• 제목/요약/키워드: pyrazolopyridine

검색결과 3건 처리시간 0.016초

Reactions with Activated Nitriles : A new route for the synthesis of new pyridine and pyrazolopyridine derivatives

  • Attaby, Fawzy-A.;Eldin, Sanaa-M.
    • Archives of Pharmacal Research
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    • 제13권3호
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    • pp.274-277
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    • 1990
  • It has been found that $\alpha, \beta$-unsaturated nitrile derivatives 1-3 reached with S- methylisothiourea to give the prpone derivatives 4-6 respectively. Cyclisation of 4-6 using ethanolic hydrochloric acid afforded the pyridine derivatives 7-9 in good yields. On the other hand, the reactions of hydrazine hydrate and of phenylhydrazine with each of 7-9 gave the corresponding pyrazolopyridine derivatives 10-15. The structures of the newly synthesised derivatives were assigned on the basis of elemental analyses, IR and $^1H$-NMR spectral data studies.

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소염진통제 개발 (II) - 접합 헤테로고리 화합물 - (Development of Antiinflammatory Agents(II) - Fused Heterocycles -)

  • 박노상;김현숙;임희종;정영식;최중권;함원훈
    • 약학회지
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    • 제35권2호
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    • pp.73-84
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    • 1991
  • Quinoline, pyrazolo-[5, 4-b]-pyridine, isoxazolo-[5, 4-b]-pyridine, pyrazolo-[4, 3-c]-quinoline, isoxazolo-[5, 4-e]-thiazine, and isothiazolo-[5, 4-e]-thiazine derivatives were prepared as possible antiinflammatory agents. Some of the synthesized compounds showed antiinflammatory activities comparable to Aspirin and Naproxen.

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Heterocyclic Synthesis with Nitriles: New Routes for Synthesis of Pyridazines, Pyridines and their Fused Derivtives

  • Negm, Abdalla-M.;Abdelrazek, Fathy-M.;Elnagdi, Mohamed-H.;Shaaban, Lina-H.
    • Archives of Pharmacal Research
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    • 제17권6호
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    • pp.411-414
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    • 1994
  • Phenylazocyanothioacetamide 1 reacts with malononitrile to afford the pyridinethione 4 which reacts with phenacylbromide to yield the pyridine-S-phenacyl derivative 6, 1 reacts with ethyl cyanoacetate to yield the pyridazine derivative, 8, and with phenacyl bromide to afford the N-phenacyl derivative 11, instead of the thiazole 10. Compound 11 afforded the pyrazolopyridine 13 on reaction with malononitrile while 10 was obtained on coupling of the thiazole 14 with diazotised aniline. Compound 10 reacts with malononitrile to afford the thizaolyl pyridazine 15. Compound 1 reacts with malononitrile dimer to afford the pyriodopyridazine derivative 17a. 1 reacts also with active methylene heterocycies to afford the pyrazolo and thiazolo-fused phridazines 20 and 23 respectively.

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