• 대한수의학회지
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• 제58권4호
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• pp.219-221
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• 2018

A 2-year-old intact female Bengal cat was presented with a 6-month history of visual impairment. The cat manifested bilateral negative menace responses and dazzle reflexes and sluggish pupillary light reflexes. Bilateral fundus changes included generalized tapetal hyperreflectivity, advanced retinal vascular attenuation, and increased pallor of the optic disc. A diagnosis of bilateral retinal degeneration was made. The clinical findings suggest that the investigated Bengal cat was most likely to have an inherited retinal degeneration. Further studies of the Bengal cat breed are needed to determine the prevalence of inherited retinal degeneration in this breed in Korea.

• 셀메드
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• 제5권1호
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• pp.7.1-7.7
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• 2015

According to Ayurveda, an individual can be classified into any one of the seven constitutional types (Prakriti) depending on the dominance of one, two, or three Doshas. A 'Dosha' is representative of fundamental mechanisms that are responsible for homeostasis, and thus, to health. In the recent years, there have been several efforts to see whether certain physiological, haematological or biochemical parameters have any relationship with the constitutional types or not. The objective of the present study was to see if the results of autonomic function tests vary according to Prakriti of an individual. We conducted this study in clinically healthy volunteers of both the gender belonging to the age group of 17 to 35 years after obtaining their written consent. The Prakriti of these volunteers was assessed on the basis of a validated questionnaire and also by traditional method of interviewing. After confirming that the primary Dosha ascertained by both these methods matched, 106 volunteers were grouped into three on the basis of primary Dosha and were subjected to various autonomic function tests such as cold pressor test, standing-to-lying ratio, Valsalva ratio and pupillary responses such as pupil cycle time and pupil size measurement in light and dark. The results suggest that, the autonomic function tests in the healthy individuals may correlate linearly with the primary Dosha expressed in an individual. In particular, people with Kapha as the most dominant Dosha showed a tendency to have either a higher parasympathetic activity or a lower sympathetic activity with respect to their cardiovascular reactivity in comparison to the individuals with Pitta or Vata as the most dominant Dosha.

• Asian-Australasian Journal of Animal Sciences
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• 제30권9호
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• pp.1350-1357
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• 2017

Objective: The present study aimed to investigate whether the long-lasting, recurrent restricting of sows leads to the physiological and psychological reaction of discomfort. Methods: Sows (Large White) that had experienced restricting for about 0.5 or 3 years and agematched sows kept in a group housing system (loose sows) were compared. Pupillary light reflex parameters were measured at the weaning stage. Immediately after slaughter, blood samples were taken to measure serum cortisol levels, and the brain was dissected, gene expression in the hippo-campus, frontal cortex and hypothalamus was analyzed. Results: The serum cortisol levels were higher in the confined sows than in the loose sows. The full maturity, but not the young adolescent, confined sows had longer latency time in the onset of pupil constriction than their loose counterparts. Real-time polymerase chain reaction analyses revealed an increased expression of interleukin 6 mRNA in the hippocampus and decreased expression of brain derived neurotrophic factor mRNA in hippocampus and hypothalamus and to a lesser extent in the frontal cortex of the full maturity confined sows, compared with the full maturity loose sows. Conclusion: Taken together, these data indicated that recurrent restricting stress in full maturity sows leads to the physiological and psychological reaction of discomfort.

• 전자공학회논문지
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• 제50권6호
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• pp.212-220
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• 2013

최근 사용자의 생체 신호 정보를 기반으로 사용자 인지향상을 위하여, 상황에 적합한 서비스를 제공하기 위한 인간-컴퓨터/기계 상호작용 (Human computer/machine interaction: HCI/HMI) 시스템이 급격하게 증가하고 있는 추세이다. 이와 같이 인간-컴퓨터/기계 상호작용 기반의 효과적인 사용자 인지향상 시스템을 개발하기 위해서는 사용자의 명시적 의도 파악과 더불어 사용자의 묵시적 의도 파악이 중요하다. 사람의 시각 운동 이론에 따르면, 사람의 안구운동 정보와 동공 반응은 사람의 의도와 행동에 대하여 많은 량의 정보를 제공한다. 이에 본 논문에서는 사용자의 묵시적 의도를 판별하기 위하여, 피험자에게 제공되는 자극영상의 관심(흥미) 영역 (area of interest: AOI) 내에서의 안구운동 패턴인 응시 시간/횟수, 동공 응답 패턴의 동공크기와 동공의 크기변화인 기울기 정보를 분석하는 새로운 접근 방법을 제안한다. 제안하는 모델은 항행적 의도 발생, 정보적 의도발생, 정보적 의도 소멸과 같은 세 가지 유형으로 인간의 묵시적 의도를 식별한다. 여기서 항행적 의도란 주어진 자극영상 내에서 무언가 흥미로운 것을 찾는 행위를 말하며, 이에 반해 정보적 의도는 특정 위치에서 특정 객체는 찾는 행위를 의미한다. 본 연구에서는 사용자 안구운동 패턴과 동공분석 정보 기반으로 서로 다른 묵시적 의도인 항행적 의도, 정보적 의도 발생, 그리고 정보적 의도 소멸 사이에서 그 천이를 감지할 수 있는 계층적 SVM (hierarchical support vector machine: H-SVM)을 이용하였다.

• 한국임상수의학회지
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• 제30권4호
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• pp.324-328
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• 2013

A 5-year-old intact male Yorkshire terrier dog was referred with a 1-week history of blindness. In both eyes, menace responses and pupillary light reflexes were absent. The indirect ophthalmoloscopy revealed multiple small gray-white and discoloration lesion in mid-nontapetum area in both eyes. Electroretinograms showed diminished amplitude of a- and b-waves. Multifocal serous retinal detachments were detected with optical coherence tomography (OCT) over the small gray-white and discoloration lesion in the fundus. After one week of treatments, the indirect ophthalmoloscopy showed that irregular patches and hyperpigmentation in the center of hyperreflectivity area. Reattachment and retinal thinning were observed by the OCT. The results indicate that OCT scanning is considered to be a useful method for retinal evaluation in dogs with chorioretinitis.

• 대한수의학회지
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• 제53권2호
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• pp.133-136
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• 2013

To report multiple congenital ocular defects in a Bedlington terrier dog aged 2.5 months with blindness. Routine ophthalmic examinations were performed for the clinical signs. Menace responses and cotton ball test were absent in both eyes (OU), but pupillary light reflexes were normal in OU. Slit lamp biomicroscopy reveled corneal dystrophy, posterior subcapsular cataract, microphthalmia in OU and lenticular coloboma in the right eye. In indirect ophthalmoscopy and ultrasonography, retinal detachment and posterior lenticonus were shown in OU. It is the first report of lenticular coloboma and posterior lenticonus in a Bedlington terrier dog.

• 한국임상수의학회지
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• 제26권5호
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• pp.480-482
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• 2009

A 2-year-old, castrated male, Scottish fold cat was referred to Veterinary Medical Teaching Hospital of Seoul National University (VMTH-SNU) for evaluation of acute bilateral blindness after general anesthesia. For dental prophylaxis in local animal hospital, general anesthesia had been induced with intravenous acepromazine and ketamine, and maintained with isoflurane after intubation. At VMTH-SNU on next day, complete blood count, electrolytes and serum chemistry values were within normal ranges. On neurologic examination, visual placing and postural reactions like as hopping, hemiwalking and wheelborrowing were reduced on right hindlimb. On ophthalmic examination, menace responses were absent on both eyes and pupillary light reflex (PLR) reduced on right eye, but other reflex and fundus were normal. Prednisolone (2 mg/kg sid for 3 days) was administrated orally and tapered. Visual placing was possible on 2nd day, and postural reactions were recovered on 4th day after dental prophylaxis. Based on the process and recovery, this case was considered as postoperative visual loss (POVL) after general anesthesia.

• 한국임상수의학회지
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• 제22권3호
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• pp.284-287
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• 2005

A 18-month-old, male Maltese dog with acute seizure was referred to Veterinary Medical Teaching Hospital, Kyungpook National University. Abnormal neurologic findings included a tendency to fall to the left, turn and circle to the right, negative bilateral menace responses and pupillary light reflexes, and diminished responses to facial sensation testing on both sides. Radiographic signs were normal, except for occipital dysplasia. Magnetic resonance imaging of the brain revealed bilateral asymmetric ventriculomegaly, which is more on left side. Cerebral edema was also suspected. The dog died after 9 days from the onset of seizure, and a necropsy was performed. Histopathologically, the brain lesions in the meninges and the cerebral cortex of this dog was presented. There was severe diffuse nonsuppurative inflammation in perivascular area of the meninges and the cerebral white matter. Based on the results, this case was diagnosed as necrotizing meningoencephalitis in Maltese dog.

• 감성과학
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• 제15권2호
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• pp.259-268
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• 2012

P300-기반 숨긴정보검사(P300 CIT)에서, 조사대상자에게 관련자극이 가치가 있는 정도는 검사결과에 큰 영향을 미친다. 관련자극의 가치가 낮을 경우, P300 CIT의 정확판단율은 낮아진다. 본 연구의 목적은 관련자극의 가치가 낮은 경우, 동공-기반 숨긴정보검사(Pupil CIT)가 P300 CIT를 보완하는 검사로 사용될 수 있는지를 파악하는 것이다. 25명의 실험참여자에게 5장(스페이드 2, 3, 4, 5, 6)의 카드 중 한 장을 뽑도록 한 다음, 실험참여자가 뽑은 카드를 숨기정보로 사용한 P300 CIT와 Pupil CIT를 실시하였다. P300은 Fz와 Cz, Pz에서 측정하였으며, 동공크기는 양쪽 눈에서 모두 측정하였다. P300 CIT에서, Fz와 Cz, Pz에서 측정한 관련자극의 P300 진폭은 무관련자극의 P300 진폭보다 통계적으로 유의하게 더 컸다. Pupil CIT에서, 왼쪽 눈과 오른쪽 눈의 동공크기는 무관련자극이 제시되었을 때보다 관련자극이 제시되었을 때 더 컸다. P300 CIT의 정확판단율은 Fz와 Cz에서 44%였으며, Pz에서 36%였다. Pupil CIT의 정확판단율은 왼쪽 눈의 동공크기를 이용한 경우 52%였으며, 오른쪽눈의 동공크기를 이용한 경우 60%였다. 전체 사례수가 크지 않아 통계적으로 유의하지는 않았지만, Pupil CIT의 정확판단율이 P300 CIT의 정확판단율보다 높은 경향이 있었다. P300 CIT의 판단과 Pupil CIT의 판단 간의 상관관계는 통계적으로 유의하지 않았다. 결과적으로, 조사대상자에게 관련자극의 가치가 높지 않을 경우에는 P300 CIT 보다는 Pupil CIT를 사용하는 것이 더 좋을 것이다. 그리고 두 가지 검사방식을 결합한다면, 더욱 높은 정확도를 가진 숨긴정보검사를 구성할 수 있을 것이다.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.210-216
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• 2000

Objectives : Head injury is one of the common causes of death in the industrialized countries, and it is a common cause of subarachnoid hemorrhage. Recently, traumatic subarachnoid hemorrhage(TSAH) has been considered as a major prognostic factor. Some suggested that a certain vasodilating agent may be effective to treat or prevent the secondary brain injury due to vasospasm from TSAH. The role of TSAH is not yet fully solved. The prognosis and clinical significance of the TSAH was evaluated. Methods : A retrospective study was performed. A total of 573 consecutive patients with head injury admitted to our institute from January 1996 to December 1997 were examined with respect to outcome and clinical features. In all patients, computerized tomographic scanning was done within 2 days after the injury. Results : TSAH was found in 68 patients(11.9%). The outcome at discharge of the patients without TSAH was favorable(good recovery and moderate disability) in 84.8%, unfavorable(severe disability and vegetative state) in 8.6%, and the mortality rate 6.7%. However, the outcome was favorable in 51.5%, unfavorable in 20.6%, and the mortality rate 27.9% in patients with TSAH. Although the outcome of the patients with thick TSAH was worse than that of the patients with scanty TSAH, the difference was not statistically significant. The difference of the outcome in patients with TSAH according to the location also lacked statistical significance. TSAH was more common in patients with age of 40 years or more, and patients with low Glasgow coma scores. Patients with TSAH had abnormal pupillary responses, diffuse axonal injuries, intubations and operative interventions more frequently than patients without TSAH. Conclusion : These results strongly suggest that the TSAH per se did not worsen the prognosis. However, it represented the injury to be more severe.