• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.1-8
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• 2021

Prostate cancer is one of the most diagnosed malignancies found across the world today. American cancer society in recent research predicted that over 174,600 new prostate cancer cases found and nearly 31,620 death cases recorded. Researchers are developing modest and accurate methodologies to detect and diagnose prostate cancer. Recent work has been done in radiology to detect prostate tumors using ultrasound imaging and resonance imaging techniques. Transrectal ultrasound and Magnetic resonance images of the prostate gland help in the detection of cancer in the prostate gland. The proposed paper is based on comparison and analysis between two novel image segmentation approaches. Seed region growing and cluster based image segmentation is used to extract the region from trans-rectal ultrasound prostate and MR prostate images. The region of extraction represents the abnormality area that presents in men's prostate gland. Detection of such abnormalities in the prostate gland helps in the identification and treatment of prostate cancer

• Applied Microscopy
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• 제27권2호
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• pp.155-163
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• 1997

Ultrastructural and histochemical studies were carried out on the prostate gland of a Korean slug (Incilaria fruhstorferi) with light and electron microscopes. The results are as follows. The endothelial tissue of the prostate gland is constituted with tall and narrow ciliated columnar cells, irregularly shaped cells and gland cells in which are included the elongated oval or ellipsoid nucleus those are surrounded by curved membrane. The endothelial tissue of the prostate gland is composed by type-A, B, C and type-D gland cells, and the glanules of type-A, B, and D gland cells are certified to neutral mucopolysaccharide because are related by PAS-alcian blue (pH 2.5) , but the other hand type-C gland cell is only weakly reacted to PAS, but strongly reacted by Million reaction. The glanules of type-A gland cell are small size (about $0.4{\mu}m$) and are seen high electron density, but the glanules of type-B gland cell are large size (about $0.7{\mu}m$) and glanule density is same type-A glanules. Long ellipsoid type-C gland cell contained round nucleus which is well developed beterochromatin in, and that small oval glanules (size, about $0.9{\mu}m$) of moderate high electron density which are formed a group of large glanule together with $4\sim5ea$, but type-D gland cell possessed round small nucleus are seen high electron dense glanules (size, $0.8{\mu}m$).

• 동의생리병리학회지
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• 제21권6호
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• pp.1660-1662
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• 2007

"BUDDEUMI is a new remedy of the synchronous combination of cupping boil and moxibustion for the exclusion of human body's waste product. It wishes the reach for improving the effect of cupping boil and moxibustion by the synchronous combination. As the negative pressure of cupping and the hot cure of moxa are made up of BUDDEUMI structural character. In order to determine the depth-hot effect of BUDDEUMI, clinical study was performed in the cancer of the prostate gland for several years. The targets of study was one person with the cancer of the prostate gland for several years. The BUDDEUMI was operated 3-4 times/ day, during 12 months on the Gowan-Won, Jang-Wan, Jeon Jung and the abdominal region & Jang-Gang, Meong-Moon, Dae-Chue and the back region. Therefore we compared PSA(prostate singular antigen: June, 2006/ June, 2007) before and after BUDDEUMI therapy. PSA significantly decreased in a comparison of before-treatment (30.76) and after 12 months (0.76). And the times of enuresis significantly decreased in a comparison of before-treatment (5-10 times) and after 12 months(1-2 times). The effects of BUDDEUMI are observed on the treatment of the cancer of the prostate gland. As "BUDDEUMI and BUDDEUMI's treatment" is expected to relieve pain, and for the healthy article of Senior-Friendly.

• 대한방사선치료학회지
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• 제20권1호
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• pp.25-29
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• 2008

목 적: Fiducial Gold Marker가 삽입된 전립선암 양성자 치료 시 DIPS를 이용하여 전립선의 위치변화를 관찰하고, 전립선의 움직임에 따른 보정 및 양성자치료에 관한 연구를 하고자 한다. 대상 및 방법: 2008년 4월 이후로 본원에서 양성자치료를 받은 10명의 전립선암환자를 대상으로 하였다. 전립선의 위치변화를 관찰하기위해 치료 전에 전립선에 3개의 Fiducial Gold Marker를 삽입하였고, 전립선의 움직임을 최소화하기 위해 치료 전에 소변을 보고, 매일 정량의 물을 섭취하며, Rectal balloon을 함께 시행하였다. 환자의 처음 치료자세는 CT 모의치료 때와 같고, DIPS (Digital Image Positioning System)를 이용하여 AP, Lat 촬영을 하여 얻은 영상과 치료계획에서 얻은 PA, Lat 영상을 비교하여, Fiducial Gold Marker 위치변화(X, Y, Z) 관찰하였고, 이에 따른 보정 후에 양성자치료를 시행하였다. 결 과: 치료계획에서 얻은 영상과 DIPS를 이용하여 얻은 영상의 각각의 Fiducial Gold Marker의 위치변화 차이는 10명 환자에 있어서 치료 중심을 기준으로 평균 X축: $\pm$0.116 cm, Y축: $\pm$0.19 cm, Z축: $\pm$0.176 cm이었다. 10명의 환자 중 X축으로 최고 RT: 0.24 cm, 최저 RT: 0.04 cm의 위치변화 차이가 나타났고, Y축으로 최고 Sup: 0.42 cm, 최저 Inf: 0.03 cm 위치변화 차이가 나타났고, Z축으로 최고 Ant: 0.35 cm, 최저 Post: 0.05 cm의 위치변화 차이가 관찰되었다. 결 론: 전립선의 움직임을 최소화 하기위해 치료 전에 전처치로 소변을 보고, 매일 정량의 물을 섭취하며, Rectal balloon을 시행하였으나, 모든 환자의 경우에서 전립선에 삽입된 3개의 Fiducial Gold Marker의 매일 움직임을 관찰할 수 있었다. 위 자료를 바탕으로 보다 정확한 치료 중심 설정이 요구되는 양성자치료에서 Gold Marker Matching System의 필요성을 확인할 수 있었으며, 본 연구에서 사용된 DIPS를 이용하여 전립선의 위치변화에 따른 치료 중심을 보정함으로써 보다 정밀한 양성자치료 효과를 향상시킬 수 있을 것으로 사료된다.

• Korean Journal of Radiology
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• 제22권8호
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• pp.1332-1340
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• 2021

Objective: To evaluate the feasibility of a new three-dimensional (3D) MR fingerprinting (MRF) technique for the prostate gland by conducting phantom and clinical studies. Materials and Methods: The new 3D MRF technique used in this study enables quick data acquisition and has a high resolution. For the phantom study, the MRF T1 and T2 values in an in-house phantom were compared with those of goldstandard mapping methods using linear regression analysis. For the clinical study, we evaluated 90 patients who underwent prostate imaging with MRF for suspected prostate cancer between September 2019 and February 2020. The mean T1 and T2 values were compared in the peripheral zone, transition zone, and focal lesions using paired t tests. The differences in the T1 and T2 values according to cancer aggressiveness were evaluated using one-way analysis of variance. Results: In the phantom study, the MRF T1 and T2 values showed a perfect correlation with the gold-standard T1 and T2 values (R > 0.99). In the clinical study, the T1 and T2 values in the peripheral zone were significantly higher than those in the transitional zone (p < 0.001, both). The T1 and T2 values in prostate cancer were significantly lower than those in the peripheral and transitional zones. The higher the grade of cancer, the lower the T2 values. Conclusion: The T1 and T2 values obtained from the 3D MRF showed a perfect correlation with the gold standard values in the phantom study. Differences in the T1 and T2 values among the different zones of the prostate gland were identified using 3D MRF in patients.

• 한국임상수의학회지
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• 제31권3호
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• pp.175-179
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• 2014

전립선의 크기를 측정하는 것은 전립선 이상을 임상학적으로 인지하고 치료에 대한 반응을 모니터링 하는데 유용하다. 전립선 질환에서 일반적으로 나타나는 전립선의 형태와 크기 변화는 방사선, 초음파 및 컴퓨터단층촬영 (CT)과 같은 영상학적 방법을 통해 평가한다. 본 연구에서는 전립선의 크기를 평가하는데 가장 많이 사용되는 초음파와 실질 장기의 평가에 높은 정확도를 보이는 CT를 이용하여, 중성화 하지 않은 정상 비글견에서 전립선 크기를 측정하고 비교하는데 목적이 있다. 또한 CT를 이용하여 전립선의 크기를 측정하여 체중과 관계없이 전립선의 크기를 평가할 수 있는 간단하고 실용적인 기준을 확인하고자 한다. 비뇨기계 및 내분비계에 이상이 없고 세포학적 검사로 정상 전립선으로 평가된 8 마리 정상 비글견에서 초음파와 CT 촬영을 실시하여 전립선의 크기를 비교 및 평가하였다. 초음파를 이용한 전립선의 부피를 측정하기 위해 서로 다른 2가지 단면에서 각 측정치를 구하고 타원체 공식 (US1, US2)에 대입하였다. CT의 경우 freehand tracing 방법을 이용해 전립선의 부피를 측정하였다. 초음파를 이용한 2가지 방법 모두 CT를 이용한 방법보다 낮은 측정치를 보였으며, 특히 US1 방법이 CT방법에 비해 통계적으로 유의성 있게 낮은 결과치를 보였다. CT를 통해 촬영된 이미지의 재구성을 통해 전립선의 길이, 높이, 너비를 측정하여 부피와의 상관관계를 평가하였다. 측정된 수치 중 길이와 너비가 부피와 가장 높은 상관관계를 나타냈다. 또한 촬영된 이미지에서 6번째 요추체의 길이를 측정하고 각 전립선 크기 (길이, 높이, 너비)와의 비율을 분석하였다. 실험에서 요추 6번과 전립선의 길이 및 높이는 약 1:1의 비율을 보였으며, 길이와 높이의 상한선은 1.3배, 너비의 상한선은 1.7배로 고려되었다. 이러한 비율에 대한 결과 중 길이와 높이에 대한 비율은 방사선 사진에서도 적용이 될 수 있을 것으로 생각되며, 전립선 크기를 체중과 상관없이 평가할 수 있는 간단하며 유용한 지표로 사용될 수 있을 것으로 생각된다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.44-44
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• 2001

Neuroendocrine (NE) cells are abundant in the prostate at birth and then disappear from the peripheral zone, only to reappear during puberty, after which their number slowly increases during adult life. NE cells are believed to play an important role in prostate growth and differentiation. The present study was undertaken to investigate the characteristics of ion channels existing in NE cells of rat prostate gland.(omitted)

• Journal of Gastric Cancer
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• 제14권2호
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• pp.135-137
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• 2014

Metastasis of gastric adenocarcinoma to the prostate gland is extremely rare. Herein, we report a case of gastric adenocarcinoma in a 56-year-old man with prostatic metastasis diagnosed through the analysis of biopsy specimens from representative lesions in the stomach and prostate gland. Immunohistochemistry of the prostatic tissue showed positive staining for cytokeratin 7 and negative staining for prostate-specific antigen (PSA), whereas the serum PSA level was normal, confirming the diagnosis of prostatic metastasis from carcinoma of the stomach.

• 대한방사선기술학회지:방사선기술과학
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• 제44권2호
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• pp.117-122
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• 2021

This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control group (NC Group), the group administered protaetia brevitarsis larvae extracts (PBE Group), irradiated group (IR Group), irradiated group after administration of protaetia brevitarsis larvae extracts (PBE+IR Group), the group administered protaetia brevitarsis larvae extracts after irradiaton (IR+PBE Group). In IR Group, 7 Gy/h of Co-60 gamma ray was irradiated to SD rats. In PBE+IR Group, protaetia brevitarsis larvae extacts wewe injected at 200 mg/kg/day for 14 days before irradiation, In IR+PBE Group, protaetia brevitarsis larvae extract was injeted after irradiation. On the 1, 7 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the changes in blood cell component, superoxide dismutase (SOD) activity, histopathological evaluation of the liver and prostate gland. As a result, the PBE+IR Group and IR+PBE Group showed a significantly recovery of white blood cell (p<0.01, p<0.01), platelet (p<0.01, p<0.01) than the IR Group. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. Also PBE+IR Group and IR+PBE Group showed less inflammatory reactions of cystoplasm in the prostate gland than the IR Group. In conclusion, the protaetia brevitarsis larvae have radioprotection effect against blood and prostate gland. It is expected to be useful for research of radiation protection agent.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9841-9846
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• 2014

Objectives: To compare the metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between grades of prostate cancer in a cross-sectional study. Materials and Methods: The study enrolled 95 cases of prostate cancer and 95 cases of benign prostatic hyperplasia (BPH). Prostate gland volume was measured using transrectal ultrasound. We compared insulin, testosterone, dihydrotestosterone, prostate specific antigen levels and lipid profile between prostate cancer of different grades and BPH. Further, prostate cancer patients were classified into low grade and high grade. Unpaired t-test for normally distributed variables and Man-Whitney U test for non-normal variables were used to assess differences. Results: We found that prostate cancer patients had significantly higher levels of insulin, testosterone, PSA, cholesterol, triglycerides, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to their BPH counterparts. Higher levels of these parameters also correlated with a higher grade of the disease. Conclusions: We conclude that higher levels of insulin, testosterone, PSA, and cholesterol correlate with a higher risk of prostate cancer, and also with a higher grade of the disease.