• Title/Summary/Keyword: preservation administration

검색결과 288건 처리시간 0.027초

플라스틱 세포치료제 보관용기의 극저온 환경 노출 시 구조적 변화에 대한 해석적 비교 (Analytical comparison of structural changes of plastic cell-based therapeutic drug storage containers when exposed to cryogenic environments)

  • 박정연;이동목;;이순례;윤길상
    • Design & Manufacturing
    • /
    • 제14권2호
    • /
    • pp.1-6
    • /
    • 2020
  • Recently, research and commercialization related to the field of cell-based therapeutic drug development has been actively conducted. In order to maintain cell viability and prevent contamination, refrigeration preservation devices, such as CRF (controlled rate freezer) or vapor type LN2 tanks have been developed. On the other hand, the storage container for liquid nitrogen tanks currently on sale minimizes the flow structure to prevent structural defects when stored in a liquid nitrogen tank having a high thermal conductivity than vapor nitrogen. If the cell-based treatment drug is stored in the gaseous LN2 tank as it is, the cell survival after thawing is greatly reduced. It was estimated that the existing storage container structure was a factor that prevented the rapid entry and circulation of gaseous nitrogen into the container. Therefore, this study intends to propose a new supercellular storage container model that can maintain the mechanical strength while maximizing the fluid flow structure. To this end, we estimated that the structural change of the storage container effects on the equivalent stress formed around the through-holes of them when exposed to a cryogenic environment using thermal-structural coupled field analysis. As a result of storage experiments in the gas phase tank of the cell-based therapeutic agent using the developed storage container, it was confirmed that the cell growth rate was improved from 66% to 77%, which satisfied the transportation standards of the FDA(Food and Drug Administration) cell-based therapeutic agent.

대학도서관 열람실 공간기준에 관한 연구 (Study on the Spatial Standard for Reading Rooms in University Libraries)

  • 임호균
    • 한국실내디자인학회논문집
    • /
    • 제25권5호
    • /
    • pp.140-147
    • /
    • 2016
  • This research aims to establish the size standard of university library's user space, and present the standard and method to calculate total area required in the planning of new building construction and remodeling. Nine university libraries newly constructed or remodeled since 2000 were selected among the libraries of large scale universities with more than 10,000 enrolled students as the target libraries in this research. The target libraries were classified into A group (five cases partially remodeled) and B group (four cases newly constructed or fully remodeled) on the basis of the change of times. A university library can be divided into three spaces (user space, administration space and public space). This research classified the reading room in the user space into bookshelf zone, reading zone, information/office zone and hall/other zone, and analyzed area ratio according to each zone. B group's bookshelf zone decreased 12% more than A group, and B group's reading zone increased 10% more than A group. However, there was no big change in the area ratio of information/office zone and hall/other zone. This can be interpreted that university library changes from book and archive preservation-oriented space to user-oriented space. This research presented a proper reading room area calculation method, based on the capacity of books, by reflecting such a change. Each zone's standard was set up through classification of domestic and international standards, based on which, the calculation method of university library's total floor area required was presented. The reason why there was difference in university library's total floor area required according to domestic standard and international standard was that the number of enrolled students per seat in the reading room was different. The area calculation methods presented in this research can be utilized as useful data upon planning university library construction or remodeling.

Co-ensiling garlic stalk with citrus pulp improves the fermentation quality and feed-nutritional value

  • Lee, Youn Hee;Ahmadi, Farhad;Kim, Young Il;Oh, Young-Kyoon;Kwak, Wan Sup
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제33권3호
    • /
    • pp.436-445
    • /
    • 2020
  • Objective: Ensiling is a simple and effective method for long-term preservation; however, less information exists about the ensilability characteristics of garlic stalk (GS). Therefore, the objectives were to examine the ensiling feasibility of GS. Methods: The GS was ensiled alone or inoculated with Lactobacillus plantarum KU5 in the presence or absence of 5% molasses and ensiled for 7, 14, and 28 d. As an alternative storage method, GS was co-ensiled with wet citrus pulp (CP) at different proportions (GS:CP: 70:30, 60:40, 50:50, and 40:60). Analysis was made on physicochemical, fermentative, and nutritional parameters. Results: The GS was found to be a biomass which is difficult to ensile. A combination of microbial inoculant and molasses was successful in the improvement of the silage fermentation quality of GS. Co-ensiling of GS with wet CP at the mixing ratio of 50:50 provided the most desirable silage fermentation parameters, including the substantial lactic acid formation, low final pH, minor effluent loss, and the more favorable organoleptic properties. Conclusion: Co-ensiling GS with CP appears to be a simple and viable method of conservation, enabling the more efficient utilization of these by-product resources over a prolonged period.

비전자기록물 이관업무 개선방안 연구 - 부산지역 기초자치단체를 중심으로 - (A Study on Improvement of Transfer of Non-Electronic Records: Focused on Local Governments in Busan Region)

  • 어은영;조지영
    • 한국기록관리학회지
    • /
    • 제12권3호
    • /
    • pp.71-92
    • /
    • 2012
  • 공공기록물 관리에 관한 법률에 따른 기록물관리전문요원의 배치가 이루어지면서 기록물관리는 어느 정도 자리를 잡아가고 있으며, 법률에 따른 기록물관리를 이루기 위해 많은 노력을 기울이고 있다. 기록물관리는 기록물의 생산 분류 정리 이관 수집 평가 폐기 보존 공개 활용 및 이에 부수되는 제반업무를 말한다. 이중에서도 기록물 이관은 해당 기록물이 처리과에서 기록관으로 관리주체가 변경되는 최초 단계를 수행하는 중요한 업무라고 할 수 있다. 이에 따라 본 연구에서는 부산지역 16개 기초자치단체의 이관현황을 살펴보고, 기관의 기록물관리전문요원들의 인터뷰를 통해 이관진행과정에서 발생하는 문제점을 살펴보고 비전자기록물 이관업무 개선방안을 제시하였다.

Scopolamine 유발 기억력손상 흰 쥐에서 영계감조탕가용골모려(笭桂甘棗湯加龍骨牡蠣)의 인지기능개선과 항산화 효과 (Anti-amnesic and Antioxidant Effect of Yeongkyekamjotanggayonggolmoryo Aqueous Extracts on Scopolamine-induced Memory Impairment in Mice)

  • 김대억;한다영;김상호;정대규
    • 동의신경정신과학회지
    • /
    • 제29권3호
    • /
    • pp.121-134
    • /
    • 2018
  • Objectives: The purpose of this in vivo study is to observe anti-amnesic effects of Yeongkyekamjotanggayonggolmoryo (YGYM), a novel mixed herbal prescription, Ossis Mastodi and Ostreae Testa added Yeongkyekamjo-tang, on scopolamine induced amnesia in C57BL/6 mice through acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effects. Methods: Six groups, total 20 intact or 100 Sco treated mice were used in this study after one week of acclimatization period. Half the animals were used for passive avoidance task tests and hippocampus ACh content, AChE activity, and ChAT mRNA expression were measured. The other half was subjected to an underwater maze test and then the cerebral cortex antioxidant defense system was measured. Results: In the passive avoidance experiment, there was significant decrease in residence time in the bright room and in the underwater maze test, escape latency to escape from the esophagus significantly increased compared with the normal control group. At the final sacrifice, ACh content and ChAT mRNA expression decreased, AChE activity increased, and cerebral cortical MDA increased GSH content, SOD and CAT activity in Sco control mice, as compared to intact vehicle control mice. However, these Sco treatment-related memory loss through AChE activation destroyed the cerebral cortex antioxidant defense system, and was inhibited dose-dependently by 28 days consecutive oral pretreatments of YGYM extracts 500, 250, 125 mg/kg. Conclusions: In the above results, YGYM extract that oral administration of YGYM extracts alleviates the antioxidant defense system, through preservation of ACh mediated by upregulation of ChAT mRNA expression, and increase of AChE inhibition and brain antioxidant defense systems.

소방기관의 화재원인조사 역량 강화 방안에 관한 연구 (A Study on Methods for Capacity Building of Fire Cause Investigation in Fire Stations)

  • 이의평
    • 한국화재소방학회논문지
    • /
    • 제25권5호
    • /
    • pp.108-118
    • /
    • 2011
  • 이 논문에서는 화재조사관련 소방기관의 강점을 분석하고 화재원인조사역량을 강화하는 방안을 제시하였다. 소방기관의 화재조사역량 강화 방안은 화재조사 인원과 조직 및 장비의 보강, 수사권 확보 등에 중점을 두기보다는 현재 소방의 잠재력과 강점을 살리고 내부역량을 강화할 수 있는 것을 중심으로 제안하였다. 제시된 방안으로 1) 화재조사 결과는 소방행정의 토대인 만큼 소방서장의 화재조사의 중요성에 대한 인식전환 필요, 2) 관계자진술을 조기에 체계적으로 확보하는 화재조사체제의 구축, 3) 2회 이상 화재현장을 조사하는 실질적인 화재원인조사 체제의 구축, 4) 기계경비 또는 CCTV 등의 자료를 화재원인조사에 활용하는 화재원인조사 체제의 구축, 5) 화재조사를 고려한 화재진화 활동과 진화 후의 현장보존 체제의 구축, 6) 119구급대 및 구조대와 연계한 화재조사체계의 구축, 7) 화재조사 요원에 대한 사기앙양대책 강구 등이다.

친환경적 설계인자를 적용한 생태복원공사의 시공성 평가 - 거제시 구천천 생태하천 조성공사를 중심으로 - (The Constructability Evaluation of Ecological Restoration Construction Using Environment-friendly Design Factor - In the case of Construction of Gucheon Eco-River in Geoge City -)

  • 안병철
    • 한국환경복원기술학회지
    • /
    • 제16권4호
    • /
    • pp.99-114
    • /
    • 2013
  • In this study, constructability of ecologocal stream restoration process was evaluated and improved approaches for habitat were suggested. The study site is Gucheon River in Geoje city where conducted ecologocal restoration work within maintaining its flood control function. Application of ecological design factors and constructability in the process from planning to construction was analyzed and its results are as follows: In the process of planning and designing, it was focused more on the naturality of Gucheon River rather than the human convinience and ecological design factors were applied within the ecological capacity of the site. First, the indexes for constructability evaluation is selected. It was classified into three major categories as construction quality, design quality and construction administration system. Each index has details, so there are twenty sub indexes for contractibility evaluation. Second, the evaluation results shows that the index most in need of improvement was plumbing construction, followed by Stone construction and pavement construction. design concept was evaluated as appropriate in entire categories. Finally it is suggested that it can be improved in both process of design to enhance the technology and process of construction to enhance the quality management. The constructability of ecological stream needs adaptive management and it must be discussed with its designing which is at the stage before construction. Also it needs discussion with its designer constantly and feed-back process.

응급실로 내원한 청장년층 급성심근경색증 환자의 임상특성 연구 (Study of Clinical Characterized of Acute Myocardiac Infarction Patients on Youth & Adults Age in Emergency Room)

  • 홍해숙;장유량
    • 대한수사과학회지
    • /
    • 제3권1호
    • /
    • pp.50-59
    • /
    • 2008
  • The purpose of this study was to figure out clinical characteristics in young and adult acute myocardial infarction patients come to emergency room. One hundred fifty four acute myocardial infarction cases were collected and analized from January 2003 to April 2006, especially focused on below the age 50. The results of the study were summarized as follows. The results were proportion up disease occur to women disease rate as men after 50 age and acute myocardial infarction occur to spring and winter most of all. Research for this patients coronary artery condition in cardiac angiography room and coronary artery condition is left anterior descending portion was obstruction and stenosis most of all at that time in emergency room. HDL-cholesterol was not normal range of this patients. About 57.9% patients downward normal range but total cholesterol was very variant condition. Investigated chest X-ray of this patients and result in upward 75% patients was C-T ratio 50% upward condition. And it was shown result from this patients 94. 7% was obesity condition and family history showed mother or father got hypertension or diabete mellitus patients but 42. 7% patients not family history. This patients not going to direct emergency room after via local medical center result in badly condition up. Have got outcomes of youth and adults age patient of acute myocardial infarction come to emergency room. Government and administration have to support advertising this results about acute myocardial infarction condition of nation people. We need to preservation and preventing this disease but if this disease occurrence, to the utmost directly and speedly emergency room for fast therapy.

  • PDF

박물관 보존과학계 영역의 공간계획 지표에 관한 연구 (A Study on the Design Guidelines for the Spatial Planing of Conservation Area in Museums)

  • 정성욱
    • 한국실내디자인학회논문집
    • /
    • 제20권5호
    • /
    • pp.197-207
    • /
    • 2011
  • In general, collections in museum are kept in storage according to a preservation and administration program in long or short term, after conservators' conservation treatment. Museum activities related to conservation science are common to do before and after exhibitions. That is, the museum collections include a flow mechanism, which circulate a space in where conservation science related activity is carried on centering around its storage. The purpose of this study is to suggest the design guidelines of a conservation area in a museum. The results of this study as follows. First, to program space planning, conservation area of museum is divided into 4 kinds of zone. Second, space for relics unloading in basically includes 'unloading room', 'control room', 'worker room', 'unpacking room', and 'unloading tools storage' and considers to install 'outdoor arrangement space', etc. In case of space for making relics collections, 'arrangement room' and 'temporary storage' are separately planned in order to arrange and temporarily store relics taken in. Conservation analysis space should be divided into 2 kinds of zone, 'conservation analysis lab' for analysis of collection characters and 'restoration lab' for conservation treatment in the bigger museum. In case of large-scale museum, conservation treatment space is basically classified with characters of museum collections. And it considers installing 'waterlogged wood lab', 'painting clothes treatment lab', 'storage of treated relics' etc. Third, for 'the spaces for analysis treatment', must consider activity contents and sizes of the department for scientific conservation every museum, can classify in detail required space, and must review the space for relics settlement in construction.

북제 서현수묘 벽화 복식 연구 (A Study on Costume in Mural Painting of Xu Xianxiu Tomb in Northern Qi period)

  • 안보연;홍나영
    • 복식
    • /
    • 제66권1호
    • /
    • pp.122-134
    • /
    • 2016
  • The Mural Tomb of Xu Xianxiu(AD 571), a high ranking official in Northern Qi period, is located in Taiyuan, Shanxi province, China. Despite having been raided, it was still discovered to contain over 530 pieces, such as artifacts and murals, in excellent state of preservation. These murals are noteworthy for their high level of detail compared to other murals from the same era, and are important for understanding the historical context of active East-West and Han-Hu cultural exchange in the $6^{th}$ to $7^{th}$ century. The murals of Xu Xianxiu's tomb depict round-collared and narrow-sleeved garments as well as straight collared robes typical of the Xianbei tribe's attire. Notable are the ermine fur overcoat and a headwear with flares on the left and right thought to be unique to the Xianbei. The wife and female servants show female attire of the Xianbei at the time; this attire can be characterized by narrow-sleeved long gowns and asymmetrical flying-bird buns. Despite the anti-Han policy of Northern Qi, influences such as the right sided gathering of the robes and embellished hair styles remain. The procession also depicts the three-cornered headdress and long-tailed hood of the Xianbei men, which have been recorded in documents. The large rounded pearl pattern containing the palmette, the divine animal, and bodhisattva's head motifs show the influence of the Western China [Xi'yu]. Considering that Northern Qi had more active interactions with the three ancient kingdoms of Korea than with the Southern Kingdoms[Nanchao], the findings of this study call for further research on the correlation between the attire of ancient Korea and Northern Qi.