• 제목/요약/키워드: proceeding bearing

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Anti-Allergic Effect of Ponciri fructus

  • Hong Seung-Heon;Kim Hyung-Min
    • 한국식품영양과학회:학술대회논문집
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    • 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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    • pp.110-115
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    • 2004
  • The immature fruits of Poncirus trifoliata L. or Ponciri fructus (PF), well known as 'Jisil' in Korea, have been used against allergic diseases for generations, and still occupy an important place in traditional Oriental medicine. Anti-allergic effects of this fruit have been investigated in a few experimental models. Immunoglobulin E (IgE) is the principal immunoglobulin involved in immediate hypersensitivities and chronic allergic diseases. The effect of an aqueous extract of PF on in vivo and in vitro IgE production was investigated. PF dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin, Bordetelia pertussis toxin and aluminum hydroxide gel. PF strongly inhibited interleukin 4 (IL-4)-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, Ponciri fructus also showed an inhibitory effect on the IgE production. On the other hand, mast cell hyperplasia can be causally related with chronic inflammation. Stem cell factor (SCF), the ligand of the c-kit protooncogene product, is a major regulator and ohernoattractant of mast cells. Ponciri fiuctus (1 mg/mL) significantly inhibited the SCF-induced migration of rat peritoneal mast cells (RPMCs). RPMCs exposed to SCF (50 ng/mL) resulted in a drastic shape change with a polarized morphology while the cells exposed to Ponciri fructus (1 mg/mL) remained resting, with little or no shape alteration. The drastic morphological alteration and distribution of polymerized actin were blocked by pretreatment with Ponciri fructus. In addition, Ponciri fructus inhibited both TNF-alpha and IL-6 secretion from RPMCs stimulated with SCF. These results suggest that Ponciri fructus has an anti-allergic activity by inhibition of IgE production from B cells. These findings also provide evidence that Ponciri fructu inhibits chemotactic response and inflammatory cytokines secretion to SCF in mast cells.

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사질토 지반에서 말뚝의 수평거동 (Lateral Behavior of Sin811e and Group Piles in Sand)

  • 김영수;김병탁
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 1999년도 가을 학술발표회 논문집
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    • pp.3-44
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    • 1999
  • This paper discusses the lateral behavior of single and group piles in homogeneous and non-homogeneous(two layered) soil. In the single pile, the model tests were conducted to investigate the effects on ratio of lower layer height to embedded pile length, ratio of soil modules of upper layer to lower layer, boundary rendition of pile head and tip, embedded pile length, pile construction condition, ground condition with saturate and moisture state in Nak-Dong river sand. Also, in the group pile, the model tests were to investigate the effects on spacing-to-diameter ratio of pile, pile array, ratio of pile spacing, boundary condition of pile head and tip, eccentric load and ground condition. The maximum bending moment and deflection induced in active piles were found to be highly dependent on the relative density, pile construction condition, boundary condition of pile head and tip. Based on the results obtained, it was found that the decrease of lateral bearing capacity in saturated sand was in the range of 31% - 53% as compared with the case of dry sand. Also, in the group pile, a spacing-to-diameter of 6.0 seems to be large enough to eliminate the group effect for the case of relative density of 61.8%, and 32.8%, and then each pile in such a case behaves essentially the same as a single pile. In this study, the program is developed by using the modified Chang method which used p - y method and the exact solution of governing equation of pile and it can be used to calculate the deflection, bending moment and soil reaction with FDM in non-homogeneous soil. In comparing the modified Chang method with field test results, the predict results shows better agreement with measured results in field tests.

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고성토 암버력 동다짐 지반에 시공된 PHC 말뚝의 거동특성 사례연구 (A Case Study of PHC Pile Behavior Characteristics on Dynamic Compacted High Rock Embankment)

  • 유남재;윤동균;배경태;김형석;이달호;박용만
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2010년도 추계 학술발표회
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    • pp.519-526
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    • 2010
  • The construction site for $\bigcirc\bigcirc$ transformer substation was located at a mountain valley. In order to prepare the site, the valley was first filled with crushed rock debris up to 63m. Since the main concern of this project is to minimize differential settlement of the foundation of transformer facilities, dynamic compaction was performed every 7m followed by reinforcement with EMP(Ez-Mud Piling). The EMP is one of bored piling methods, in which a hole is bored by means of air percussion and maintain by injecting Ez-Mud. Then a PHC pile (Pretensioned spun High strength Concrete pile) is embedded and finalized with a hammer. In this study, bearing capacities and long term behavior of a pile installed by EMP were investigated. To achieve these objectives, a series of tests such as static and dynamic load tests were conducted. In addition, a construction quality control standard was proposed based on the test results.

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고속 정밀 가공기의 공구셋업 측정기술 (Tool-Setup Measurement Technology of High Speed Precision Machining Tool)

  • 박경택;신영재;강병수
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 2004년도 추계학술대회 논문집
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    • pp.1066-1069
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    • 2004
  • Recently the monitoring system of tool setup in high speed precision machining tool is required for manufacturing products that have highly complex and small shape, high precision and high function. It is very important to reduce time to setup tool in order to improve the machining precision and productivity and to protect the breakage of cutting tool as the shape of product is smaller and more complex. Generally, the combination of errors that geometrical clamping error of fixing tool at the spindle of machining center and the asynchronized error of driving mechanism causes that the run-out of tool reaches to 3∼20 times of the thickness of cutting chip. And also the run-out is occurred by the misalignment between axis of tool shank and axis of spindle and spindle bearing in high speed rotation. Generally, high speed machining is considered when the rotating speed is more than 8,000 rpm. At that time, the life time of tool is reduced to about 50% and the roughness of machining surface is worse as the run-out is increased to 10 micron. The life time of tool could be increased by making monitoring of tool-setting easy, quick and precise in high speed machining center. This means the consumption of tool is much more reduced. And also it reduces the manufacturing cost and increases the productivity by reducing the tool-setup time of operator. In this study, in order to establish the concept of tool-setting monitoring the measuring method of the geometrical error of tool system is studied when the spindle is stopped. And also the measuring method of run-out, dynamic error of tool system, is studied when the spindle is rotated in 8,000 ∼ 60,000 rpm. The dynamic phenomena of tool-setup is analyzed by implementing the monitoring system of rotating tool system and the noncontact measuring system of micro displacement in high speed.

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과수육종에 있어 생명공학의 이용 전망 (The Prospectss and Utilization of Biotechnology for the Improvement of Fruit Breeding)

  • 이돈균;김휘천;신용억;강상조;예병우
    • 한국식물학회:학술대회논문집
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    • 한국식물학회 1995년도 제9회 식물생명공학 심포지움 식물육종과 분자생물학의 만남 The 9th Plant Biotechnology Symposium -Breeding and Molecular Biology-
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    • pp.133-170
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    • 1995
  • The major objectives of fruit breeding lie in improvement of cultivar, easy to be cultivated and of high quality, in order to produce unexpensive, delicious fruit both for fresh fruit market and processing. Recently, fruit breeding in Korea has contributed to breeding of several superior cultivars in major fruit crops, resulting in appreciable improvement in qualities such as skin color, taste and fruit-bearing habit concerned with productivity. In spite of accomplishments mentioned above, the need for both highly disease-resistant cultivars and long-keeping, physiological disorder-resistant cultivars to meet long distance transsportation in the temperate fruit crops of apples, oriental pears, stone fruits such as peaches, and grapes grown in Korea is rapidly pressing more than ever, as cultivars of today susceptible to pests and diseases and vulnerable to physiological disorders are very expensive and time-consuming in post-harvest handling and management. Thus, imporvements made in the above problems through breeding level will lead to the really enhanced productivity in fruit industry. The major impediments of tree size, the long length of juvenile period and the highly heterogeneous genetic composition to the improvement of fruit crops are responsible for the lower amount and rate of improvements of fruit crops as compared to annuals. Considering the expected limitations of the above problems to be solved through conventional breeding methods and strategy, a turning point of breeding a near perfect cultivar would be laid down if innovative breakthroughs in biological technology will be realized in applying some of the techniques of genetic manipulation at the molecular level to the cultivar improvement of fruit crops, such as the selective insertion of DNA carrying genes that govern desirable characteristics. More than anything else, those traits such as fruiting habit deciding productivity, elements of fruit qualities conditioned by monogene, and disease-and pest-resistance of vital importance for successful fruit growing are urgently desired to be improved by advancement of biotechnology for they are more than difficult and need long period to be attained through conventional breeding method.

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무시멘트형 인공고관절 대치술후 초기의 경계면 미세운동의 3차원 FEM 연구 (A Study on the Interface Micromotions of Cementless Artificial Hip Replacement by Three-Dimensional FEM)

  • 김성곤;채수원;최형연
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1994년도 추계학술대회
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    • pp.71-74
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    • 1994
  • In cementless total hip arthroplasty(THA), an initial stability of the femoral component is mandatory to achieve bony ingrowth and secondary long term fixation. Bone ingrowth depends strongly on relative micromotion and stress distributions at the interface. Primary stability of the femoral component can be obtained by minimizing the magnitude of relative micromotions at bone-prosthesis interface, Hence an accurate evaluation of interface behavior and stress/strain fields in the bone implant system may be relevant for better understanding of clinical situations and improving THA design. However, complete evaluation of load transfer in the bone remains difficult to assess experimentally, Hence, recently finite element method (FEM) was introduced in orthopaedic research field to fill the gap due to its unique capacity to evaluate stress in structure of complex shape, loading and material behavior. The authors developed the 3-dimensional numerical finite element model which is composed of totally 1179 elements off and 8 node blick. We also analyzed the micromotions at the bone-stem interface and mechanical behavior of existing bone prosthesis for a loading condition simulating the single leg stance. The result indicates that the values of relative motion for this well fit Multilock stem were $150{\mu}m$ in maximum, $82{\mu}m$ in minimum, and the largest relative motion developed in medial region of proximal femur with anterior-posterior direction. The proximal region of the bone was much larger in motion than the distal region and the stress pattern shows high stress concentration on the cortex near the tip of the stem. These findings indicates that the loading in the proximal femoral bone in the early postoperative situation can produce micromotions on the interface and clinically cementless TEA patient should not be allowed weight bearing strictly early in the postoperative period.

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APT의 지역 표준화기구 운영과 현안 이슈 (Operation and Current Issues of Asia-Pacific Regional Standardization Organization)

  • 김영태;손홍;박기식
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2000년도 추계종합학술대회
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    • pp.129-134
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    • 2000
  • 아시아·태평양 지역의 정보통신 관련 업무를 관장하고 있는 APT(아·태 전기통신협의체)는 1998년 ASTAP(APT 표준화 프로그램)이라는 지역 표준화기구를 설려 및 운영하고 있다. 지역 표준화기구로서의 ASTAP은 매년 1회씩 정기적 포럼을 통해 표준화 활동 방향 등을 정립하고 있으며, 2000년 6월에 개최된 제3차 ASTAP Forum을 통해서는 보다 실질적인 결과물 창출과 산업체의 참여 활성화 유도를 위한 조직의 개편이 단행된 바 있다. APT의 이러한 지역 표준화기구 운영은 효율적 정보통신표준화를 위한 지역 국가간의 긴밀한 협력 체계를 유도하고, 나아가 정보통신표준화 활동을 통한 지역의 공동 이익 및 세계 시장에서의 위상 강화를 추구해 나아갈 수 있는 기반이 되고 있다. 따라서, 본 논문에서는 아·태 지역 표준화기구(ASTAP)의 운영 방안과 현안 이슈들을 분석함으로써, 우리 나라가 동 지역에서의 정보통신표준화 활동을 보다 효율적으로 할 수 있는 방안을 모색하는데 역점을 두었다.

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인공고관절 직선형 대퇴 stem과 곡선형 대퇴 stem의 미세운동비교 - FEM 3차원 모델을 이용한 분석 - (Three-Dimensional Finite Element Analysis of Micromotion of the Straight and the Curved Femoral Stem in Cementless Hip Arthroplasty)

  • 김성곤;채수원;정중환
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 춘계학술대회
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    • pp.245-248
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    • 1997
  • Excessive stress on the bone-stem interface may cause local micromotion that could produce midthigh pain, interface bone resorption and prevent bony ingrowth. It is important for clinician and prosthetic designer to develop an understanding of the load transfer mechanism, its associated stress pattern and its relationships with the particular mechanical characteristics of the femoral stem designs. Finite element method (FEM) is preeminently suited to provide information in this respect. The authors developed 3-dimensional numerical finite element models implanted with the straight stem which is composed of total 1170 elements of 8 nodes and with the curved stem which is composed of total 885 elements of 8 node, and analysed the relative micromotions between the straight stem and the curved stem in immediate postoperative stage of an uncemented total hip replacement in load simulating the single leg stance. The results showed that the rotational displacement was occupied over 90% of total micromotion in both types of stem and was peak at the proximal medial portion of the stem, but markedly less distally. The curved stem was more stable especially in terms of rotational stability. It is recommended that surgeons do not allow the patient weight bearing until bony ingrowth was achieved. In the future more attention should be drawn to increase initial rotational stability of the two types of femoral stem to prevent loosening from excessive micromotion.

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LED광학 시스템이 포함된 3등대형 수은조식 해상용 등명기 개량 (3rd Order Type Mercury Rotate Marine Light with LED Optical System)

  • 김영재;강대웅;이용재;정환;이종복;신경호;박광우;유성환
    • 한국항해항만학회:학술대회논문집
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    • 한국항해항만학회 2017년도 추계학술대회
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    • pp.206-208
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    • 2017
  • 최근 100여년이 지난 수은조식 3등대형 개량사업을 거문도 등대에서 시행하였으며 독성 있는 수은제거 및 광원의 LED화, 무중단을 대비한 2중화 시스템등을 설치하였으며 이는 국내 최초의 LED 회전식 등명기 설치 및 운용사례라고 볼 수 있다. 등명기 전체 프레임에 대한 원형 복원이 이루어졌으며 2중구조 베어링 설치와 원격제어시스템을 통해 실시간 현황파악이 가능하다. 설치후 한빛호를 통한 광학측정을 통해 유효광도 200만cd 부동광도 300cd의 광학적 성능을 확보하여 LED 광원을 사용한 국내 회전식 등명기 도입의 효율적인 가능성을 입증했다.

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In vitro shoot initiation of Artocarpus heterophyllus Lam. (Jak Fruit) Effect of the explant type and the season of explant collection

  • Kahk, Kasturiarachchi;Wtpsk, Senarath;Lee, Kui-Jae
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 2003년도 제10차 국제학술회의 및 추계정기 학술발표회
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    • pp.2-3
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    • 2003
  • A method for rapid propagation of mature Jack fruit was developed. Four types of explants (mature embryos, apical meristems of young seedlings, apices from mature plants and nodal segments) were used. It has been found 88% of young apical meristems produced shoots in Campbell and Durzan (CD) medium compared to 60% in Murashige and Skoog (MS) medium. Only 1/3 of them produced multiple shoots. Shoot initiation from nodal segments was very rare. Mature apices produced callus. Although removal of the sheathing cover around mature buds enhanced the shoot initiation but success rate was low in growth regulator free medium. Embryos respond to the CD medium but not to the MS medium. Embryos from seeds soaked in water for 24 hours produced shoots after 8 weeks of incubation and the success rate was 70% while embryos from dry seeds only produced roots. There was no significant effect of cold storage (refrigeration) for 7 days on shoot initiation from mature embryos (65%) but the ability for shoot induction declines with storage time (55% after 21 days of cold storage). Mature axillary buds were established in Modified Campbell and Durzan (CD) medium supplemented with 0.5mg/1 and IBA. There was a significant difference in the growth performance of shoots according to the period of the year in which explants were collected. Highest (60%) was observed in November-January period. It was only 30% when the explants were collected in February-April or May-July and decreased to 20% in August-October. The shoots produced in November-January showed a higher vigor than those produced in other months. Since Jak fruit show seasonal changes in fruit bearing and shedding of leaves, it can be suggested that the difference in growth performances of tissues cultured in artificial culture media would have been affected by endogenous rhythms.

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