• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6557-6559
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• 2015

Background: Cervical human papillomavirus (HPV) infection among young women (20-25 years of age) is common and normally transient. There are growing concerns that referral to a colposcopy clinic may lead to unnecessary treatment with an increased risk of obstetric complications. Therefore, the purpose of this study was to determine the level of intervention for cervical abnormalities in this age group of the Northern Ireland population. Materials and Methods: A review of all serial new patients under 25 years of age, who were referred to colposcopy clinics in Northern Ireland between January 1, 2009 to June 30, 2009 formed the basis of this study. Results: During the study period, a total of 4,767 women under 25 years of age were screened. Two-hundred-and-thirty-four (4.9%) cases were referred to the colposcopy clinics. The cervical cytology results were: high-grade abnormality in 35%, and low-grade abnormality in 31% of these cases. One-hundred-and-seventy-eight (76%) of the referred women received at least one treatment. One-hundred-and-twenty-one of 234 (51.5%) women underwent an excisional treatment with histology showing the presence of high-grade abnormalities (CIN2-3) in 52%, CIN1 in 28%, and Koilocytosis or normal tissue in 20% of this sub-group of cases. Conclusions: Screening women under the age of 25 years cause unnecessary referral for colposcopy. This may also result in considerable anxiety and psychosexual morbidity. It leads to an over-treatment with a potential of negative impact on the future pregnancy outcomes (including pre-term delivery, low birth weight, and pre-term premature rupture of membranes).

• 한국학교보건학회지
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• 제9권2호
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• pp.161-170
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• 1996

This research was performed to screen eye health status for pre-school children (4~5 age) and establish as eye health checking system m community health center. This data was collected from 1st February, 1995 to 31st October, 1995. To screen the state of their vision, the Developed Visuual Test (D.V.T) was used for pre-school children. This is used at home by their parents and then it is also used among the kindergarten health team at Jung-gu health center in Seoul. This was done with the and of Randot and Han Choun Souk tests. The total number of children who were tested was 1441. Among the children, children aged 5 were 707, and those aged 4 were 734. The results of this study were as follows; * Description of the health status for the pre-school children. 1. The rate of children average vision in both eyes, whose was below 05 by Han Choun Souk are 7.6% (age 4) and 4.8% (age 5). 2. Only 20 4% (age 5) and 30 8% (age 4) of the pre-school children had been tested through the ophthalmic department. 3. The children with a level below 05 (Han Choun Souk test) had been tested only 43% (age 4), and 12% (age 5) 4. There was no particular difficulty in understanding the D.Y.T: 13.9% (age 4), 11.6% (age 5) of the tested children had eye problems. 5. 231 cases were trichiasis, entropin, strabismus, and amblyopia. * The different visual tests. The results of the visual tests between the two groups (parents and health teams) are similar and it shows that parents can easily test at home. * Delivery system of the D.V.T questionnaire The way children's parents received the D.V.T questionnaire were carried out by two ways By mall from the community health center. Send through the institution, for example the kindergarten school The receipt rate of this D.V.T questionnaire sent through the institution was higher than sent by mall.

• Journal of Preventive Medicine and Public Health
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• 제56권2호
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• pp.111-127
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• 2023

Objectives: Pre-pregnancy diet has an important role in preparing for healthy generation. However, evidence on this issue has been scarce. A scoping review synthesising current evidence will support the demand to map 'what has been researched' on pre-pregnancy diet and maternal and child health. Methods: Systematic search was performed using PICOS (Population, Intervention, Comparison, Outcomes, and Study design) framework in electronic databases. Articles were screened for eligibility, summarized, and the quality was assessed using the National Institute of Health assessment tool. The review structure complies with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guide. Results: Forty-two articles were included after full-text screening. Twenty-five studies were in high-income countries (HICs), six in each upper-middle income, five in lower-middle income countries (LMICs), and one in low-income countries (LIC). Based on the regions: North America (n=16), Europe (n=5), South America (n=4), Australia (n=4), Asia (n=5), Middle East (n=2), and sub-Saharan Africa (n=1). The two-most observed diet-related exposures were dietary pattern (n=17) and dietary quality (n=12). The most assessed outcome was gestational diabetes mellitus (n=28) and fetal and newborn anthropometry (n=7). The average quality score±standard deviation was 70±18%. Conclusions: Research related to pre-pregnancy diet is still concentrated in HICs. The context of diet may vary; therefore, future research is encouraged in LMICs and LICs context, and Mediterranean, South-East Asia, Pacific, and African regions. Some maternal and child nutrition-related morbidity, such as anemia and micronutrient deficiencies, have not been discussed. Research on these aspects will benefit to fill in the gaps related to pre-pregnancy diet and maternal and child health.

• 대한조선학회논문집
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• 제54권6호
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• pp.476-484
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• 2017

The purpose of this paper is to verify the structural integrity of a region with numerous penetration-holes in offshore structures such as semi-submersible rig and FPSO. In order to effectively check the yielding and buckling strength of plate members with penetration-holes, a screening analysis program was developed with the FE analysis tool to generate fine meshed model using the theoretical and analysis methods. When a hole is appeared in the plate structure members, the flow of stress is altered such that concentrations of stress form near the hole. Stress concentrations are of concern during both preliminary and detail design and need to be addressed from the perspectives of strength. To configure the geometrical shape, very fine meshed FE analysis is needed as the most accurate method. However, this method is practically impossible to apply for the strength verifications for all perforated plates. In this paper, screening analysis method was introduced to reduce analysis tasks prior to detailed FE analysis. This method is applied to not only the peak stress calculation combined stress concentration factor with nominal stress but also nominal equivalent stress calculation considering cutout effects. The areas investigated by very fine meshed analysis were to be chosen through screening analysis without any reinforcements for penetration-holes. If screening analysis results did not satisfy the acceptance criteria, direct FE analysis method as the 2nd step approach were applied with one of the coarse meshed model considering hole or with the very fine meshed model considering the hole shape and size. In order to effectively perform the local fine meshed analysis, automatic model generating program was developed based on the MSC/PATRAN which is pre-post FE analysis program. Buckling strength was also evaluated by Common Structure Rule (CSR) adopted by IACS as the stress obtained from very fine meshed FE analysis. Due to development of the screening analysis program and automatic FE modeling program, it was able to reduce the design periods and structural analysis costs.

• 디지털융복합연구
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• 제19권10호
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• pp.491-500
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• 2021

유방암 환자의 제 특성을 파악하여, 유방암 조기 검진의 중요성과 젊은 유방암의 심각성을 알리기 위해 시행하였다. 2010년 5월 1일부터 2020년 4월 30일까지(10년간) 일 유방 클리닉에 내원한 환자 23,200명 중 유방암으로 진단받은 483명의 의무기록을 이용한 후향적 조사연구이다. 유방암으로 진단받은 483명의 나이는 40대(36.0%)가 가장 많았으며, 30대(25.9%)가 다음으로 많았다. 유방암 가족력이 있는 경우가 5.4%, 폐경 상태는 29.2%였으며, 내원 동기로는 종괴가 54.2%로 가장 많았고, 유방 검진 경험은 출산 경험자가 비출산자보다 많았으며, 20-30대에서 유방검사 경험이 가장 적었다. 젊은 여성을 대상으로 유방암 검진의 중요성을 교육할 필요가 있으며, 유방암의 국가암검진 연령에 대한 재검토를 제언한다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.134-138
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• 2005

The design of ion channel targeted library is a valuable methodology that can aid in the selection and prioritization of potential ion channel-likeness for ion-channel-targeted bio-screening from large commercial available chemical pool. The differences of property profiling between the 93 ion-channel active compounds from MDDR and CMC database and the ACDSC compounds were classified by suitable descriptors calculated with preADME software. Through the PCA, clustering, and similarity analysis, the compounds capable of ion channel activity were defined in ACDSC compounds pool. The designed library showed a tendency to follow the property profile of ion-channel active compounds and can be implemented with great time and economical efficiencies of ligand-based drug design or virtual high throughput screening from an enormous small molecule space.

• BMB Reports
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• 제38권5호
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• pp.517-525
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• 2005

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and reagent mixture synthesis. Combining surface chemistry with the recent technology of microelectronic semiconductor fabrication system, the peptide microarray synthesis methods on a planar solid support are developed, which leads to spatially addressable peptide library. There are two kinds of peptide microarray synthesis methodologies: pre-synthesized peptide immobilization onto a glass or membrane substrate and in situ peptide synthesis by a photolithography or the SPOT method. This review also discusses the application of peptide libraries for high-throughput bioassays, for example, peptide ligand screening for antibody or cell signaling, enzyme substrate and inhibitor screening as well as other applications.

• Toxicological Research
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• 제32권4호
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• pp.327-335
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• 2016

This study aimed to evaluate the potential toxicity and safety of ethyl hydrogen adipate (EHA) by determining its effect on the reproductive function and development of Sprague-Dawley (SD) rats at dose levels of 0 (control), 200, 400, and 800 mg/kg/day. One male and five females of the 800 mg/kg/day died. Body weight loss was observed in the males of the 800 mg/kg/day and in females of the 400 and 800 mg/kg/day. In addition, mating indices decreased and pre-implantation loss rates increased in parental animals of the 400 and 800 mg/kg/day. The gestation index decreased in the male and female rats of the 800 mg/kg/day. Moreover, the body weight of the pups from the 800 mg/kg/day group decreased on post-parturition day 4. These results indicated that the no-observed-adverse-effect level of EHA for parental males and females was 400 mg/kg/day and 200 mg/kg/day, respectively, and that for pups was 400 mg/kg/day.

• 응용통계연구
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• 제26권3호
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• pp.389-399
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• 2013

본 연구에서는 가우시안 과정회귀방법을 소개하고 시계열 마이크로어레이 유전자 발현데이터에 대해 가우시안 과정회귀를 적용한 사례를 보이고자한다. 가우시안 과정회귀를 적합하여 로그 주변우도함수 비를 이용한 유전자를 선별방법에 대한 모의실험을 통해 민감도, 특이도, 위발견율 등을 계산하여 선별방법으로의 활용성을 보였다. 실제 효모세포주기 데이터에 대해 제곱지수공분산함수를 고려한 가우시안 과정회귀를 적합하여 로그 주변우도함수 비를 이용하여 차변화된 유전자를 선별한 후, 선별된 유전자들에 대해 가우시안 모형기반 군집화를 하고 실루엣 값으로 군집유효성을 보였다.

• 한국식물병리학회지
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• 제14권5호
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• pp.491-495
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• 1998

A fungal disease of the cultivated mushroom, Ganoderma lucidum, caused by Xylogone sphaerospora was epidemic throughout all cultivation areas in Korea which caused a lot of yield losses in the mushroom production. For controlling the disease, the screening of effective fungicides against the pathogenic fungus were conducted. Thirty seven commercially available fungicides were tested for their inhibitory activities on potato dextrose agar media supplemented with these fungicides at various concentrations. Twenty one fungicides significantly inhibited mycelial growth of the pathogen, Xylogone sphaerospora, but 16 fungicides had no inhibitory effect. Among these 21 fungicides, 17 fungicides also inhibited mycelial growth of Ganoderma lucidum as well, but imazalil, procymidone, triforine, and vinclozolin had no inhibitory effects. However, vinclozolin showed no inhibitory effect on mycelial growth of the mushroom even at the concentration of 50 $\mu\textrm{g}$/ml vinclozolin solution for 2 hours, and then the pathogen was inoculated. After two month-cultivation of the mushroom, over 90% of logs treated with vinclozolin without pathogen inoculation produced fruiting bodies. However, fruiting bodies were not produced form the logs inoculated with the pathogen, but not treated with vinclozolin. Fifty seven percent of logs. which were pre-treated with vinclozolin and then inoculated with the pathogen produced fruiting bodies. Based on the results, vinclozolin is effective for the control of yellow disease of the Ganoderma lucidum caused by Xylogone sphaerospora.