• Earthquakes and Structures
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• 제23권4호
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• pp.385-401
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• 2022

Uncertainty quantification is the most important challenge in seismic fragility assessment of structures. The precision increment of the quantification method leads to reliable results but at the same time increases the computational costs and the latter will be so undesirable in cases such as reliability-based design optimization which includes numerous probabilistic seismic analyses. Accordingly, the authors' effort has been put on the development and validation of an approach that has reduced computational cost in seismic fragility assessment. In this regard, it is necessary to apply the appropriate methods for consideration of two categories of uncertainties consisting of uncertainties related to the ground motions and structural characteristics, separately. Also, cable-stayed bridges have been specifically selected because as a result of their complexity and the according time-consuming seismic analyses, reducing the computations corresponding to their fragility analyses is worthy of studying. To achieve this, the fragility assessment of three case studies is performed based on existing and proposed approaches, and a comparative study on the efficiency in the estimation of seismic responses. For this purpose, statistical validation is conducted on the seismic demand and fragility resulting from the mentioned approaches, and through a comprehensive interpretation, sufficient arguments for the acceptable errors of the proposed approach are presented. Finally, this study concludes that the combination of the Capacity Spectrum Method (CSM) and Uniform Design Sampling (UDS) in advanced proposed forms can provide adequate accuracy in seismic fragility estimation at a significantly reduced computational cost.

• 한국압력기기공학회 논문집
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• 제19권2호
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• pp.130-139
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• 2023

This paper examines the quantification of uncertainty for welding residual stresses in dissimilar metal welds used in nuclear power plants. A mock-up of a dissimilar metal weld pipe, consisting of carbon and stainless steel pipes, was fabricated to measure the residual stress. A Round-Robin analysis was conducted by Korean institutions to assess the welding residual stress. The analysis was carried out in the second order, and the data obtained by each institution was evaluated based on the information provided. Using the Round-Robin results, the distribution of uncertainty in welding residual stresses among Korean institutions was evaluated. The quantification of uncertainty for Korean institutions was found to have a wider range compared to the distribution of welding residual stresses observed in overseas institutions. This study is considered useful in the establishment of comprehensive strategies for evaluating welding residual stress analysis methods used by domestic institutions.

• 한국안전학회지
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• 제38권6호
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• pp.72-78
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• 2023

The purpose of this paper is to derive a quantified approach for Operator Manual Actions (OMAs) based on the existing fire Human Reliability Analysis (HRA) methodology developed by the Korea Atomic Energy Research Institute (KAERI). The existing fire HRA method was reviewed, and supplementary considerations for OMA quantification were established through a comparative analysis with NUREG-1852 criteria and the review of the existing literature. The OMA quantification approach involves a timeline that considers the occurrence of Multiple Spurious Operations (MSOs) during a Main Control Room Abandonment (MCRA) determination and movement towards the Remote Shutdown Panel (RSP) in the event of a Main Control Room (MCR) fire. The derived failure probability of an OMA from the approach proposed in this paper is expected to enhance the understanding of its reliability. Therefore, it allows moving beyond the deterministic classification of "reliable" or "unreliable" in NUREG-1852. Also, in the event of a nuclear power plant fire where multiple OMAs are required within a critical time range, it is anticipated that the OMA failure probability could serve as a criterion for prioritizing OMAs and determining their order of importance.

• 한국콘텐츠학회논문지
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• 제17권7호
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• pp.215-221
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• 2017

본 연구는 two-point Dixon기법을 이용한 간의 지방정량화 검사 시 가돌리늄 조영제인 Gd-EOB-DTPA가 지방정량화에 어떠한 영향을 미치는지 알아보고자 하였다. 연구방법은 2016년 4월부터 동년 9월까지 two-point Dixon 기법을 이용해 간의 지방정량화 검사를 시행한 60명을, 두 그룹(정상의 간기증자 30명, 비정상의 간 지방증 환자 30명)으로 분류한 후 조영제 주입에 따른 지방분율의 변화를 비교 평가하였다. 연구 결과, 두 그룹 모두 조영제 주입 전 보다 후의 지방분율이 크게 감소(간 기증자 -33.8%, 간 지방증 환자 -47.2%)하는 것으로 나타나 Gd-EOB-DPTA가 지방정량화에 영향을 미친다는 것을 알 수 있었다. 결론적으로 two-point Dixon기법을 이용해 간 지방정량화 검사를 시행할 경우, Gd-EOB-DTPA 주입 전에 영상을 획득해야 지방분율의 변화를 최소화 할 수 있어 정확한 진단을 할 수 있다.

• Journal of Microbiology and Biotechnology
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• 제19권7호
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• pp.658-665
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• 2009

Quality control QC for spot-uniformity is a critical point in fabricating an oligonucleotide array, and quantification of targets is very important in array analysis. We developed two new types of QC probes as a means of confirming the quality of the uniformity of attached probes and the quantification of targets. We compared the signal intensities and fluorescent images of the QC and target-specific probes of arrays containing only target-specific probes and those containing both QC and target-specific probes. In a comparison of quality control methods, it was found that the arrays containing QC probes could check spot-uniformity or spot defects during all processes of array fabrication, including after spotting, after washing, and after hybridization. In a comparison of quantification results, the array fabricated by the method using QC probes showed linear and regular results because it was possible to normalize variations in spot size and morphology and amount of attached probe. This method could avoid errors originating in probe concentration and spot morphology because it could be normalized by QC probes. There were significant differences in the signal intensities of all mixtures (P<0.05). This result indicates that the method using QC probes is more useful than the ordinary method for quantification of mixed target. In the quantification of mixed targets, this method could determine a range for mixed targets of various amounts. Our results suggest that methods using QC probes for array fabrication are very useful to the quality control of spots in the fabrication processes of quantitative oligonucleotide arrays.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5229-5235
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• 2016

Prostate cancer (PCa) remains one of the most widespread and perplexing of all human malignancies. Assessment of gene expression is thought to have an important impact on cancer diagnosis, prognosis and therapeutic decisions. In this context, we explored combined expression of PCa related target genes AMACR and PCA3 in 126 formalin fixed paraffin embedded prostate tissues (FFPE) from Moroccan patients, using quantitative real time reverse transcription-PCR (RT-qPCR). This quantification required data normalization accomplished using stably expressed reference genes (RGs). A panel of twelve RG was assessed, data being analyzed using GenEx V6 based on geNorm, NormFinder and statistical methods. Accordingly, the hnRNP A1 gene was identified and selected as the most stably expressed RG for reliable and accurate gene expression quantification in prostate tissues. The ratios of both PCA3 and AMACR gene expression relative to that of the hnRNP A1 gene were calculated and the performance of each target gene for PCa diagnosis was evaluated using receiver-operating characteristics. PCA3 and AMACR mRNA quantification based on RT-qPCR may prove useful in PCa diagnosis. Of particular interesting, combining PCA3 and AMACR quantification improved PCa prediction by increasing sensitivity with retention of good specificity.

• 공업화학
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• 제34권4호
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• pp.450-454
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• 2023

플럭스 코어 아크 용접(flux cored arc welding, FCAW)에서 플럭스(flux)로 사용되는 합금 분말 내의 염소이온은 용접 금속의 비드 표면에 기공을 유발하여 불량을 유발하거나, 합금 분말에 잔류한 염소가 금속의 부식을 유발할 수 있다. 합금 분말의 염소이온 정량은 주로 연소-이온크로마토그래피법이 사용되나, 장비가 고가이며 고도의 전문성이 요구되는 한계가 있다. 따라서, 본 연구에서는 합금 분말의 염소이온 정량으로 주로 쓰이는 방법인 연소-이온크로마토그래피 법과 X-선 형광분석법, 그리고 전위차 적정법을 비교하여 현장에서 적용하기 쉽고 정확한 정량법을 찾고자 한다. 염소이온 정량의 대상으로는 플럭스로 가장 흔히 사용되는 마그네슘-알루미늄 합금 분말을 대상으로 한다. 본 연구의 결과를 통해, 전위차 적정법을 현장에서 합금 분말의 염소이온 정량에 적용할 수 있다.

• 한국정밀공학회지
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• 제22권4호
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• pp.188-193
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• 2005

The purpose of this paper is to develop a more precise damper model of the joint for the quantification of the joint mechanical properties. We modified the linear damper model of a knee joint model to nonlinear one. The normalized RMS errors between the simulated and measured joint angle trajectories during passive pendulum test became smaller with the nonlinear damper model than those of the linear one which indicates the nonlinear damper model is better in precision and accuracy. The error between the experimental and simulated knee joint moment also reduced with the nonlinear damper model. The reduction in both the trajectory error and the moment error was significant at the latter part of the pendulum test where the joint angular velocity was small. The nonlinearity of the damper was significantly greater at thin subject group and this indicates the nonlinearity is a useful index of joint mechanical properties.

• Journal of the Korean Data and Information Science Society
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• 제8권2호
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• pp.173-181
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• 1997

한의학에서 환자의 병적상태를 분석하고 진단하기위한 전문가시스템은 진단과정에서 환자로부터 받아들인 지식에 기초하므로 지식은 정확하게 표현되어야 한다. 그러나 대부분의 한의진단과정에서 환자로부터 받아들인 지식은 주로 질적자료에 기초하여 기준이 애매한 개념의 지식을 많이 포함하므로 이에 대한 처리가 요구된다. 본 논문에서는 한의전문가시스템 구축에 이용되는 정보의 정확도를 높이기 위하여 Hayashi의 수량화II류를 기반으로 하여 한의진단과정에서 얻어지는 지식을 수량화하는 방법을 제안하였다.

• 한국정밀공학회지
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• 제17권2호
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• pp.227-234
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• 2000

The human sensibility caused by the motion of an object grasped by a human operator is defined as kinesthetic sense of arm. Due to nonlinearity and ambiguity of human sense, there is no absolute standard for quantification of kinesthetic sense. In this research, a so-called 2-dimensional arm motion generator is developed to present various mechanical impedance (i.e., stiffness or damping) characteristics to a human arm. The kinesthetic words representing arm kinesthetic sense are selected and then the subject's satisfaction levels on these words for given impedance values are measured and processed by the SD method and factor analysis. In addition, the quantification method using neural network is proposed to take into account the individual difference between the mean sensibility and each subject's sensibility. Through this proposed algorithm, the sensibility of human motion described qualitatively can be converted into engineering data ensuring objectivity, reproducibility, and universality.