• Journal of Microbiology and Biotechnology
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• v.24 no.10
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• pp.1427-1437
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• 2014

Enzymatic hydrolysis of lignocellulosic biomass into fermentable sugars is a key step in the conversion of agricultural by-products to biofuels and value-added chemicals. Utilization of a robust microorganism for on-site production of biomass-degrading enzymes has gained increasing interest as an economical approach for supplying enzymes to biorefinery processes. In this study, production of multi-polysaccharide-degrading enzymes from Aspergillus aculeatus BCC199 by solid-state fermentation was improved through the statistical design approach. Among the operational parameters, yeast extract and soybean meal as well as the nonionic surfactant Tween 20 and initial pH were found as key parameters for maximizing production of cellulolytic and hemicellulolytic enzymes. Under the optimized condition, the production of FPase, endoglucanase, ${\beta}$-glucosidase, xylanase, and ${\beta}$-xylosidase was achieved at 23, 663, 88, 1,633, and 90 units/g of dry substrate, respectively. The multi-enzyme extract was highly efficient in the saccharification of alkaline-pretreated rice straw, corn cob, and corn stover. In comparison with commercial cellulase preparations, the BCC199 enzyme mixture was able to produce remarkable yields of glucose and xylose, as it contained higher relative activities of ${\beta}$-glucosidase and core hemicellulases (xylanase and ${\beta}$-xylosidase). These results suggested that the crude enzyme extract from A. aculeatus BCC199 possesses balanced cellulolytic and xylanolytic activities required for the efficient saccharification of lignocellulosic biomass feedstocks, and supplementation of external ${\beta}$-glucosidase or xylanase was dispensable. The work thus demonstrates the high potential of A. aculeatus BCC199 as a promising producer of lignocellulose-degrading enzymes for the biomass conversion industry.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.2
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• pp.252-256
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• 2010

The structural join is one of core operators for efficient processing of XML queries. It can be mainly used for path-represented XML queries as it efficiently retrieves the node pairs that form a hierarchical relationship (i.e., ancestor-descendant, Parent-child relationship) among large-scale XML nodes. However, the structural join algorithms still suffer potential overhead in the middle of processing of XML path queries. In addressing this problem, the structural semi-join is proposed as a novel operator that retrieves only the ancestor or descendant nodes as join results for efficient processing. In this paper, we describe the algorithms for the structural semi-join and present the methods of XML path processing based on the structural semi-join algorithms. The experimental results show that the structural semi-join algorithms are very efficient in processing XML path processing.

• Tunnel and Underground Space
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• v.16 no.6 s.65
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• pp.451-466
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• 2006

Analysis of slope behavior concerning the structural characteristics of field rock mass can be processed by virtue of borehole information of joint orientation and position acquired from DOM drilled core. Anticipated sliding potential of pre-failed rock slope is analyzed and the regional slope instability is investigated by inspecting the hazardous joints and blocks the traces of which is projected on the cut-face. Cross section has been set at the center of rock slope and the traces of both joints and tetrahedral blocks, which potentially can induce the slope failure, are drawn to investigate the failure modes and the triggering mechanism. Automated monitoring system has been established to measure the slope movement and especially, inclinometer has been installed inside DOM borehole to analyze the slope movement by considering the internal rock structure. Algorithms for predicting the slope failure time have been reviewed and the significance of heavy rainfall on the slope behavior has been investigated.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.18 no.2
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• pp.109-116
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• 2007

The objective of this review is to establish practice parameters for pharmacological treatment of children and adolescents with pervasive developmental disorders. We performed a detailed review of the literature, including a wide range of controlled clinical trials, open trials, case reports, and side-effect profiles of related drugs. Few medications have a treatment indication for pervasive developmental disorders, and few studies with well-controlled methodology are available for evaluating treatment results. Pharmacological treatments focus on associated target symptoms because symptom reduction may improve educational and social ability and enhance quality of life. Well-controlled trials have been conducted for some SSRI(selective serotonin reuptake inhibitor) antidepressants, risperidone, and methylphenidate, and showed reduction of some target symptoms. Since the medications are not specific to autism and do not treat core symptoms of the disorder, their potential side effects should be carefully considered. Family education is necessary to give proper information on target symptoms, limitation of drug treatments, and risks.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.95-95
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• 2014

The mass measurement of neutron stars or black holes is of fundamental importance in our understanding of the evolution of massive stars and core-collapse supernova explosions as well as some exotic physics of the extreme conditions. Despite the importance, however, it's very difficult to measure mass of these objects directly. One way to do this, if they are in binary systems, to measure their binary motions (i.e., Doppler shifts) which can give us direct information on their mass. Recently many new highly-obscured massive X-ray binaries have been discovered by new hard X-ray satellites such as INTEGRAL and NuSTAR. The new highly-obscured massive X-ray binaries are faint in the optical, but bright in the infrared with many emission lines. Based on the near-infrared spectroscopy, one can first understand the nature of stellar companions to the compact objects, determining its spectral types and luminosity classes as well as mass losses and conditions of (potential) circumstellar material. Next, spectroscopic monitoring of these objects can be used to estimate the mass of compact objects via measuring the Doppler shifts of the lines. For the former, broad-band spectroscopy is essential; for the latter, high-resolution spectroscopy is critical. Therefore, IGRINS appears to be an ideal instrument to study them. An IGRINS survey of these new highly-obscured massive X-ray binaries can give us a rare opportunity to carry out population analyses for understanding the evolution of massive binary systems and formation of compact objects and their mass ranges. In this talk, we will present a sample near-infrared high resolution spectra of HMXB, IGR J19140+0951 and discuss about its spectral feature. These spectra are obtained on 13th July, 2014 from IGRINS commissioning run at McDonald 2.7m telescope. And at final, we will introduce the upgrade plan of IGRINS Operation Software (IGOS), to gather the input from IGRINS observer.

• Journal of the Korean Institute of Gas
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• v.6 no.4 s.18
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• pp.8-16
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• 2002

Since hydrate has been discovered on the earth, many numbers of experimental studies have been conducted for characterizing the fundamental properties of hydrates, such as equilibrium conditions, thermodynamic properties, structures, kinetics, etc. It is considered naturally occurred hydrates in porous rocks have a great potential as a future of unconventional energy resources, and the investigations of formation and dissociation of hydrates in porous media are required. In this study, an experimental apparatus was designed to perform experiments of hydrates in porous core. With the apparatus developed, firstly, isochoric experiments were conducted to find hydrate equilibrium conditions in porous media, and the results were compared with reference data to verify experimental apparatus and methods in this study. Secondly, experiment of formation was examined by observing the behaviors of pressure and electrical resistance and the effects of initial water saturation on formation were analysed.

• Journal of The Korean Association For Science Education
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• v.32 no.8
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• pp.1356-1366
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• 2012

As the recent demand for human resources in science, technology, engineering, and mathematics (STEM), the development of professional STEM teacher is called worldwide. It is becoming a critical need in teacher education in order to educate student teachers, and prepare pre-service and beginning teachers for high quality of teaching competency. To promote the competency for $21^{st}$ century STEM teachers, the epistemology of technological pedagogical content knowledge (TPACK) is currently considered as the essential qualities of knowledge for highly qualified teachers. The aim of this study is explore the effect of case-based learning approach on TPACK competency of pre-service STEM teachers. In order to develop the pre-service teachers' competency regarding effective integration of technologies into teaching specific content areas, a series of innovative case study teaching in science and mathematics was presented to 43 participants of pre-service physics, chemistry, biology, mathematics, and computer teachers during a course of information and communication technology (ICT) in Education at Khon Kaen University, Thailand. After finishing a case presentation, the pre-service teachers were encouraged into a forum of critical open discussion by considering the potential impact of the case and the TPACK framework. They were investigated instructional design competency of using ICT tools into student learning process and their personal beliefs about ICT in educational process both before and after. The participant's reactions and learning was evaluated by using a self-reported questionnaire and an implementation log of content-specific learning process design, respectively. Results showed a change of their beliefs and the transformation of their TPACK competency in STEM teaching. In an effort to better serve the needs of high quality STEM teachers, the results of this study illustrated that the competency of TPACK could be particularly considered as a core attributes for future STEM teachers. By the way, case-based learning approach can play an effective part in preparing and professing the TPACK competency for STEM teachers.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.90-90
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• 2003

The acetylation of histone is one of the mechanisms involved in the regulation of gene expression and is tightly controlled by two core enzymes, histone acetyltransferase (HAT) and deacetylase (HDAC). There are several reports that imbalance of HAT and HDAC activity is associated with abnormal behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Recently, an increasing number of structurally diverse HDAC inhibitors have been identified that inhibit proliferation and induce differentiation and/or apoptosis of tumor cells in vivo and in vitro. In this study, we have investigated the effects of novel HDAC inhibitors, IN2001 on ER positive and ER negative human breast cancer cell lines. The growth inhibition, cell cycle arrest and apoptosis of cells by HDAC inhibitors were determined using SRB assay, DNA fragmentation, and flow cytometry. We found that IN 2001 as well as Trichostatin A inhibited cell growth dose-dependently in both ER positive and ER negative human breast cancer cell lines. The growth inhibition with HDAC inhibitors was associated with profound morphological change. The result of cell cycle analysis after 24 h exposure of IN2001 showed G2-M cell cycle arrest in MCF-7 cell and apoptosis in T47D and MDA-MB-231 cell. In summary, IN2001 has antiproliferative effect on human breast cancer cells regardless of the expression of estrogen receptor. These findings heights the possibility of developing HDAC inhibitors as potential anticancer therapeutic agents for the treatment of breast cancer.

• Molecules and Cells
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• v.41 no.3
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• pp.179-187
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• 2018

Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for which expression levels varied by cancer stage (P-value < 0.05). While urine represents a valuable, non-invasive specimen for biomarker discovery in urologic cancers, there is a high degree of intra- and inter-individual variability in urine samples. The enrichment of urinary EV demonstrated its capability and applicability of providing a focused identification of biologically relevant proteins in urological diseases.

• Information Systems Review
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• v.7 no.1
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• pp.219-239
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• 2005

The interest in economics and efficiency of IT investment is growing as the amount of overall organizational IT investment steadily increases. In order to accurately analyze the economics of IT investment, there is a strong need for organization of IT management process and evaluation index, which can be used to determine whether the expenditure incurs effectively for IT investment. This study discusses the prior researches on concepts regarding the analysis of IT investment effect in an organization as proposed from academic and professional perspectives. This study makes contribution in examining the potential issues and their relevant solutions when implementing the management process/system of IT investment based on the case of Company A. We partly try to distinguish the concepts and realities by understanding the core issues involving the IT investment management process/system and make practical suggestions for the companies that plan to implement the efficient IT investment management process/system in the future.