• 한방안이비인후피부과학회지
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• 제31권4호
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• pp.22-30
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• 2018

Objectives : The aim of this study is to investigate the relationship between chronic low grade inflammation theory, psoriasis, and herbal medicine. Methods : We reviewed recent studies on the relationship between chronic low-grade inflammation, psoriasis, and herbal medicine through Pubmed. Results : The pathological basis for psoriasis is the action of inflammatory mediators by the activation of the immune response, which can be a cause of various cardiovascular, metabolic and psychological symptoms of psoriasis patients, in addition to skin lesions. The herbal medicines improve these inflammatory conditions and improve local lesions through herbal medicine such as Qingdai, which have a strong inhibitory effect on IL-17,22 production. Conclusions : Herbal medicines used in psoriasis are thought to be effective not only for the improvement of local psoriasis lesions through anti-inflammatory effect but also for the improvement of systemic inflammation associated with chronic low grade inflammation.

• 사상체질의학회지
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• 제27권1호
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• pp.171-177
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• 2015

고기를 먹고 체한 이후 재발한 소양인 건선 환자가 하지의 건선만 호소하고, 야간 소양감,오후의 재발하는 편두통, 어두운 설질과 어반 등의 증상을 호소하여, 장누수증후군과 소양인 식체비만과의 연관성을 고려하여 독활지황탕을 투여하여 증상이 호전된 치험례로, 향후 건선환자의 사상의학적 치료에 보탬이 되고자 보고하는 바이다.

• 한방안이비인후피부과학회지
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• 제27권4호
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• pp.87-100
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• 2014

Objectives : This study is aimed to analyse immunohistochemical research trend on psoriasis and consider the results in terms of Korean medicine. Methods : We analyse both immunohistochemical research papers and Korean medical papers on psoriasis, which I searched using KISS(Korean studies Information Service System) and OASIS(Oriental Medicine Advanced Searching Integrated System). Results : Psoriasis is characterized by hyperporliferation of the epidermis, inflammatory cell accumulation and increased tortuosity and dilatation of dermal papillary blood vessels. Recently, angiogenesis is considered to play a major role in pathogenesis of psoriasis. Conclusion : In Korean medicine, blood-tonifying, blood-cooling and blood-activating medicinal herbs have generally been used to treat psoriasis. I consider these herbs which also treat vessel problem can have an effect on angiogenesis of psoriasis.

• 한방안이비인후피부과학회지
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• 제31권1호
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• pp.106-116
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• 2018

Objectives : The aim of this study is to report the effect of Traditional Korean Medicine Including SaengRyoSaMultang-Gamibang and Hwangryunhaedok-tang Herbal-Acupuncture on the treatment of psoriasis. Methods : A patient with psoriasis was treated with SaengRyoSaMultang-Gamibang, Hwangryunhaedok-tang Herbal-Acupuncture, Aroma therapy, Acupuncture. The severity of psoriasis was assessed with Psoriasis Area and Severity Index(PASI). Results : After treatment, the patient showed that itching symptoms was disappeared and score of PASI changed from 23.4 to 2.9. Conclusions : According to the result, These findings suggest that Traditional Korean Medicine can be effective for the treatment of psoriasis.

• 동의생리병리학회지
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• 제18권2호
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• pp.468-473
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• 2004

Psoriasis is a chronic inflammatory disease of the skin characterized by epidermal hyperplasia, dermal angiogenesis, infiltration of activated T cells, and increased cytokine levels, and affects 1-3% of the world-wide population. Although many immunological and clinical reports indicate a role for the immune system in the pathogenesis of psoriasis, puzzling questions about psoriasis remain unsolved. During the several decade, immunosuppressor and PUVA treatment are ubiquitously used to psoriasis therapy. But recently, to promote terminal differentiation of keratinocytes, block either NK-Tcell or T-cell activation, and interrupting the angiogenic switch represent another therapeutic opportunity in psoriasis. To keep face with immunological therapy, the needs of newly designed prescription on the psoriasis treatments were demanded. With the object of understand the psoriasis from an orient medical point of view, patients were administrated the GY during several weeks. We investigated the changes of gene expression in involved and uninvolved skin samples during the oriental remedy. Microarray data showed several important results. First, Gene expression profiling is similar to each patient. Second, precursor proteins that organize cornified envelops are decreased at the end of remedy. But genes which related to apoptosis, G-protein signalling, and lipid metabolism are increased. Third, 68.5% of clustering genes localized on the psoriasis susceptibility locus. In our results indicated that GY influence on the keratinocytes hyperproliferation by regulating the gene, which located on the psoriasis susceptibility locus.

• Natural Product Sciences
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• 제24권1호
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• pp.21-27
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• 2018

Psoriasis is an auto-immune skin disease, which is characterized by the excessive generation of plaques on the skin with typically a long-lasting red, itchy and scaly symptoms. Imiquimod, which has been used for the treatment of external genital warts, actinic keratosis, and superficial basal cell carcinoma, induced of psoriasis-like skin disorders with skin erythema and thickness in mice. In the present study, we tried to find the bioactive herbal extract against imiquimod-induced psoriasis-like skin disorder in mice. During the searching of the herbal extract with anti-psoriatic effect, the ethanolic extract of Cnidium officinale ameliorated imiquimod-induced psoriasis-like skin disorder in mice. The morphological evaluation, H&E staining and Psoriasis Area and Severity Index (PASI) score showed that ear and back thickness, and erythema induced by imiquimod were significantly reversed after the treatment of the cream of the ethanolic extract of C. officinale. The overexpressed myeloperoxidase (MPO) and keratin 6A levels were decreased by the treatment of C. officinale cream. Also, $IFN-{\gamma}$, c-fos and $I{\kappa}B-{\alpha}$ mRNA levels, which are related to the progression of psoriasis, were reduced by C. officinale cream. Thus, the ethanolic extract of C. officinale ameliorated psoriasis-like skin disorder induced by imiquimod and might be the therapeutic agent for psoriasis.

• 대한한의학회지
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• 제37권1호
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• pp.158-168
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• 2016

Objectives: The purpose of this study is to present two case reports on the treatments of psoriasis with qi deficiency. Methods: We administered herbal medicine to two patients who showed psoriasis with overwork and evaluated the results by Psoriasis Area and Severity Index(PASI). Results: After the treatment two patients showed improvements in PASI. PASI of patient 1 changed from 11 to 1.6; patient 2 from 10.8 to 1. Conclusions: The results suggest that herbal medicine can be an effective treatment for psoriasis who has overwork.

• 대한한의학회지
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• 제36권3호
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• pp.126-134
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• 2015

Objectives: The purpose of this study is to present four case reports on the treatments of psoriasis initiated after acute tonsillitis. Methods: We administered herbal medicine to four patients who showed psoriasis symptoms after acute tonsillitis and evaluated the results by Psoriasis Area and Severity Index(PASI). Results: After the treatment all four patients showed improvements in PASI. PASI of patient 1 changed from 27.7 to 1.8; patient 2 from 19.8 to 0.4; patient 3 from 28.8 to 0; patient 4 from 6.9 to 0. Conclusions: The results suggest that herbal medicine can be an effective treatment for psoriasis of which the occurrence is related to acute tonsillitis.

• 한방안이비인후피부과학회지
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• 제17권3호
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• pp.131-137
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• 2004

In clinical practice, Psoriasis is commomly difficult to be completely cured that only repeats improvement and to be worsen. We experienced one case of Psoriasis patient who had had generalized expoliative Psoriasis for more than one year. After hospitalization treatment of ten days and outpatient treatment of three months, he's chief complain improved continuously and there was not worsen sign any more. So, He could return to his usual life, We still did't know the mechanism that Saengkankunbi-Tang brought his improvement by, but we think that more case studies are necessary focusing on damp-heat because of much drinking for long time and years of duration of skin disease.

• 한방안이비인후피부과학회지
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• 제28권4호
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• pp.208-214
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• 2015

Objectives : The purpose of this study is to present two case reports on the treatments of psoriasis who has functional gastrointestinal disorder.Methods : We administered herbal medicine to two patients who showed psoriasis with functional gastrointestinal disorder and evaluated the results by Psoriasis Area and Severity Index(PASI).Results : After the treatment two patients showed improvements in PASI. PASI of patient 1 changed from 8.8 to 0.8; patient 2 from 7.0 to 0.2Conclusions : The results suggest that herbal medicine can be an effective treatment for psoriasis who has functional gastrointestinal disorder.