• 약학회지
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• 제25권3호
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• pp.109-114
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• 1981

The authors investigated drug interaction of ibuprofen and prednisolone in antiinflammatory and antipyretic activities. We have found significant differences of the antiinflammatory and antipyretic activities between single and concurrent administration of ibuprofen and prednisolone, using Sprague-Dawley Strain rats, carrageenin as a phlogistic agent and brewer's yeast as a fever inducing agent. 1) Ibuprofen(20mg/kg) was administered to the rats orally and resulted in significant reduction of (31.70 %) the swelling of rat paw induced by carrageenin, 2) prednisolone (9mg/kg) showed significant reduction of (45.76%) the swelling, 3) concurrent administration of ibuprofen (20mg/kg) and prednisolone (9mg/kg) also reduced (57.40%) the swelling. In ibuprofen (125mg/kg) administration, the inhibition rate of edema was 39.32% and in prednisolone (1mg/kg) administration, the rate was 39.04%. In concurrent administration of ibuprofen (125mg/kg) and prednisolone (1mg/kg), the inhibition rate of edema was 63.09%. Concurrent administration of ibuprofen and prednisolone showed more anti-inflammatory effects than single administration of ibuprofen and prednisolone respectively. Prednisolone itself did not show antipyretic effect, but concurrent administration of ibuprofen and prednisolone showed more antipyretic effects than ibuprofen single administratron.

• Journal of Pharmaceutical Investigation
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• 제4권4호
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• pp.26-37
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• 1974

Having measured physical canstant and dissolution rate of prednisolone powder, and tablets, also particle size, particle number of powder disintegration, hardness, friability of prednisolone tablets and having also compared it's interrelationship. We obtained the results as following. 1) Dissolution rate of prednisolone powder was determinded cube root rule and: the slope $({\alpha})$ was $3.1915{\times}10^{-2}$. 2) The tablet used in this study was fourteen kind of prednisolone tablets, two kinds of which were not conformity with prednisolone dissolution rate test of U.S.P. XVIII, but the rest of them were conformity with the same test (t60% was 4.3minute in average) 3) There was no significant interrelationship between disintegration, hardness, friability and dissolution rate of prednisolone tablet used in this study but we recognized the disintegration time was greatly influenced by the dissolution rate.

• 약학회지
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• 제22권3호
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• pp.128-137
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• 1978

Aspirin and prednisolone have been used alone or in combination in the treatment of rheumatic diseases. We have investigated the significance of the difference of the anti-inflammatory and antipyretic activities between single and concurrent administration of aspirin and prednisolone in rats by using carrageenan as a phlogistic agent and brewer's yeast as a fever inducing agent. When prednisolone (9mg/kg) and aspirin (24mg/kg) were administered orally alone or in combination, both of the concurrent and single adminstration inhibited highly significantly the swelling of rat paw and the concurrent adminstraiton of aspirin and prednisolone showed the significantly higher inhibitory effects than aspirin single adminstration did, whereas there were not any significant differences between the prednisolone single adminstration and combined adminstration. The combined drug of aspirin and prednisolone marketed in Korea contains 148mg of aspirin and 1.15mg of prednisolone in a tablet. Therefore, we examined the anti-inflammatory and antipyretic activities of aspirin (150mg/kg), prednisolone (1mg/kg) and their combination. In anti-inflammatory effects, both of the concurrent and single administration inhibited higly significantly the swelling of rat paw, and the concurrent adminstration exhibited the significantly higher inhibitory effects than aspirin or prednisolon alone did. In antipyretic effects both of the concurrent and the single adminstration reduced significantly the brewer's yeast-induced fever. The effect of concurrent administration was greater than that of prednisolone single adminstration, whereas the effect of aspirin single adminstration was similar to that of combination. The results suggest that the anti-inflammatory and antipyretic effects are intensified by the concurrent adminstration of aspirin and prednisolone, but the antipyretic effects of enough doses of aspirin (150mg/kg) is comparable to that of the combination preparation.

• 한국미생물·생명공학회지
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• 제2권3호
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• pp.127-131
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• 1974

Hydrocortisone에서 Prednisolone을 발효학적으로 제조함에 있어서 발생하는 산화분해 현상을 방지하기 위하여 저해제를 이용한 방법이 연구되었다. 첫째, A. simplex (ATCC 6946)의 생균을 사용하여 발효시키는 과정에서 Prednisolone이 분해된다는 현상을 밝혔다. 발효후 3시간만에 기질인 hydrocortisone의 72% 이상이 prednisolone으로 전환되었으나 시간이 경과하여 8시간이 지나면 이균의 생균세포는 상당량의 prednisolone을 산화 분해하였으며 한편으로는 분해중간산물을 생성하였다. 두째로는, prednisolone의 산화분해를 억제하기 위하여 $\alpha$$\alpha$'-dipyridyl과 같은 chelating agents를 발효액에 첨가하였다. 그 결과 이균의 생균세포에 의한 steroid 핵의 산화분해는 현저히 억제되었으며 또한 산화중간산물이 축적되었다. 이 중간산물은 $\alpha$$\alpha$'-dipyridyl의 첨가에 의하여 한층 현저하게 나타났다.

• 한국미생물·생명공학회지
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• 제17권1호
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• pp.24-28
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• 1989

미생물에 의해 hydrocortisone을 $\Delta$'-dehydrogenation하여 prednisolone 생산을 위한 공정에 있어 여러 발효변수들의 영향이 조사되었다. 미생물 전환공정은 pseudo-crystallo-fermentation 방법을 이용하였으며, 생물 전환을 위한 최적 온도는 35$^{\circ}C$였다. 발효배지의 초기 pH 6.5-7.8 범위에서는 prednisolone 생산에 pH의 영향이 거의 없었으며, 또한 계면활성제 Tween 80의 영향도 거의 없는 것으로 나타났다. Prednisolone의 생산속도는 소포제 neolin 을 첨가함으로써 현저하게 감소하였다. 발효조 조업시에는 높은 공기주입 속도로 인해 발생되는 기포를 제거하기 위해 많은 양의 소포제가 사용되었으며, 따라서 shake flask 조업시보다 prednisolone 생산속도가 낮은 것으로 나타났다.

• 대한수의학회지
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• 제23권2호
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• pp.149-151
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• 1983

Prednisolone acetate was administered in deers sedated with xylazine hydrochloride. Sleeping time in deers given prednisolone after xylazine sedation was shortened a little in Red deers, approximately one half in Elk and Sika deers comparing with deers sedated with xylazine alone. It was proved that prednisolone acetate shortened the recovery time of deers sedated with xylazine hydrochloride.

• Parasites, Hosts and Diseases
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• 제23권1호
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• pp.165-172
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• 1985

Naegleria fowleri의 감염에 의한 생쥐의 원발성 아메바성 뇌수막염의 발생에 prednisolone투여가 어떠한 영향을 주는가를 관찰한 바 다음과 같은 결론을 얻었다. 1. 각 실험군 별로 $1{\times}10^5$의 N. fowleri를 감염시킨 후 생존기간을 관찰하였더니, prednisolone을 투여한 제1군의 평균 생존기간은 10.2일, 제2군은 10.6일, 제3군은은 11.3일로써 prednisolon을 투여한 군이 비투여군에 비하여 유의하게 생존기간이 단축됨을 알 수 있었으며, prednisolon투여군인 제1, 2, 3군 사이에 유의한 차이는 없었으나 전투여군인 제1군에서 생존시간이 단축되는 경향을 나타내었다. 2. 각 실험군 별로 감염 이후 20일까지 체중의 변화를 관찰한 결과, prenisolone 투여군에서는 서로 비슷한 양상을 나타내었는데 투여하는 시기부터 어느 정도 감소하다가 일정한 시간이 지나면서 회복현상을 나타내었다. 또한 prednisolon만 투여한 제 IV군에 비하여 제1, 2, 3군에서 체중이 더욱 심하게 감소하는 현상을 나타내었다. 그리고 대조군은 감염 8일 후부터 감소하기는 하였으나 큰 차이는 없는 것으로 보아 체중감소현상은 주로 prednisolone에 의해 영향을 받는 것으로 보인다. 3. Prednisolone 투여한 감염군은 대조군에 비하여 뇌와 폐조직에서 비교적 심한 병변이 나타났음을 알 수 있었다. 4. 감염된 생쥐의 임상증세는 감염 후 며칠이 지나면 머리를 비비고 고개를 떨구며, 식욕부진이 나타나 먹이를 먹지 않다가 발작이 오고, 빈사상태가 되어 사망하게 된다. 대부분의 생쥐에서 이러한 증세가 나타나는데, prednisolone 투여군에서는 감염 5일 이후부터 증세가 나타나는 경향을 보였고, 대조군은 감염 8일 이후에야 나타나 10일경에 사망하였다. 이상의 결과를 종합항 보면 prednisolone을 투여하여 인위적으로 면역반응을 억제시켜 줄 경우 N. fowleri에 감염된 생쥐의 생존기간은 단축되고 병변도 더욱 심하게 나타나며, 감염전에 투여해 주는 것이 가장 치명적인 영향을 줄 수 있음을 알 수 있었다.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.964-968
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• 2002

Colon drug delivery is advantageous in the treatment of colonic disease and oral delivery of drugs unstable or suceptible to enzymatic degradation in upper GI tract. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of prednisolone. Variously coated tablets containing prednisolone were fabricated using chitosan and cellulose acetate phthalate (CAP) as coating materials. Release aspects of prednisolone in simulated gastrointestinal fluid and rat colonic extracts (CERM) were investigated. Also, colonic bacterial degradation study of chitosan was performed in CERM. From these results, a three layer (CAP/Chitosan/CAP) coated system exhibited gastric and small intestinal resistance to the release of prednisolone in vitro most effectively. The rapid increase of prednisolone in CERM was revealed as due to the degradation of the chitosan membrane by bacterial enzymes. The designed system could be used potentially used as a carrier for colon delivery of prednisolone by regulating drug release in stomach and the small intestine.

• Journal of Pharmaceutical Investigation
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• 제5권3호
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• pp.58-65
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• 1975

In the preparation of prednisolone tablets, when microfine cellulose$(Elcema^{\circledR})$ was used as diluents, stability and physical characteristics of prednisolone tablets are as follows; 1. Weight of the plain $Elcema^{\circledR}$ tablets increased by 75% of relative humidity and hardness was weakend, but the temperature $(60^{\circ}C)$ caused no change of thickness and decreased the weight and hardness. 2. In experimental tableting of prednisolone tablets, the addition of $Elcema^{\circledR}$ caused no difficulty in direct compression method, and the shortening of the disintegration time and increase of the hardness were satisfactory. 3. Dissolution rate test exhibited the result similiar to disintegration test. 4. In the comparison test of $Elcema^{\circledR}$ and $Avicel^{\circledR}$ as adjuvants the physical constants of prednisolone tablets showed nearly a similar tendency.

• 한국임상수의학회지
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• 제39권4호
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• pp.192-196
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• 2022

A two-year-old, intact male, 45 kg Doberman Pinscher was referred with dermal nodular lesions affecting the left hindlimb. The cytological examination revealed eosinophilic inflammation. Skin biopsy specimens showed canine eosinophilic granuloma (CEG). The dog was administered oral prednisolone (1.5 mg/kg/day) and azathioprine (2 mg/kg/day). After one week, the skin lesions diminished dramatically, but the dog presented with severe watery diarrhea. The prednisolone dose was reduced by 0.9 mg/kg/day. The lesions and diarrhea improved markedly after one week. Prednisolone was tapered by 25% of the previous dose every week to 0.2 mg/kg/day. Azathioprine was also reduced to therapy every other day. After seven weeks of combination treatment, the medications were withdrawn, but the dog had a recurrence one week later. Azathioprine (2 mg/kg/EOD) was reintroduced for two weeks. There was no relapse after all the medications had been withdrawn. This case indicates that CEG can be managed with prednisolone and azathioprine. Azathioprine may be an effective adjunctive immunosuppressive agent, and may be considered as a well-tolerated prednisolone sparing agent to treat CEG.