• Title/Summary/Keyword: precipitation enhancement

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Design and Pharmaceutical Evaluation of Biphenyl Dimethyl Dicarboxylate Elastic Capsules (비페닐디메칠디카르복실레이트 연질캅셀제의 설계 및 제제학적 평가)

  • 전인구;곽혜선;문지현
    • Biomolecules & Therapeutics
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    • v.4 no.4
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    • pp.419-427
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    • 1996
  • To solubilize practically insoluble biphenyl dimethyl dicarboxylate (DDB), which has been used for the treatment of chronic hepatitis as tablets or hard capsules, the solubilities of DDB in various hydrophilic, oily and hydrocarbon vehicles, and aqueous surfactant solutions were measured by high performance liquid chromatography. It was found that, among the vehicles studied, polyethylene glycol (PEG) 300 revealed the best solvency, and the solubility reached 17.6 mg/ml at 37$^{\circ}C$. The addition of glycyrrhizic acid ammonium salt (GAA) to DDB-PEG 300 solution (5-20 mg/g) inhibited the formation of precipitates, and at the concentration of 10 mg/g, any precipitaction was not observed even after 2 years at 4$^{\circ}C$. Furthermore, GAA markedly enhanced the permeation of DDB through the rabbit duodenal mucosa in a concentration dependent manner. The addition of copolyvidone (ca. 1.0%) to DDB-GAA-PEG 300 system (1 : 0.5 97.5 w/w) was most effective in preventing the considerable precipitation of DDB-PEG 300 solution (7.5 mg/750 mg) when mixed with water of 300-900 ml at 37$^{\circ}C$. GAA showed a synergistic effect in the prevention of precipitate formation. This finding suggests that this DDB formulation may form less precipitation when DDB soft capsules disintegrate and diffuse into the gastrointestinal fluid, resulting in improving the bioavailability Dissolution rate of DDB (7.5 mg) from sort elastic capsules of DDB-GAA-PEG 300 system was rapid. The supersaturation state was maintained for 2 hr at the concentration of 7.35$\pm$3.3 mg in 900 ml of water without precipitation. The total amount of DDB dissolved from this new formulation was 5.3 and 6.1 times higher, when compared to marketed DDB tablets (25 mg) and capsules (7.5 mg), respectively.

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Future Changes in Surface Radiation and Cloud Amount over East Asia under RCP Scenarios (RCP 시나리오에 따른 미래 동아시아 지표복사에너지와 운량 변화 전망)

  • Lee, Cheol;Boo, Kyung-On;Shim, Sungbo;Byun, Youngwha
    • Journal of Climate Change Research
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    • v.7 no.4
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    • pp.433-442
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    • 2016
  • In this study, we examine future changes in surface radiation associated with cloud amount and aerosol emission over East Asia. Data in this study is HadGEM2-CC (Hadley Centre Global Environmental Model version 2, Carbon Cycle) simulations of the Representative Concentration Pathways (RCPs) 2.6/4.5/8.5. Results show that temperature and precipitation increase with rising of the atmosphere $CO_2$. At the end of $21^{st}$ century (2070~2099) relative to the end of $20^{st}$ century (1981~2005), changes in temperature and precipitation rate are expected to increase by $+1.85^{\circ}C/+6.6%$ for RCP2.6, $+3.09^{\circ}C/+8.5%$ for RCP4.5, $+5.49^{\circ}C/10%$ for RCP8.5. The warming results from increasing Net Down Surface Long Wave Radiation Flux (LW) and Net Down Surface Short Wave Radiation Flux (SW) as well. SW change increases mainly from reduced total Aerosol Optical Depth (AOD) and low-level cloud amount. LW change is associated with increasing of atmospheric $CO_2$ and total cloud amount, since increasing cloud amounts are related to absorb LW radiation and remit the energy toward the surface. The enhancement of precipitation is attributed by increasing of high-level cloud amount. Such climate conditions are favorable for vegetation growth and extension. Expansion of C3 grass and shrub is distinct over East Asia, inducing large latent heat flux increment.

Analysis of Available Time of Cloud Seeding in South Korea Using Radar and Rain Gauge Data During 2017-2022 (2017-2022년 남한지역 레이더 및 지상 강수 자료를 이용한 인공강우 항공 실험 가능시간 분석)

  • Yonghun Ro;Ki-Ho Chang;Yun-kyu Lim;Woonseon Jung;Jinwon Kim;Yong Hee Lee
    • Journal of Environmental Science International
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    • v.33 no.1
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    • pp.43-57
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    • 2024
  • The possible experimental time for cloud seeding was analyzed in South Korea. Rain gauge and radar precipitation data collected from September 2017 to August 2022 in from the three main target stations of cloud seeding experimentation (Daegwallyeong, Seoul, and Boryeong) were analyzed. In this study, the assumption that rainfall and cloud enhancement originating from the atmospheric updraft is a necessary condition for the cloud seeding experiment was applied. First, monthly and seasonal means of the precipitation duration and frequency were analyzed and cloud seeding experiments performed in the past were also reanalyzed. Results of analysis indicated that the experiments were possible during a monthly average of 7,025 minutes (117 times) in Daegwallyeong, 4,849 minutes (81 times) in Seoul, and 5,558 minutes (93 times) in Boryeong, if experimental limitations such as the insufficient availability of aircraft is not considered. The seasonal average results showed that the possible experimental time is the highest in summer at all three stations, which seems to be owing to the highest precipitable water in this period. Using the radar-converted precipitation data, the cloud seeding experiments were shown to be possible for 970-1,406 hours (11-16%) per year in these three regions in South Korea. This long possible experimental time suggests that longer duration, more than the previous period of 1 hour, cloud seeding experiments are available, and can contribute to achieving a large accumulated amount of enhanced rainfall.

Proposing Research and Development Activities for Utilizing the Global Precipitation Measurement (GPM) (전구강수관측(GPM) 활용을 위한 제언)

  • Sohn, Byung-Ju;Nam, Jae-Cheol;Park, Seon-Ki;Ahn, Myung-Hwan;Yoo, Jung-Moon;Lee, Hee-Sang;Chang, Dong-Eon;Ho, Chang-Hoi;Bae, Deg-Hyo;Kim, Seong-Jun;Oh, Hyun-Jong;Park, Seong-Chan;Kim, Ju-Hong
    • Atmosphere
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    • v.15 no.1
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    • pp.47-57
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    • 2005
  • Extending the success of the Tropical Rainfall Measuring Mission (TRMM), the spaceborne measurement of precipitation by Global Precipitation Measurement (GPM) is initiated. The GPM consists of a core satellite which will have a dual-frequency precipitation radar (DPR) and a constellation of small satellites equipped with microwave radiometers. The GPM is inherently a global program. Responding to the GPM plan, many other nations are much interested in participating in the GPM team or simply utilizing GPM products aiming at the development of meteorological technology. Korea can fully function its role if Korea is selected as a CAL/VAL site for the GPM because Korea maintains a well-established dense rain gauge network (AWS), precipitation radars, and the Haenam super site for surface observation. In this feasibility study, the necessities of the GPM project in the context of academical and social backgrounds and associated international and domestic activities are investigated. And GPM-related core technologies and application areas are defined. As a result, it is found that GPM will represent a great opportunity for us because of its ability to provide not only much enhanced three-hourly global rain products but also very useful tools for the enhancement of weather forecasting capabilities, management of water resources, development and implementation of monitoring techniques for severe weather phenomena, agricultural managements and climate application. Furthermore, rain retrieval and CAL/VAL technologies obtained during the involvement in the international GPM project will serve as basic knowledges to run our own geostationary satellite program.

Fabrication of YBa_2Cu_3O_{7-x}$ceramic using the Sol-Gel process (졸-겔 법으로 YBa_2Cu_3O_{7-x}$세라믹의 제조)

  • Kim, Hyun-Taek;Kang, Hyung-Boo;Kim, Bong-Heup
    • Proceedings of the KIEE Conference
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    • 1989.07a
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    • pp.299-301
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    • 1989
  • This study presents a method of preparing $YBa_2Cu_3O_{7-x}$ ceramic and chlorine doping in it for the purpose of Jc enhancement us ins sol-gel process.Tetramethylammonium-hydroxide and pottasium carbonate solution were added to the aqueous solution of Yttrium nitrate, Barium chloride and Copper nitrate for pH control as well as forming hydroxy-carbonate precipitation. Instead of Barium nitrate, Barium chloride was used for doping chloride impurities in the specimen. The resulted materal showed good high Tc-superconductivity after calcination. Tc and Jc value are 92 K and 120.8 $A/cm^2$ respectively.

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Characteristics of the Reduction of Fine Particles in an Indoor Air Cleaner Using Electrostatic Precipitation Technique (전기집진기형 공기청정기의 미세 먼지 저감 특성에 관한 연구)

  • Mok, Young-Sun;Lee, Ho-Won
    • Journal of the Korean Society of Industry Convergence
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    • v.7 no.1
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    • pp.115-120
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    • 2004
  • An indoor air cleaner consisting of a dielectric barrier discharge system and an electrostatic precipitator (ESP) was experimentally investigated. The function of the dielectric barrier discharge is to precharge particles by producing nonthermal plasma before indoor air enters ESP, leading to an enhancement in dust collection efficiency. The dependence of particle size distribution on the plasma discharge was examined to understand the mechanism of the particle precharging. The plasma discharge was found to increase the electrical force of the particles, rather than agglomerate them. Coarse particles in the range of 0.5 to $5.0{\mu}m$ were observed to be easily collected by this indoor air cleaner, and the present study laid emphasis on the removal of fine particles of $0.3{\mu}m$. The collection efficiency of the fine particles was largely enhanced by the plasma discharge.

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Enhancement of Surface Hardness and Corrosion Resistance of AISI 310 Austenitic Stainless Steel by Low Temperature Plasma Carburizing Treatment

  • Lee, Insup
    • Journal of the Korean institute of surface engineering
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    • v.50 no.4
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    • pp.272-276
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    • 2017
  • The response of AISI 310 type austenitic stainless steel to the novel low temperature plasma carburizing process has been investigated in this work. This grade of stainless steel shows better corrosion resistance and high temperature oxidation resistance due to its high chromium and nickel content. In this experiment, plasma carburizing was performed on AISI 310 stainless steel in a D.C. pulsed plasma ion nitriding system at different temperatures in $H_2-Ar-CH_4$ gas mixtures. The working pressure was 4 Torr (533Pa approx.) and the applied voltage was 600 V during the plasma carburizing treatment. The hardness of the samples was measured by using a Vickers micro hardness tester with the load of 100 g. The phase of carburized layer formed on the surface was confirmed by X-ray diffraction. The resultant carburized layer was found to be precipitation free and resulted in significantly improved hardness and corrosion resistance.

Surface hardening and enhancement of Corrosion Resistance of AISI 310S Austenitic Stainless Steel by Low Temperature Plasma Nitrocarburizing treatment.

  • Lee, Insup
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2012.11a
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    • pp.175-177
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    • 2012
  • A corrosion resistance and hard nitrocarburized layer was distinctly formed on 310 austenitic stainless steel substrate by DC plasma nitrocarburizing. Basically, 310L austenitic stainless steel has high chromium and nickel content which is applicable for high temperature applications. In this experiment, plasma nitrocarburizing was performed in a D.C. pulsed plasma ion nitriding system at different temperatures in $H_2-N_2-CH_4$ gas mixtures. After the experiment structural phases, micro-hardness and corrosion resistance were investigated by the optical microscopy, X-ray diffraction, scanning electron microscopy, micro-hardness testing and Potentiodynamic polarization tests. The hardness of the samples was measured by using a Vickers micro hardness tester with the load of 100 g. XRD indicated a single expanded austenite phase was formed at all treatment temperatures. Such a nitrogen and carbon supersaturated layer is precipitation free and possesses a high hardness and good corrosion resistance.

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New doping technique of Mn Activator on ZnS Host for Photoluminescence Enhancement

  • Wentao, Zhang;Lee, Hong-Ro
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2008.11a
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    • pp.9-10
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    • 2008
  • Triple layers structure of $SiO_2$/ZnS:Mn/ZnS was synthesized by using ion substitution and chemical precipitation method. Each layer thickness was controlled by adjusting the concentration of manganese (II) acetate ($Mn(CH_3COO)_2$) and tetraethyl orthosilicate (TEOS). The structure and morphology of prepared phosphors were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and electron probe microscopic analyzer (EPMA). Photoluminescence (PL) properties of ZnS with different layer thickness and amount of Mn activator were analyzed by PL spectrometer. PL emission intensity and PL stability were analyzed for evaluating effects of Mn activator.

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Neodymium doped mixed metal oxide derived from CoAl-layered double hydroxide: Considerable enhancement in visible light photocatalytic activity

  • Khodam, Fatemeh;Amani-Ghadim, Hamid Reza;Aber, Soheil;Amani-Ghadim, Ali Reza;Ahadzadeh, Iraj
    • Journal of Industrial and Engineering Chemistry
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    • v.68
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    • pp.311-324
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    • 2018
  • Herein,the Neodymium ion ($Nd^{3+}$) doped CoAl-LDH have been successfully prepared via co-precipitation method and was used as a precursor of Nd-doped CoAl-mixed metal oxides (MMO). The photocatalytic activity of doped LDH and MMO was investigated in the degradation of an azo dye, C.I. Acid Red 14, under visible light irradiation. DRS and PL analysis demonstrated decreasing in the band gap energy and recombination of photo-induced charge carriers of Nd-doped LDH and MMO compared with the pristine CoAL-LDH. Due to significant difference in photocatalytic performance. A power law empirical kinetic model was obtained for predicting the photocatalytic degradation efficiency.