• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2005년도 Proceedings of ISRS 2005
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• pp.656-658
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• 2005

KAERI (Korea Atomic Energy Research Institute) has been performing the project named PEFP (proton engineering frontier project). PEFP has been performing the project of a high power proton accelerator. Control system for 20 MeV proton accelerating structure has developed. We use the EPICS(Experimental Physics and Industrial Control System) tool kit as a foundation of the control system. EPICS is adopted for control systems which have OPI(OPerator Interface) and IOqlnput Output Controller). We have performed the PEPF control system on SUN workstation host computer. In this paper, we present the vacuum monitor, RFQ, and DTL Turbo pump control system.

• Rapid Communication in Photoscience
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• 제2권2호
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• pp.52-55
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• 2013

Proteorhodopsin (PR) is a photoinduced proton pump found abundantly in ocean and fresh water habitat, and has an important role in photoenergy conversion to bioenergy in the living cells. Numerous sequences that encode PR protein variants were discovered by environmental genome sequencing and they indicated the high sequence similarity. A new-type of PR (YS-PR) which had been discovered from the surface of Yellow Sea was found to have only 5 amino acid differences from the previously known green-light absorbing PR (GPR) protein, but showed different photochemical properties. This YS-PR showed a 10 nm red-shifted absorption maximum, when compared with GPR. It also showed slower photocycling rate than GPR. However, the photoconversion rate of YS-PR was fast enough to pump protons. Four different amino acids out of 5 were similar to Blue-light absorbing PR (BPR), suggesting that those residues might be responsible for the observed spectral and photoconverting properties.

• Clinical and Experimental Pediatrics
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• 제62권10호
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• pp.384-385
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• 2019

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 2002년도 춘계심포지움
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• pp.13-15
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• 2002

• Journal of Microbiology and Biotechnology
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• 제10권4호
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• pp.441-448
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• 2000

The production and cation flux-mediated activation of the P-type ATPase in Helicobacter pylori was investigated. Using the polymerase chain reaction (PCR), the proton pump genotype of H. pylori was found to be positive for both F-type and P-type ATPases. Yet, their production in terms of enzyme specific activity varied substantially depending on H. pylori strains, ranging over 3-fold. Its main constituent appeared to be the P-type ATPase pool, in contrast to other common bacterial compositions. Interestingly, the F-type ATPase was observed only when intact H. pyloricells were exposed to pH 4.5 or above (37$^{\circ}C$ for 1 h). In contrast, significant amounts of the P-type ATPase still remained after 1 h of cell treatment even at pH below 4.5. By enriching the acidic medium with RPMI(pH 3.0), the P-type ATPase was stabilized, accompained by inactivation of the F-type ATPase. Using H. pylori membrane vesicles, it was found that ammionia-mediated cation flux increased the rate of ATP hydrolysis by the P-type ATPase. Accordingly, these data strongly suggest that the P-type ATPase is involved or functions as an effective regulator for the cation flux across the H. pylori membrane, thereby reducing the risk of excess proton influx.

• Journal of Photoscience
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• 제9권2호
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• pp.320-322
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• 2002

Archaerhodopsin (aR), a light-driven proton pump found in HaIonubrum sp. aus-l, was crystallized into an octahedral crystal belonging to the space group P4$_3$2$_1$2. It is shown that aR is composed of7 helical segments and an anti-para1leI ${\beta}$ sheet. The main-chain sIrudure of aR is nearly identical to that of bacteriorhodopsin, but a significant structural difference is observed in the protein surface, especially at lipid binding sites.

• 공업화학
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• 제4권2호
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• pp.416-422
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• 1993

성능이 우수한 킬레이트막을 개발하고자 chitosan에 글루타르알데히드를 가교시켜 막을 제조하였으며, 이 막을 통한 금속 이온의 투과 특성을 조사하였다. 막을 통한 이온의 투과는 downstream 용액의 pH의 영향을 크게 받았으며, 이 현산에 대하여 proton pump 메카니즘을 제안하였다. 막 표면에서의 착물형상에 의한 선택흡착성이 선택투과성에 영향을 미친다고 생각되며, $Mg^{2+}$과 $Cu^{2+}$의 혼합 용액에서 $Cu^{2+}$의 선택도는 9.5이었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.311.1-311.1
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• 2003

Dose-independent pharmacokinetic parameters of KR-60436, a new proton pump inhibitor, were evaluated after an intravenous, iv (5, 10, and 20 mg/kg) and an oral (20, 50, and 100 mg/kg) administration to rats. The hepatic, gastric, and intestinal first-pass effects were also measured after iv, intraportal (ip), intragastric (ig), and intraduodenal (id) administration at a dose of 20 mg/kg to rats. (omitted)

• 대한후두음성언어의학회지
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• 제20권2호
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• pp.141-147
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• 2009

Background and Objectives: Although laryngopharyngeal reflux disease (LPRD) is a widely recognized disease in the field of otolaryngology, controversies still exist regarding the diagnosis and treatment for it. The purpose of this survey was to find out current trends in diagnosis and management of LPRD among Korean otolaryngologists. Materials and Method: Questionnaires were obtained from 26 Korean otolaryngology specialists by electronic balloting, and 46 members of the Korean Society of Head and Neck Surgery (KSHNS) bye-mail. Survey participants were asked about their preferences in diagnostic policy, duration/dosage of antireflux treatment, and their familiarity to the reflux symptom index (RST) and the reflux finding scores (RFS). Results: The majority of the survey participants (64%) preferred empiric therapy trial with proton pump inhibitors (PPIs) based on patients' symptoms and their laryngeal findings. PPIs alone (27%) or PPIs with prokinetics (32%) were usually prescribed as a first line treatment mostly with once daily schedule in the morning before meal and for less than 4 months of duration (86%). More than 90% of participants were aware of the RSI and RFS, but less than 50% of them were actually using those items in the clinics. Conclusion: Most of Korean otolaryngologists who participated in this survey answered that they prefer starting empirical treatments with proton pump inhibitors mainly based on the patient's symptoms and their laryngeal findings.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.141-144
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• 2013

Hyperplastic gastric polyps (HPPs) are the most common type of gastric polyps. They are assumed to be caused by chronic inflammation and regenerative proliferation, although this has not been clearly investigated yet. Many studies suggested the development of fundic gland polyps and carcinoid during long-term proton pump inhibitor (PPI) therapy, but the relationship between PPIs and HPPs is still unclear. We encountered a patient who showed aggravation of HPPs after long-term use of PPIs. A 58-year-old male patient with liver cirrhosis visited our hospital because of hematemesis. We started PPI medication after confirming esophageal variceal bleeding and duodenal ulcer with blood clot in its base via emergency endoscopy. He took PPIs for three years because of an intractable duodenal ulcer. There was a marked increase in the size of the pre-existing polyps and in the development of new polyps. We presumed that the PPIs caused the aggravation of the HPPs, so we stopped their administration. After five months, the HPPs shrank and the polyps were partially degraded. More prospective studies are needed to investigate the relationship between HPPs and PPIs.