• Bulletin of the Korean Chemical Society
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• 제30권11호
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• pp.2799-2802
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• 2009

• Bulletin of the Korean Chemical Society
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• 제18권11호
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• pp.1192-1195
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• 1997

A divergent approach to 2-(hydroxymethyl)pyrrolidine-3,4-diols has been studied with 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1), a potent glycosidase inhibitor. D-AB1 was efficiently synthesized from 2,3-epoxyalcohol 6a in overall 11% yield.

• 대한화학회지
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• 제34권5호
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• pp.469-475
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• 1990

2,6-dichloroquinoxaline (13)과 m-chloroperbenzoic acid를 반응시켜 2,6-dichloroquinoxaline 4-oxide (14)를 합성하고, 이것과 pyrrolidine 혹은 indoline을 반응시켜 2-substituted 6-chloroquinoxaline 4-oxide류(15)를 합성하였다. 그리고 이들과 dimethyl acetylenedicarboxylate를 반응시키니 isoxazolo[2,3-a]quinoxaline류(16)와 pyrrolo[1,2-a]quinoxaline류 (17)가 선택적으로 합성되었다. 더욱이 pyrrolo[1,2-a]quinoxaline류 (17)는 isoxazolo[2,3-a]quinoxaline류 (16)의 고리변환에 의하여 생성된다는 것을 알았다.

• 대한화학회지
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• 제51권3호
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• pp.244-250
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• 2007

항암작용이 기대되는 일련의 새로운 6-allylthio-3-aminopyridazine 유도체를 allylthiolation, amination을 이용하여 합성하였다. 피리다진 핵은 hydrazine monohydrate와 maleic anhydride의 축합반응으로 제조하였다. 3,6- Dichloropyridazine은 3,6-dihydroxypyridazine을 POCl3에 가하여 합성하였다. 6-Allythio-3-chloropyridazine은 3,6- dichloropyridazine에 allylmercaptan과 sodium hydroxide을 이용하여 얻었다. Morpholine, piperazine, pyrazole, imidazole, pyrrolidine, piperidine, perhydroazepine 및 perhydroazocine와 같은 질소 친핵체를 갖는 hetero환을 피리 다진 환의 3번 위치에 도입시켜 6-allylthio-3-aminopyridazine 합성하였다. 이 과정은 아민 친핵체의 친핵성 치환반응 으로 n-buthanol에서 NH4Cl를 가하고 24~48시간 동안 환류시켜 진행하였다.

• Bulletin of the Korean Chemical Society
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• 제24권10호
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• pp.1433-1436
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• 2003

A new method for the simultaneous determination of heavy metal ions in cigarette material by microwave digestion and reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed. The cigarette material was digested by microwave digestion. Lead, cadmium, mercury, nickel and tin ions in the digested samples were pre-column derivatized with tetra-(2-chlorophenyl)-porphyrin ($T_2$-CPP) to form color chelates, which were then enriched by solid phase extraction with a $C_{18}$ cartridge. The chelates were separated on a Waters Xterra$^{TM}RP_{18}$ column by gradient elution with methanol (containing 0.05 mol/L pyrrolidine-aceticacid buffer salt, pH = 10.0) and acetone (containin0.05 mol/L pyrrolidine-acetic acid buffer salt, pH = 10.0)as mobile phase at a flow rate of 0.5mL/min and analyzed with a photodiode array detector from 350-600 nm. The detection limits of lead, cadmium, mercury, nickel and tin were 4,3,3,8 and 5 ng/L, respectively, in the original samples. This method was afforded good results.

• 분석과학
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• 제8권3호
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• pp.321-334
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• 1995

흔적량 금속이온인 Co(II), Ni(II) 및 Cu(II)의 ammonium pyrrolidine dlthiocarba-mate(APDC) 착물을 용매추출하기 위한 기초적인 연구를 수행하였다. 킬레이트제인 $4{\times}10^{-5}M$ APDC의 클로로포름에 대한 추출에서 가장 큰 분포비 (log D=1.3543)는 pH 2.0에서 나타났으며, 이때 분배계수($K_{p.HPDC}$)는 2.489였다. 수용액과 유기용매층에서 이들 착물의 UV/Vis 스펙트럼을 얻었는데, 안정한 착물을 형성하는 pH는 각각 Co(II):5.0, Ni(II):8.0 및 Cu(II):8.0이었고 금속이온과 APDC는 1:2의 착물을 형성하였으며, 1분만 흔들어 주어도 정량적으로 유기층에 분배되었다. 유기용매로의 분배 및 추출평형을 조사하기 위하여, $M(PDC)_2$ 착물을 합성하여 클로로포름에 $10.0{\mu}g/ml$가 되게 녹이고, HCl 용액과 NaOH 용액으로 pH를 조절한 수용액으로 역추출을 하였다. 분포비와 추출률은 $Co(PDC)_2$의 경우 PH6.5~8.5에서 log D=2.834 : E(%)=99.a%9 $Ni( PDC)_2$는 pH 11.0에서 log D=5.699 : E(%)=100%, 그리고 $Cu(PDC)_2$는 pH 6.0에서 log D=2.025 : E(%)=99.1%의 최대값을 나타내었다. 추출상수와 착물의 생성상수는 각각 $Co(PDC)_2$는 log $K_{ex}=9.671$ : log ${\beta}_2=6.938$, $Ni(PDC)_2$는 log $K_{ex}=9.646$ : log ${\beta}_2=7.071$, $Cu(PDC)_2$는 log $K_{ex}=9.074$ : log ${\beta}_2=7.049$였다. 이런 결과들로부터 흔적량 금속이온을 분리 농축하는 최적의 추출과정을 작성할 수 있으며, 정밀소재 및 환경시료 등에서 매트릭스의 영향없이 정량할 수 있음이 기대된다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.1038-1039
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• 2004

We developed a new photoresist which was composed of polyaniline, uv-curing agent, N-methyl-2- pyrrolidine (NMP) and N-Butyl alcohol (BuOH) as solution. The photoresist is characterized by the capability of being developed in water. We successfully patterned pentacene thin film, which was vulnerable to organic solvent and thus could not be patterned by the conventional photolithography process, with the water soluble photoresist and the minimum feature size was found to be 2um.

• 약학회지
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• 제30권4호
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• pp.163-168
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• 1986

Thirteen compounds were synthesized by condensing the N-heterocyclic amines (piperidine, pyrrolidine, morpholine) and secondary aliphatic amines (dimethylamine, diethylamine) with 3,4-methylenedioxyphenylalkenoic acid chlorides for developing CNS depressants. Among them, N, N-diethyl-3,4-methylenedioxycinnamamide (IX) and N, N-dimethyl-5-(3,4-methylenedioxyphenyl)-2, 4-pentadienoic acid amicle (XII) exhibited strong activity in antagonism against pentylenetetrazole-induced convulsion, strychnine-induced convulsion and maximal electroshock seizure. N, N-Dimethyl-3, 4-methylenedioxycinnamide (VIII) showed more potent activity in antagonism against strychnine-induced convulsion and maximal electroshock seizure and in the prolongation of hexobarbital sleeping time.

• Archives of Pharmacal Research
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• 제24권5호
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• pp.385-389
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• 2001

Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds 6c and 6e bearing p-anisidine and pyrrolidine side chain were more active than the others.

• Bulletin of the Korean Chemical Society
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• 제16권9호
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• pp.839-844
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• 1995

The kinetics and mechanism of the reactions of phenyl benzoates with benzylamines and pyrrolidine are investigated in acetonitrile. The variations of ρX (ρXY>0) and ρZ (ρYZ<0) with respect to the substituent in the substrate (σY) indicate that the reactions proceed through a tetrahedral intermediate, T±, with its breakdown in the rate determining step. The large magnitudes of ρZ, ρXY and ρYZ as well as the effects of secondary kinetic isotope effects involving deuterated nucleophiles are also in line with the proposed mechanism.