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Studies on Hepatic and Renal Toxicities Possibly Induced by Administration of Farfarae Flos in Rats (관동화 및 관동화 가미방이 흰쥐의 간독성 및 신독성에 미치는 영향)

  • Kim, Eun Jin;Min, Sang Yeon;Kim, Jang Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • v.30 no.3
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    • pp.69-77
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    • 2016
  • Objectives This study is to investigate whether oral administration of Farfarae flos, JCT (Jeong-cheon-tang), CPT (Cheong-pye-tang) and CPK (Cheong-pye-tang- ga-kwandonghwa) will affect both the levels of serum GOT, GPT, blood urea nitrogen (BUN) and creatinine in SD rats or not, and will change body weight of the rats. Materials and Methods 18 SD rats were randomly divided into 6 groups - including a control group (vehicle 2 ml/rat), Farfarae flos water extract (extract 2 ml/rat), Farfarae flos fine powder (emulsion 2 ml/rat), JCT (extract 2 ml/rat), CPT (extract 2 ml/rat) and CPK (extract 2 ml/rat) group. The drugs were administered to rats for 2 weeks or 30 days (for control and Farfarae flos fine powder group only) and serum GOT/GPT activities and BUN/creatinine concentrations were measured. Also, the changes of body weights of each rat was measured. Results (1) Farfarae flos water extract, Farfarae flos fine powder emulsion, JCT and CPT and CPK did not cause any changes in serum GOT/GPT activities and BUN/creatinine concentrations compared to the ones in control group. (2) There are no significant changes in rats' body weight among the experimental groups during the experimental period. Conclusions Contrary to the reports on human data, 2 weeks or 30 days of oral administrations of Farfarae flos itself and decoctions containing Farfarae flos did not provoke hepatotoxicity and nephrotoxicity.

Fabrication of Ultra Fine β-phase Ti-Nb-Sn-HA Composite by Pulse Current Activated Sintering

  • Woo, Kee-Do;Wang, Xiaopeng;Kang, Duck-Soo;Kim, Sang-Hyuk;Woo, Jeong-Nam;Park, Sang-Hoon;Liuc, Zhiguang
    • Journal of Powder Materials
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    • v.17 no.6
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    • pp.443-448
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    • 2010
  • The $\beta$ phase Ti-Nb-Sn-HA bio materials were successfully fabricated by high energy mechanical milling and pulse current activated sintering (PCAS). Ti-6Al-4V ELI alloy has been widely used as biomaterial. But the Al has been inducing Alzheimer disease and V is classified as toxic element. In this study, ultra fine sized Ti-Nb-Sn-HA powder was produced by high energy mechanical milling machine. The $\beta$ phase Ti-Nb-Sn-HA powders were obtained after 12hr milling from $\alpha$ phase. And ultra fine grain sized Ti-Nb-Sn-HA composites could be fabricated using PCAS without grain growth. After sintering, the microstructures and phase-transformation of Ti-Nb-Sn-HA biomaterials were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD). The relative density was obtained by Archimedes principle and the hardness was measured by Vickers hardness tester. The $\beta$-Ti phase was obtained after 12h milling. As result of hardness and relative density, 12h milled Ti-Nb-Sn-HA composite has the highest values.

A Study of Bi-Axial Stretching Process for the PTFE Membrane(I) (이축연신 PTFE 막 제조 공정에 관한 연구(I))

  • Shin, Hong-Chul;Kim, Sung-Chul;Cho, Ur-Ryong
    • Elastomers and Composites
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    • v.42 no.2
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    • pp.86-92
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    • 2007
  • A few of polytetrafluoroethylene(PTFE) membranes and PTFE fine powders were analyzed to chooce an optimum resin. The bi-axial stretching process was developed to set up the foundation of the preparation process and control the pore size and porosity of PTFE membrane. The pretreatment of PTFE fine powder used in the preparation process for PTFE was needed. The mixing of additives, the ripening of mixture, paste extrusion process of ripening powder, calendering process and the bi-axial process were conducted for controlling pore size, porosity and thckness of membrane. The aftertreatment which strengthened the mechanical properties was necessary. The control of pore size and porosity of the membrane were determined. The ratio of PTFE fine powder and additives at the paste extrusion process, the ripening time, the ripening temperature and the parameters of temperature and pressure at the paste extrusion process were optimized.

Evaluation of the Flowability of the Heavyweight Concrete using Magnetite Powder and Copper Slag as Fine Aggregate (자철석 분말 및 동슬래그를 잔골재로 활용한 중량 콘크리트의 유동성 평가)

  • Moon, Hoon;Kim, Ji-Hyun;Chung, Chul-Woo;Lee, Jae-Yong
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2018.05a
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    • pp.195-196
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    • 2018
  • The Research is underway to utilize heavyweight concrete for various applications. One of them is to use heavy concrete as a marine concrete such as a breakwater to resist wave. Marine concrete is often complex in shape and requires high fluidity. When the heavyweight concrete is high fluidity, there is a high risk of segregation due to the high density of the coarse aggregate. Therefore, we evaluate the fluidity of heavyweight concrete using heavy fine aggregate. As a result of the fluidity evaluation of the heavyweight concrete, the fluidity of the heavy fine aggregate was similar to that of ordinary concrete. Therefore, it is considered that the use of heavy fine aggregate in the development of high fluidity heavyweight concrete will be one of the methods.

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A Study on Properties of the High-Strength Concrete Admixed with II-Anhydrite and Pozzolanic Fine Power (불산부생 II 형 무수석고와 포졸란 미분체가 혼입된 고강도콘크리트의 특성에 관한 연구)

  • 조민형;길배수;전진환;김도수;남재현;노재성
    • Proceedings of the Korea Concrete Institute Conference
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    • 1997.04a
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    • pp.136-145
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    • 1997
  • The purpose of this study is to develope of alternative adimixture for manufacture of PHC pile(compressive strength above 800kg/$\textrm{cm}^2$). For the investigation, properties of alternative admixture admixed with II-anhydrite and pozollanic fine powders(e.q., Fly-ash, Silica-Fume), the fluidity and viscosity in the cement pastes, the fluidity and compressive strength in mortars at steam curing condition, were respectively examined. Also, properties of compressive strength of concretes with exiting admixture(specimen name SM) and alterantive admixture(specimen name AP) for PHC pile, at steam and standard curing condition, were compared each other. As a result of this experimental study, it was found that specimens admixed with II-anhydrite and pozollanic fine powders had an increase on the fluidity of cement paste and mortar, and compressive strength of mortar and concrete was as good as concrete with SM.

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Microwave Synthesis of Hydrotalcite by Urea Hydrolysis

  • Yang, Zhiqiang;Choi, Kwang-Min;Jiang, Nanzhe;Park, Sang-Eon
    • Bulletin of the Korean Chemical Society
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    • v.28 no.11
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    • pp.2029-2033
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    • 2007
  • Hydrotalcite, layered double hydroxides (LDH), with hexagonal morphology has been rapidly synthesized by microwave reaction within 1 hour by urea hydrolysis from homogeneous solution. Different synthesis parameters, Mg/Al molar ratio, microwave reaction temperature and microwave power were systematically investigated. Pure hydrotalcite phase was obtained for Mg/Al ratios of 2:1 and 3:1, and higher reaction temperature gave higher crystallinity. The hydrotalcite synthesized at 600W power shows the highest crystallinity and more homogeneous crystal size distribution. The hydrotalcite samples were characterized by powder X-ray diffraction (XRD), simultaneous thermogravimetric/differential thermal analysis (TG/DTA), Fourier Transform Infrared (FT-IR) and Scanning electron micrograph (SEM).

A Study on Application of Recycled Aggregate for Improving Fluidity of Concrete (콘크리트의 유동성 개선을 위한 순환골재 활용에 관한 연구)

  • Song, Il-Hyun;Ryou, Jae-Suk
    • Proceedings of the Korea Concrete Institute Conference
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    • 2009.05a
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    • pp.219-220
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    • 2009
  • The PillPose of this study, powder containing the recycled fine aggregate is appropriate for developing high strength and liquidity, the characteristic of the SCC and it was increased the ratio of mixing the recycled fine aggregates resulted from waste concrete and the natural fine aggregates by 25%, making differential in total 5 levels and applied to SCC. After all, this study was reviewed the physical properties of the fresh concrete, mechanics and durability of the hardened concrete and tried to ensure the possibility of utilizing the recycled fine aggregates as a material for SCC.

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Conversion of Carbon Fiber into Silicon Carbide Fiber by Pack-Cementation

  • Joo, Hyeok-Jong;Kim, Jung-Il;Lee, Jum-Kyun
    • Carbon letters
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    • v.1 no.1
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    • pp.12-16
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    • 2000
  • Carbon fiber was reacted with gaseous silicon monoxide which is produced from pack-powder mixture at elevated temperature. As a result of the reaction, two kinds of SiC fiber were obtained. The first one was SiC fibers which were converted from carbon fiber. The fiber is constituted with polycrystal like fine grains or monolithic crystals that have a size from sub-micron to $10\;{\mu}m$. Their size depends on the temperature during the conversion reaction. The second one was ultra-fine SiC fibers that were found on the surface of the converted SiC fibers. The ultra-fine fibers have diameters from 0.08 to $0.2\;{\mu}m$ and their aspect ratio were larger than 100. The chemical composit ion of the ultra-fine fibers was analyzed using an Auger electron spectroscopy. In result, the fibers consist of 51% silicon, 38% carbon and 11% oxygen by weight.

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Consolidation and casting technology of fine poly-Si powders for economical production of Si ingot (경제적인 Si 잉곳 생산을 위한 poly-Si 미세분말의 성형과 용해주조기술)

  • Moon, Byung-Moon;Kim, Bong-Hwan;Shin, Je-Sik;Lee, Sang-Mok;Park, Gi-Seong;Kim, Dae-Suk;Kim, Ki-Young
    • 한국신재생에너지학회:학술대회논문집
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    • 2007.06a
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    • pp.261-264
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    • 2007
  • In this study, the consolidation and casting processes of fine Si powders, by-products of making high purity Poly-Si rods in the current method, were systematically investigated for use as economical solar-grade feedstock. Morphology, size, and contamination type of the poly-Si fine powders were inspected by combined analysis of SEM, particle size analyzer, and FT-IR. Poly-Si powder compacts were tried to fabricate by a consolidation process without a binding agent and then their density ratio and strength were evaluated. Finally, the electrical resistivity of the specimens prepared by an electromagnetic casting method was examined for purity assessment.

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Effect of Suspension Property on Granule Characteristics and Compaction Behavior of Fine Si3Na4 Powder (분산계 특성이 질화규소 미분의 과립특성 및 충진거동에 미치는 영향)

  • 이해원;오성록
    • Journal of the Korean Ceramic Society
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    • v.32 no.4
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    • pp.462-470
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    • 1995
  • The characteristics of spray-dried granules are important for dry pressing operation since they have great influences on die-filling, compaction ratio, and resulting green microstructure. An attempt was made to control granule morphology and the packing structure of fine Si3N4 particles in granules by adjusting suspension property. Mercury porosimetry was used to characterize the pore structures of both granules and green compacts. Finally, the effects of particle packing structure in granules and green microstructure on sintering behavior were investigated.

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