• Title/Summary/Keyword: progression level

Search Result 601, Processing Time 0.025 seconds

Correlation between Microvascular Density and Matrix Metalloproteinase 11 Expression in Prostate Cancer Tissues: a Preliminary Study in Thailand

  • Kanharat, Nongnuch;Tuamsuk, Panya
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.15
    • /
    • pp.6639-6643
    • /
    • 2015
  • Background: Prostate cancer is a major concern of public health. Microvascular density (MVD) is one of the prognostic markers for various solid cancers. Matrix metalloproteinase 11 (MMP11) plays an important role in angiogenesis and changes in its expression level are known to be associated with tumor progression and clinical outcome. Aim: To investigate the relationship between MVD and MMP11 expression in prostatic adenocarcinoma tissues. Materials and Methods: The expression levels of MMP11 and MVD were analyzed immunohistochemically for 50 specimens of prostatic adenocarcinoma. Results: MMP11 was mainly expressed in stromal cells but rarely seen in epithelial cells. Mean MVD was $36/mm^2$, and it was correlated significantly only with bone metastases. MVD was also significantly correlated with MMP11 expression (r=0.29, p=0.044). Conclusions: MMP11 may alter the stromal microenvironment of prostate cancer to stimulate tumor angiogenesis.

Anatomic Consideration of Spondylolysis and Spondylolisthesis type (척추 분리증과 척추 전방 전위증의 분류에 따른 해부학적 특성)

  • Kim gi-won
    • The Journal of Korean Physical Therapy
    • /
    • v.15 no.4
    • /
    • pp.24-33
    • /
    • 2003
  • Spondylolysis and spondylolisthesis are two conditions that directly involve changes in the vertebra. Spondylolysis is defined as a defect in the pars interarticularis, the region of the lamina between the superior and inferior articular facets. Progression of the defect can result in spondylolisthesis, which is defined as a subluxation or 'slippage' of two adjacent vertebrae. In the low back it occurs most commonly at the lumbosacral level; next in frequency is spondylolisthesis of the fourth lumbar vertebra on the fifth. To provide the reader with information about the aetiology and anatomical consideration of spondylolysis and spondylolisthesis type. Spondylolisthesis has recently been classified by Wiltse and others into five types based on the suspected aetiology; dysplastic, isthmic, degenerative, posttraumatic, pathologic and postsurgical. Of these five types, isthmic spondylolisthesi and degenerative spondylolisthesis, both of which are frequently associated with low back and lower limb pain.

  • PDF

Nontraumatic Cervical Disc Herniation Mimicking Guillain-Barre Syndrome (길랑-바레 증후군과 유사한 비외상성 경추 추간판 탈출)

  • Kang, Sa-Yoon;Choi, Jay Chol;Lee, Chang Sub
    • Annals of Clinical Neurophysiology
    • /
    • v.8 no.2
    • /
    • pp.193-195
    • /
    • 2006
  • Acute paraplegia attributable to disc herniation is known to occur most frequently at the thoracic level. A 50-year-old male presented with progressive limb weakness and hypoactive deep tendon reflexes. On the basis of clinical features and neurological findings, the diagnosis of Guillain-Barre syndrome was suspected. Spinal MRI showed cervical disc herniation. He underwent emergency surgery consisting of removal of herniated disc and anterior fusion. We emphasize that there is a possibility of acute progression of paralysis secondary to nontraumatic enlargement of cervical disc herniation.

  • PDF

Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells

  • Youm, Yun-Hee;Kim, Se-Yoon;Bahk, Young-Yil;Yoo, Tag-Keun
    • BMB Reports
    • /
    • v.41 no.10
    • /
    • pp.722-727
    • /
    • 2008
  • The present study compared the proteomic characteristics of a low passage number (L-33) and high passage number (H-81) LNCaP cell clone. Marked differences in protein expression were noted in the response of L-33 and H-81 cells to androgens. To investigate if regulation of these proteins was androgen-dependent, expression of the androgen receptor was silenced via small interfering RNA. Consistent with the proteomic data, abrogation of androgen receptor production in H-81 cells resulted in the reversed expression level into L-33 cells compared with non-treated H-81 LNCaP cells. The results clarify the progression into an androgen-independent phenotype.

Physical Therapeutic Procedures for Applying Joint Mobilization (관절 모빌라이제이숀 적용기법에 대한 물리치료적 소고)

  • Park, Ji-Whan
    • Journal of Korean Physical Therapy Science
    • /
    • v.1 no.1
    • /
    • pp.195-202
    • /
    • 1994
  • The following are suggested joint distraction and gliding techniques for use by entry level therapists and those attempting to gain a foundation in joint mobilization. A variety of adaptations can be made from these techniques. The distraction and glide techniques should be applied with respect to the dosage, frequency, progression, precautions, and procedures as described in this section. Basic concepts of joint mobilization were presented, including definitions of terminology and the two grading systems. Joint mobilization techniques are one part of a total treatment for decreased function. Therapy should also include appropriate range of motion, strengthening, and functional techniques.

  • PDF

Primary Hyperparathyroidism Presenting as Acute Pancreatitis (급성 췌장염으로 발현된 일차성 부갑상선 기능항진증 1예)

  • Kim Sung-Do;Chang Hang-Seok;Chung Woung-Yoon;Park Cheong-Soo
    • Korean Journal of Head & Neck Oncology
    • /
    • v.15 no.1
    • /
    • pp.76-79
    • /
    • 1999
  • The relationship between acute pancreatitis and hyperparathyroidism has been described extensively in the past. Despite the rarity, the clinical progression of pancreatitis associated with hyperparathyroidism has been known to be so rapid and severe that it may cause death. When, furthermore, the pancreatitis is caused by hyperparathyroidism, the recovery from disease can be hardly expected unless the hyperparathyroidism is corrected. We present a case of acute pancreatitis in a 68-year-old man that have been caused by primary hyperparathyroidism. The clues of hyperparathyrodism were hypercalcemia and elevated parathyroid hormone, but he showed subtle or negative symptoms of hypercalcemia. After the excision of parathyroid adenoma, serum calcium level returned to normal and the symptoms and function of pancreas were recovered.

  • PDF

Landscape Structure and Ecological Restoration of Mt. Hwangryung in Pusan, korea (부산시 황령산의 경관구조와 생태적 복원)

  • 이창석;조현제
    • The Korean Journal of Ecology
    • /
    • v.21 no.6
    • /
    • pp.791-797
    • /
    • 1998
  • An attempt to clarify the landscape structure of urban areas was carried out on Mt. Hwangryung located in the center of Pusan, southern Korea. By means of aerial photographs and field survey, a vegetation map including land-use pattern was made. Landscape structure was described by analyzing the vegetation map. Landscape element types were classified into secondary forest, introduced plantation, and other elements including urbanized area. almus firma and Pinus thunbergii communities, introduced plantation elements, formed matrix and some secondary forest elements and the other artificial plantations of small scale tended to distribute as small patches in such matrix. The number of patches per unit area in secondary forest elements was more than that in introduced plantation element. The result on patech size was vice versa. As the results of landscape ecological analyses, it was estimated that differentiation of patches recognized in community level would be related to artificial interference and those in sub-communities levels to natural process such as progression of succession. On the other hand, restoration plans in viewpoints of restoration and landscape ecology were suggested to improve ecological quality of Mt. hwangryung.

  • PDF

High level of estradiol in a Holstein-Friesian cow with sacroiliac luxation after calving

  • Mamuad, Lovelia L.;Seo, Bosung;Kang, Seogjin;Cho, Yong-Il
    • Korean Journal of Veterinary Research
    • /
    • v.60 no.4
    • /
    • pp.237-240
    • /
    • 2020
  • This is the report of sacroiliac luxation in a Holstein-Friesian cow, describing the progression of the sacroiliac luxation from the onset of its development with changes in estradiol (E2) and serum chemistry. The high estrogen concentration was assumed to be a predisposing factor of the disease that relaxed the pelvic muscles and a secondary slippery finally caused the sacroiliac luxation. The E2 was present at levels four times higher in the cow with sacroiliac luxation (167 pg/mL) than in normal cows. Above normal levels of creatinine kinase, aspartate aminotransferase, and lactate dehydrogenase were also observed in cow with sacroiliac luxation.

A Case of Primary Squamous Cell Carcinoma of The Thyroid Gland (갑상선에서 발생한 원발성 편평상피세포암 1예)

  • Kang, Sihyung;Park, Gi Cheol
    • Korean Journal of Head & Neck Oncology
    • /
    • v.37 no.2
    • /
    • pp.91-95
    • /
    • 2021
  • Primary squamous cell carcinoma of thyroid is a very rare malignant tumor with poor prognosis. It is usually diagnosed as an advanced disease infiltrating adjacent organs, and characterized by aggressive clinical course with an average postoperative survival time of less than 1 year. Recently, we had a 79- year-old woman with a painful neck mass who was diagnosed as primary squamous cell carcinoma of thyroid gland. She underwent total thyroidectomy and selective neck dissection(level III, VI) with no further postoperative managements such as radiation therapy or chemotherapy; she died of poor general condition and pneumonia resulting from rapid progression of the lesion on the 38th day after surgery. We report this case with a review of relevant literatures.

Non-invasive quantification methods for glucose monitoring (포도당 모니터링을 위한 비침습적 정량화 방법)

  • Young Ho, Kim;Yeong-Seo, Park;Byeong Uk, Park;inkwon, Yoon;Hee-Jae, Jeon
    • Journal of Industrial Technology
    • /
    • v.42 no.1
    • /
    • pp.13-18
    • /
    • 2022
  • Diabetes mellitus is an abnormally high glucose level in the bloodstream. Several pharmaceuticals are administered to diabetic patients to control their glucose levels. Early diagnosis and proper glycemic management are essential in this situation to prevent further progression and complications. Biosensor-based detection has progressed and shown potential in portable and inexpensive daily assessment of glucose levels because of its simplicity, low cost, and convenient operation without sophisticated instrumentation. This review discusses various systemic aspects of non-invasive glucose monitoring, including materials for monitoring and managing diabetes.