• Korean Journal of Soil Science and Fertilizer
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• v.45 no.1
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• pp.112-117
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• 2012

The Revised Universal Soil Loss Equation (RUSLE) is a revision of the Universal Soil Loss Equation (USLE). However, changes for each factor of the USLE have been made in RUSLE which can be used to compute soil loss on areas only where significant overland flow occurs. RUSLE which requires standardized methods to satisfy new data requirements estimates soil movement at a particular site by utilizing the same factorial approach employed by the USLE. The rainfall erosivity in the RUSLE expressed through the R-factor to quantify the effect of raindrop impact and to reflect the amount and rate of runoff likely is associated with the rain. Calculating the R-factor value in the RUSLE equation to predict the related soil loss may be possible to analyse the variability of rainfall erosivity with long time-series of concerned rainfall data. However, daily time step models cannot return proper estimates when run on other specific rainfall patters such as storm and daily cumulative precipitation. Therefore, it is desirable that cross-checking is carried out amongst different time-aggregations typical rainfall event may cause error in estimating the potential soil loss in definite conditions.

• Advances in aircraft and spacecraft science
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• v.2 no.2
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• pp.125-168
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• 2015

Dynamic aeroelastic behavior of structurally nonlinear Joined Wings is presented. Three configurations, two characterized by a different location of the joint and one presenting a direct connection between the two wings (SensorCraft-like layout) are investigated. The snap-divergence is studied from a dynamic perspective in order to assess the real response of the configuration. The investigations also focus on the flutter occurrence (critical state) and postcritical phenomena. Limit Cycle Oscillations (LCOs) are observed, possibly followed by a loss of periodicity of the solution as speed is further increased. In some cases, it is also possible to ascertain the presence of period doubling (flip-) bifurcations. Differences between flutter (Hopf's bifurcation) speed evaluated with linear and nonlinear analyses are discussed in depth in order to understand if a linear (and thus computationally less intense) representation provides an acceptable estimate of the instability properties. Both frequency- and time-domain approaches are compared. Moreover, aerodynamic solvers based on the potential flow are critically examined. In particular, it is assessed in what measure more sophisticated aerodynamic and interface models impact the aeroelastic predictions. When the use of the tools gives different results, a physical interpretation of the leading mechanism generating the mismatch is provided. In particular, for PrandtlPlane-like configurations the aeroelastic response is very sensitive to the wake's shape. As a consequence, it is suggested that a more sophisticate modeling of the wake positively impacts the reliability of aerodynamic and aeroelastic analysis. For SensorCraft-like configurations some LCOs are characterized by a non-synchronous motion of the inner and outer portion of the lower wing: the wing's tip exhibits a small oscillation during the descending or ascending phase, whereas the mid-span station describes a sinusoidal-like trajectory in the time-domain.

• Journal of Preventive Medicine and Public Health
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• v.33 no.2
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• pp.165-173
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• 2000

Objectives : To assess the availability of the glycophorin A (GPA) assay to detect the biological effect of ionizing radiation in workers exposed to low-doses of radiation. Methods : Information on confounding factors, such as age and cigarette smoking was obtained on 144 nuclear power plant workers and 32 hospital workers, by a self-administered questionnaire. Information on physical exposure levels was obtained from the registries of radiation exposure monitoring and control at each facility. The GPA mutant assay was performed using the BR6 method with modification by using a FACScan flow cytometer. Results : As confounders, age and cigarette smoking habits showed increasing trends with GPA variants, but these were of no statistical significance. Hospital workers showed a higher frequency of the GPA variant than nuclear power plant workers in terms of the NO variant. Significant dose-response relationships were obtained from in simple and multiple linear regression models. The slope of the regression equation for nuclear power plant workers was much smaller than that of hospital workers. These findings suggest that there may be apparent dose-rate effects. Conclusion : In population exposed to chronic low-dose radiation, the GPA assay has a potential to be used as an effective biologic marker for assessing the bone marrow cumulative exposure dose.

• Clinical and Experimental Pediatrics
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• v.59 no.9
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• pp.374-380
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• 2016

Purpose: Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research. Methods: We evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell cycle progression and apoptosis were evaluated using flow cytometric analysis, and migration and wound healing assay were performed. Fourteen female Balb/c-nude mice received KHOS/NP cell grafts in their thigh, and were allowed access to metformin containing water (2 mg/mL) ad libitum. Tumor volume was measured every 3-4 days for a period of 4 weeks. Results: Metformin had a significant antiproliferative effect on human osteosarcoma cells. In particular, metformin inhibited the proliferation and migration of KHOS/NP cells by activation of AMP-activated protein kinase and consequent inhibition of the mammalian target of rapamycin pathway. It also inhibited the proliferation of cisplatin-resistant KHOS/NP clone cells. Analysis of KHOS/NP xenograft Balb/c-nude models indicated that metformin displayed potent in vivo antitumor effects. Conclusion: Further studies are necessary to explore metformin's therapeutic potential and the possibilities for its use as an adjuvant agent for osteosarcoma.

• 한국전산유체공학회:학술대회논문집
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• 2003.08a
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• pp.200-205
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• 2003

The Canard rotor/wing (CRW) aircraft concepts offer great potential for application by allowing the use of a common propulsion system for high-speed cruise and low-speed powered lift. Using the rotor for lift in both flight modes increases its utility. In the hovering mode, the exhausted gas from an gas turbine engine is accelerated through the duct system and it provides the tipjet power for rotor system enough to lift the aircraft. In the cruise mode, the rotor is fixed and the exhausted gas is extracted through the main nozzle, such that the aircraft is able to flight with high speed. The duct system was designed using 1-D fanno line flow theory and empirical data. However, the empirical data of the pressure loss coefficient for various bending and dividing ducts were not enough to design our duct system adaptively. Therefore, using 3-D CFD analysis we obtained the pressure loss coefficient for our duct models and chose the appropriate bending or diving duct type. In this paper, we used the CFD-ACE+ software package for the CFD analysis and the modeling of duct system. Through the 3-D CFD analysis, we investigated also the pressure loss and the velocity distributions of the designed whole duct system as well as the blade duct. Comparing the 3-D CFD result with 1-D analysis result, we lessened the uncertainty of the designed duct system and speculated the problem that was not concerned in design state.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1079-1083
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• 2010

Due to summer rainfall is concentrated in the construction of the reservoir and the dam was inevitable. The character of these structures are different from the common rivers have been characterized. According to this problem, we need to adopt to this area with three dimensional model. Construction of dams for preservation of land, utilization of water resources, and exploitation of energy potential, which is a basic element of countries' development, is regarded as indispensable for peoples. In addtion, the development of the Nakdong River nutrient and pathogen Total Maximum Daily Loads (TMDL) required that the full range of pollutants, sources, and flow conditions, typical of heavily urbanized areas, be addressed for a single water body with 1-D simulation model (river) and 3-D simulation model (reservoir). The objective of this study is to simulate the applicability of reservoir with the coupling of 3-D hydrodynamic and water quality models to estimate water balance and pollutant loading in Namgang Dam(Jinyang reservoir).

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.350-356
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• 2015

Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have not yet been fully established, the available studies suggest that the etiology of FD is invariably multifactorial. Benachio-F$^{(R)}$ (BF) is a proprietary liquid formulation of 7 herbal extracts that has been proposed to address this multifactorial etiology using multi-drug phytotherapy. The pharmacological effects of BF, in comparison with those of two other herbal products (Whalmyungsu$^{(R)}$; WM and Iberogast$^{(R)}$; IB) were evaluated in rats. In a laparotomy-induced rat model of delayed GI transit, BF significantly accelerated the delayed gastric emptying caused by morphine, apomorphine, and cisplatin, and also significantly increased mean gastric transit, as compared to the control animals. BF markedly increased gastric accommodation in rats and produced higher gastric volume values than did the control treatment. The effects of BF were generally comparable or superior to those of WM and IB in these models. Furthermore, BF significantly stimulated biliary flow, as compared to the control treatment. These results indicated that BF might have great potential as an effective phytotherapeutic agent capable of reducing GI symptoms and increasing quality of life in FD patients.

• Geomechanics and Engineering
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• v.11 no.1
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• pp.1-39
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• 2016

The finite element method (FEM), discrete element method (DEM), and Discontinuous deformation analysis (DDA) are among the standard numerical techniques applied in computational geo-mechanics. However, in some cases there no possibility for modelling by traditional finite analytical techniques or other mesh-based techniques. The solution presented in the current study as a completely Lagrangian and mesh-free technique is smoothed particle hydrodynamics (SPH). This method was basically applied for simulation of fluid flow by dividing the fluid into several particles. However, several researchers attempted to simulate soil-water interaction, landslides, and failure of soil by SPH method. In fact, this method is able to deal with behavior and interaction of different states of materials (liquid and solid) and multiphase soil models and their large deformations. Soil indicates different behaviors when interacting with water, structure, instrumentations, or different layers. Thus, study into these interactions using the mesh based grids has been facilitated by mesh-less SPH technique in this work. It has been revealed that the fast development, computational sophistication, and emerge of mesh-less particle modeling techniques offer solutions for problems which are not modeled by the traditional mesh-based techniques. Also it has been found that the smoothed particle hydrodynamic provides advanced techniques for simulation of soil materials as compared to the current traditional numerical methods. Besides, findings indicate that the advantages of applying this method are its high power, simplicity of concept, relative simplicity in combination of modern physics, and particularly its potential in study of large deformations and failures.

• International Journal of Internet, Broadcasting and Communication
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• v.16 no.2
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• pp.237-246
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• 2024

In recent years, the frequent occurrence of fire accidents in university libraries has posed significant threats to the safety of students' lives and property, alongside negative social impacts. Accurately analyzing the factors affecting evacuation during library fires and proposing optimized measures for safe evacuation is thus crucial. This paper utilizes a specific university library as a case study, simulating fire evacuation scenarios using the Pathfinder software, to assess and validate evacuation strategies and propose relevant optimizations. Pathfinder, developed by Thunderhead Engineering in the United States, is an intuitive and straightforward personnel emergency evacuation assessment system, offering advanced visualization interfaces and 3D animation effects. This study aims to construct evacuation models and perform simulation analysis for the selected university library using Pathfinder. The library's structural layout, people flow characteristics, and the nature of fire and smoke spread are considered in the analysis. Additionally, evacuation scenarios involving different fire outbreak locations and the status of emergency exits are examined. The findings underscore the importance of effective evacuation in fire situations, highlighting how environmental conditions, individual characteristics, and behavioral patterns significantly influence evacuation efficiency. Through these investigations, the study enhances understanding and optimization of evacuation strategies in fire scenarios, thereby improving safety and efficiency. The research not only provides concrete and practical guidelines for building design, management, and emergency response planning in libraries but also offers valuable insights for the design and management of effective evacuation systems in buildings, crucial for ensuring occupant safety and minimizing loss of life in potential hazard situations

• Journal of the Korean Society for Marine Environment & Energy
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• v.20 no.1
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• pp.37-44
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• 2017

Complexity of multiphase flows due to existence of more than two interface including free-surface in one system, cannot be simulated easily. Since more than two fluids affect to flows and disturb interface, non-linearities such as instabilities can be appeared. Among several instabilities on multiphase flows, one of representative is Rayleigh-taylor instability. In order to examine in importance of density disparity, several cases with numerous Atwood number are set. Moreover, investigation of influence on initial disturbance were also considered. Moving particle simulation (MPS) method, which was employed in this paper, was not widely used for multiphase problem. In this study, by adding new particle interaction models such as self-buoyance correction, surface tension, and boundary condition at interface models, MPS were developed having more strength of physics and robust. By applying newly developed multiphase MPS, considered cases are performed and compared each other. Additionally, though existence of disagreement of magnitude of rising velocity between theoretical values from linear potential theory and that of numerical simulation, agreement of tendency can be proved of similarity of result. the discordance of magnitude can be explained due to non-linear effects on numerical simulation which was not considered in theoretical result.