• Proceedings of the Korea Information Processing Society Conference
• /
• 2006.05a
• /
• pp.399-402
• /
• 2006

한국 원자력 연구소는 PEFP(Proton Enginnering Frontier Poject)라고 하는 프로젝트를 수행 중이며, PEFP는 고에너지 양성자 가속기에 대한 프로젝트이다. 양성자 가속기에 대한 제어 시스템은 안정적인 운전 제어를 위해서 장치의 상태를 주기적으로 모니터링 할 뿐만 아니라 장치상태를 저장하여 일정시간 후에 확인이 요구되면 저장된 데이터를 이용하여 이전 정보를 추적할 수 있어야한다. 따라서 양성자 가속기 제어시스템에서는 실시간으로 들어오는 진공 데이터 정보를 저장 및 저장된 데이터를 열람이 가능한 저장 시스템으로 구성하였다. 저장된 데이터들은 RFQ(Radio Frequency Quadrupole) Cryopump, Turbo Pump, Press Gauge, Gate Valve, Compressor와 DTL(Drift Tube Linac) Multi-Gauge, Turbo Pump등의 진공도 및 제어변수 등이 있다. 이들 각각의 진공장치로부터 전달되는 진공 데이터들을 저장하기 위해 EPICS Extension toolset중에서 저장하는 기능을 가진 Channel Archiver를 양성자 가속기 제어 시스템에 추가하였다

• Journal of Microbiology
• /
• v.42 no.2
• /
• pp.156-159
• /
• 2004

In general, the salinity of the ocean is close to 3.5％ and marine vibrios possess the respiratory chain-linked Na$\^$+/ pump. The influence of sodium chloride and the proton conductor carbonylcyanide m-chlo-rophenylhydrazone (CCCP) on the production of extracellular proteases in a marine Vibrio strain was examined. At the concentration of 0.5 M, sodium chloride minimally inhibited the activity of extra-cellular proteases by approximately 16％, whereas at the same concentration, the producton of extra-cellular proteases was severely inhibited. On the other hand, the production of extracellular proteases was completely inhibited by the addition of 2 ${\mu}$M CCCP at pH 8.5, where the respiratory chain-linked Na$\^$+/ pump functions.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.3005-3006
• /
• 2012

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.169-170
• /
• 2002

It has been well known for the stereoselectivity in pharmacodynamic effects of many xenobiotics including therapeutic agents, which have lead to the development of enantiomer drugs. Compared to pharmacodynamic stereoselectivity, stereoselective pharmacokinetics of each enantiomer has not been seriously considered in the development of enantiomer drugs although many reports have been demonstrated the stereoselective absorption and metabolism of racemic drug (e.g verapamil). (omitted)

• Proceedings of the Korean Society of Fisheries Technology Conference
• /
• 2003.05a
• /
• pp.389-390
• /
• 2003

리소즘은 가수분해효소와 같은 각종 효소를 저장하고 있고, 이러한 효소는 지방, 지질 및 단백질에 특이적으로 반응하여 세포내로 들어오는 이들 물질을 분해하는 기능을 담당한다. 또한 리소좀은 여러 가지 Xenobiotics에도 반응하는 것으로 알려지고 있다(Lowe et al., 1995, Shepard and Bradley, 2000), 리소즘막의 손상은 결국 Xenobiotic의 세포내 출입의 조절능을 상실하게 되고, 나아가 ATP-dependent proton pump의 손상을 일으키게 된다(Lowe et al., 1992). (중략)

• Proceedings of the PSK Conference
• /
• 2000.10a
• /
• pp.271.2-272
• /
• 2000

• Proceedings of the PSK Conference
• /
• 2001.04a
• /
• pp.238.1-238.1
• /
• 2001

• Proceedings of the PSK Conference
• /
• 2000.10a
• /
• pp.266.1-266.1
• /
• 2000

• Journal of Microbiology and Biotechnology
• /
• v.23 no.3
• /
• pp.430-435
• /
• 2013

Multidrug resistance, especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters, is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as well as of cancer cells. Streptococcus mutans is considered one of the primary causative agents of dental caries and periodontal disease, which comprise the most common oral diseases. A fragment of chromosomal DNA from S. mutans KCTC3065 was cloned using Escherichia coli KAM32 as host cells lacking major multidrug efflux pumps. Although E. coli KAM32 cells were very sensitive to many antimicrobial agents, the transformed cells harboring a recombinant plasmid became resistant to several structurally unrelated antimicrobial agents such as tetracycline, kanamycin, rhodamin 6G, ampicillin, acriflavine, ethidium bromide, and tetraphenylphosphonium chloride. This suggested that the cloned DNA fragment carries a gene encoding a multidrug efflux pump. Among 49 of the multidrug-resistant transformants, we report the functional gene cloning and characterization of the function of one multidrug efflux pump, namely MdeA from S. mutans, which was expressed in E. coli KAM32. Judging from the structural and biochemical properties, we concluded that MdeA is the first cloned and characterized multidrug efflux pump using the proton motive force as the energy for efflux drugs.

• Archives of Pharmacal Research
• /
• v.23 no.1
• /
• pp.72-78
• /
• 2000

The general pharmacological properties of YJA20379-1 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol[1,2-a]benzoimidazole, a novel proton pump inhibitor with antiulcer activities were investigated in mice, rats, guinea pigs and rabbits. YJA20379-2 at oral doses of 50, 100 and 200 mg/kg did not affect the general behaviour, hexobarbital hypnosis and motor coordination in mice. The drug did not have analgesic or anticonvulsant action at 200 mg/kg. Locomotor activity and body temperature were not influenced at 100 mg/kg. At a concentration up to 2{\times}10^{-4} g/ml$, YJA20379-2 did not produce any contraction or relaxation of isolated preparations, such as the rat fundus, the guinea pig ileum and the rat uterus, and did not antagonize the contractile response to several spasmogens, such as histamine, acetylcholine, serotonin and oxytocin. At dosages up to 200 mg/kg p.o. YJA20379-2 did not affect the pupil size of mice. Intestinal propulsion of mice was not affected up to 200 mg/kg p.o. and the drug did not affect urinary excretion at 100 mg/kg p.o. These results indicate that at dosages up to 100 gm/kg p.o. YJA20379-2 was found not to affect this pharmacological profile. However, at 200 mg/kg the drug lowered body temperature and showed decreased in locomotor activity and urine volume.