Park, Jeong-Yeon;Lee, Dong-Mok;Lee, Jienny;Lee, Sun-ray;Yoon, Gil-Sang
Design & Manufacturing
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v.14
no.2
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pp.1-6
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2020
Recently, research and commercialization related to the field of cell-based therapeutic drug development has been actively conducted. In order to maintain cell viability and prevent contamination, refrigeration preservation devices, such as CRF (controlled rate freezer) or vapor type LN2 tanks have been developed. On the other hand, the storage container for liquid nitrogen tanks currently on sale minimizes the flow structure to prevent structural defects when stored in a liquid nitrogen tank having a high thermal conductivity than vapor nitrogen. If the cell-based treatment drug is stored in the gaseous LN2 tank as it is, the cell survival after thawing is greatly reduced. It was estimated that the existing storage container structure was a factor that prevented the rapid entry and circulation of gaseous nitrogen into the container. Therefore, this study intends to propose a new supercellular storage container model that can maintain the mechanical strength while maximizing the fluid flow structure. To this end, we estimated that the structural change of the storage container effects on the equivalent stress formed around the through-holes of them when exposed to a cryogenic environment using thermal-structural coupled field analysis. As a result of storage experiments in the gas phase tank of the cell-based therapeutic agent using the developed storage container, it was confirmed that the cell growth rate was improved from 66% to 77%, which satisfied the transportation standards of the FDA(Food and Drug Administration) cell-based therapeutic agent.
This research aims to establish the size standard of university library's user space, and present the standard and method to calculate total area required in the planning of new building construction and remodeling. Nine university libraries newly constructed or remodeled since 2000 were selected among the libraries of large scale universities with more than 10,000 enrolled students as the target libraries in this research. The target libraries were classified into A group (five cases partially remodeled) and B group (four cases newly constructed or fully remodeled) on the basis of the change of times. A university library can be divided into three spaces (user space, administration space and public space). This research classified the reading room in the user space into bookshelf zone, reading zone, information/office zone and hall/other zone, and analyzed area ratio according to each zone. B group's bookshelf zone decreased 12% more than A group, and B group's reading zone increased 10% more than A group. However, there was no big change in the area ratio of information/office zone and hall/other zone. This can be interpreted that university library changes from book and archive preservation-oriented space to user-oriented space. This research presented a proper reading room area calculation method, based on the capacity of books, by reflecting such a change. Each zone's standard was set up through classification of domestic and international standards, based on which, the calculation method of university library's total floor area required was presented. The reason why there was difference in university library's total floor area required according to domestic standard and international standard was that the number of enrolled students per seat in the reading room was different. The area calculation methods presented in this research can be utilized as useful data upon planning university library construction or remodeling.
Lee, Youn Hee;Ahmadi, Farhad;Kim, Young Il;Oh, Young-Kyoon;Kwak, Wan Sup
Asian-Australasian Journal of Animal Sciences
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v.33
no.3
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pp.436-445
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2020
Objective: Ensiling is a simple and effective method for long-term preservation; however, less information exists about the ensilability characteristics of garlic stalk (GS). Therefore, the objectives were to examine the ensiling feasibility of GS. Methods: The GS was ensiled alone or inoculated with Lactobacillus plantarum KU5 in the presence or absence of 5% molasses and ensiled for 7, 14, and 28 d. As an alternative storage method, GS was co-ensiled with wet citrus pulp (CP) at different proportions (GS:CP: 70:30, 60:40, 50:50, and 40:60). Analysis was made on physicochemical, fermentative, and nutritional parameters. Results: The GS was found to be a biomass which is difficult to ensile. A combination of microbial inoculant and molasses was successful in the improvement of the silage fermentation quality of GS. Co-ensiling of GS with wet CP at the mixing ratio of 50:50 provided the most desirable silage fermentation parameters, including the substantial lactic acid formation, low final pH, minor effluent loss, and the more favorable organoleptic properties. Conclusion: Co-ensiling GS with CP appears to be a simple and viable method of conservation, enabling the more efficient utilization of these by-product resources over a prolonged period.
Journal of Korean Society of Archives and Records Management
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v.12
no.3
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pp.71-92
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2012
As records managers are assigned in accordance with act on public records management, the record management has settled down a bit, and also much effort is put to perform the record management in accordance with law. The record management includes all the works like production, classification, organization, transfer, collection, evaluation, disuse, preservation, opening to the public and application. Among them, the record transfer is an important work that performs the initial stage in which the main agent of management is changed from administration department to record center. Thus this study suggested the improvement measures for non-electronic record transfer after examining the current transfer state of 16 local governments in Busan region and also problems occurring in the process of transfer through interviews with institutional records managers.
Kim, Dae-eok;Han, Da-young;Kim, Sang-ho;Chung, Dae-kyoo
Journal of Oriental Neuropsychiatry
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v.29
no.3
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pp.121-134
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2018
Objectives: The purpose of this in vivo study is to observe anti-amnesic effects of Yeongkyekamjotanggayonggolmoryo (YGYM), a novel mixed herbal prescription, Ossis Mastodi and Ostreae Testa added Yeongkyekamjo-tang, on scopolamine induced amnesia in C57BL/6 mice through acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effects. Methods: Six groups, total 20 intact or 100 Sco treated mice were used in this study after one week of acclimatization period. Half the animals were used for passive avoidance task tests and hippocampus ACh content, AChE activity, and ChAT mRNA expression were measured. The other half was subjected to an underwater maze test and then the cerebral cortex antioxidant defense system was measured. Results: In the passive avoidance experiment, there was significant decrease in residence time in the bright room and in the underwater maze test, escape latency to escape from the esophagus significantly increased compared with the normal control group. At the final sacrifice, ACh content and ChAT mRNA expression decreased, AChE activity increased, and cerebral cortical MDA increased GSH content, SOD and CAT activity in Sco control mice, as compared to intact vehicle control mice. However, these Sco treatment-related memory loss through AChE activation destroyed the cerebral cortex antioxidant defense system, and was inhibited dose-dependently by 28 days consecutive oral pretreatments of YGYM extracts 500, 250, 125 mg/kg. Conclusions: In the above results, YGYM extract that oral administration of YGYM extracts alleviates the antioxidant defense system, through preservation of ACh mediated by upregulation of ChAT mRNA expression, and increase of AChE inhibition and brain antioxidant defense systems.
In this study, strengths related with fire investigation of fire stations are analyzed and methods for the capacity building of their fire cause investigation are suggested. The methods for capacity building of fire cause investigation suggested are focused on using potential and strengths of current fire fighting and enhancing internal capacity rather than reinforcing investigation personnel, organization, and equipment and ensuring investigation power. The methods suggested in this study are as follows. 1) Because fire investigation results are the basis of fire administration, fire marshals should change their awareness of the need of fire investigation; 2) A fire investigation system should be established to ensure statements of people concerned systematically; 3) A substantial system of fire cause investigation should be established to investigate fire scenes more than twice; 4) A substantial system of fire cause investigation should be established to use such materials as CCTV; 5) Extinguishing should be made in consideration of fire cause investigation and a scene preservation system after extinguishing should be established; 6) A fire investigation system should be established in connection with 119 first-aid and rescue teams and 7) Steps to raise the morale of fire investigation staff should be taken.
Journal of the Korean Society of Environmental Restoration Technology
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v.16
no.4
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pp.99-114
/
2013
In this study, constructability of ecologocal stream restoration process was evaluated and improved approaches for habitat were suggested. The study site is Gucheon River in Geoje city where conducted ecologocal restoration work within maintaining its flood control function. Application of ecological design factors and constructability in the process from planning to construction was analyzed and its results are as follows: In the process of planning and designing, it was focused more on the naturality of Gucheon River rather than the human convinience and ecological design factors were applied within the ecological capacity of the site. First, the indexes for constructability evaluation is selected. It was classified into three major categories as construction quality, design quality and construction administration system. Each index has details, so there are twenty sub indexes for contractibility evaluation. Second, the evaluation results shows that the index most in need of improvement was plumbing construction, followed by Stone construction and pavement construction. design concept was evaluated as appropriate in entire categories. Finally it is suggested that it can be improved in both process of design to enhance the technology and process of construction to enhance the quality management. The constructability of ecological stream needs adaptive management and it must be discussed with its designing which is at the stage before construction. Also it needs discussion with its designer constantly and feed-back process.
The purpose of this study was to figure out clinical characteristics in young and adult acute myocardial infarction patients come to emergency room. One hundred fifty four acute myocardial infarction cases were collected and analized from January 2003 to April 2006, especially focused on below the age 50. The results of the study were summarized as follows. The results were proportion up disease occur to women disease rate as men after 50 age and acute myocardial infarction occur to spring and winter most of all. Research for this patients coronary artery condition in cardiac angiography room and coronary artery condition is left anterior descending portion was obstruction and stenosis most of all at that time in emergency room. HDL-cholesterol was not normal range of this patients. About 57.9% patients downward normal range but total cholesterol was very variant condition. Investigated chest X-ray of this patients and result in upward 75% patients was C-T ratio 50% upward condition. And it was shown result from this patients 94. 7% was obesity condition and family history showed mother or father got hypertension or diabete mellitus patients but 42. 7% patients not family history. This patients not going to direct emergency room after via local medical center result in badly condition up. Have got outcomes of youth and adults age patient of acute myocardial infarction come to emergency room. Government and administration have to support advertising this results about acute myocardial infarction condition of nation people. We need to preservation and preventing this disease but if this disease occurrence, to the utmost directly and speedly emergency room for fast therapy.
In general, collections in museum are kept in storage according to a preservation and administration program in long or short term, after conservators' conservation treatment. Museum activities related to conservation science are common to do before and after exhibitions. That is, the museum collections include a flow mechanism, which circulate a space in where conservation science related activity is carried on centering around its storage. The purpose of this study is to suggest the design guidelines of a conservation area in a museum. The results of this study as follows. First, to program space planning, conservation area of museum is divided into 4 kinds of zone. Second, space for relics unloading in basically includes 'unloading room', 'control room', 'worker room', 'unpacking room', and 'unloading tools storage' and considers to install 'outdoor arrangement space', etc. In case of space for making relics collections, 'arrangement room' and 'temporary storage' are separately planned in order to arrange and temporarily store relics taken in. Conservation analysis space should be divided into 2 kinds of zone, 'conservation analysis lab' for analysis of collection characters and 'restoration lab' for conservation treatment in the bigger museum. In case of large-scale museum, conservation treatment space is basically classified with characters of museum collections. And it considers installing 'waterlogged wood lab', 'painting clothes treatment lab', 'storage of treated relics' etc. Third, for 'the spaces for analysis treatment', must consider activity contents and sizes of the department for scientific conservation every museum, can classify in detail required space, and must review the space for relics settlement in construction.
The Mural Tomb of Xu Xianxiu(AD 571), a high ranking official in Northern Qi period, is located in Taiyuan, Shanxi province, China. Despite having been raided, it was still discovered to contain over 530 pieces, such as artifacts and murals, in excellent state of preservation. These murals are noteworthy for their high level of detail compared to other murals from the same era, and are important for understanding the historical context of active East-West and Han-Hu cultural exchange in the $6^{th}$ to $7^{th}$ century. The murals of Xu Xianxiu's tomb depict round-collared and narrow-sleeved garments as well as straight collared robes typical of the Xianbei tribe's attire. Notable are the ermine fur overcoat and a headwear with flares on the left and right thought to be unique to the Xianbei. The wife and female servants show female attire of the Xianbei at the time; this attire can be characterized by narrow-sleeved long gowns and asymmetrical flying-bird buns. Despite the anti-Han policy of Northern Qi, influences such as the right sided gathering of the robes and embellished hair styles remain. The procession also depicts the three-cornered headdress and long-tailed hood of the Xianbei men, which have been recorded in documents. The large rounded pearl pattern containing the palmette, the divine animal, and bodhisattva's head motifs show the influence of the Western China [Xi'yu]. Considering that Northern Qi had more active interactions with the three ancient kingdoms of Korea than with the Southern Kingdoms[Nanchao], the findings of this study call for further research on the correlation between the attire of ancient Korea and Northern Qi.
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