• Natural Product Sciences
• /
• 제7권3호
• /
• pp.63-67
• /
• 2001

${\beta}-Glucuronidase-inhibitory$ and hepatoprotective effects of Chungpesagan-tang, which has been used for liver diseases and stroke, on $CCl_4-induced$ hepatotoxicity of rats was investigated. Chungpesagan-tang potently inhibited ${\beta}-glucuronidases$. Serum AST, ALT and LDH levels of the $CCl_4$ group orally treated with Chungpesagan-tang (100 mg/kg) were lowered to 47, 28 and 58% of the $CCl_4-treated$ group, respectively. Among the ingredients of Chungpesagan-tang, Puerariae Radix, Scutellariae Radix and Rhei Rhizoma potently inhibited the ${\beta}-glucuronidase$ and protected $CCl_4-induced$ liver injury. The hepatoprotective activity of Puerariae Radix was affected by ingredients of Chungpesagan-tang: Scutellariae Radix had the synergistic activity, but Angelicae Tenussimae Radix exhibited the antagonistic activity. These results suggest that the ${\beta}-glucuronidase$ inhibitor of herbal medicines may protect $CCl_4-induced$ liver injury and puerarin should be a natural prodrug for the hepatoprotective effect.

• 한국영양학회:학술대회논문집
• /
• 한국영양학회 2004년도 춘계학술대회
• /
• pp.160-160
• /
• 2004

• 한국영양학회:학술대회논문집
• /
• 한국영양학회 2004년도 춘계학술대회
• /
• pp.161-161
• /
• 2004

• 한국식품영양과학회지
• /
• 제29권4호
• /
• pp.669-675
• /
• 2000

칡추출물이 알코올성 뇌손상에 미치는 영향 을 구명하기 위해 알코올을 투여한 흰쥐에게 갈화와 갈근을 수준별 (I;1.2 g/kg B.W., II;2.4 g/kg B.W.) 로 5주간 급여한 후 \ulcorner 열수추출물이 알코올 대사와 유리기 생성 및 제거효소 활성에 미치는 영향을 관찰하였다. ADH 활성응ㄴ 갈화 및 갈근추출물 급여시 에탄올만 투 여한 대조군에 비하여 유의적으로 감소한 반면, ALDH 활성은 갈근추출물 급여군에서 유의 적으로 증가하였는데 1수준군의 증가정도가 현저하였다. P450 함량과 AD, AH 활성은 대조 군에 비하여 칡 열수추출물 급여시 감소되는 경향이었는데 갈근 급여군의 감소효과가 현저 하게 나타났다. AO와 XO 활성은 갈화 및 갈근추출물 급여군이 대조군에 비하여 감소되었 는데 특히 갈근추출물 1수준군에서 현저하게 나타났다. SOD 활성은 칡 열수추출물 급여시 증가하였으며 CAT와 GSH-Px 활성은 에탄올 투여로 증가된 활성이 갈근 열수추출믈 I 수 준 급여시 유의적으로 증가되었다. 이상의 결과에서 갈화 및 갈근 열수추출물 급여는 뇌조 직 중의 에탄올 대사효소계의 활성을 촉진시켰으며, 유리기제거 효소의 활성을 억제하고 항 산화효소계를 활성화하여 에탄올 투여에 인한 뇌조직의 산화적 스트레스를 완화시킬 수 있 을 것으로 사료된다.

• 대한한의학방제학회지
• /
• 제7권1호
• /
• pp.167-181
• /
• 1999

Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae, Radixi, Radix Ledeboutriellae, Rhizoma Atractylodis, Herba Ephedrae, Radix Puerariae and Radi Aconitx Bupleuri have been used in Korea for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of several herbs on norepinephrine(NE) induced blood vessel contraction in rabbits and pigs. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response $(ED_{50})$ was obtained from cumulative dose response curves for NE $(10^{-6}{\sim}10^{-3}M)$. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae and Herba Ephedrae in abdominal aorta. Contractions evoked by NE $(ED_{50})$ were inhibited significantly be Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Herba Ephedrae, Radix Puerariae and Radix Bupleuri in femoral artery. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Radix Sophorae Subprostratae, Radix Aconiti and Herba Ephedrae in renal artery. These results indicate that each herb can relax NE induced contraction of rabbit and pig blood vessel selectively, and that this relaxation relates to Gui-Gyung(歸經).

• 대한한의학방제학회지
• /
• 제11권1호
• /
• pp.91-98
• /
• 2003

Through the research into the date of Radix Thichosanthis main blended 21 kinds of prescriptions Radix Thichosanthis from Donguibogam. This study summrized as follows; The suitable dosage of Radix Thichosanthis per one application is one to two don(about $4{\sim}8g$). Radix Thichosanthis Radix main blended prescriptions broadly use in the symptoms of diabetes, excessive thirst, cabuncles and eye diseases In diabetes and excessive thirst, the structes of Radix Thichosanthis main blended prescriptions are commonly used Seng Mak San(生脈散), Radix Puerariae(葛根), Frectus Schisandrae(五味子), Radix Ophiopogonis(麥門冬) In Furuncles, Carbuncles and Cancer like diseases, the structes of Radix Thichosanthis main blended prescriptions are generally used Kumeunhwasan(金銀花散), Jipaesan(芷貝散), Twonongsan(透膿散).

• 생약학회지
• /
• 제29권4호
• /
• pp.365-373
• /
• 1998

In order to estimate accurate quality of crude drugs in which pest was found during the storage, damaged 15 items were collected on current markets. We identified insect name by investigation of insect morphology, bug cluster, and morphology of damaged crude drugs. Three kind of pests were identified in the above 15 items as follows: A: Pyralis sp. (Pyralidae) was observed in damaged Platycodi Radix. B: Anthreus verbasci (Anobiidae) was found out in damaged Angelicae gigantis Radix, and Dioscoreae Rhizoma. C: Stegobium pamceum (Anobiidae) was discovered in the 12 crude drugs as follows: Puerariae Radix, Angelicae koreanae Radix, Angehcae tenuissimae Radix, Codonopsis Radix, Ledebouriellae Radix, Ginseng Radix alba, Angelicae dahuricae Radix, Belamcandae Rhizoma, Paeoniae Radix, Cnidii Rhizoma, Alismatis Rhizoma, and Fritillariae Bulbus.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.202.1-202.1
• /
• 2000

• 대한약학회:학술대회논문집
• /
• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
• /
• pp.144.3-144.3
• /
• 2001

• 대한약학회:학술대회논문집
• /
• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
• /
• pp.181.1-181.1
• /
• 2001