• 한국사회복지학
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• 제57권3호
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• pp.195-222
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• 2005

본 연구는 청소년 인터넷 중독의 각 유형에 따른 비교분석에 초점을 두고, 인터넷 중독유형에 대한 위험요인과 보호요인의 상대적 영향력을 확인하며, 중독유형간의 공통적 요인과 상이한 요인을 밝혀보고자 하였다. 또한 인터넷 중독유형이 정신건강에 미치는 영향을 파악하였다. 1,830명의 청소년들을 대상으로 한 연구결과는 첫째, 청소년의 62.3%는 인터넷 중독이었고, 15.9%는 인터넷 게임중독, 10.9%는 인터넷 섹스중독으로 나타났다. 둘째, 모든 인터넷 중독유형에서 위험요인이 보호요인보다 더 높은 영향력을 나타냈으며, 보호요인의 보상효과는 인터넷 중독과 게임중독에서는 나타났으나, 섹스중독에서는 나타나지 않았다. 셋째, 인터넷 중독유형에서의 공통적인 위험요인은 우울, 공격성, 부모 통제, 친구 영향력이었고, 보호요인은 자기통제력 이었다. 상이한 위험요인은 PC접근성이었고, 보호요인은 자기효능감, 교사지지, 친구지지, 부부관계로 나타났다. 넷째, 3개 중독유형 모두에서 일반이용집단보다 중독집단이 더 높은 수준의 정신과적 증상을 경험하는 나타났다. 다섯째, 3개 중독유형 중 섹스중독, 게임중독, 인터넷 중독 순으로 정신과적 증상차원에 높은 부정적 영향을 미치는 것으로 나타났으며, 중독의 정도가 높을수록 정신과적 증상이 심해지는 것으로 나타났다.

• 벤처창업연구
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• 제13권2호
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• pp.159-175
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• 2018

본 연구는 요양보호사의 이직의도에 직업적응이 미치는 영향에 대한 이해를 통해 요양보호사의 위기와 역경을 극복할 수 있는 요인을 규명하고 장기적으로는 요양보호사의 다양한 문제 해결에 기여하는 것을 목적으로 한다. 이를 실증적 연구과제로 확인하고자 위험요인과 보호요인, 조사대상자의 일반적 특성요인, 직업적응 및 이직의도를 선정하였으며, 요양보호사의 위험요인과 보호요인이 이직의도에 영향을 미치는데 있어서 직업적응이 매개역할을 하는지를 검증하고자 하였다. 이에 서울 경기지역의 노인의료복지시설에 재직 중인 요양보호사 291명을 대상으로 설문을 실시하여 분석한 결과는 다음과 같다. 첫째, 요양보호사의 위험요인 및 보호요인과 직업적응의 관계에서 요양보호사의 관계갈등이 심할수록, 직장문화에 대한 부적응이 높을수록 직무만족과 조직몰입에 악영향을 미치고, 정서적지지, 평가적지지, 정보적 지지가 높을수록 직무에 만족감을 느끼고 직무에 몰입하게 되는 것으로 나타났다. 둘째, 요양보호사의 위험요인 및 보호요인과 이직의도의 관계에서 요양보호사의 관계갈등이 높을수록, 직장이 불안정하다고 느길수록, 직장문화에 적응하는 것이 어렵게 느껴질수록 이직의도를 더 많이 갖게 되는 것으로 확인되었다. 마지막으로 요양보호사의 위험요인 및 보호요인과 이직의도의 관계에서 직업적응의 매개효과에 대한 검증결과, 직업적응의 하위요인인 직무만족은 매개역할을 하는 것으로 나타났지만 조직몰입은 위험요인인 직무스트레스와 이직의도의 관계에서만 매개역할을 하고, 보호요인인 자기효능감이나 사회적 지지와 이직의도의 관계에서는 매개변인 역할을 하지 않는 것으로 나타났다. 즉, 요양보호사가 평소 직무에 대한 만족감을 느끼고 있다면 직무에 대한 스트레스도 덜 받게 되고, 자기효능감이 향상될 것이며, 사회적 지지에 대한 긍정적 사고방식을 갖게 되어 이직률을 낮출 수 있다는 사실을 알 수 있다. 또한 요양보호사가 조직에 몰입하면 할수록 직무스트레스를 덜 받게 되고 이직의도를 감소시킬 수 있으나 자기효능감이나 사회적 지지에 대한 인식에는 큰 영향을 미치지 못하는 것으로 확인되었다. 이를 바탕으로 시설장은 요양보호사들이 보다 직업에 적응할 수 있도록 갈등해소를 위한 노력과 직장문화에 대한 적응도를 높일 수 있는 방안을 모색하여 시설운영의 안정을 도모하고 질 높은 서비스 제공을 위한 노력을 해야 하며, 요양보호사들의 직무만족과 조직몰입의 향상을 위한 적극적 경영전략 및 제도적 뒷받침을 위한 개발이 요구되어진다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.27-28
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• 2003

It is widely accepted that free-radical induced oxidative damages are involved in pathogenic processes of major diseases including cancer, atherosclerosis, rheumatoid arthritis and diabetes. A number of epidemiological studies have indicated that frequent consumptions of plant foods rich in antioxidants reduce the risk of developing cancer and cardiovascular diseases, while many intervention trials have failed to prove the protective role of major dietary antioxidants.(omitted)

• Journal of Ginseng Research
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• 제47권2호
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• pp.169-172
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• 2023

The coronavirus disease 2019 (COVID) pandemic began in December 2019. Many countries have implemented restrictions such as mandatory mask wearing and social distancing. These measures have caused diverse and complex health problems, particularly in women's health, anxiety, and depression. This review examines an alternative approach to the treatment of endometriosis during the COVID pandemic. The efficacy of ginseng with anti-inflammatory activity and ability to relieve or prevent symptoms of endometriosis is discussed and reviewed.

• Journal of Ginseng Research
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• 제31권1호
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• pp.51-53
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• 2007

Ginseng shows protective and trophic effects in neurodegenerative diseases in experimental models, and showed cognitive improvement in normal population. To investigate the efficacy of ginseng in patients with Alzheimer's disease, patients, who met NINDS-ADRDA criteria for AD were studied Subjects were randomly assigned to ginseng group and control group, and ginseng group was treated with Korean white ginseng powder (4.5 g/day) for 12 weeks. Efficacy variables included changes in mini-mental status exam (MMSE) and cognitive subscales of Alzheimer's disease assessment scale (ADAS-cog) at 4 weeks and 12 weeks. Baseline MMSE and ADAS scores showed no difference between the two groups. Results showed that ginseng improved ADAS-cog compared to the control group at 12 weeks (p<0.05). MMSE was also increased by ginseng treatment compared to the control at 12 weeks (p<0.01). This study suggests the symptomatic efficacy of ginseng in patients with Alzheimer's disease.

• 한국식물병리학회지
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• 제10권4호
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• pp.284-291
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• 1994

In order to establish an appropriate spray schedule to reduce the infection, 11 kinds of chemicals were tested for their properties on the inhibition of spore germination at the surface of apple fruits and the duration of the inhibitory effect after spray of each chemical was examined from late June to early September with basically 10 day intervals. Actual control efficacy of each chemical by the 8 successive spray and the patterns of waterborne spore dispersals during that periods were also examined. Combining those results with the meteorological observation data, actual control efficacy of each chemical in the given periods could be estimated. It was revealed that folpet, Brodeaux mixture, mancozeb, oxine copper and imminoctadine-triacetate could be used at any time during the possible infection periods. Captan and dithianon could also be used except the rainy season due to the short duration of inhibitory efficacy against spore germination under heavy rain. However, the usefulness of propineb, benomyl and chlorothalonil against the apple white rot could not be demonstrated in this experiment. Thiram, even though has not been used for apple white rot, can also be used before or after the rainy season to control not only white rot but also alternaria blotch.

• 대한한의학회지
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• 제32권4호
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• pp.83-99
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• 2011

Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.

• 대한한의학회지
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• 제32권2호
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• pp.63-78
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• 2011

Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model. Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue. Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.

• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.184-192
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• 1986

Since the wide spread application of hyperbaric oxygenation in clinical setting, the problems of oxygen toxicity have been attracting a deep interest from the researchers on hyperbaric medicine as a practical issue. Among extensive research trials, the study on the protective agents against oxygen toxicity occupied one of the most challenging field. As the mechanisms of oxygen toxicity, the role of the oxygen free radicals produced by peroxidation process are strongly accepted by the leading researchers on oxygen toxicity, the probable protective effects of antioxidant against oxygen toxicity are sustaining a sufficient rationale. In this study, the author attempted to evaluate the effect of vitamin E as a protective agent against oxygen toxicity through the observation of death rate, convulsion rate, time to convulsion, and macroscopic and microscopic pathological changes of experimental rats exposed to 100% oxygen at 5 ATA for 120 minutes. The findings observed are as follows: 1) The death rate, convulsion rate, time to convulsion, organ/body weight ratio and microscopic pathological findings were identified as reliable objective and quantitative indices for oxygen toxicity. 2) Vitamin E showed excellent protective effects against CNS and pulmonary oxygen toxicity as a strong antioxidant. The most effective dose seemed to be around 400 mg/kg 3) The results of this study are supporting the oxygen free radical hypothesis on oxygen toxicity.

• 한국미생물·생명공학회지
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• 제50권3호
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• pp.375-386
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• 2022

In the present study, four distinctly colored bacterial isolates that show intense pigmentation upon brief ultraviolet (UV) light exposure are chosen. The strains are identified as Micrococcus luteus (Milky yellow), Cryseobacterium pallidum (Yellow), Cryseobacterium spp. (Golden yellow), and Kocuria turfanensis (Pink) based on their morphological and 16S rDNA analysis. Moderate salinity (1.25%), 25-37℃ temperature, and pH of 7.2 are found to be the most favorable conditions of growth and pigment production for all the selected isolates. The pigments are extracted using methanol: chloroform (1:1) and the purity of the pigments are confirmed by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC). Further, Fourier transform infrared (FTIR) and UV-Visible spectroscopy indicate their resemblance with carotenoids and flexirubin family. The antioxidant activities of the pigments are estimated, and, all the pigments have shown significant antioxidant efficacy in 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl-hydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays. The UV protective property of the pigments is determined by cling-film assay, wherein, at least 25% of UV sensitive Escherichia coli survive with bio-pigments even after 90 seconds of UV exposure compared to control. The pigments also hold a good sun protective factor (SPF) value (1.5-4.9) which is calculated with the Mansur equation. Based on these results, it can be predicted that these bacterial pigments can be further developed into a promising antioxidant and UV-protectant for several biomedical applications.