• 제목/요약/키워드: quantification

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각속도 측정시스템을 이용한 특발성 파킨슨병 환자의 완서증 정량화:운동기능검사 항목에 대한 UPDRS 점수와의 상관관계 분석 (Quantification of the Bradykinesia in Idiopathic Parkinson's Disease Patients using Angular velocity measurement system: The Correlation between angular velocity and UPDRS scores in motor examination part)

  • 김지원;이경미;엄광문;권도영;고성범;박건우
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 2009년도 춘계학술대회 논문집
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    • pp.71-72
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    • 2009
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Biplot of Ranked Data

  • Han, Sang-Tae;Huh, Myung-Hoe
    • Journal of the Korean Statistical Society
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    • 제24권2호
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    • pp.439-451
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    • 1995
  • Ranked data are widely used in the area of social sciences, for instance in polls and preference surveys, in which a number of objects (or stimuli) are evaluted and ranked by a panel of judges (or subject) according to their preference. We propose a graphical method for ranked data by quantifying objects and judges. In a plot for judges, the interpoint distances can be interpreted as Spearman or Kendall distance between two rankings given by respective judges. Similarly, we also construct a plot for objects with a sensible relationship to the previous plot for judges.

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이상적인 외형을 가진 입자의 표면원자 수계산법 (Quantification of Surface Sites of Ideally Shaped Particles)

  • 이수재;김수진
    • 한국광물학회지
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    • 제11권2호
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    • pp.126-134
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    • 1998
  • Surface site and areas of particles are geometrically calculated for the cubic structures to investigate how the surface sites vary with the variation of morphology and particle size. The numbers of surface site and area become smaller when the particles become equi-dimensional shape. The ratios of surface site to surface area are almost constant except the case of anion of fluorite structure. The ratios of the number of surface site to area are almost constant regardless of particle size except the size of up to 5 to 10 times of the unit cell dimension. This quantification method can be used to obtain data related to the surface reaction.

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Skin biopsy: an emerging method for small nerve fiber evaluation

  • Sohn, Eun Hee
    • Annals of Clinical Neurophysiology
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    • 제20권1호
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    • pp.3-11
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    • 2018
  • Skin biopsy and staining the specimens with immuno-reactive markers has been proven to be a useful method to demonstrate the pathologic status of small nerve fibers. Quantification of intraepidermal nerve fiber density using anti-protein gene product 9.5 antibody is a standard method to diagnose small fiber neuropathy. Skin biopsy also makes it possible to differentiate the nerve fibers according to their function by using different markers. Quantification of dermal structures with different types of nerve fibers could reveal the pathophysiologic mechanism of the disease state.

Quantification of Gadolinium Concentration Using GRE and UTE Sequences

  • Park, So Hee;Nam, Yoonho;Choi, Hyun Seok;Woo, Seung Tae
    • Investigative Magnetic Resonance Imaging
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    • 제21권3호
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    • pp.171-176
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    • 2017
  • Purpose: To compare different MR sequences for quantification of gadolinium concentration. Materials and Methods: Gadolinium contrast agents were diluted into 36 different concentrations. They were scanned using gradient echo (GRE) and ultrashort echo time (UTE) and R1, $R2^*$ and phase values were estimated from collected data. For analysis, ROI masks were made for each concentration and then ROI value was measured by mean and standard deviation from the estimated quantitative maps. Correlation analysis was performed and correlation coefficient was calculated. Results: Using GRE sequence, R1 showed a strong linear correlation at concentrations of 10 mM or less, and $R2^*$ showed a strong linear correlation between 10 to 100 mM. The phase of GRE generally exhibited a negative linear relationship for concentrations of 100 mM or less. In the case of UTE, the phase had a strong negative linear relationship at concentrations 100 mM or above. Conclusion: R1, which was calculated by conventional GRE, showed a high performance of quantification for lower concentrations, with a correlation coefficient of 0.966 (10 mM or less). $R2^*$ showed stronger potential for higher concentrations with a correlation coefficient of 0.984 (10 to 100 mM), and UTE phase showed potential for even higher concentrations with a correlation coefficient of 0.992 (100 mM or above).

Alternating Acquisition Technique for Quantification of in vitro Hyperpolarized [1-13C] Pyruvate Metabolism

  • Yang, Seungwook;Lee, Joonsung;Joe, Eunhae;Lee, Hansol;Song, Ho-Taek;Kim, Dong-Hyun
    • Investigative Magnetic Resonance Imaging
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    • 제20권1호
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    • pp.53-60
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    • 2016
  • Purpose: To develop a technique for quantifying the $^{13}C$-metabolites by performing frequency-selective hyperpolarized $^{13}C$ magnetic resonance spectroscopy (MRS) in vitro which combines simple spectrally-selective excitation with spectrally interleaved acquisition. Methods: Numerical simulations were performed with varying noise level and $K_p$ values to compare the quantification accuracies of the proposed and the conventional methods. For in vitro experiments, a spectrally-selective excitation scheme was enabled by narrow-band radiofrequency (RF) excitation pulse implemented into a free-induction decay chemical shift imaging (FIDCSI) sequence. Experiments with LDH / NADH enzyme mixture were performed to validate the effectiveness of the proposed acquisition method. Also, a modified two-site exchange model was formulated for metabolism kinetics quantification with the proposed method. Results: From the simulation results, significant increase of the lactate peak signal to noise ratio (PSNR) was observed. Also, the quantified $K_p$ value from the dynamic curves were more accurate in the case of the proposed acquisition method compared to the conventional non-selective excitation scheme. In vitro experiment results were in good agreement with the simulation results, also displaying increased PSNR for lactate. Fitting results using the modified two-site exchange model also showed expected results in agreement with the simulations. Conclusion: A method for accurate quantification of hyperpolarized pyruvate and the downstream product focused on in vitro experiment was described. By using a narrow-band RF excitation pulse with alternating acquisition, different resonances were selectively excited with a different flip angle for increased PSNR while the hyperpolarized magnetization of the substrate can be minimally perturbed with a low flip angle. Baseline signals from neighboring resonances can be effectively suppressed to accurately quantify the metabolism kinetics.

철도건널목 위험도 정량평가 방법론 적용성 연구 (Feasibility Study on the Risk Quantification Methodology of Railway Level Crossings)

  • 강현국;김만철;박주남;왕종배
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2007년도 춘계학술대회 논문집
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    • pp.605-613
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    • 2007
  • 위험 분석을 위한 방법론은 결정론적 정성적 접근과 확률론적 정량적 접근으로 대별될 수 있는데, 보다 현실적으로 다양한 요인을 적극적으로 고려할 수 있는 정량적 방법론은 효율성이 높으나 모델의 복잡성과 자료수집의 어려움을 극복하는 것이 필요하다. 본 연구에서는 복잡한 모델링을 체계적으로 수행하여 철도 건널목에서의 사고로 인한 위험도를 정량적으로 평가하기 위한 방법론을 도출하고 기본적인 적용성 연구를 통해, 정량평가 방법론의 유용성을 입증하고 추후 철도 통합 위험도 평가 시스템의 개발에 반영하는 목적으로 수행되었다. 제안된 위험도 평가를 위한 방법론은 다음과 같이 요약될 수 있다. 먼저 Preliminary Hazard Analysis 결과로부터 철도 사고에 대한 위험요인 목록을 작성하고 사건수목(Event Tree)을 이용하여 위험요인별로 사고 시나리오를 전개한다. 사건수목중 사건수목 분기확률을 정량화하기위해 보조논리를 필요로 하는 경우에 대해서 고장수목(Fault Tree)을 작성한다. 작성된 사건수목과 고장수목에 정량화를 위해 필요한 평가 자료를 입력하고 통합 정량화 방법론을 적용하여 최종 정량화를 수행한다. 정량화된 결과에 사고 상황을 고려한 해석을 수행하고 필요하다면 민감도 분석이나 불확실성 분석이 수행한다. 본 연구에서는 이러한 분석 방법론을 전국 철도건널목 사고 분석에 시범 적용하였다. 또한 2005년 국내 철도 건널목에서 발생한 사고자료를 이용하여 시범적인 정량화를 수행하여 그 적용성을 보였다.

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전국자연환경조사 자료를 이용한 생물다양성 정량화의 적정공간단위 연구 (Study on the Appropriate Spatial unit to Measure Biodiversity Using National Ecosystem Survey Data)

  • 이경일;황진후;장래익;류지은;전성우
    • 한국환경복원기술학회지
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    • 제21권5호
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    • pp.29-37
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    • 2018
  • Biodiversity refers to the diversity of organisms originating from all sources, including terrestrial ecosystems, aquatic ecosystems, and complex ecosystems and it is considered to be the standard of the area to be preserved and protected. So The Importance of environmental assessment for biodiversity conservation is increasing and International efforts to quantify biodiversity and to develop indices have been made, but there are insufficient researches on the use of biomass databases and their quantification in Korea. In this study, the biodiversity map was constructed using the 3rd National Ecosystem Survey Mammal Data with three spatial units(Administrative Area, 1:5,000 index map, hexagonal lattice). and the difference of map constructed by spatial unit was suggested to help research on quantification and evaluation of biodiversity in the future. As a result of the study, biodiversity index for the same area varied according to the spatial unit and overall average and standard deviation were different too. Therefore it is necessary to utilize appropriate spatial unit considering the suitability and purpose of quantification rather than using specific unit. It also showed the necessity of establishing a standard for biodiversity index as a result of comparative analysis with ecosystem and nature map. Based on this research, comprehensive efforts should be made for the sustainable development of the country through further research and institutional improvement for quantification and evaluation of biodiversity, set standards.