• BioChip Journal
• /
• 제12권4호
• /
• pp.309-316
• /
• 2018

Microneedles (MNs) are being developed to overcome the limitations of the conventional hypodermic needle, e.g. the injection pain. In this study, we conducted an analysis of clinical pain and bleeding at the site of MN insertion and evaluated the insulin pharmacodynamic profile compared with parameters obtained with a conventional pen needle. MN insertion into the skin of 25 healthy adults or 15 patients with type 2 diabetes (T2D) revealed significantly less pain relative to a conventional hypodermic pen needle, thus reducing pain scores from $2.1{\pm}1.9$ to $21.3{\pm}1.4$ ($mean{\pm}standard$ deviation [SD]). Besides, no bleeding was observed when the MN was used. In the insulin pharmacodynamic assay, no significant differences were observed in the blood glucose-lowering effect between the pen needle and MN. Based on these results, the MN is expected to be a good substitute for conventional hypodermic pen needles and improve the quality of life of patients by significantly reducing the pain associated with insulin treatment.

• 한국수소및신에너지학회논문집
• /
• 제28권3호
• /
• pp.300-307
• /
• 2017

This study is to investigate particle size and velocity profile of gasoline port injector using Phase Doppler Particle Analyzer (PDPA). In this experiment, a GV 250 Delphi port injector used for motorcycles was used for liquid injection. The injector consists of four holes and has a static flow rate of 2.13 g/s. The fuel used in the injection was N-heptane, which is similar to gasoline, as an alternative fuel. The test fuel was injected at an atmospheric temperature of $20^{\circ}C$ and an open atmosphere of 1 atm. The injection time was 10 ms and the injection pressure was 3.5 bar in PDPA experiment. The experimental target position was fiexd at 30, 50 and 75 mm from the nozzle tip and data were collected for a total of 10,000 samples. The experimental results show that the length diameter (D10), the Sauter mean diameter ($D_{32}$), and the mean droplet velocity (MDV) are $45-54{\mu}m$, $99-115{\mu}m$ and 15-21 m/s, respectively.

• Biomolecules & Therapeutics
• /
• 제22권3호
• /
• pp.260-266
• /
• 2014

This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the pharmacokinetic profile and therapeutic efficacy of PX after intramuscular (IM) injection. In the pharmacokinetic study in rats, systemic exposure and pharmacokinetic parameters of PX after a single IA dose were compared with systemic exposure and pharmacokinetic parameters of PX after administration of the same dose IM (0.6 mg/kg). The anti-inflammatory and analgesic effects of IA PX were evaluated simultaneously in a monoiodoacetate-induced osteoarthritis rat model. The plasma PX concentration rapidly rose following IA injection, and it was comparable to the plasma PX concentration following IM injection, suggesting the rapid efflux of the drug molecule from the joint cavity. However, in the efficacy study, the IA PX administration significantly reduced the knee swelling by reducing the level of prostaglandin $E_2$ in the joint, compared to that following administration of IA vehicle and after administration of the IM PX dose. In addition, we found that the anti-inflammatory and anti-nociceptive efficacies of IA PX were synergistically increased upon co-treatment with hyaluronic acid (HA), a potent agent for the treatment of osteoarthritis, at the weight ratio of 1:1 or 1:2, and these effects were more pronounced than those following administration of HA or PX alone. In conclusion, this study demonstrated the efficacy of the IA use of PX alone and/or in combination with HA in osteoarthritis.

• Elastomers and Composites
• /
• 제52권4호
• /
• pp.309-316
• /
• 2017

In injection molding, the quality of an injection molded product varies greatly depending on the molding conditions. Many researche studies have been conducted on the quality analysis of molded parts according to the molding conditions such as injection pressure, injection temperature, and packing pressure. However, there have not been many studies on the V/P switchover timing. It is known that when a large pressure is applied to a cavity in the packing phase, the cavity pressure is most affected by the packing pressure. In addition, depending on the position (timing) of the packing pressure, it can have a direct influence on quality based on the shrinkage and dimensions of the molded parts. In this study, the change in pressure profile in the cavity according to the V/P switchover position is confirmed. A CAE analysis program (Moldflow) was used to simulate and analyze two models using the PC and PBT materials. In order to compare these results with the actual injection molding results, injection molding was performed for each V/P switchover position, and the correlation between simulation and experiment, especially for the shrinkage of molded parts, was evaluated.

• 대한기계학회논문집A
• /
• 제26권11호
• /
• pp.2342-2354
• /
• 2002

The present study has numerically predicted both the flow -induced and thermally-induced residual stresses and birefringence in injection o. injection/compression molded center -gated disks. Analysis system for entire molding process was developed based on an ap propriate physical modeling including a nonlinear viscoelastic fluid model, stress-optical law, a linear viscoelastic solid model, free volume theory for density relaxation phenomena and a photoviscoelasticity and so on. Part I presents physical modeling a nd typical numerical analysis results of residual stresses and birefringence in the injection molded center-gated disk. Thermal residual stress was found to be extensional near the center, compressive near the surface and tend to become toward tensional at the surface. A double-hump profile was obtained across the thickness in birefringence distribution: nonzero birefringence is found to be thermally induced, the outer peak is due to the shear flow and subsequent stress relaxation during the filling stage a nd the inner peak is due to the additional shear flow and stress relaxation during the packing stage. Predicted birefringence including both the flow -induced and thermally-induced one becomes quite similar to the experimental one.

• 설비공학논문집
• /
• 제19권12호
• /
• pp.811-820
• /
• 2007

A Study on the optimal design of the AIG(Ammonia Injection Grid) to improve the performance of DeNOx facilities in the HRSG(Heat Recovery Steam Generator) was performed using the CFD analysis. On the basis of the flow analysis results in the case that the AIG in the HRSG was not installed, the numerical analyses according to the positions of AIG, injection angles of nozzle and the control of ammonia injection quantity were carried out. The standard deviation according to factors was calculated for quantitative comparison. As the results, the AIG in the HRSG should be installed in the position that the uniform flow field shows through the exact flow analysis in the previous of the AIG design and installation. In the case the AIG has already been installed and non uniform flow distribution shows, it is recommended that flow correction device or KoNOx catalyst should be used. Otherwise, the control of ammonia injection angle or the ammonia injection quantity using the velocity profile analysis is demanded to accomplish the optimal performance.

• 한국정밀공학회지
• /
• 제22권6호
• /
• pp.55-60
• /
• 2005

This paper has been focused in developing of plastic lens with ultra-precision and low birefringence ability using by injection molding simulation tools. The simulation tools, $3D-Timon^{TM}\;and\;Asu-Mold^{TM}$ were applied to visualize indirectly the flow pattern of melted polymer enter the mould and the simulation results are verified as compared with the experimental results. Birefringence and polarized light generated in injection molding process was also calculated for each injection conditions and compared with .the pictures of experimented optical lens go through the polarized light plates device. A spherical radius of plastic optical lens transcribed from profile of mould core surface was measured to estimate the geometrical accuracy fer the each injection conditions. It is confirmed that the simulation results about flow pattern and polarized light area coincided in experimental results. It is known that increasing in thickness shrinkage at center of lens, the spherical radius is larger from comparing the graph measured spherical radius and the thickness shrinkage at center of lens

• 한국산학기술학회논문지
• /
• 제18권4호
• /
• pp.711-717
• /
• 2017

디젤엔진은 저온 상태의 냉시동 조건에서 디젤 미립화 특성 악화로 인한 시동성 및 유해배출가스 생성의 문제를 안고 있다. 본 연구에서는 냉시동 시의 연소개선을 위한 방안으로 다단분사 전략 적용 시의 연소 특성을 파악하고자 하였다. 본 연구에서는 냉시동성 개선을 위해 방안으로 다단분사 적용 시의 연소 특성을 파악하고자 하였다. 정적 연소 챔버 내에 설치한 압력센서를 이용하여 취득한 연소압 및 열방출율, 직접 화염 가시화기법을 적용한 화염강도를 이용하여 연소현상을 분석하고자 하였다. 시험 결과 단일 분사 대비하여 다단 분사 적용 시, 주분사에 의한 최대 연소압력 및 열방출 상승률이 증가하며, 주분사에 의한 화염 감지 기간이 단축됨을 확인하였다. 파일럿 분사량 변경을 통해 분사량 증대 시 파일럿 연소에 의한 열방출 향상에 기인한 주분사에 의한 연소가 개선됨을 확인하였다. 또한 분사압력 증대 시 연료 미립화 개선으로 인한 연소개선을 화염 강도 증대를 통해 확인할 수 있었다. 다만 분사량 및 분사압 증대는 벽면적심현상으로 인한 HC, CO의 배출 수준 악화를 초래할 수 있으므로, 실제 엔진 개발 시 이에 대한 정밀한 선정이 필요할 것으로 판단된다.

• 한국분무공학회지
• /
• 제25권1호
• /
• pp.8-14
• /
• 2020

Recently, 1-D model-based engine development using virtual engine system is getting more attention than experimental-based engine development due to the advantages in time and cost. Injection rate profile is the one of the main parameters that determine the start and end of combustion. Therefore, it is essential to set up a sophisticated model to accurately predict the injection rate as starting point of virtual engine system. In this research, procedure of 1-D model setup based on AMESim is introduced to predict the dynamic behavior and injection rate of diesel injector. As a first step, detailed 3D cross-sectional drawing of the injector was achieved, which can be done with help of precision measurement system. Then an approximate AMESim model was provided based on the 3D drawing, which is composed of three part such as solenoid part, control chamber part and needle and nozzle orifice part. However, validation results in terms of total injection quantity showed some errors over the acceptable level. Therefore, experimental work including needle movement visualization, solenoid part analysis and flow characteristics of injector part was performed together to provide more accuracy of 1-D model. Finally, 1-D model with the accuracy of less than 10% of error compared with experimental result in terms of injection quantity and injection rate shape under normal temperature and single injection condition was established. Further work considering fuel temperature and multiple injection will be performed.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제7권1호
• /
• pp.15-24
• /
• 2002

현재 원위치 bioremediation을 목적으로 EK (electrokinetlc)기법에 의한 영양분과 TEAs (Terminal electron accepters) 공급이 연구되고 있으나, 아직까지 다양한 토질에서의 EK 주입특성 연구는 미비하다. 따라서 본 연구에서는 카올린과 모래시료에 대하여 영양분인 암모늄이온과 TEAs로서 황산염이온의 EK주입실험을 수행하였다. EK주입에 의한 암모늄이온의 경우 카올린에서는 주입부(양극)에서 높은 농도분포를 보이며, 특별히 모래의 경우는 음극에서 더욱 높은 농도분포를 보인다. 황산염이온의 주입분포는 두 시료에서 모두 균일한 주입분포를 보이지만 두 시료에서의 농도차는 크게 달랐다. 따라서 원위치 bioremediation에 EK 주입기법을 이용할 경우 토질에 따른 주입특성의 평가가 가장 중요하게 고려되어야 한다.