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Breast Density and Risk of Breast Cancer in Asian Women: A Meta-analysis of Observational Studies

  • Bae, Jong-Myon;Kim, Eun Hee
    • Journal of Preventive Medicine and Public Health
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    • v.49 no.6
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    • pp.367-375
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    • 2016
  • Objectives: The established theory that breast density is an independent predictor of breast cancer risk is based on studies targeting white women in the West. More Asian women than Western women have dense breasts, but the incidence of breast cancer is lower among Asian women. This meta-analysis investigated the association between breast density in mammography and breast cancer risk in Asian women. Methods: PubMed and Scopus were searched, and the final date of publication was set as December 31, 2015. The effect size in each article was calculated using the interval-collapse method. Summary effect sizes (sESs) and 95% confidence intervals (CIs) were calculated by conducting a meta-analysis applying a random effect model. To investigate the dose-response relationship, random effect dose-response meta-regression (RE-DRMR) was conducted. Results: Six analytical epidemiology studies in total were selected, including one cohort study and five case-control studies. A total of 17 datasets were constructed by type of breast density index and menopausal status. In analyzing the subgroups of premenopausal vs. postmenopausal women, the percent density (PD) index was confirmed to be associated with a significantly elevated risk for breast cancer (sES, 2.21; 95% CI, 1.52 to 3.21; $I^2=50.0%$). The RE-DRMR results showed that the risk of breast cancer increased 1.73 times for each 25% increase in PD in postmenopausal women (95% CI, 1.20 to 2.47). Conclusions: In Asian women, breast cancer risk increased with breast density measured using the PD index, regardless of menopausal status. We propose the further development of a breast cancer risk prediction model based on the application of PD in Asian women.

Analysis and Proposals Concerning Big Deals of Scholarly Journals (학술지 빅딜판매의 문제점 및 개선 방안)

  • Shin, Eun-Ja
    • Journal of the Korean Society for Library and Information Science
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    • v.41 no.1
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    • pp.373-389
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    • 2007
  • The most remarkable business model to Have merged in electronic publishing is the so-called 'Big Deal'. Major Publishers have begun offering libraries bundled packages that are across journals and across print and electronic versions. This paper examined consortium conditions of scholarly journals in the light of big deal. The result skewed that various pricing models have been appeared and freedoms to choose collections have been on the increase in comparison with the past. But many major Publishers have adopted a typical big deal contract condition that a library enters into a long-term arrangement to get access to large electronic journal collections at a dramatic discount interchange of a promise not to cut print subscriptions. The publishing and library communities need to find alternative pricing models that provide better deals for those disadvantaged by the prevalence of the big deal. Much in the world of scholarly publication is changing, combination of traditional publishing and open access publishing may well be gained public favor in the future.

Population-Based Cancer Registration in Indonesia

  • Wahidin, Mugi;Noviani, Rini;Hermawan, Sofia;Andriani, Vita;Ardian, Ardi;Djarir, Hernani
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1709-1710
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    • 2012
  • Cancer is a major public health problem in Indonesia, becoming the 7th largest cause of death based on a national survey in 2007, accounting for 5.7 of all mortality. A cancer registry was started in 1970, but it was partial and was stopped mainly because no government body was responsible. Realizing the above situation, the Indonesian government established the Sub Directorate of Cancer Control within the Ministry of Health, with responsibility for developing a national cancer control program, including a cancer registry. A sustainable cancer registry was then started in 2007 within Jakarta Province, first hospital-based but then expanded to be population-based. Steps of cancer registration in Jakarta are data collection, data verification, data validation, data management and analysis, and data publication. Data collection is conducted by health facilities (hospitals, laboratories, primary health centers) at the district/municipal level, with reports to the provincial level. Data are collected passively by holding meetings every three months in the district/municipality. Verification of data is the responsibility of the medical doctor or pathologist in each data source. Data validation is conducted by a team in the cancer registry, consisting of district/municipal/province health officers, pathologists, and registrars. Data management and analyses are conducted by a cancer registry team at the provincial level, assisted by the national team. We use software named Indonesian Cancer Registry System (SRIKANDI) which is adopted from CanReg4 IARC. Data from the population-based cancer registry in Jakarta Province showed the leading cancers among females in 2005-2007 to be breast cancer, cervical cancer, ovarian cancer, colorectal cancer and among males are bronchus and lung cancer, colorectal cancer, liver cancer, pharyngeal cancer, and prostate cancer. The leading childhood cancers are leukaemia and retinoblastoma.

Body Mass Index Effects on Risk of Ovarian Cancer: A Meta-Analysis

  • Poorolajal, Jalal;Jenabi, Ensiyeh;Masoumi, Seyyedeh Zahra
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.18
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    • pp.7665-7671
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    • 2014
  • Objectives: The association between body mass index (BMI) and ovarian cancer risk is unclear and requires further investigation. The present meta-analysis was conducted to assess the effect of overweight and obesity on ovarian cancer risk in the premenopausal and postmenopausal periods. Data sources: Major electronic databases were searched until February 2014 including Medline and Scopus. Reference lists and relevant conference databases were searched and the authors were contacted for additional unpublished references. Review Methods: All cohort and case-control studies addressing the effect of BMI on ovarian cancer were included, irrespective of publication date and language. The effect measure of choice was risk ratio (RR) for cohort studies and odds ratio (OR) for case-control studies. The results were reported using a random effects model with 95% confidence intervals (CIs). Results: Of 3,776 retrieved studies, 19 were ultimately analyzed including 10 cohort studies involving 29,237,219 person-years and 9 case-control studies involving 96,965 people. The results of both cohort and case-control studies showed being overweight and obesity increased the risk of ovarian cancer compared to women with normal weight during both premenopausal and postmenopausal periods: RR=1.08 (95%CI: 0.97, 1.19) and OR=1.26 (95%CI: 0.97, 1.63) for overweight and RR=1.27 (95%CI: 1.16, 1.38) and OR=1.26 (95%CI: 1.06, 1.50) for obesity. Conclusions: There is sufficient evidence that an increase in BMI can increase the risk of ovarian cancer regardless of the menopausal status, mimicking a dose-response relationship although the association is not very strong.

The Regulations by Criminal Law against any Libel in Cyberspace (사이버명예훼손행위와 형사법적 대응방안)

  • Yoo, In-Chang
    • Journal of the Korea Society of Computer and Information
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    • v.17 no.5
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    • pp.177-183
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    • 2012
  • There occur various crimes in cyber space hiding behind anonymity to avoid punishment by criminal law. One of the most serious crimes committed in cyber space is defamation against others under the cloak of freedom of expression. The infringements by defamations in cyber space are made all of a certain and widespread that the victims have no time to react, and for that reason, the shocks by the defamation are much serious and severe compared with that committed in off line. However, press and publication shouldn't infringe on other's honors, right, public order or social ethics in liberal democrat society which values much the human dignities and values as stipulated in Article 21 section 4 of the Constitution. Protection of personal honor is also the basic rights guaranteed by the Constitution as much as the freedom of expression, and by extension, such harmful behaviour shouldn't be included in the freedom of expression area. In this way, slander can be considered as the minimum limitation of the freedom of expression.

A Study of Life Table of Korean People : Based on 1986 Data (한국인의 생명표 작성에 관한 연구)

  • 김연희
    • Korea journal of population studies
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    • v.12 no.2
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    • pp.45-55
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    • 1989
  • In recent years the life expectancy of the Korean people has been increasing appreciably because of the improvement in living conditions and public health facilities as well. However, there exist considerable constraints in the measurement of Korea's mortality rate. In elaboration, there are quite a few persons who do not submit birth and death reports, thereby lowering the reliability of statistical data. The 1978-1979 life table of the Korean people is still considered the latest one. Nevertheless, a decade has passed since its publication, and the need for a better life table reflecting realities is inc-reasingly growing. Capitalizing on the annual report of demographic statistics and demographic sample survey data m 1988, I have worked out the 1986 tentative life table of the Korean people and found out the following : 1. The male life expectancy in the 1978-1979 life table of the Korean people is 62.7 years old, and that of the female sex is 69.1 years old whereas the average life expectancy of the male sex in the 1986 life table stands at 66.3 years old, and that of the female sex is 74.5 years old. The average life expectancy is up by 3.5 years old for the male sex and also, up 5.4 years old for the female sex, res-pe ctively. 2. A gap between the male and female life expectancies in the 1978-1979 life table was 6.4 years old, while that of the 1986 life table was 8.2 years old. It means the female life expectancy has increased substantially. 3. The infant mortality rate has decreased, compared with the 1978-1979 level, yet it is still above those of Japan and Taiwan. 4. The mortality rate of the middle - aged men in the forties remains high, as was the case in the 1978-1979 period.

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Association between the DICER rs1057035 Polymorphism and Cancer Risk: Evidence from a Meta-analysis of 1,2675 Individuals

  • Yu, Yan-Yan;Kuang, Dan;Yin, Xiao-Xv
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.1
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    • pp.119-124
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    • 2015
  • Background: DICER, one of the microRNA (miRNA) biogenesis proteins, is involved in the maturation of miRNAs and is implicated in cancer development and progression. The results from previous epidemiological studies on associations between DICER rs1057035 polymorphism and cancer risk were inconsistent. Thereforewe performed this meta-analysis to summarize possible associations. Materials and Methods: We searched all relevant articles on associations between DICER rs1057035 polymorphism and cancer risk from PubMed, EMBASE, Chinese Biomedical Literature and Chinese National Knowledge Infrastructure until August 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess any associations. Heterogeneity tests, sensitivity analyses and publication bias assessments were also performed in this meta-analysis. All analyses were conducted using STATA software. Results: Seven case-control studies, including 4,875 cancer cases and 7,800 controls were included in the meta-analysis. Overall, the results indicated that the C allele of DICER rs1057035 polymorphism was significantly associated with decreased cancer risk in allelic comparison, heterozygote and dominant genetic models (C vs T: OR=0.88, 95%CI 0.81-0.95, p=0.002; TC vs TT: OR=0.85, 95%CI 0.77-0.93, p=0.001; CC/TC vs TT: OR=0.86, 95%CI 0.78-0.94, p=0.001). In the subgroup analysis by ethnicity, a significantly decreased cancer risk was found in Asian but not Caucasian populations. Conclusions: The present meta-analysis suggests that the C allele of the DICER rs1057035 polymorphism probably decreases cancer risk. However, this association may be Asian-specific and the results should be treated with caution. Further well-designed studies based on larger sample sizes and group of populations are needed to validate these findings.

A Longitudinal Study on the Changes to Copyright Policies for Korean KCI Journals (국내 학술지 저작권 정책 변화 의미 분석)

  • Joung, Kyoung Hee;Kim, Gyuhwan
    • Journal of the Korean Society for information Management
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    • v.34 no.2
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    • pp.159-180
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    • 2017
  • This study analyzed changes to copyright policies in KCI journals comparatively using the previous 2 research results published in 2008 and 2016 and then gave insight into the meaning of the changes. The results of the study are as follows: Journals making the subject of copyright public had increased from 34% in 2008 to 67% in 2016. Journals transferring copyright from authors remained almost the same, with only a slight increase from 90% to 91% in the same period. Journals using the term 'publication rights' instead of 'copyright' had decreased; on the other hand, journals using the term 'reproduction right' and 'right of transmission' had increased. Use of copyright transfer agreement had increased from 25% to 50%; on the other hand, self archiving policy remained almost the same, decreasing slightly from 13% to 12%. This study argues that these changes mean the establishment of copyright industrialization for Korean journals and that the publishing bodies appear to be the most powerful main agent among stakeholders participating in scholarly publishing in this process.

Special contribution: Dr. Junbo Kim's contributions to the advancement of statistics in Korea and implications (특별기고: 국내 통계학계에 기여한 김준보 선생의 업적과 시사점)

  • Choi, Jong Hoo
    • The Korean Journal of Applied Statistics
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    • v.33 no.3
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    • pp.229-238
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    • 2020
  • The very first statistics department in Korean universities was founded in 1962, meaning it has been 57 years since Korean academia has regarded statistics as a wholly independent field of study. Dr. Junbo Kim was the first faculty member hired by Korea University's statistics department. He made a seminal contribution to the development and publication of statistics textbooks in those early years, and in 1971, spearheaded the efforts to found the Korean Statistical Society, serving as its first president. Naturally, Dr. Kim's significant contributions have laid the cornerstones for the advancement of statistics as an independent field of study in Korea. In this paper, I will explore two main subjects: one is the early history of the Korean Statistical Society with a special emphasis on Dr. Kim's contributions, and the other is an analytical overview his publications. Specifically, I will focus on Modern Statistics: A Synthesis of Statistics and Estimates』(Kim, 1954), and 『Inferential Statistics: An Introduction to Sample Survey and Experimental Design』(Kim, 1956).

Activation of Publishing Domestic SCIE Journals Based on the Situation Analysis (국내 SCIE 학술지의 출판 현황과 활성화에 관한 연구)

  • Shin, Eun-Ja
    • Journal of the Korean Society for Library and Information Science
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    • v.45 no.4
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    • pp.157-178
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    • 2011
  • In the field of science and technology, influential international journals can easily be found in SCIE. A total number of journals published by societies or institutes in Korea are only 82 of the 8,300 SCIE titles. In this study, in light of the SCI criteria the detailed analysis, of these journals was performed for Korean SCIE journals. The results show that in general domestic journals were not actively cited, had a low level of internationality, and user services through the website was insufficient. Korean SCIE journals should continue to complement these points and elevate its reputation. Candidate journals should concentrate on recruiting more excellent papers, promoting communication with foreign researchers, enhancing domestic and international public relations, and the like. To actively support the domestic publication of excellent journals, long-term and short-term measures should be established and consistently practiced at the national level.