• Bulletin of the Korean Chemical Society
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• v.16 no.2
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• pp.143-148
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• 1995

Ketene (CH2CO) adsorption on Ag(111) has been studied in ultrahigh vacuum using electron energy loss spectroscopy and temperature programmed desorption. Ketene adsorbs molecularly on Ag(111) at temperatures below 126 K. The coverage increases linearly with exposure until saturation. No multilayer formation and no shift in desorption temperature with coverage were observed, indicating a lack of attractive interaction between adsorbate molecules. The desorption activation energy is estimated to be 7.8 kcal/mol by assuming first order kinetics and a pre-exponential factor of 1013 sec-1. The adsorption geometry of ketene on the surface is determined from the relative intensities of the vibrational energy loss peaks. The CCO axis of CH2CO is found to be almost parallel to (∼4°away from) the surface and the molecular plane is almost perpendicular to the surface (∼3°tilt).

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1999.04a
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• pp.13-13
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• 1999

본 논문에서는 해석영역의 형상변화, 즉 로켓노즐 내열재의 삭마로 인해 야기된 경계 면의 이동을 고려하면서 2차원 비정상 비등방성 재료의 열전달 문제를 해석할 수 있는 수치해석에 대해 기술하였다. 수치해석 알고리즘은 유한요소법이며 열해석시 경계면 이동으로 인한 격자계의 절점 좌표점이 계산과정 동안에 이동하는 변형 가능한 유한요소격자(transformable finite-element grid)를 사용하였다. 본 수치해석기법의 타당성 입증을 위해 극심한 열하중이 부여된 조건하에서 엄밀해가 존재하는 비정상 축대칭문제 및 고체로켓 노즐내열재에 대해 열해석을 수행하였으며, 그 결과 수치해는 엄밀해 또는 실험치와 잘 일치함을 보이었다. 여러 가지 복합재로 구성된 내삽노즐 또는 외삽노즐에 대해서도 안정된 수치해를 얻을 수 있었다. 아울러 노즐목삽입재로 탄소-탄소 복합재를 적용한 고체추진기관 내삽노즐을 해석모델로 택하여 열전달 해석을 수행하고 해석결과를 분석하였다. 노즐의 표면산화반응에 대한 열반응상수, 즉 Arrhenius 형태로 표시된 식에서 pre-exponential factor 및 activation energy 변화가 탄소-탄소 복합재 및 탄소-페놀릭 복합재의 삭마량에 미치는 영향에 대해서 고찰하였다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.05a
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• pp.107-113
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• 2002

We examined the psychophysiological effects of navigation in a virtual reality (VR). Subjects were exposed to the VR, and required to detect specific objects. Ten electrophysiological signals were recorded before, during, and after navigation in the VR. Six questionnaires on the VR experience were acquired from 45 healthy subjects. There were significant changes between the VR period and the pre-VR control period in several psychophysiological measurements. During the VR period, eye blink, skin conductance level, and alpha frequency of EEG were decreased but gamma wave were increased. Physiological changes associated with cybersickness included increased heart rate, eye blink, skin conductance response, and gamma wave and decreased photoplethysmogram and skin temperature. These results suggest an attentional change during VR navigation and activation of the autonomic nervous system for cybersickness. These findings would enhance our understanding for the psychophysiological changes during VR navigation and cybersickness.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.05a
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• pp.691-694
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• 2022

최근 고해상도 영상이 필요하게 되었으며, 저해상도 영상을 고해상도 영상으로 변환하는 딥러닝 기반의 초해상도 알고리즘에 대한 연구가 활발히 진행되고 있다. 그럼에도 불구하고 딥러닝 기반의 초해상도 알고리즘은 하드웨어의 한계로 인해 임베디드 시스템에서 실행시간이 느린 단점이 있다. 본 논문에서는 심층신경망 기반의 초해상도 알고리즘의 네트워크 구조를 제시하고 다양한 활성화 함수에 따른 화질 및 실행시간 성능을 분석한다. 실험 결과, 젯슨 나노보드의 다양한 활성화 함수 중 화질과 실행 시간의 관계에서 도출한 최적의 활성화 함수가 PReLU 함수임을 확인하였다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.8B
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• pp.473-481
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• 2007

We are interested in the PON which is easy to install and inexpensive to maintain, as it is a solution of the FTTH that is a core technology of the BcN access network. When a new ONU is connected, TDMA PON has a procedure called ranging that OLT measures the distance and allocates the equalized delay to it in order to provide the same logical distance to all ONUs. For the procedure, the OLT has to open a time window several times and already activated ONUs cannot transmit a data to the upstream during the periods. Accordingly, it is important to reduce the window size for saving the bandwidth and providing a user the service smoothly. In this paper, we investigate the ONU activation method of G-PON based on ITU-T G984.3 and suggest an advanced method(algorithm I) that minimizes the window size without information of ONU distance. The size can be reduced by calculating the pre-assigned delay obtained during Serial number state. Also, we compare it with another(algorithm II) with information of distance. As a result, the window size reduces to $50{\sim}90%$ for the algorithm I and 99% for algorithm II during the ONU activation process.

• Molecular & Cellular Toxicology
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• v.5 no.4
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• pp.298-303
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• 2009

(-)-Epigallocatechin-3-gallate (EGCG), a major flavonoid in green tea has multiple health benefits including chemoprevention, anti-inflammatory, anti-diabetic, and anti-obesity effects. In connection with these effects, EGCG can be a candidate to help the treatment of metabolic diseases. Metformin is a widely used anti-diabetic drug regulating cellular energy homeostasis via AMP-activated protein kinase (AMPK) activation. Therefore, the combination of metformin with EGCG may have additive or synergistic effects on treatment of type 2 diabetes. Nevertheless, there is no report for the pharmacokinetic and/or pharmacodynamic interaction of EGCG with metformin. Here, we evaluated the pharmacokinetic and pharmacodynamic interaction between metformin and EGCG in rats. Pharmacokinetics parameters of metformin were measured after oral administration of metformin in rats pre-treated with EGCG (10 mg/kg) or saline for 7 days. The results showed that there is no significant difference in pharmacokinetic parameters between saline control and EGCG-treated group. In addition, the hepatic AMPK activation by metformin in EGCG-treated rats was also similar to the control. The lack of additive effects of EGCG on AMPK activation or intracellular uptake of metformin was also evaluated in cells in the presence or absence of EGCG. Treatment of HepG2 cells with EGCG inhibited the metformin-induced AMPK activation. Combined results suggested that EGCG has no effect on the pharmacokinetics of metformin but may contribute to metformin action.

• Korean Journal of Animal Reproduction
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• v.26 no.3
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• pp.245-252
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• 2002

This study was to evaluate the in vitro survival of bovine enucleated MII (eMII) oocytes according to minimum volume cooling (MVC) freezing method and activation timing, and their in vitro development after somatic cell nuclear transfer (SONT). in vitro matured bovine oocytes for 20 h were stained with 5 $\mu\textrm{g}$/$m\ell$ Hoechst, and their 1st polar body and MII plate were removed by enucleation micropipette under UV filter. Also, eMII oocytes were subjected to activation after (group II) and before (group III) vitrification in 5 ${\mu}{\textrm}{m}$ ionomycin added CRlaa medium for 5 min. For vitrification, eMll oocytes were pretreated with EG10 for 5 min, exposed to EG30 for 30 sec and then directly plunged into L$N_2$. Thawing was taken by 4-step procedures at 37$^{\circ}C$. Survived eMII oocytes were subjected to SONT with cultured adult bovine ear cells. Reconstructed oocytes were cultured in 10 $\mu\textrm{g}$/$m\ell$ of cycloheximide and 2.5 $\mu\textrm{g}$/$m\ell$ of cytochalasin D added CRlaa medium for 1 h, and then in 10 $\mu\textrm{g}$/$m\ell$ of cycloheximide added CRlaa medium for 4 h. Subsequently, the reconstructed oocytes were incubated for 2 days and cleaved embryos were further cultured on cumulus-cell monolayer drop in CRlaa medium for 6 days. Survival rates of bovine vitrified-thawed eMII oocytes in group II (activation after vitrification and thawing) and III (activation before vitrification) were 81.0% and 84.9%, respectively. Fusion rates of cytoplasts and oocytes in group II and III were 69.0% and 70.0%, respectively, and their results were not different with non-frozen NT group (control, 75.2%). Although their cleaved rates (53.4% and 58.4%) were not different, cytoplasmic fragment rate in group II (32.8%) was significantly higher than that in group III (15.6%)(P<0.05). Also, subsequent development rate into >morula in group II (8.6%) was low than that in group III(15.6%). However, in vitro development rate in group III was not different with that in control (24.8%). This result suggested that MVC method was appropriate freezing method for the bovine eMII oocytes and vitrified eMII oocytes after pre-activation could support in vitro embryonic development after SONT as equally well as fresh oocytes.

• Journal of Trauma and Injury
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• v.28 no.4
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• pp.241-247
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• 2015

Purpose: To evaluate the influence of how the trauma care system is applied on the management of trauma patients. Methods: We divided the patients into a pre-trauma system group and a post-trauma system group according to the time when we began to apply the trauma care system in our institution. We compared the general characteristics, injury severity score, initial response time to the trauma patients, number of preventable deaths, and clinical outcomes between the two groups. Results: The numbers of patients in the pre-trauma system group and the post-trauma system group were 188 and 257, respectively. No differences in the patient's median ages, trauma scores (ISS, RTS, TRISS) and proportions of severe trauma patients (ISS>15) were observed between the two groups. The number and the proportion of patients who were admitted to our hospital were increased in the post-trauma system group. The time interval from trauma CP activation to emergency surgery or angio-embolization, and the patient's time spent in emergency room were shortened in the post-trauma system group. However, the lengths of the ICU stay and the hospital stay, and the number of in-hospital mortalities were not improved in the post-trauma system group. In severe trauma patients (ISS>15), there were no differences between the two groups in the number and the proportion of admitted patients, and the time interval from trauma CP activation to performing a diagnostic and therapeutic procedure was not shortened in the post-trauma system group. Conclusion: Application of the trauma care system has shortened the time between the initial response and patient management. However, this improvement was not enough to result in better clinical outcomes. More trauma physicians, multidisciplinary cooperation, and a well-organized trauma management process will be needed if the maximum efficacy of the trauma system is to be achieved.

• Korean Journal of Ichthyology
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• v.12 no.1
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• pp.38-45
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• 2000

Depending on the fish species the vascular tone is distinctively regulated by numerous vasoactive substances. In most fish species the regulatory role of autonomic neurotransmitters and other vasoactive substances are not well defined. This research was designed to delineate the regulatory role of various endogenous autonomic neurotransmitters known to be important in mammalian vascular systems on isolated Israeli carp ventral aorta. Acetylcholine(ACh) contracted the aorta regardless of the pre-existing level of vascular tone, and the contraction was almost completely abolished by a cholinergic-muscarinic antagonist atropine. Endogenous, multiple receptor ($\alpha$ and $\beta$)-acting adrenergic agonist epinephrine (Epi) relaxed the vessel in the presence and absence of the pre-existing tones. Another endogenous multiple receptoracting agonist norepinephrine (NE) weakly contracted the aorta in non-preconstrcted state, but the response was reversed to relaxation when preconstricted. Isoproterenol, ${\alpha}\;{\beta}$ adrenergic receptor agonist, was a potent vasodilator whereas an ${\alpha}_1$ agonist phenyephrine was a contractor. The ${\alpha}_2$ adrenergic receptor agonist clonidine has not any significant effect in altering the vascular tone. The vasorelaxing action of Epi, NE and isoproterenol was significantly attenuated by $\beta$ receptor antagonist propranolol. These results imply that ACh may primarily play a contractor role via muscarinic receptor activation while adrenergic agonists, Epi and NE, are relaxants through activation of $\beta$ adrenergic receptors in vivo.

• The Journal of Internal Korean Medicine
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• v.26 no.1
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• pp.74-92
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• 2005

Objectives/Methods : To analyze the effect of Injinchunggantang(IJCGT) to Interferon-${\alpha}/{\beta}$ signal transmission system in HepG2 cells, HepG2 Cell were treated with IJCGT. Also, revelation of MxA, 2'5'-OAS mRNA leaded by Interferon-${\alpha}/{\beta}$ and revelation and activation of Jak1, TYK1, and STAT 1, all main signal transmission factors, were analyzed. Results : The analysis resulted in the following 1. With interferon ${\alpha}/{\beta}$ there was no affect cell propagation of Hep G2 cells. With IJCGT alone, cell propagation of HepG2 was promoted, and cell propagation control function was recovered. 2. With interferon ${\alpha}/{\beta}$ cell death was unaffected. With IJCGT apoptosis of HepG2 cell was restrained, and the cell's reaction to interferon was unaffected. 3. With interferon ${\alpha}/{\beta}$ treatment mRNA revelation of MxA and 2'5'-OAS was induced. When HepG2 cells were injected with IJCGT without interferon ${\alpha}/{\beta}$ treatment, mRNA revelation of MxA and 2'5'-OAS increased in proportion to the treatment density. With pre-treatment of IJCGT, leaded with interferon ${\alpha}/{\beta}$, promoted revelation of MxA, 2'5' -OAS mRNA. 4. Though mRNA revelation of lakl, TYK1 and STAT1 was unaffected with IJCGT, activation of STAT1 was promoted with an increase of phosphorylation of STAT1 protein. With pre-treatment of IJCGT, Jak1, TYK2, STAT1 phosphorylation, leaded with interferon, strengthened. 5. TNF-a, IL-1b and LPS present, revelation of MxA and 2'5'-OAS mRNA leaded by interferon was restrained when HepG2 cells were treated with IJCGT, and the interferon signal transmission system restraint action leaded by inflammatory cytokines was moderated. Conclusion : These results support a role for IJGCT in promotion of anti-virus action through maintainance of the liver's sensibility toward interferon. A clinical study of an interferon treated patient treated also with IJGCT is needed to determine its efficacy.