• Journal of Life Science
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• v.17 no.12
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• pp.1627-1633
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• 2007

c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP1), also known as Islet-brain 1 (IB1), is a scaffold protein that is highly expressed in neurons and pancreatic ${\beta}-cells$. In this study subcellular localization of JIP was investigated in cultured rat hippocampal neurons using an antibody that recognize all variants of JIP1, JIP-2 and JIP-3. The overall expression profile of JIP is punctate throughout soma and dendrites. Statistic analysis showed that $54.8{\pm}4.0%\;and\;94.1{\pm}4.5%$ of total JIP immunopuncta overlapped with those of excitatory postsynaptic markers SD-95 and ${\alpha}Camik$, respectively. In contrast, only $8.6{\pm}0.5%\;and\;7.3{\pm}0.5%$ of JIP clusters overlapped with those of inhibitory postsynaptic markers glycine receptor (GlyR) and gephyrin, respectively. JIP clusters overlapped or juxtaposed with SV2 but not GAD, markers for general and inhibitory nerve terminals, respectively. A substantial fraction $(29.3{\pm}1.0%)$ of flotillin immunopuncta, a marker for lipid rafts, clusters overlapped with those of JIP. In addition, JIP was highly expressed in some select ends of dendrites but minimal in axons. These data suggest important roles of JIP in excitatory postsynaptic sites, lipid rafts and dendritic ends.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.11
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• pp.5094-5101
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• 2011

In order to investigate recurrence rate and risk factors for recurrence of gastric cancer after curative resection, we examined blood biochemical profile and clinicopathological features of 386 gastric cancer patients by using medical charts and data of hospital cancer registry from September 2010 to May 2011. Chi-square test and logistic regression analyses were performed to identify risk factors. The recurrence rate of all gastric cancer patients was 2.6%; The recurrence rate by gender was 3.45% in male and 0.89% in female, and that was 4 times higher in male than in female. On univariate logistic regression analyses, lymph node metastases(OR=8.793), Helicobactor pylori infecton(OR=6.495), abnormal total cholesterol(OR=14.333) were related to recurrence. On multivariate logistic regression analyses, lymph node metastases and H. pylori infection were very important risk factors for recurrence of gastric cancer. In conclusion, lymph node metastases, H. pylori infection, and total cholesterol control were very important to prevent recurrence of gastric cancer, and it needs to monitor blood biochemical (C-reactive protein, carcinoembryonic antigen, etc) for the early detection of gastric cancer recurrence.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3452-3459
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• 2012

The purpose of this study was to analyze the relationships on participation on health education program toward skin care and the improvement of healthy life habit. The subject of the study was selected by multi-stage stratified cluster random sampling among the skin care education center to learn health education program toward skin care among women in the Seoul and Kyunggi area. The data were collected through a questionnaire adapted from Payne and Hahn's(1986) 'Understanding Your Health-A personal profile; Evaluating Your Health'. The pilot test was executed after the questionnaire was translated into Korean. The statistics employed the study were validity and reliability test, $x^2$ verification, frequency, ANOVA, multiple classification analysis, ANCOVA and Multiple Regression Analysis. The results that were derived from these processes were as follows: First, before and after on health education program toward skin care, the student's healthy life habit is partially changed. Second, the relationship the period of education program and the characteristic healthy life habit, long-term skin care education is positively affected sleeping habit, anti-stress treatment, exercise and nutrition. Third, the relationship on the frequency of education program and the characteristic healthy life habit, more frequently participation on skin care education is positively affected on healthy life habit and exercise.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2971-2980
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• 2014

To find the risk of cardiovascular disease for breast cancer patients received postoperative adjuvant anticancer therapy, this study was investigated the change of serum lipid profile (total cholesterol and trigyiceride) and the 10 year risk score of ischemic heart disease. Medical data of 432 breast cancer patients diagnosed at the breast cancer center in an university hospital from January, 2003 to December, 2006 were collected and analysed. The results showed that the levels of total cholesterol and triglyceride were increased at the points of 2 and 5 years after operation. The margin of increase of total cholesterol was higher in the patients without endocrine therapy compared to them with endocrine therapy, however there were no changes in the level of triglyceride regardless of endocrine therapy. There were also no significant changes in total cholesterol and triglyceride levels between chemotherapy, radiotherapy and endocrine therapy. 10 year-risk score of ischemic heart disease was increased by 0.44%p in the final observation compared to that of a baseline.

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.2
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• pp.127-131
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• 1993

To evaluate an effect of dietary protein on lipoprotein profile serum of carbon tetrachloride-treated rats, carbon tetrachloride (50% in olive oil) was twice given at 0.1ml/100g body weight at intervals of 24hours to the male rats and then the degree of liver damage in carbon tetrachloride-treated animals fed a low protein diet was compared with that fed a high protein diet. The increasing rate of liver weight/body weight and the serum levels of alanine aminotransferase in carbon tetrachloride-treated rats to the control group were higher in rats fed high protein diet than those fed low protein diet. In the serum levels of lipid (total lipid, total cholesterol and triglyceride) remarkable differences were not found between low protein diet group and high protein diet group. But these serum lipids in carbon tetrachloride-treated rats were decreased and the decreasing rate of serum lipids to control group were higher in carbon tetrachloride-treated rats fed high protein diet than those fed low protein diet. Under the animal model as identified by the present data herein, serum pre $\beta$-lipoprotein and $\alpha$-lipoprotein fractions were decreased in carbon tetrachloride-treated rats, but the serum levels of $\beta$-lipoprotein were rather increased in the both group by the injection of carbon tetrachloride. Especially, the decreasing rate of $\alpha$-lipoprotein fraction was higher in $CCl_4$-treated rats fed a high protein diet than those fed a low protein diet to its control group and the increasing rate of serum $\beta$-lipoprotein fraction was also higher in $CCl_4$-treated rats fed high protein diet than those fed low protein diet.

• Journal of agriculture & life science
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• v.43 no.2
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• pp.1-8
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• 2009

The limestone area covers the narrow range of the Korean Peninsula, and it consists of a peculiar ecosystem and topography. Therefore, this study on limestone area was carried out classification of vegetation type, physicochemical properties of forest soils and correlation between environment factors and vegetation types in order to furnish fundamental data for the forest management of limestone area. Forest vegetation was classified into two community groups such as Quercus variabilis community group and Quercus mongolica community group, and it was classified into eight vegetation units. Soil texture of survey sites showed largely silt loam and soil pH indicated the value of mean 7.55 in the A layer of soil profile. Content of exchangeable cation such as calcium ion ($Ca^{2+}$) and magnesium ion ($Mg^{2+}$) showed $26.04cmol_{c}/kg$ and $2.93cmol_{c}/kg$, respectively, which was about ten times higher than average of other regions of Korea. According to corelation between environmental factors and vegetation units, Q. variabilis community group was positively correlated to soil pH, slope degree and the rate of bare rock, and content of calcium ion ($Ca^{2+}$), and then Q. mongolica community group was positively correlated to altitude, respectively.

• Journal of vocational education research
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• v.33 no.3
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• pp.145-167
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• 2014

The purpose of this research is to prepare the measures for evaluating the job of horse-riding instructor and improvement related to it and for distributing horse-riding industry effectively. Forsuch, we tried to analyze job of horse-riding instructor. Inparticular, we have developed DACUM chart of horse-riding instructor through DACUM method and experts related to it. As result, we found out eight duties and hundreds of job and arranged seven duty areas in total and eighty-two executed works. In addition, as experts said, the horse-riding instructor is the one who 'instructs people learning horse-riding in horse-riding facility and manages horses, horse-riding equipment and man-power.' Such results provide the procedure of horse-riding instructor cultivation which has been presently underway with many viewpoints. Especially, there are three educational processes and subject materials related to horse-riding instructor's examination(Hipologia, Horse-treatment technique, Horse Health management). However, as result of analysis on duty, we found out that racecourse management and horse-riding education theory has been needed to be added and complemented as well. In addition, the work and duty of analysis can be used to be made use up of as work profile and specification and such data can be also made use of as standard of training and submission. Through this study there should be a necessary work to distinguish between re-drafting and role of duty in its own right related to certification of horse-riding instructor in future and it would be necessary to develop study that is able to connect them all to certificate. What is more, there should be work and measure required for rethinking of utility of certification.

• Environmental and Resource Economics Review
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• v.28 no.2
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• pp.307-326
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• 2019

The electric vehicle is a representative measure to reduce greenhouse gas and local air pollutants in the transportation sector. Most countries provide purchase subsidies and tax reductions to promote electric vehicle sales. The electric vehicles have been considered as zero-emission vehicles(ZEV) in light of the fact that there has been no pollutant emission during driving. However, recent studies have pointed out that the pollutant emitted from the process of generating electricity used for charging the electric vehicles need to be treated as emissions of the electric vehicles. Furthermore, the environmental benefits of electric vehicle replacing the internal combustion vehicle vary with the power mix. In line with the recent studies, this study analyzes the impact of electric vehicles based on the current power mix and future energy transition scenarios in Korea. To estimate the precise air pollutants emission profile, this study uses hourly electricity generation and TMS emission data for each power plant from 2015 to 2016. The estimation results show that the electric vehicles under the current power mix generate the environmental benefits of only -0.41~10.83 won/km. Also, we find that the environmental benefit of electric vehicle will significantly increase only when the ratio of the coal-fired power plant is reduced to a considerable extent.

• Parasites, Hosts and Diseases
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• v.57 no.4
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• pp.341-357
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• 2019

Acanthamoeba, one of free-living amoebae (FLA), remains a high risk of direct contact with this protozoan parasite which is ubiquitous in nature and man-made environment. This pathogenic FLA can cause sight-threatening amoebic keratitis (AK) and fatal granulomatous amoebic encephalitis (GAE) though these cases may not commonly be reported in our clinical settings. Acanthamoeba has been detected from different environmental sources namely; soil, water, hotspring, swimming pool, air-conditioner, or contact lens storage cases. The identification of Acanthamoeba is based on morphological appearance and molecular techniques using PCR and DNA sequencing for clinico-epidemiological purposes. Recent treatments have long been ineffective against Acanthamoeba cyst, novel anti-Acanthamoeba agents have therefore been extensively investigated. There are efforts to utilize synthetic chemicals, lead compounds from medicinal plant extracts, and animal products to combat Acanthamoeba infection. Applied nanotechnology, an advanced technology, has shown to enhance the anti-Acanthamoeba activity in the encapsulated nanoparticles leading to new therapeutic options. This review attempts to provide an overview of the available data and studies on the occurrence of pathogenic Acanthamoeba among the Association of Southeast Asian Nations (ASEAN) members with the aim of identifying some potential contributing factors such as distribution, demographic profile of the patients, possible source of the parasite, mode of transmission and treatment. Further, this review attempts to provide future direction for prevention and control of the Acanthamoeba infection.

• 한국노년학
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• v.37 no.3
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• pp.669-686
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• 2017

The purpose of this study is to investigate types of neighborhood environments and to verify whether the types of neighborhood environments are directly related to life satisfaction of older adults. To achieve this goal, I used'2014 National Survey on Older Koreans' data which surveyed the older adults aged 65 and over living in the community and a total of 10,281 respondents were analyzed. To determine the types of neighborhood environment, the time taken by walking from community organizations or places such as grocery stores, medical centers, administrative agencies, welfare centers, public transportation was used as an neighborhood environment indicators. As a results, there were six types of neighborhood environment: a leisure-welfare walk-limited type(20.3%), a leisure-welfare long-distance type(15.5%), a balanced proximity type(7.8%), a store-traffic type(35.8%), a traffic proximity type(10.1%), and a marginalized area type(11.3%). Compared to the balanced proximity type, older adults living in a store-traffic type and a marginalized area type were more likely to have negative life satisfaction. older adults who have higher life satisfaction were more likely to be female, more educated, get higher household income, and have a spouses or partner. Moreover, the better the health conditions, the higher the frequency of contact with children, siblings, friends and neighbors, the higher the satisfaction of life. Finding from the study highlight the importance of neighborhood environment in late life and provide implications for building age-friendly community.