• Nuclear Engineering and Technology
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• v.41 no.9
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• pp.1215-1222
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• 2009

The present work pertains to a research program to study Molten Fuel-Coolant Interactions (MFCI), which may occur in a nuclear power plant during a hypothetical severe accident. Dynamics of the hot liquid (melt) droplet and the volatile liquid (coolant) were investigated in the MISTEE (Micro-Interactions in Steam Explosion Experiments) facility by performing well-controlled, externally triggered, single-droplet experiments, using a high-speed visualization system with synchronized digital cinematography and continuous X-ray radiography. The current study is concerned with the MISTEE-NCG test campaign, in which a considerable amount of non-condensable gases (NCG) are present in the film that enfolds the molten droplet. The SHARP images for the MISTEE-NCG tests were analyzed and special attention was given to the morphology (aspect ratio) and dynamics of the air/ vapor bubble, as well as the melt drop preconditioning. Energetics of the vapor explosion (conversion ratio) were also evaluated. The MISTEE-NCG tests showed two main aspects when compared to the MISTEE test series (without entrapped air). First, analysis showed that the melt preconditioning still strongly depends on the coolant subcooling. Second, in respect to the energetics, the tests consistently showed a reduced conversion ratio compared to that of the MISTEE test series.

• Archives of Pharmacal Research
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• v.28 no.12
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• pp.1392-1399
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• 2005

This study evaluated the effect of $\alpha$-tocopherol ($\alpha$-TC), ischemic preconditioning (IPC) or a combination on the extent of mitochondrial injury caused by hepatic ischemia/reperfusion (I/R). Rats were pretreated with $\alpha$-TC (20 mg/kg per day, i.p.) for 3 days before sustained ischemia. A rat liver was preconditioned with 10 min of ischemia and 10 min of reperfusion, and was then subjected to 90 min of ischemia followed by 5 h or 24 h of reperfusion. I/R increased the aminotransferase activity and mitochondrial lipid peroxidation, whereas it decreased the mitochondrial glutamate dehydrogenase activity. $\alpha$-TC and IPC individually attenuated these changes. $\alpha$-TC combined with IPC ($\alpha$-TC+IPC) did not further attenuate the changes. The mitochondrial glutathione content decreased after 5 h reperfusion. This decrease was attenuated by $\alpha$-TC, IPC, and $\alpha$-TC+IPC. The significant production of peroxides observed after 10 min reperfusion subsequent to sustained ischemia was attenuated by $\alpha$-TC, IPC, and $\alpha$-TC+IPC. The mitochondria isolated after I/R were rapidly swollen. However, this swelling rate was reduced by $\alpha$­TC, IPC, and $\alpha$-TC+IPC. These results suggest that either $\alpha$-TC or IPC reduces the level of mitochondrial damage associated with oxidative stress caused by hepatic I/R, but $\alpha$- TC combined with IPC offers no significant additional protection.

• Journal of Chest Surgery
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• v.34 no.11
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• pp.809-822
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• 2001

Background: Ischemic preconditioning(IP) is known to be effective in the protection of myocardial necrosis, arrhythmia, and the restoration of the myocardial function in the ischemia-reperfusion state of the heart. However the exact mechanism is not clearly understood. The purpose of this study was to elucidate the trigger mechanism 7f IP on the restoration of the myocardial function after ischemia-reperfusion. Material and Method: By connecting a Langendorff perfusion apparatus with an isolated heart of a rat, the normal temperature of the heart was maintained. The experiment was conducted in seven groups, which were divided according to the preconditioning stimuli and blockage methods Group I(n=10) was a group without IP, Group II(n=10) a group of three-minute IP, Group III(n=10) a group of PEIP, Group IV(n=10) a group of clonidine IP, Group V(n=10) a group of If after reserpine, Group Vl(n=10) a group of PE & prazosin IP, and Group Vll(n=10) a group of clonidine & yohimbine IP. Hemodynamic parameters of DP, LVEDP, $\pm$dP/dT and the changes of perfusion in the coronary artery were evaluated. Result: Developed pressure and +dP/dT changed per unit time. After 20 minutes of reperfusion, those of Group II and III were 63.1$\pm$3.7%, 64.8$\pm$4.6% and 64.5$\pm$4.6%, 63.8$\pm$4.4%, which improved more significantly than those of Group I(P<0.05), However, there were no significant differences between the Groups V and Vl, and Group I. Conclusion: The Brief ischemic preconditioning and pharmacological preconditioning using $\alpha$-receptor sympatho-mimetics have protecting effects on the restoration of myocardial function after reperfusion. And the protecting effect of preconditioning seems to be related to sympathetic neurotransmitters and to the selective action of the $\alpha$$_1$-adrenergic receptor.

• 한국전산유체공학회:학술대회논문집
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• 2009.11a
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• pp.177-184
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• 2009

Cavitating flow simulation is of practical importance for many engineering systems, such as marine propellers, pump impellers, nozzles, injectors, torpedoes, etc. The present work has focused on the simulation of cavitating flow past cylinders with strong side flows. The governing equation is the Navier-Stokes equation based on the homogeneous mixture model. The momentum and energy equation is in the mixture phase while the continuity equation is solved liquid and vapor phase, separately. An implicit dual time and preconditioning method are employed for computational analysis. For the code validation, the results from the present solver have been compared with experiments and other numerical results. A fairly good agreement with the experimental data and other numerical results have been obtained. After the code validation, the strong side flow was applied to include the wake flow effects of the submarine or ocean tide.

• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.149-154
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• 2009

The cavitating flow simulation is of practical importance for many engineering systems, such as marine propellers, pump impellers, nozzles, injectors, torpedoes, etc. The present work has focused on the simulation of cavitating flow past cylinders with strong side flow. The governing equation is the Navier-Stokes equation based on homogeneous mixture model. The momentum and energy equation is in the mixture phase while the continuity equation is solved liquid and vapor phase, separately. An implicit dual time and preconditioning method are employed for computational analysis. The results from the present solver have been in a fairly good agreement with the experimental data and other numerical results. After the code validation the strong side flow was applied to include the wake flow effect of the submarine.

• Journal of computational fluids engineering
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• v.9 no.3
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• pp.57-65
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• 2004

The incompressible Navier-Stokes equations in two dimensions are stabilized by a modified residual method, and then discretized by hierarchical elements. The stabilization is necessary to escape from the Ladyzhenskaya-Babuska-Brezzi(LBB) constraint and hence to achieve an equal order formulation. To expedite a standard iterative method such as the conjugate gradient squared(CGS) method, a preconditioning technique called the Hierarchical Iterative Procedure(HIP) has been applied. In this paper, we increased the order of interpolation within an element up to cubic. The hierarchical elements have been used to achieve a higher order accuracy in fluid flow analyses, but a proper efficient iterative procedure for higher order finite element formulation has not been available so far The numerical results by the present HIP for the lid driven cavity flow and others showed the present procedure to be stable, very efficient and useful in flow analyses in conjunction with hierarchical elements.

• 한국전산유체공학회:학술대회논문집
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• 2005.10a
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• pp.169-177
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• 2005

A high resolution scheme for solving gas-liquid two-phase flows with cavitation is described. This scheme uses the curvilinear coordinate grid and solves the density based momentum equations for mixture of gas-liquid medium with a preconditioning method to treat both compressible and incompressible flow characteristics. The present preconditioned method is based on the Runge-Kutta explicit finite-difference scheme, and is improved by using the diagonalization, the flux difference splitting and the MUSCL-TVD schemes to save computational effort and to increase stability and resolvability, especially at gas-liquid contact surfaces. A homogeneous equilibrium cavitation model is used to treat the gas-liquid two-phase medium in cavitating flow as a locally homogeneous pseudo-single-phase medium. Therefore, it is easy to solve cavitating flow, including wave propagation, large density changes and incompressible flow characteristic at low Mach number. Some numerical results obtained by the present scheme are shown.

• 한국연소학회:학술대회논문집
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• 2005.10a
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• pp.269-272
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• 2005

Due to the high density and heating value, liquid fuel is attractive for ramjet propulsion system. Liquid fuel requires time to evaporation and mix with incoming air before ignition; insufficient evaporation and mixing result in low combustion efficiency and instability. So the numerical studies are conducted to investigate the spray and combustion characteristics of a liquid-fueled dump type Integrated Rocket Ramjet combustor. The governing equations are solved by means of a finite-volume using time derivative preconditioning method for chemical reacting flow. The liquid phase is treated by solving Lagrangian equations of motion and transport for the life histories of a statistically significant sample of individual droplets.

• Journal of applied mathematics & informatics
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• v.15 no.1_2
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• pp.299-312
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• 2004

ILUS factorization has many desirable properties such as its amenability to the skyline format, the ease with which stability may be monitored, and the possibility of constructing a preconditioner with symmetric structure. In this paper we introduce a new preconditioning technique for general sparse linear systems based on the ILUS factorization strategy. The resulting preconditioner has the same properties as the ILUS preconditioner. Some theoretical properties of the new preconditioner are discussed and numerical experiments on test matrices from the Harwell-Boeing collection are tested. Our results indicate that the new preconditioner is cheaper to construct than the ILUS preconditioner.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.115-121
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• 2010

Cavitating flow is widely shown in many engineering systems, such as marine propellers, pump impellers, nozzles, injectors, torpedoes, etc. The present work focuses on the numerical analysis of the multiphase flow around the underwater vehicle which was launched from a submarine. The governing equation is the Navier-Stokes equation with a homogeneous mixture mode. The multiphase flow solver uses an implicit preconditioning scheme in curvilinear coordinate. For the code validation, the results from the present work are compared with the existing experimental and numerical results, and a reasonably good agrements are obtained. The multiphase flow around an underwater vehicle is simulated which includes submarine wake effects.