• Korean Journal of Veterinary Research
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• v.41 no.3
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• pp.327-332
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• 2001

In recent years, experimental evidence have been suggested that melatonin has either contractive or relaxing effects on the vascular smooth muscle in vitro. But the effect of melatonin on the cardiovascular system in vivo had been emphasized about the hypotensive effect. In this work, we found not only hypotensive effect but also hypertensive effect of melatonin in rats and attempted to determine the mechanism of these effects elicited by melatonin. Regadless of concentration, melatonin(0.002~5 mg/kg) produced increase in mean blood pressure (MBP) in 36% (54/150 cases) and decrease in mean blood pressure in 64%(96/150 cases). As a whole melatonin caused an increase or a decrease in MBP without compensatory decrease or increase in heart rate. The melatonin-induced hypertension was abolished by the pretreatment of phenoxybenzamine, a ${\alpha}$-adrenoceptor antagoninst. The melatonin-induced hypotension was abolished by the pretreatment of propranolol, a ${\beta}$-adrenoceptor antagonist, ODQ, a NO-sensitive guanylate cyclase inhibitor, or nifedipine, a L-type $Ca^{2+}$ channel blocker, but not by bilateral cervical vagotomy. The results indicate that melatonin-induced hypertension may be related to ${\alpha}$-adrenoceptor stimulation and melatonin-indued hypotension may be related to ${\beta}$-adrenoceptor stimulation, inhibition of $Ca^{2+}$ channel and/or activation of guanylate cyclase.

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.851-857
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• 2000

SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(防風), Radix Cocculi or Stephaniae(防己), Semen Armeniacae(杏仁), Cortex Cinnamomi(肉桂), Radix Scutellariae(黃芩), Radix Paeoniae Lactiflorae(白芍藥), Radix Ginseng(人蔘), Rhizoma Cnidll(川芎), Herba Ephedrae(麻黃), Radix Glycyrrhizae(甘草), Radix Aconiti(附子?), Fructus Zizyphi Jujubae(大棗), Rhizoma Zingiberis(生薑) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.

• Journal of the Ergonomics Society of Korea
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• v.32 no.4
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• pp.345-353
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• 2013

Objective: This research measured physiological and psychological effects of Vibroacoustic stimulation(VA) to scapular and sacrum of supine position on the mattress. Background: When vibroacoustic stimulation applies to human body, it has a positive influence on physiological and psychological effects by stimulating the organs, tissues and cells of whole body. Method: This experiment was conducted to 10 normal males in two conditions: no stimulation and vibroacoustic stimulation. No stimulation experiment was executed as a supine position for 30 minutes without any vibrational stimulus, while vibroacoustic stimulation was transmitted by the vibrational speaker, which uses 40Hz frequency. Subjects had a laser Doppler flowmeter probe in scapular, sacrum, and also had 8 channel electroencephalogram(EEG) measurement sensor in the scalp. Blood pressure and skin temperature were measured in two conditions with an underlying posture for 30 minutes. Additionally, blood flow rate and EEG were measured before and after for two minutes on two conditions. Results: According to the vibroacoustic stimulation, blood flow rate and skin temperature were increased, while blood pressure was decreased. When using vibroacoustic stimulation compared to no stimulation, blood flow rate went approximately two times higher, and skin temperature also higher 3~4 times. Furthermore, the relative alpha power of brain wave was significantly increased when we applied to vibroacoustic stimulation. Conclusion: This experiment tested the VAT embedded in mattress in two conditions. According to this experiment, VAT decreases blood pressure, improves not only a physiological effect on blood flow rate as well as skin temperature, but also psychological functions by increasing relative alpha power. Application: The results of the publishing trend analysis might help physiological and psychological effects of vibroacoustic stimulation.

• Korean Journal of Veterinary Research
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• v.42 no.1
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• pp.123-130
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• 2002

To investigate the cardiopulmonary and anesthetic effects of propofol in dogs, experimental dogs were randomly divided into 4 groups (propofol infusion anesthesia, P/INF, propofol intermittent anesthesia, P/INTER, propofol induction anesthesia, P/ISO, thiopental Na induction anesthesia, T/ISO) and monitored analgesic and anesthetic effects, recovery time, body temperature, heart rate, mean arterial pressure, respiratory rate, systolic and diastolic pressure. In all groups, apnea was not observed. In the P/INF group, the respiratory rate(RR) was slightly decreased, but in the P/INTER group, RR was increased and shallowing. In the groups of P/ISO and T/ISO, the respiratory rate was decreased. Heart rate(HR) was increased after induction anesthesia in all groups, but gradually decreased. Mean arterial pressure(MAP) was decreased after injection anesthesia in the groups of P/INF and P/INTER. In the groups of P/ISO and T/ISO, however, MAP was slightly increased. Systolic and diastolic arterial pressure were gradually decreased after induction anesthesia, but not significantly. In the groups of P/INF and P/ISO, recovery time was shorter than the groups of P/INTER and T/ISO. In all groups, body temperature of animals was decreased gradually according to time but no significant changes were observed. Propofol injection doesn't make the complete loss of responses of animals, especially, in the P/INTER group. In the P/INF group, deep pain was present until the end of anesthetic period. During recovery period, any other side effects except incoordination were not monitored. The present study suggested that infusion anesthesia was superior to intermittent anesthesia as injection anesthetic agent, and propofol was better than thiopental Na as induction anesthetic agent.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1122-1127
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• 2004

an isolated droplet combustion exposed to pressure perturbations in stagnant gaseous environment is numerically conducted. Governing equations are solved for flow parameters at gas and liquid phases separately and thermodynamic parameters at the interfacial boundary are matched for problem closure. For high-pressure effects, vapor-liquid interfacial thermodynamics is rigorously treated. A series of parametric calculations in terms of mean pressure level and wave frequencies are carried out employing a n-pentane droplet in stagnant gaseous air. Results show that the operating pressure and driving frequency have an important role in determining the amplitude and phase lag of a combustion response. Mass evaporation rate responding to pressure waves is amplified with increase in pressure due to substantial reduction in latent heat of vaporization. Phase difference between pressure and evaporation rate decreases due to the reduced thermal inertia at high pressure. In addition to this, augmentation of perturbation frequency also enhances amplification of vaporization rate because the time period for the pressure oscillation is much smaller than the liquid thermal inertia time. The phase of evaporation rate shifts backward due to the elevated thermal inertia at high acoustic frequency.

• The Journal of Korean Physical Therapy
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• v.27 no.6
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• pp.434-438
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• 2015

Purpose: The purpose of this study was to determine the effects of calcaneal taping on peak plantar pressure of rearfoot and forefoot while walking. Methods: Fifteen healthy subjects with normal feet participated in this study. Inclusion criteria were as follows: (1) no disturbance of gait and foot pain, (2) normal range of motion of ankle joint, (3) no foot deformity. Pedoscan was used for recording of plantar pressure data during walking. The participants walked along a 12-m walkway before and after application of calcaneal taping. The plantar pressure gait was measured 3 times under barefoot and calcaneal taping conditions randomly at a speed practiced with the metronome during gait. The peak plantar pressure data were calculated for medial and lateral areas of the rearfoot and forefoot. The paired t-test was used to determine significant differences in peak plantar pressure of rearfoot and forefoot before and after application of calcaneal taping. A p-value less than 0.05 was accepted as significant. Results: The calcaneal taping resulted in statistically significant decreases in peak plantar pressure of the rearfoot (medial side: p=0.03; lateral side: p=0.01). However, there were no significant changes in peak plantar pressure of the forefoot (medial side: p=0.45; lateral side: p=0.40). Conclusion: The calcaneal taping is recommended to reduce plantar pressure of the rearfoot in weight-bearing activities in subjects with plantar heel pain caused by atrophy of the fat pad.

• Journal of Korean Physical Therapy Science
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• v.11 no.4
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• pp.29-37
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• 2004

Measurements of plantar pressure provide an indication of foot and ankle function during gait and other functional activities because the foot and ankle provide necessary support and flexibility for weight bearing and weight shifting while people are performing these activities. Plantar pressure is being increasingly used in both research and clinical practice to measure the effects of various footwear and physical therapy intervention. The influence of walking speed and ground inclination on plantar pressure parameters However has not been evaluated in detail. So, in this study to determine the effect of changes in walking speed and ground inclination on plantar pressure treadmills with different walking speeds and inclination were used. Plantar pressure parameters were measured with the Parotec system using the walking and running in 20 healthy participants(10 male, 10 female) aged $20{\sim}28$(mean 22.22, S.D.2.26 years) when slow walking and running. The result of this study with increased die walking speed, the peak pressure of 1st, 5th metatarsal head and total contact time and impulse total at the forefoot was affected by walking speed; however, die peak pressure, contact time and impulse total at the forefoot was not affected by ground inclination.

• Transactions on Electrical and Electronic Materials
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• v.9 no.1
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• pp.38-43
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• 2008

Using an arterial pressure-volume (APV) model, we performed an analysis of the conventional blood pressure estimation method using an oscillometric sphygmomanometer with computer simulation. Traditionally, the maximum amplitude algorithm (MAA) has been applied to the oscillation waveforms of the APV model to obtain the mean arterial pressure and the characteristic ratio. The estimation of mean arterial pressure and characteristic ratio was significantly affected by the shape of the blood pressure waveforms and the cutoff frequency of high-pass filter (HPF) circuitry. Experimental errors result from these effects when estimating blood pressure. To determine an algorithm independent of the influence of waveform shapes and parameters of HPF, the volume oscillation of the APV model and the phase shift of the oscillation with fast Fourier transform (FFT) were tested while increasing the cuff pressure from 1 mmHg to 200 mmHg (1 mmHg/s). The phase shift between ranges of volume oscillation was then only observed between the systolic and the diastolic blood pressures. The same results were obtained from simulations performed on two different arterial blood pressure waveforms and one hyperthermia waveform.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.7 no.1
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• pp.17-26
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• 2011

CANDU reactor core is composed a few hundreds pressure tubes, which support and locate the nuclear fuels in the reactor. Each pressure tube provides pressure boundary and flow path of primary heat transport system in the core region. In order to guarantee the structural integrity of pressure tube flaws which can be found by in-service inspection, crack growth and fracture initiation assessment have to be performed. Stress intensity factors are important and basic information for structural integrity assessment of planar and laminar flaws (e. g. crack). This paper reviews and confirms the stress intensity factor of axial crack, proposed in CSA N285.8-05, which is an fitness-for-service evaluation code for pressure tubes in CANDU nuclear reactors. The stress intensity factors in CSA N285.8-05 were compared with stress intensity factors calculated by three methods (finite element results, API 579-1/ASME FFS-1 2007 Fitness-For-Service and ASME Boiler and Pressure Vessel Code Section XI). The effects of Poisson's ratio and anisotropic elastic modulus on stress intensity factors were also discussed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1070-1073
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• 2002

The biomechanical interaction between the stump and the prosthetic socket is critically important to achieve close-to-normal ambulation. Many investigators suggested that the pressure changes during gait of transfemoral amputees are closely related to the prosthetic alignment, the socket shape, the stump size, and the residual muscle activity. The effects of the prosthetic alignment, the socket shape, and the stump size on the interface pressure were investigated previously. However, there is no report how the residual muscle activities in the transfemoral stump affect the socket interface pressure characteristics during gait. Since designs of socket fur lower limb amputees need to consider the socket interface pressure characteristics, the interface pressure patterns by the residual muscle activities during gait should be investigated. In this study, myoelectric signals (MES) and socket interface pressure in residual limb of transfemoral amputees were measured during the stance and swing phases of gait. For the purpose, specially designed quadrilateral sockets that MES electrodes could be instrumented were fabricated. A total of two transfemoral amputees were participated in the experiments. The measured temporal MES amplitude and interface pressure in knee flexor (biceps femoris) and extensor (rectus femoris) had significant correlations (P ＜ 0.05). Based on the test results, It was suggested that the residual muscle activity of transfemoral amputees stump is an important factor affecting socket pressure changes during walk.