• YAKHAK HOEJI
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• v.25 no.3
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• pp.109-114
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• 1981

The authors investigated drug interaction of ibuprofen and prednisolone in antiinflammatory and antipyretic activities. We have found significant differences of the antiinflammatory and antipyretic activities between single and concurrent administration of ibuprofen and prednisolone, using Sprague-Dawley Strain rats, carrageenin as a phlogistic agent and brewer's yeast as a fever inducing agent. 1) Ibuprofen(20mg/kg) was administered to the rats orally and resulted in significant reduction of (31.70 %) the swelling of rat paw induced by carrageenin, 2) prednisolone (9mg/kg) showed significant reduction of (45.76%) the swelling, 3) concurrent administration of ibuprofen (20mg/kg) and prednisolone (9mg/kg) also reduced (57.40%) the swelling. In ibuprofen (125mg/kg) administration, the inhibition rate of edema was 39.32% and in prednisolone (1mg/kg) administration, the rate was 39.04%. In concurrent administration of ibuprofen (125mg/kg) and prednisolone (1mg/kg), the inhibition rate of edema was 63.09%. Concurrent administration of ibuprofen and prednisolone showed more anti-inflammatory effects than single administration of ibuprofen and prednisolone respectively. Prednisolone itself did not show antipyretic effect, but concurrent administration of ibuprofen and prednisolone showed more antipyretic effects than ibuprofen single administratron.

• Journal of Pharmaceutical Investigation
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• v.4 no.4
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• pp.26-37
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• 1974

Having measured physical canstant and dissolution rate of prednisolone powder, and tablets, also particle size, particle number of powder disintegration, hardness, friability of prednisolone tablets and having also compared it's interrelationship. We obtained the results as following. 1) Dissolution rate of prednisolone powder was determinded cube root rule and: the slope $({\alpha})$ was $3.1915{\times}10^{-2}$. 2) The tablet used in this study was fourteen kind of prednisolone tablets, two kinds of which were not conformity with prednisolone dissolution rate test of U.S.P. XVIII, but the rest of them were conformity with the same test (t60% was 4.3minute in average) 3) There was no significant interrelationship between disintegration, hardness, friability and dissolution rate of prednisolone tablet used in this study but we recognized the disintegration time was greatly influenced by the dissolution rate.

• YAKHAK HOEJI
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• v.22 no.3
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• pp.128-137
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• 1978

Aspirin and prednisolone have been used alone or in combination in the treatment of rheumatic diseases. We have investigated the significance of the difference of the anti-inflammatory and antipyretic activities between single and concurrent administration of aspirin and prednisolone in rats by using carrageenan as a phlogistic agent and brewer's yeast as a fever inducing agent. When prednisolone (9mg/kg) and aspirin (24mg/kg) were administered orally alone or in combination, both of the concurrent and single adminstration inhibited highly significantly the swelling of rat paw and the concurrent adminstraiton of aspirin and prednisolone showed the significantly higher inhibitory effects than aspirin single adminstration did, whereas there were not any significant differences between the prednisolone single adminstration and combined adminstration. The combined drug of aspirin and prednisolone marketed in Korea contains 148mg of aspirin and 1.15mg of prednisolone in a tablet. Therefore, we examined the anti-inflammatory and antipyretic activities of aspirin (150mg/kg), prednisolone (1mg/kg) and their combination. In anti-inflammatory effects, both of the concurrent and single administration inhibited higly significantly the swelling of rat paw, and the concurrent adminstration exhibited the significantly higher inhibitory effects than aspirin or prednisolon alone did. In antipyretic effects both of the concurrent and the single adminstration reduced significantly the brewer's yeast-induced fever. The effect of concurrent administration was greater than that of prednisolone single adminstration, whereas the effect of aspirin single adminstration was similar to that of combination. The results suggest that the anti-inflammatory and antipyretic effects are intensified by the concurrent adminstration of aspirin and prednisolone, but the antipyretic effects of enough doses of aspirin (150mg/kg) is comparable to that of the combination preparation.

• Microbiology and Biotechnology Letters
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• v.2 no.3
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• pp.127-131
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• 1974

Inhibition of over-oxidation of prednisolone in the fermentation has been studied by using vegetative cells as enzyme source. firstly, A. simplex (ATCC 6946) was demonst.ated to degrade p.ednisolone in the vegetative culture of the microorganism. Over 72％ of hydrocortisone was transformed into prednisoloneby 3 hours of the fermentation. However, the prednisolone produced was considerably oxidized forming over-oxidation product in 8hours of fermentation period with the intact cells. Secondly, in order to depress the over-oxidation and the breakdown of the steroid skeleton of prednisolone, chelating agents such as $\alpha$$\alpha$'-dipyridyl, o-phenanthroline and 8-hydroxyruinoline were added to the fermentation broth. Conseauently, the breakdown of prednisolone by the iutact cells was able to be remarkably retatded and an intermediate regarded as an oxidized product derived from prednisolone was accumulated, by the addition of $\alpha$$\alpha$'-dipytidyl in the fermentation.

• Microbiology and Biotechnology Letters
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• v.17 no.1
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• pp.24-28
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• 1989

Effect of various fermentation parameter was investigated on the production of prednisolone by microbial $\Delta$'-dehydrogenation of hydrocortisone. The microbial conversion process was conducted by using pseudo-crystallo-fermentation techniques. The optimum temperature for the bioconversion process was found to be 35$^{\circ}C$. It was noted that the production rate of prednisolone was little affected within the initial pH range of 6.5-7.8, and also by the use of surfactant, Tween 80. Production rate of prednisolone was significantly reduced by the use of the antifoam agent, neolin. In a fermentor operation, however, large amount of antifoam agent should be used to remove foams generated by the high aeration rate, which resulted in n lower production rate of prednisolone than that from the shake flask experiment.

• Korean Journal of Veterinary Research
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• v.23 no.2
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• pp.149-151
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• 1983

Prednisolone acetate was administered in deers sedated with xylazine hydrochloride. Sleeping time in deers given prednisolone after xylazine sedation was shortened a little in Red deers, approximately one half in Elk and Sika deers comparing with deers sedated with xylazine alone. It was proved that prednisolone acetate shortened the recovery time of deers sedated with xylazine hydrochloride.

• Parasites, Hosts and Diseases
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• v.23 no.1
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• pp.165-172
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• 1985

Present study aimed to elucidate the immunosuppressive effect of prednisolone on Naegleria fowlsri infection in mice. N. fowleri was cultured in CGVS medium (Willert and Le Ray, 1973) . White female mice, weighing about 18g, used for experiments were divided into five groups; untreated control group, prednisolone treated groups (before, during and after infection), and only prednisolone treated group. In the prednisolone treated group, the hormone was injected intramuscularly 5 doses of 10 mg/kg every other day. According to designated time of treatment, each mouse was challenged with $1{\times}10^5$ N. fowleri intranasally. Changes of body weights, clinical manifestations and number of dead mouse were observed. Brain and lung tissues of dead mice were cultured in the non-nutrient agar (Kasprzak and Mazur, 1972), or stained with hematoxylin.rosin for the examination of histopathological changes. Results of the experiment are summarized as follows: Mortality among the prednisolone treated groups was higher than that in untreated control group, and among the treated groups, the pretreated group showed shorter survival time. Body weights among untreated control mice showed no significant increase, however, treated groups of mice showed the decrease during the administration and recovery of the weights were observed at 2 to 3 days after the completion of treatment. In the treated control groups, the infected mice began to show the pathologic findings 5 days after infection while, the untreated mice began to show the findings 8 days after infection. Tissue damages in brain and lung occurred due to virulence of amoeba were more severe among treated mice than that in untreated control group. The above mentioned results suggest that the treatment with prednisolone weaken the resistance of mice against N. fowleri infection, and probably induce more severe primary amoebic meningoencephalitis. Especially severe pathological findings were shown in pre-treated group, compared with untreated group.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.964-968
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• 2002

Colon drug delivery is advantageous in the treatment of colonic disease and oral delivery of drugs unstable or suceptible to enzymatic degradation in upper GI tract. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of prednisolone. Variously coated tablets containing prednisolone were fabricated using chitosan and cellulose acetate phthalate (CAP) as coating materials. Release aspects of prednisolone in simulated gastrointestinal fluid and rat colonic extracts (CERM) were investigated. Also, colonic bacterial degradation study of chitosan was performed in CERM. From these results, a three layer (CAP/Chitosan/CAP) coated system exhibited gastric and small intestinal resistance to the release of prednisolone in vitro most effectively. The rapid increase of prednisolone in CERM was revealed as due to the degradation of the chitosan membrane by bacterial enzymes. The designed system could be used potentially used as a carrier for colon delivery of prednisolone by regulating drug release in stomach and the small intestine.

• Journal of Pharmaceutical Investigation
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• v.5 no.3
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• pp.58-65
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• 1975

In the preparation of prednisolone tablets, when microfine cellulose$(Elcema^{\circledR})$ was used as diluents, stability and physical characteristics of prednisolone tablets are as follows; 1. Weight of the plain $Elcema^{\circledR}$ tablets increased by 75% of relative humidity and hardness was weakend, but the temperature $(60^{\circ}C)$ caused no change of thickness and decreased the weight and hardness. 2. In experimental tableting of prednisolone tablets, the addition of $Elcema^{\circledR}$ caused no difficulty in direct compression method, and the shortening of the disintegration time and increase of the hardness were satisfactory. 3. Dissolution rate test exhibited the result similiar to disintegration test. 4. In the comparison test of $Elcema^{\circledR}$ and $Avicel^{\circledR}$ as adjuvants the physical constants of prednisolone tablets showed nearly a similar tendency.

• Journal of Veterinary Clinics
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• v.39 no.4
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• pp.192-196
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• 2022

A two-year-old, intact male, 45 kg Doberman Pinscher was referred with dermal nodular lesions affecting the left hindlimb. The cytological examination revealed eosinophilic inflammation. Skin biopsy specimens showed canine eosinophilic granuloma (CEG). The dog was administered oral prednisolone (1.5 mg/kg/day) and azathioprine (2 mg/kg/day). After one week, the skin lesions diminished dramatically, but the dog presented with severe watery diarrhea. The prednisolone dose was reduced by 0.9 mg/kg/day. The lesions and diarrhea improved markedly after one week. Prednisolone was tapered by 25% of the previous dose every week to 0.2 mg/kg/day. Azathioprine was also reduced to therapy every other day. After seven weeks of combination treatment, the medications were withdrawn, but the dog had a recurrence one week later. Azathioprine (2 mg/kg/EOD) was reintroduced for two weeks. There was no relapse after all the medications had been withdrawn. This case indicates that CEG can be managed with prednisolone and azathioprine. Azathioprine may be an effective adjunctive immunosuppressive agent, and may be considered as a well-tolerated prednisolone sparing agent to treat CEG.