• 동의신경정신과학회지
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• 제15권2호
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• pp.11-22
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• 2004

Objects : This study was aimed to investigate relation to the Psychologic factor and Mental disorder of Women. Methods : Research data is based on Booindaejoenyangbang(婦人大全良方) and Dongyipogam(東醫寶鑑). And study the psycho elements in Mental disorder of Women. Results : 1. Psychologic factor have a part in A cause for mental disorder of women, certainly. 2. The weakness is fundamental cause for mental disorder of women and the Wind is an immediate cause frequently. 3. Most mental disorder of women develop severe psychiatric symptoms. 4. Psychologic factor is concerned to causing and symptoms at various diseases of women. Conclusion : The results suggest that women is delicate at the psychologic factor, so mental disorders are taken easily.

• 스마트미디어저널
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• 제9권3호
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• pp.9-17
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• 2020

Hippocampus is a complex brain structure embedded deep into the temporal lobe. Studies have shown that this structure gets affected by neurological and psychiatric disorders and it is a significant landmark for diagnosing neurodegenerative diseases. Hippocampus features play very significant roles in region-of-interest based analysis for disease diagnosis and prognosis. In this study, we have attempted to learn the embeddings of this important biomarker. As conventional metric learning methods for feature embedding is known to lacking in capturing semantic similarity among the data under study, we have trained deep Siamese convolutional neural network for learning metric of the hippocampus. We have exploited Gwangju Alzheimer's and Related Dementia cohort data set in our study. The input to the network was pairs of three-view patches (TVPs) of size 32 × 32 × 3. The positive samples were taken from the vicinity of a specified landmark for the hippocampus and negative samples were taken from random locations of the brain excluding hippocampi regions. We have achieved 98.72% accuracy in verifying hippocampus TVPs.

• 수면정신생리
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• 제18권2호
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• pp.72-75
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• 2011

Sleep disorders such as insomnia, obstructive sleep apnea (OSA), and restless legs syndrome (RLS) are very common disorders and may cause significant burden in terms of individual as well as societal aspects. Sleep insufficiency from such sleep disorders may cause deleterious effects on daily work life and may be associated with other major medical or psychiatric disorders including cardiovascular disease, diabetes mellitus, depression, and anxiety disorder. Various motor or occupational accident may result from the sleep problems. In addition, recent researches provide the method to evaluate the lost productivity time in terms of absenteeism and presenteeism. Moreover, several studies on cost-effectiveness of treatment of sleep disorders show that it is cost-effective.

• 비만대사연구학술지
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• 제1권1호
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• pp.39-42
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• 2022

Obesity is a chronic disease associated with severe complications. A major complication of obesity is depression, which can worsen obesity and vice versa. In addition, most antidepressants or antipsychotics cause weight gain, and the relationship between obesity and depression is clinically critical. However, treatment of obese patients with major depressive disorder is complicated. Bariatric physicians should provide appropriate behavioral interventions alongside pharmacological treatment, considering psychiatric symptoms, drug side effects, and drug interactions. Two successful cases of moderate-to-severe obese patients with major depressive disorder who had been treated for obesity using behavioral intervention therapy along with liraglutide will be discussed. This report highlights the safety and efficacy of liraglutide treatment of obesity in patients with depression who take antidepressants and antipsychotics.

• 대한조현병학회지
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• 제24권2호
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• pp.45-51
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• 2021

The coronavirus disease 2019 (COVID-19) pandemic has drastically impacted our society and health care system. People with schizophrenia are more vulnerable to this burden of illness and related societal changes. In addition, they are more susceptible to the transmission of COVID-19 and have a significantly higher mortality rate compared to the general population. In a recent study, vaccinated patients with schizophrenia showed a greatly decreased mortality level similar to that of the general population. However, patients with schizophrenia were less likely to be vaccinated. Mental health professionals should provide them with appropriate information on prevention strategies against COVID-19 and vaccination. Long-lasting social distancing and social disconnection can make people with schizophrenia more vulnerable to loneliness and depression. Furthermore, patients with schizophrenia may face challenges continuing psychiatric treatment due to the COVID-19 pandemic. Social support and suitable mental health services using novel technologies should be developed and provided to patients with schizophrenia.

• 수면정신생리
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• 제29권2호
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• pp.29-34
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• 2022

Coronavirus disease 2019 (COVID-19), which was a global pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is still a serious public health problem. COVID-19 causes various symptoms not only in the respiratory system but also in various parts of the body and has a significant effect on sleep. Insomnia and poor sleep quality were observed at high rates in patients with COVID-19 as well as in the uninfected general population. Obstructive sleep apnea is also considered a risk factor in patients with severe COVID-19. Virus-induced central nervous system damage is likely to be the cause of many sleep disorders in COVID-19, but psychosocial influences also seem to have played a significant role. Sleep problems persisted at high rates for a considerable period after the infection phase was over. More attention and research on the effect of COVID-19 on sleep is needed in the future.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권4호
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• pp.215-221
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• 2023

Advancements in digital technology have led to increased usage of digital devices among teenagers. The coronavirus disease 2019 pandemic and the subsequent implementation of social distancing policies have further accelerated this change. Consequently, a new concept called the metaverse has emerged. The metaverse is a combination of a virtual reality universe that allows individuals to meet, socialize, work, play, entertain, and create. This review provides an overview of the concept and main features of the metaverse and examples of its utilization in the real world. It also explains the unique developmental characteristics of childhood and adolescence, as well as the possible negative influences of the metaverse on them, including addiction, antisocial behavior, cyberbullying, and identity confusion. This review summarizes several suggestions for future research because the metaverse is a relatively new concept.

• 정신신체의학
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• 제28권2호
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• pp.99-107
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• 2020

섬유근통은 피로, 수면장애, 기분변화, 인지장애 및 만성 전신통증을 핵심 증상으로 하는 질환이다. 섬유근통은 유전적 취약성, 통증 처리과정 및 스트레스 반응 체계의 변화 등을 포함하는 생물학적 요인과 불안, 우울, 분노, 스트레스 등의 심리적 요인, 그리고 감염, 발열 질환, 외상 등의 환경적 요인이 함께 작용하여 발생하는 것으로 알려져 있으며, 핵심 병인으로 감각 자극이 인식되는 과정에서 증폭되어 통증이 증진되는 중추성 감작의 역할이 강조되고 있다. 가이드라인들은 개별 환자의 필요에 따라 선택된 다원적 접근을 권고하며, 임상의는 충분한 교육을 통해 지적 이해의 틀을 제공하고 자기 관리의 중요성을 강조해야 한다. 섬유근통에서 정신건강 문제의 유병률은 일반인구집단의 7~9배로 유의하게 높으며, 특정 정신병리 및 수면장애와의 관련성도 제기되고 있다. 정신과적 상태는 섬유근통과 양방향성 상호작용을 하며 경과에 영향을 주고, 취약성을 공유하며 서로의 위험 요인으로 작용할 수 있으므로, 동반질환을 면밀히 평가하여 보다 통합적인 관리가 필요할 것이다.

• 한국철학논집
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• 제28호
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• pp.363-386
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• 2010

이 논문은 유가 공부론과 명상의 관계에 대해 살펴본 것이다. 최근 우리 사회에는 마음의 병에 대한 관심이 높아지고 있다. 흔히 세계관과 인생관, 가치관에 대한 왜곡된 인식에서 비롯된 마음의 병은 정신의학적 방법으로 치료될 수 없다는 점에서 신경정신과적 질병과는 구분된다. 철학을 비롯하여 문학, 예술 등 다양한 인문학을 활용한 대체치료가 주목받고 있는 것도 이러한 이유에서이다. 명상 또한 이들 가운데 하나이다. '명상'은 흔히 불교에서 발전해 온 것으로 생각되지만, 유학과도 밀접한 연관성을 가지고 있다. 불교의 명상은 현실의 삶을 부정하지만, 유가의 명상 철학은 현실과 자아를 인정하는 데서 출발하고 있다. 또한 유가의 수양론과 명상 철학은 방법론적으로 중요한 의미를 지니고 있다. 일반적으로 진행되는 정신치료나 심리치료는 그 방법이 대개 대화를 통해 이루어진다. '대화치료(talking cure)'는 내담자 스스로 자신의 현 상황을 인지하고, 그 문제를 스스로 발견하는 것을 전제로 한다. 일반적으로 현재 인문학을 응용한 치료가 대상으로 삼고 있는 교정기관이나 군부대와 같은 특수기관 수용자에게는 사용하기에도 적합한 방법이 아니다. 이 점에서 '마음 다스리기'를 강조한 유가의 공부론과 명상법은 응용할 만한 충분한 가치가 있어 보인다. 여기에서는 유가 공부론과 명상의 관계가 이론적으로 어떤 관계인가를 살펴보고, 퇴계의 『활인심방』을 응용하여 인문치료의 한 모형을 제시하였다. 동양의 수양론이 '마음의 병'에 대해 의미있는 이론을 제시하고 있긴 하지만, 이를 구체적으로 현장에서 응용하기란 쉬운 일이 아니다. 이는 수양론 자체가 일생을 두고 수행해야 할 지침이며, 그 성격상 일시적인 수행이나 실습을 통한 효과를 기대하기 어렵기 때문이다. 여기에서 제시하는 수양 치료 모형은 이러한 한계를 전제로 한 것으로, 인문치료의 한국적 모형 개발이라는 목적에 따른 시도이다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.80-80
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• 2003

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms, accompanied by marked cell death in the striatum and cortex. Stereotaxic injection of quinolinic acid (QA) into striatum results in a degeneration of GABAergic neurons and exhibits abnormal motor behaviors typical of the illness. The objective of this study was carried out to obtain basic information about whether parthenogenetic mouse embryonic stem (PmES) cells are suitable for cell replacement therapy of HD. To establish PmES cell lines, hybrid F1 (C57BL/6xCBA/N) mouse oocytes were treated with 7% ethanol for 5 min and cytochalasin-B for 4 hr to initiate spontaneous cleavage. Thus established PmES cells were induced to differentiate using bFGF (20ng/ml) followed by selection of neuronal precursor cells for 8 days in N2 medium. After selection, cells were expanded at the presence of bFGF (20 ng/ml) for another 6 days, then a final differentiation step in N2 medium for 7 days. To establish recipient animal models of HD, young adult mice (7 weeks age ICR mice) were lesioned unilaterally with a stereotaxic injection of QA (60 nM) into the striatum and the rotational behavior of the animals was tested using apomorphine (0.1mg/kg, IP) 7 days after the induction of lesion. Animals rotating more than 120 turns per hour were selected and the differentiated PmES cells (1$\times$10$^4$cells/ul) were implanted into striatum. Four weeks after the graft, immunohistochemical studies revealed the presence of cells reactive to anti-NeuN antibody. However, only a slight improvement of motor behavior was observed. By Nissl staining, cell mass resembling tumor was found at the graft site and near cortex which may explain the slight behavioral improvement. Detailed experiment on cell viability, differentiation and migration explanted in vivo is currently being studied.