• Journal of the Optical Society of Korea
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• 제17권3호
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• pp.249-254
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• 2013

In ophthalmology, a pupillometer, a device to measure the diameter of the pupil of the eye, can provide information on the function of the autonomic nervous system. The current pupillometers on the market are either too large to be a handheld instrument, or relatively expensive. In this study, a pupillometer based on a smartphone was designed. Both white and infrared LEDs and a 3M pixel camera of a smartphone were applied for the visual stimuli to an eye and for the acquisition of the eye images, respectively. Contrary to the existing method of pupil measurement that usually observe the variation of pupil diameter, the proposed algorithm in this study was applied to calculate the constriction ratio of the pupillary area in response to pupillary light reflex. The results showed that the constriction ratio of the pupillary area were all in the normal range (above 4.0) from the sixteen healthy participants. It is believed that the approach to pupil measurement used in this study is suitable for a mobile interface, and this system can be applied to clinical research, home-use healthcare, and distributed to some areas which suffer from problems like a lack of medical support.

• 한국임상수의학회지
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• 제32권1호
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• pp.130-134
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• 2015

A 13-year-old, castrated male Yorkshire terrier was presented with acute blepharospasm 2 months after phacoemulsification with intraocular lens implantation in the left eye. Menace response was weakly positive in the left eye. Intraocular pressure (IOP) was 98 mmHg in the left eye. On ophthalmic examination using slit lamp biomicroscope, episcleral injection and corneal edema were observed in the left eye. Aqueous flare (1+) and iris bombe with peripheral anterior synechia were also detected in the left eye. In spite of medical treatments, IOP was remained more than 50 mmHg. Synechiolysis and radial iridectomy with irrigation/aspiration of anterior chamber were performed in the left eye. One week after the surgery, tissue plasminogen activator was injected to resolve the blood and fibrin clot in the left anterior chamber. Menace response was recovered completely 1 month after the surgery and IOP was maintained less than 20 mmHg more than 6 months.

• 감성과학
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• 제21권4호
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• pp.43-54
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• 2018

본 연구는 멀미증상이 동공 리듬에 미치는 영향을 확인하는 것을 그 목적으로 하였다. 본 연구는 2D와 HMD를 통해 동일한 가상현실 콘텐츠를 실험참가자에게 15분 동안 경험하게 한 이후에 동공반응을 비교하였고 본 실험에는 16명(남자 8명, 여자 8명, 평균 나이: $25.67{\pm}2.43$세)의 피험자가 참여하였다. 연구 결과, 영상멀미를 경험한 이후에 동공 리듬이 불규칙한 패턴을 나타내었고 이것은 동공 크기(mPD) 및 동공 리듬의 편차(sPD)가 증가하는 결과로 확인되었다. 이러한 동공 반응의 결과는 인지부하와 밀접한 관련이 있고 영상멀미를 처리해야 할 시각 정보량의 증가 및 감각정보들 사이의 충돌 혹은 불일치로 인한 인지부하 현상으로 해석이 가능하다. 본 연구에서 제안된 방법은 기존의 센서 기반의 평가 방법에 비해 멀미 증상을 카메라 기반의 비접촉식으로 측정할 수 있는 가능성을 확인하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제12권3호
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• pp.89-94
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• 2008

In order to reproduce chronic cerebral hypoperfusion as it occurs in human aging and Alzheimer's disease, we introduced permanent, bilateral occlusion of the common carotid arteries (BCCAO) in rats (Farkas et al, 2007). Here, we induced BCCAO in two different rat strains in order to determine whether there was a strain difference in the pathogenic response to BCCAO. Male Wistar and Sprague-Dawley (SD) rats (250-270 g) were subjected to BCCAO for three weeks. Kluver-Barrera and cresyl violet staining were used to evaluate white matter and gray matter damage, respectively. Wistar rats had a considerably higher mortality rate (four of 14 rats) as compared to SD rats (one of 15 rats) following BCCAO. Complete loss of pupillary light reflex occurred in all Wistar rats that survived, but loss of pupillary light reflex did not occur at all in SD rats. Moreover, BCCAO induced marked vacuolation in the optic tract of Wistar rats as compared to SD rats. In contrast, SD rats showed fewer CA1 hippocampal neurons than Wistar rats following BCCAO. These results suggest that the neuropathological process induced by BCCAO takes place in a region-specific pattern that varies according to the strain of rat involved.

• 대한수의학회지
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• 제59권2호
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• pp.109-111
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• 2019

A 10-year-old intact female Jindo dog was presented with a 1-week history of conjunctival redness and ocular discharge in the left eye. There was an absence of menace response, dazzle reflex, and direct pupillary light reflex. Slit-lamp biomicroscopy revealed corneal edema, ciliary flush, and aqueous flare. Intraocular pressure was 68 mmHg. Based on the information available, a diagnosis of glaucoma and uveitis was made. Subsequent histopathologic examination showed the glaucoma was produced by the effects of goniodysgenesis, posterior synechia, and pigment dispersion in the trabecular meshwork. This is the first report of primary glaucoma caused by goniodysgenesis in Jindo dogs.

• 대한수의학회지
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• 제59권2호
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• pp.113-117
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• 2019

A 6-year-old intact male Maltese dog presented with a history of blindness and ataxia. Neuro-ophthalmic examination revealed dilated pupils with absent pupillary light reflexes and menace response in both eyes. Mild peripapillary edema was noted in the fundus of the right eye. After magnetic resonance imaging, the dog was provisionally diagnosed with meningoencephalitis of unknown etiology. Follow-up funduscopy was performed to monitor the condition of the optic discs for three years. Despite of the treatment with prednisolone, the optic nerve progressed to atrophy and the dog couldn't restore vision.

• 한국임상수의학회지
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• 제16권1호
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• pp.203-209
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• 1999

A 4-year-old female Shih-tzu with severe episcleral congestion and buphthalmos in left eye was referred to the Veterinary Teaching Hospital, Chonnam National University in October 1998. During two months in local veterinary clinics, the dog had been treated unsuccessfully with tarsorrhaphy and antibiotics. By history taking, cause of the glaucoma was ascertained as accidental nonpenetrated cornea trauma by owner, Ophthalmic examination revealed that the left eye was buphthalmic with severe episcleral congestion, pain and fever. The direct pupillary light response could not be evaluated in the left eye, but right eye had normal reaction. The intraocular pressure was 4.5 mmHg in the right eye and 33 mmHg in the left eye, as measured with a Schiotz tonometer, Ultrasonographic finding revealed hyperechoic vitrous body and central echofree material. The Schirmer tear test showed 20 mm in the left eye and 8 mm in the right eye. The hematologic examination revealed monocytosis. The initial medical treatment was admitted, but there was no response. Transpalpebral enucleation in the left eye under inhalation anesthesia with enflurane 1.2 vol% in oxygen was performed. The day after operation the left eye ravealed no exudate, and pain, and the systemic vital signs were normal. The prognosis is excellent.

• 대한간호학회지
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• 제36권4호
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• pp.621-629
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• 2006

Purpose. The purpose of this study was to identify the clinical variables that predict functional and cognitive recovery at 1- and 6-month in both severe and moderate/mild traumatic brain injury patients. Methods. The subjects of this study were 82 traumatically brain-injured patients who were admitted to a Neurological Intensive Care Unit at a university hospital. Potential prognostic factors included were age, motor and pupillary response, systolic blood pressure, heart rate, and the presence of intracranial hematoma at admission. Results. The significant predictors of functional disability in severe traumatic brain injury subjects were, age, systolic blood pressure, the presence of intracranial hematoma, motor response, and heart rate at admission. In moderate/mild traumatic brain injury patients, motor response, abnormal pupil reflex, and heart rate at admission were identified as significant predictors of functional disability. On the other hand, the significant predictors of cognitive ability for severe traumatic brain injury patients were motor response and the presence of intracranial hematoma at admission, whereas those for moderate/mild patients were motor response, pupil reflex, systolic blood pressure at admission, and age. Conclusions. The results of the present study indicate that the significant predictors of TBI differ according to TBI severity on admission, outcome type, and outcome measurement time. This can be meaningful to critical care nurses for a better understanding on the prediction of brain injury patients. On the other hand, the model used in the present study appeared to produce relatively low explicabilities for functional and cognitive recovery although a direct comparison of our results with those of others is difficult due to differences in outcome definition and validation methods. This implies that other clinical variables should be added to the model used in the present study to increase its predicting power for determining functional and cognitive outcomes.

• 방송공학회논문지
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• 제25권6호
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• pp.973-979
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• 2020

본 연구에서는 동공 반응 데이터를 수집하여 공감의 사회 감성을 객관적이고 정량적으로 추정하는 데 목적이 있다. 52명(남 26명, 여 26명)의 피험자가 실험에 참여하였다. 실험은 30초의 참조 데이터 측정 후, 공감 유무에 따라 얼굴 표정 모방 과제와 자발적 표현과제로 구분되어 두 사람은 상호작용하였고 동공을 촬영하였다. 이진화 및 원형 윤곽선 검출법의 영상처리를 활용하여 동공 데이터를 수집하였고, 이상 데이터 제거 기법을 활용해 눈 깜빡임 노이즈를 제거하였다. 공감 유무에 따른 동공 크기 데이터는 정규성 검증 및 독립표본 t 검정을 통해 통계적 유의성을 확인하였다. 분석 결과, 공감하는 경우(M ± SD = 0.050 ± 1.817)와 공감하지 않은 경우(M ± SD = 1.659 ± 1.514) 동공 크기가 통계적으로 유의미한 차이를 보였다(t(92) = -4.629, p = 0.000). 판별분석을 통해 동공 크기에 따른 공감 유무를 추정하는 규칙을 정의하였고, 새로운 실험참가자 12명(남 6명, 여 6명, M ± SD = 22.84 ± 1.57세)을 대상으로 규칙을 검증(추정 정확도 75%)하였다. 본 연구에서 제안한 동공 크기 데이터를 이용한 공감의 사회 감성 추정 기술은 비접촉식 카메라 기반의 기술로 스마트 글래스와 접목되어 다양한 가상 현실 분야에 활용도가 높을 것으로 기대된다.

• 대한물리치료과학회지
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• 제9권1호
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• pp.103-111
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• 2002

The purpose of this study was NIHSS(National Institutes of Health stroke scale) to activities of Daily Living stroke patient. We designed a 17 item neurogic Examination NIHSS use in acute stroke therapy trials. In a study of stroke patient. Assessment were measured by the NIHSS and by the MBI (Modified Barthel Index) to evaluate activities of daily living(ADL). Fifty patients were subject in this study. Collected data analysis were completed by using t-test, ANOVA, correlation analysis and Multiple regression analysis. The following were as follow; Among the test of NIHSS(National Institutes of Health stroke scale) was significantly correlated with changes in MBI(Modified Barthel Index) score in 50 stroke patients. Among the subitems of NIHSS, Pupillary Response, a level of consciousness, best motor arm, best motor leg were the best predictors of functional improvement.