• 한국수소및신에너지학회논문집
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• 제23권4호
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• pp.323-329
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• 2012

A thermal management system of a proton exchange membrane fuel cell is taken charge of controlling the temperature of fuel cell stack by rejection of electrochemically reacted heat. Two major components of thermal management system are heat exchanger and pump which determines required amount of heat. Since the performance and durability of PEMFC system is sensitive to the operating temperature and temperature distribution inside the stack, it is necessary to control the thermal management system properly under guidance of operating strategy. The control study of the thermal management system is able to be boosted up with hardware in the loop simulation which directly connects the plant simulation with real hardware components. In this study, the plant simulation of fuel cell stack has been developed and the simulation model is connected with virtual data acquisition system. And HIL simulator has been developed to control the coolant supply system for the study of PEMFC thermal management system. The virtual data acquisition system and the HIL simulator are developed under LabVIEWTM Platform and the Simulation interface toolkit integrates the fuel cell plant simulator with the virtual DAQ display and HIL simulator.

• 한국수소및신에너지학회논문집
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• 제22권2호
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• pp.161-167
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• 2011

Proton conductors have attracted considerable attention for solid oxide fuel cell (SOFC), hydrogen pump, gas sensor, and membrane separators. Doped $SrCeO_3$ exhibits appreciable proton conductivity in hydrogen-containing atmosphere at high temperature. However commercial realization has been hampered due to the reactivity of $SrCeO_3$ with $CO_2$. The chemical stability and proton conductivity are dependent on dopant type. The purpose of this work is to investigate chemical stability of $SrCe_{0.95}Gd_{0.05}O_{3-\alpha}-Ce_{0.9}Gd_{0.1}O_{2-\beta}$ composites in $CO_2$ and $H_2$ gases. Thermogravimetric analysis (TGA) was performed in gaseous $CO_2$ and electrical conductivity of the composites were also measured between 500 and $900^{\circ}C$ in air and $H_2$ atmosphere. $SrCe_{0.95}Gd_{0.05}O_{3-\alpha}-Ce_{0.9}Gd_{0.1}O_{2-\beta}$ composite membranes showed good chemical stability of in $CO_2$ atmosphere and high conductivity at hydrogen condition. The hydrogen permeation of $SrCe_{0.95}Gd_{0.05}O_{3-\alpha}-Ce_{0.9}Gd_{0.1}O_{2-\beta}$ composite membranes was investigated as a function of volumetric content of $SrCe_{0.95}Gd_{0.05}O_{3-\alpha}$. The $SrCe_{0.95}Gd_{0.05}O_{3-\alpha}-Ce_{0.9}Gd_{0.1}O_{2-\beta}$(6:4) membrane with a thickness of 1.0 mm showed the highest hydrogen permeability with the flux reaching of 0.12 $ml/min{\cdot}cm^2$ at $800^{\circ}C$ in 100%$H_2/N_2$ as feed gas.

• 식물조직배양학회지
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• 제27권1호
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• pp.31-37
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• 2000

인삼 (Panax ginseng C.A. Meyer)의 뿌리로부터 유도한 모상근의 proton 방출은 철이온의 결핍 또는 nitrate나 ammonium이온에 의해 증가되었다. 철이온 결핍에 의한 수소이온 방출의 증가는 정단 조직에서 나타나는 반면에 nitrate와 ammonium 이온에 의한 수소이온 방출은 기저부위에서 높게 나타났다. 배지의 pH변화에 따른 무기이온의 흡수는 무기이온의 종류에 따라 다양한 양상을 나타냈다. $Ca^{2＋}$, $Mg^{2＋}$ 그리고 Fe$^{2＋}$ 는 pH 4.8 에서 가장 높은 흡수를 나타냈으며, Mn$^{2＋}$, $Zn^{2＋}$ 그리고 Cu$^{2＋}$ 는 pH 3.8에서 가장 높았다. HPLC를 이용한 유리당 및 ginsenoside분석에서, 인삼모상근 유리당 구성의 주성분은 sucrose, glucose 그리고 fructose 였으며, glucose와 fructose는 pH 6.8에서 sucrose는 pH 4.8 에서 함량이 가장 높았다. 반면에 ginsenosides와 phenolic compound의 함량은 MS 배지의 표준인 pH 5.8 에서 가장 높았다. pH 변화에 대한 인삼모상근의 이러한 생리적 반응은 인삼근의 적변유발과 관련된 무기이온의 mobilization 및 흡수기작의 구명을 위한 모델 시스템으로 이용할 수 있는 가능성을 제시하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.96-96
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• 1997

YJA 20379-1(YJA-1)은 영진약품(주)에서 합성한 Thiazole유도체로서 급만성 위궤양 및 십이지장 궤양에 유효한 proton pump 억제 작용물질이다. 이 실험은 신약개발을 지향한 한 단계로서 YJA-1의 일반약리작용에 관한 것이다. 실험은 YJA-1에 대하여 중추신경계작용, 진통작용, 정상체온에 대한 작용, 항경련작용 및 장수송능시험을 실시하였고, 용량은 50, 100 및 200$\mu\textrm{g}$/$m\ell$를 경구투여하였고, 혈압 및 호흡에의 작용은 토끼에 10, 20 및 40mg/kg을 정맥주사하여 실시하였으며, 적출장기 실험에서는 100 및 200$\mu\textrm{g}$/$m\ell$를 적용시켰다.

• The Korean Journal of Pain
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• 제31권1호
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• pp.3-9
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• 2018

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific medications and/or electrolyte imbalance. This review provides insights into the risk for QT prolongation associated with drugs frequently used in the treatment of chronic pain. In the field of pain medicine all the major drug classes (i.e. NSAIDs, opioids, anticonvulsive and antidepressant drugs, cannabinoids, muscle relaxants) contain agents that increase the risk of QT prolongation. Other substances, not used in the treatment of pain, such as proton pump inhibitors, antiemetics, and diuretics are also associated with long QT syndrome. When the possible benefits of therapy outweigh the associated risks, slow dose titration and electrocardiography monitoring are recommended.

• 한국미생물·생명공학회지
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• 제27권5호
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• pp.354-358
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• 1999

In order to know the antifungal characteristics of saturated fatty acids having 6 to 12 carbons, their minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) were estimated against Saccharomyces cerevisiae. Fatty acids from C6 to C11 exhibited increasing activity with chain length, but C12 fatty acid did not show activity at all. In relation to antifungal modes of actions, fatty acids investigated showed on inhibitory activity toward the plasma membrane H+-ATPase of Saccharomyces cerevisiae. Their inhibitions to the glucose-induced acidification and ATP hydrolysis caused by the proton pump were found to be in common wiht antifungal activities. At the test concentration of 1mM, hexanoic acid (C6) showed the lowest inhibition of about 30%, while undecanoic acid(C11) showed the strongest inhibition of over 90%. In addition, as seen with antifungal activity, the inhibitory activity of dodecanoic acid (C12) was suddenly reduced to less than 50%.

• 대한후두음성언어의학회지
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• 제18권2호
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• pp.102-107
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• 2007

Laryngopharyngeal reflux disease (LPRD) is the result of retrograde flow of gastric contents to the laryngopharynx. Laryngoscopic findings and special questionnaires are first step of diagnosis of LPRD. Empiric trials of Proton pump inhibitor' test (PPI test) is recommended as treatment and diagnosis. However confirmation of reflux is then recommended primarily in patients with persistent symptoms despite acid-suppressive therapy. The 24 hour ambulatory double pH monitoring has been a gold standard method in diagnosis of LPRD even though it has some limitation. The combined multichannel intraluminal impedance and pH monitoring is a new-rising test tool. It can detect acid/non-acid, liquid/gaseous reflux and clearance of refluxate. The water siphon test is also used for diagnosis of LPRD.

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 1999년도 제8차 추계학술대회 및 정기총회
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• pp.44-44
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• 1999

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.84-86
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• 2016

Globus pharyngeus or globus sensation is the painless sensation of a lump in the throat and may be described as a foreign body sensation, a tightening or choking feeling. It is often associated with persistent clearing of the throat, chronic cough, hoarseness, and catarrh. Its etiology remains unclear ; however, laryngopharyngeal reflux may play a role in a subset of patients. Psychogenic problems have often been thought to cause or trigger the globus sensation. Personality studies have found higher levels of alexithymia, neuroticism, and psychological distress (including anxiety, low mood, and somatic concerns) and lower levels of extraversion in patients presenting with globus. Globus patients with laryngopharyngeal reflux exhibited weaker psychological symptoms than non- laryngopharyngeal reflux globus patients, and globus patients who did not respond to proton pump inhibitor had significantly higher anxiety scores. In cases with negative clinical investigations and consistent globus symptom, other treatment strategies, including speech therapy, antidepressants, and cognitive-behavioral therapy, should be considered.

• Childhood Kidney Diseases
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• 제14권2호
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• pp.120-131
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• 2010

Renal tubular acidosis (RTA) is a metabolic acidosis due to impaired excretion of hydrogen ion, or reabsorption of bicarbonate, or both by the kidney. These renal tubular abnormalities can occur as an inherited disease or can result from other disorders or toxins that affect the renal tubules. Disorders of bicarbonate reclamation by the proximal tubule are classified as proximal RTA, whereas disorders resulting from a primary defect in distal tubular net hydrogen secretion or from a reduced buffer trapping in the tubular lumen are called distal RTA. Hyperkalemic RTA may occur as a result of aldosterone deficiency or tubular insensitivity to its effects. The clinical classification of renal tubular acidosis has been correlated with our current physiological model of how the nephron excretes acid, and this has facilitated genetic studies that have identified mutations in several genes encoding acid and base ion transporters. Growth retardation is a consistent feature of RTA in infants. Identification and correction of acidosis are important in preventing symptoms and guide approved genetic counseling and testing.