-carotene intakes showed significant negative relation with BUA. This study showed that children living in the rural area of Chungnam need extra care to keep their health and nutrient intakes especially for the nutrients known to affect growth. Tailored nutrition education needs to be more focused on the improvement of bone health status of children.

• 한국연소학회:학술대회논문집
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• 2002.06a
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• pp.85-94
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• 2002

Computational flow dynamics(CFD) has been frequently applied to the waste incinerators to understand the flow performance for various design and operating parameters. Though it needs many simplifications and complicated flow models, the reasonability of its results is not fully evaluated. For example, the inlet condition is calculated from an arbitrarily assumed properties of combustion gas release from the waste bed, since the combustion in the bed is difficult to be predicted. In this study, the computational modeling and calculation procedures of CFD for the grate type waste incinerator were evaluated using comparative simulations. Though the assumption method on the generation of the combustion gas directly affected the temperature and gas species concentrations, the overall flow pattern was dominated by the secondary air jets. The gaseous reaction could be included by assuming the release of the products of incomplete combusion from the bed. However, the reaction effficiency cannot not be directly evaluated from the species concentration, since it is not possible to simulate the actual co-existence of fuel rich or oxygen rich puffs over the bed. In predicting the turbulence, the higher order model, such as Reynolds stress model, gave difference shape of local recirculation zones, but similar results was acquired from the standard $k-{\varepsilon}$ model. Introducing radiation model was required for accurate temperature prediction, but it also caused heat imbalance due to the fixed temperature of the inlet, i.e. the waste bed. Thus, the computational modeling procedures on incinerators and the analysis of the predicted results should be progressed carefully. Though not validated experimentally, current simulation method is capable of comparative evaluation on the flow-related parameters such as the furnace shape and secondary air injection using identical inlet conditions. Quantitative analysis using measures of the residence time and mixing is essential to compare the flow performance efficiently.

• Korean Journal of Agricultural and Forest Meteorology
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• v.7 no.1
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• pp.15-27
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• 2005

The water and carbon cycles in terrestrial ecosystems are the essential database for better understanding of the causes and the current processes of climate change and for the prediction of its future change. CarboKorea and HydroKorea are dedicated research efforts to develop technologies to quantitatively interpret and forecast carbon/water cycles in typical landscapes of Korea. For this, stable isotope studies have been launched to genetically partition various components of carbon/water cycles in terrestrial ecosystems. From stable isotope studies, practical deliverables such as evaporation, transpiration and gross primary productivity (GPP) can be provided at scales from tower (footprint) to large watersheds. Such reliable field-based information will form an important database to be used for validation of the results from various eco-hydrological models and satellite image analysis which constitute main components of Carbo/HydroKorea project. Stable isotope studies, together with other relevant researches, will contribute to derive quantitative interpretation of carbon/water cycles in terrestrial ecosystems and support Carbo/HydroKorea to become a leading research infrastructure to answer pending scientific and socio-economic questions in relation to global changes.

• Proceedings of KOSOMES biannual meeting
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• 2003.11a
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• pp.7-11
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• 2003

Ship is being operated under a highly dynamic environments and many factors are related with ship's collision and those factors are interacting. So, an analysis on the ship's collision causes is very important to prepare countermeasures which will ensure the safe navigation. And the analysis confirmed that ship's collision is occurred most frequently and the cause is closely related with human factor. The main purpose of this study is to build a model of human factors in ship's collision cause using SD(System Dynamics} approach and to measure a effect which is risk control countermeasures of ship's collision. To achieve this aim, the structure analysis on the causes of ship's collision using FSM are performed, and the structure was changed by quantitative, qualitative factors and their feedback loops in casual map. This model was performed over 20 years(1993-2012) in a standard simulation model and 8 policy simulation models.