• Title/Summary/Keyword: product of chains

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Supplier Selection and Assignment of Order Quantities to suppliers for the Efficient Purchasing Management in Supply Chain Management (공급사슬경영에서의 효율적인 구매 관리를 위한 공급자 선택 및 주문량 할당에 관한 연구)

  • 정주기;이영해
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2000.10a
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    • pp.99-102
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    • 2000
  • In the supply chain network design, how to select the best location, capacity configuration of the suppliers and to assign manufacturers orders are a challenging issue. Especially when multi-tiers'suppliers are existed, the performance of supply chain is influenced by 2$\^$nd/ and 3$\^$rd/ suppliers. Supplier selection is multi-criteria problem which includes both qualitative and quantitative factors in supply chains. In order to select the best supplier it is necessary to make a trade off between these two factors such as cost, product quality, capacity, production lead time, deliver lead time and transportation lead tine of supplier constraints existed in multi-tiers supplier purchasing chain. In these circumstances, purchasing agents should decide two problems: which is the best supplier in each tier and how much should be purchased from each selected supplier. This research is intended to develop an integration of an analytical hierarchy process (AHP) and mathematical modeling proposed to consider two factors which may be conflicted in choosing the best supplier in each tier and placing the optimum order quantities to the supplier among multi-tiers suppliers.

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Antecedents of Manufacturer's Private Label Program Engagement : A Focus on Strategic Market Management Perspective (제조업체 Private Labels 도입의 선행요인 : 전략적 시장관리 관점을 중심으로)

  • Lim, Chae-Un;Yi, Ho-Taek
    • Journal of Distribution Research
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    • v.17 no.1
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    • pp.65-86
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    • 2012
  • The $20^{th}$ century was the era of manufacturer brands which built higher brand equity for consumers. Consumers moved from generic products of inconsistent quality produced by local factories in the $19^{th}$ century to branded products from global manufacturers and manufacturer brands reached consumers through distributors and retailers. Retailers were relatively small compared to their largest suppliers. However, sometime in the 1970s, things began to slowly change as retailers started to develop their own national chains and began international expansion, and consolidation of the retail industry from mom-and-pop stores to global players was well under way (Kumar and Steenkamp 2007, p.2) In South Korea, since the middle of the 1990s, the bulking up of retailers that started then has changed the balance of power between manufacturers and retailers. Retailer private labels, generally referred to as own labels, store brands, distributors own private-label, home brand or own label brand have also been performing strongly in every single local market (Bushman 1993; De Wulf et al. 2005). Private labels now account for one out of every five items sold every day in U.S. supermarkets, drug chains, and mass merchandisers (Kumar and Steenkamp 2007), and the market share in Western Europe is even larger (Euromonitor 2007). In the UK, grocery market share of private labels grew from 39% of sales in 2008 to 41% in 2010 (Marian 2010). Planet Retail (2007, p.1) recently concluded that "[PLs] are set for accelerated growth, with the majority of the world's leading grocers increasing their own label penetration." Private labels have gained wide attention both in the academic literature and popular business press and there is a glowing academic research to the perspective of manufacturers and retailers. Empirical research on private labels has mainly studies the factors explaining private labels market shares across product categories and/or retail chains (Dahr and Hoch 1997; Hoch and Banerji, 1993), factors influencing the private labels proneness of consumers (Baltas and Doyle 1998; Burton et al. 1998; Richardson et al. 1996) and factors how to react brand manufacturers towards PLs (Dunne and Narasimhan 1999; Hoch 1996; Quelch and Harding 1996; Verhoef et al. 2000). Nevertheless, empirical research on factors influencing the production in terms of a manufacturer-retailer is rather anecdotal than theory-based. The objective of this paper is to bridge the gap in these two types of research and explore the factors which influence on manufacturer's private label production based on two competing theories: S-C-P (Structure - Conduct - Performance) paradigm and resource-based theory. In order to do so, the authors used in-depth interview with marketing managers, reviewed retail press and research and presents the conceptual framework that integrates the major determinants of private labels production. From a manufacturer's perspective, supplying private labels often starts on a strategic basis. When a manufacturer engages in private labels, the manufacturer does not have to spend on advertising, retailer promotions or maintain a dedicated sales force. Moreover, if a manufacturer has weak marketing capabilities, the manufacturer can make use of retailer's marketing capability to produce private labels and lessen its marketing cost and increases its profit margin. Figure 1. is the theoretical framework based on a strategic market management perspective, integrated concept of both S-C-P paradigm and resource-based theory. The model includes one mediate variable, marketing capabilities, and the other moderate variable, competitive intensity. Manufacturer's national brand reputation, firm's marketing investment, and product portfolio, which are hypothesized to positively affected manufacturer's marketing capabilities. Then, marketing capabilities has negatively effected on private label production. Moderating effects of competitive intensity are hypothesized on the relationship between marketing capabilities and private label production. To verify the proposed research model and hypotheses, data were collected from 192 manufacturers (212 responses) who are producing private labels in South Korea. Cronbach's alpha test, explanatory / comfirmatory factor analysis, and correlation analysis were employed to validate hypotheses. The following results were drawing using structural equation modeling and all hypotheses are supported. Findings indicate that manufacturer's private label production is strongly related to its marketing capabilities. Consumer marketing capabilities, in turn, is directly connected with the 3 strategic factors (e.g., marketing investment, manufacturer's national brand reputation, and product portfolio). It is moderated by competitive intensity between marketing capabilities and private label production. In conclusion, this research may be the first study to investigate the reasons manufacturers engage in private labels based on two competing theoretic views, S-C-P paradigm and resource-based theory. The private label phenomenon has received growing attention by marketing scholars. In many industries, private labels represent formidable competition to manufacturer brands and manufacturers have a dilemma with selling to as well as competing with their retailers. The current study suggests key factors when manufacturers consider engaging in private label production.

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Semantic Representation and Translation of Electronic Product Code(EPC) data in EPC Network (EPC 네트워크의 전자물품코드(EPC) 데이터 의미표현과 해석)

  • Park, Dae-Won;Kwon, Hyuk-Chul
    • Journal of KIISE:Software and Applications
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    • v.36 no.1
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    • pp.70-81
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    • 2009
  • Ontology is an explicit specification of concepts and relationships between concepts in an interest domain. As considered as one of typical knowledge representation methods, ontology is applied to various studies such as information extraction, information integration, information sharing, or knowledge management. In IT based industries, ontology is applied to research on information integration and sharing in order to enhance interoperability between enterprises. In supply chains or logistics, several enterprises participate as business partners to plan movements of goods, and control goods and logistics flows. A number of researches on information integration and sharing for the effective and efficient management of logistics or supply chains have been addressed. In this paper, we address an ontology as a knowledge-base for semantic-based integration of logistics information distributed in the logistics flow. Especially, we focus on developing an ontology that enables to represent and translate semantic meaning of EPC data in the EPC Network applied logistics. We present a scenario for tracing products in logistics in order to show the value of our ontology.

Functional Polythiophene Bearing Hydroxyethyl Groups and Their Derivatives

  • Kim Hyun-Chul;Kim Jong-Seong;Baek Sung-Sik;Ree Moon-Hor
    • Macromolecular Research
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    • v.14 no.2
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    • pp.173-178
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    • 2006
  • Poly(3-(2-hydroxyethyl)thiophene) (P3HET) was synthesized using oxidative coupling polymerization that involved the protecting and deprotecting of hydroxyl groups but not the chlorine substitution or oxidative decomposition of the hydroxyl groups. The resulting P3HET exhibited good solubility in aprotic solvents, in contrast to the insoluble polymer product synthesized directly from the monomer, 3-(2-hydroxyethyl)thiophene (3HET). P3HET had low conductivity due to the strong hydrogen bonding of its hydroxyl groups. The ester-functionalized poly(3-(2-acetoxyethyl)thiophene) and poly(3-(4-pentylbenzoateethyl)thiophene) were also prepared with reasonably high molecular weights in order to examine how this functionalization modified the physical and chemical properties of P3HET. These polymers exhibited better solubility in common solvents and higher conductivity than P3HET. All these polymers exhibited bathochromic shifts of their film state absorption maxima with respect to those found in the UV-visible spectra of their solution phases. The extent of the bathochromic shift was found to vary with the lengths of the side chains of the ester-functionalized polymers.

Characterization of Acid- and Pepsin-soluble Collagens from Rockfish Sebastes schlegeli Skin

  • Kim, Hyung-Jun;Jee, Seong-Joon;Yoon, Min-Suck;Youn, Mu-Ho;Kang, Kyung-Tae;Lee, Dong-Ho;Heu, Min-Soo;Kim, Jin-Soo
    • Fisheries and Aquatic Sciences
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    • v.12 no.1
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    • pp.6-15
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    • 2009
  • Biochemical and functional properties of acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) from rockfish skin were characterized. Yield of PSC (90.0%) was higher than that of ASC (63.2%). Both ASC and the PSC consisted of ${\alpha}1$ and ${\alpha}2$ chains, and $\alpha$-cross-linked components. According to the results of hydroxylation of proline and lysine, and FT-IR, no difference between the helical structure of ASC and PSC was identified. Thermal denaturation temperature (TDT) of ASC from rockfish skin was $22.8^{\circ}C$, the same as exhibited in PSC. Both ASC and PSC were higher in water absorption capacity (WAC) and oil absorption capacity (OAC) than other vegetable proteins. According to the results of emulsifying activity (EA) and cooking stability (CS), both ASC and PSC from rockfish skin were inferior compared to the commercial emulsifier (Tween-80). The results of FT-IR suggested that the structure of PSC was slightly different when compared to that of ASC. No differences in solubility were established between ASC and PSC from rockfish skin at various pH and NaCl concentrations.

Production of a Recombinant Anti-Human CD4 Single-Chain Variable-Fragment Antibody Using Phage Display Technology and Its Expression in Escherichia coli

  • Babaei, Arash;Zarkesh-Esfahani, Sayyed Hamid;Gharagozloo, Marjan
    • Journal of Microbiology and Biotechnology
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    • v.21 no.5
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    • pp.529-535
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    • 2011
  • Single-chain variable fragment (scFv) is a fusion protein of the variable regions of the heavy (VH) and light (VL) chains of immunoglobulin, connected with a short linker peptide of 10 to about 20 amino acids. In this study, the scFv of a monoclonal antibody against the third domain of human CD4 was cloned from OKT4 hybridoma cells using the phage display technique and produced in E. coli. The expression, production, and purification of anti-CD4 scFv were tested using SDS-PAGE and Western blot, and the specificity of anti-CD4 scFv was examined using ELISA. A 31 kDa recombinant anti-CD4 scFv was expressed and produced in bacteria, which was confirmed by SDS-PAGE and Western blot assays. Sequence analysis proved the ScFv structure of the construct. It was able to bind to CD4 in quality ELISA assay. The canonical structure of anti-CD4 scFv antibody was obtained using the SWISS_MODEL bioinformatics tool for comparing with the scFv general structure. To the best of our knowledge, this is the first report for generating scFv against human CD4 antigen. Engineered anti-CD4 scFv could be used in immunological studies, including fluorochrome conjugation, bispecific antibody production, bifunctional protein synthesis, and other genetic engineering manipulations. Since the binding site of our product is domain 3 (D3) of the CD4 molecule and different from the CD4 immunological main domain, including D1 and D2, further studies are needed to evaluate the anti-CD4 scFv potential for diagnostic and therapeutic applications.

Effect of ArsA, Arsenite-Specific ATPase, on Inhibition of Cell Division in Escherichia coli

  • Lee, Sung-Jae;Lee, Soo-Chan;Choi, Seung-Ho;Chung, Mi-Kyung;Rhie, Ho-Gun;Lee, Ho-Sa
    • Journal of Microbiology and Biotechnology
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    • v.11 no.5
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    • pp.825-830
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    • 2001
  • Escherichia coli, which harbored the ars operon from a plasmid pMH12 of Klebsiella oxytoca D12, showed filamentation due to the expression of ars genes in the presence of arsenite. The continued DNA replication in the absence of cell division was revealed, since nucleoids abound with DAPI appeared to be arranged in chains. In contrast to overexpression of arsA, its frame-shift mutant and knock-out mutant lost filamentation in the presence of arsenite, which suggested that ars-induced division block was dependent on expression of arsA. ArsA-induced division inhibition was not a consequence of an inhibition of DNA replication, and the inability of arsenite to induce an SOS response indicated that arsA-mediated division inhibition was dependent on the expression of the gene product encoded by the minB operon. ArsA is a peripheral membrane protein with an ATP-binding domain, which is homologous to MinD that requires ATP-dependent efflux. These results suggested that ArsA could possibly recruit MinC to the membrane and modulate cytoplasmic FtsZ to block assembly at the middle of the cell.

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Nutritional Value of Mealworm, Tenebrio molitor as Food Source

  • Ravzanaadii, Nergui;Kim, Seong-Hyun;Choi, Won-Ho;Hong, Seong-Jin;Kim, Nam-Jung
    • International Journal of Industrial Entomology and Biomaterials
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    • v.25 no.1
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    • pp.93-98
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    • 2012
  • Nutrition value of mealworm, Tenebrio molitor was analyzed due to increasing demand of usage as a protein source for domestic animals and even further for human consumption. The purpose of the present work was to determine the chemical compostion of the Tenebrio molitor larvae, adult that were maintained under standard condition for further usage of mass-rearing system and its exuvium, and excreta. Tenebrio molitor, larvae, adult, exuvium and excreta contained 46.44, 63.34, 32.87, and 18.51% protein respectively, suggested that even excreta could be used as an additional supplement in food recycling process. This protein was also rich in amino acids such as Isoleucine, leucine and Lysine which all met the nutritional value recommended by the Food and Agriculture Organization. Fatty acid composition was detected with high component of oleic acid (C18:1), along with linoleic acid (C18:2) and palmitic acid (C16) in all adult, larvae, exuvium and excreta. These oleic acid (C18:1), linoleic acid (C18:2) and palmitic acid (C16) components were the same or even highly contained in excreta of mealworm 22.29, 47.19 and 19.17% respectively. Longer chains of unsaturated fatty acids consisted of two to three double bonds are known as healthy product was recognized in large amount. These results show new ways to consume mealworms and its waste for animal and human consumption.

Digitization of Supply Chain Management : Key Elements and Strategic Impacts (공급망관리의 디지털화 : 구성요소와 전략적 파급효과)

  • Park, Seong Taek;Kim, Tae Ung;Kim, Mi Ryang
    • Journal of Digital Convergence
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    • v.18 no.6
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    • pp.109-120
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    • 2020
  • The supply chain without digitization is just a series of discrete, siloed steps taken through marketing, product development, manufacturing, and logistics, and finally into the hands of the customer. Digitization brings down those walls, and the chain becomes a completely integrated network fully transparent to all the parties involved. The ulitimate goals of digitizatized supply chain management are velocity and visibility. This network will depend on a number of key technologies including integrated planning and execution systems, supply chain analytics, autonomous logistics, smart warehousing and factory, etc, enabling companies to react to disruptions in the supply chain, and even anticipate them, by fully modeling the network, creating "what-if" scenarios, and adjusting the supply chain in real time as conditions change. This paper presents a number of studies on digitalization of supply chains and provides a discussion on issues raised in the process of technology adoption. Implications of the study findings are also provided.

Characterization of the arfA Gene from Bacillus stearothermophilus No. 236 and Its Protein Product, $\alpha$-L-Arabinofuranosidase

  • Kim, Kyoung-Ju;Kim, Kyung-Nam;Choi, Yong-Jin
    • Journal of Microbiology and Biotechnology
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    • v.14 no.3
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    • pp.474-482
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    • 2004
  • The $\alpha$-L-arabinofuranosidase (Arfase) gene of Bacillus stearothermophilus No. 236 was cloned and sequenced. The ORF of the gene, designated arfA, encoded a 507 -residue polypeptide with calculated molecular mass of 57 kDa. The Arfase produced by a recombinant Escherichia coli strain containing the arfA gene was purified to apparent homogeneity and characterized. The molecular mass of the Arfase determined by SDS-PAGE was 60 kDa. However, according to gel filtration, it was estimated to be approximately 190 kDa. These results indicated that the functional form of the Arfase is trimeric. The optimal pH and temperature for the enzyme activity were pH 6.5 and $55^{\circ}C$, respectively. The half-life of the enzyme at $60^{\circ}C$ was about 6 h. Kinetic experiments at $45^{\circ}C$ with pNPM (p-nitrophenyl $\alpha$-L-arabinofuranoside) as a substrate gave the $K_m and V_{max}$ values of 1.19 mM and 26.1 U/ mg, respectively. When the enzyme was combined with Bacillus stearothermophilus No. 236 endoxylanase and $\beta$-xylosidase, it hydrolyzed arabinoxylan into L-arabinose and xylose more efficiently than Arfase alone. This synergistic effect suggested that the complete hydrolysis of xylan with large amounts of arabinose side chains required Arfase as well as endoxylanase and $\beta$-xylosidase.