• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권3호
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• pp.163-172
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• 2012

Purpose: Diabetes mellitus (DM) has been shown to alter the properties of the bone and impair bone healing around a titanium implant. The aim of this study is to investigate whether the low-intensity pulsed ultrasound (LIPUS), which has been known to stimulate the bone healing, improve the osseointegration of the titanium implant in tibia of DM-induced rats. Methods: 16 rats were received streptozotocin (60 mg/kg) for inducing diabetes. A total number of 32 titanium implants were placed bilaterally into both tibiae of these rats. The right tibia of each rat received LIPUS application (10 min/day) during 7 days post-operation, while the left side received no treatment. The study was carried on for six weeks and the rats were sacrificed at 1, 2, 4, and 6 weaks postoperatively (4 rats for each week) for histomorphometric and histologic analysis. Bone-implant contact and bone area were measured. Comparisons between the groups were made using statistical analysis on histomorphometric analysis. Results: The histomorphometry parameters showed that the bone-implant contact and the bone area values have decreased in the late osseointegration periods (4, 6 weeks) compared to the early osseointegration periods (1, 2 weeks) in both two groups. The bone-implant contact values of the LIPUS group were somewhat higher than those of controls at 1, 2 weeks, but the difference was not statistically significant. The bone area values of the LIPUS group were also higher than those of controls at 1, 2 weeks, but the difference was not statistically significant as well. Conclusion: Results of this study indicate that LIPUS may have positive effects on early osseointegration but could not improve the long term stability of dental implants.

• Journal of Periodontal and Implant Science
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• 제47권5호
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• pp.312-327
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• 2017

Purpose: This study assessed marginal bone remodeling and soft tissue esthetics after the loading of single bone-level implants in the anterior maxilla. Methods: An open, single-arm observational clinical trial with 3 years of follow-up was performed, including 22 implants. The patients presented with a single tooth gap in the anterior maxilla (tooth positions 14-24), with natural or restored adjacent teeth. An implant was placed at least 8 weeks post-extraction and healed submerged for 6 weeks. After the second-stage operation, a fixed provisional prosthesis was provided. The final restoration was placed 6 months after the provisional restoration. The time of the provisional crown connection was considered to be the baseline in this study. Esthetic parameters and the marginal bone level were assessed at 6, 12, 24, and 36 months. Results: All implants were well integrated in the bone. A statistically significant increase was found in the mean implant stability quotient between the time of the provisional prosthesis and the time of the final prosthesis. Most implants (95.5%) revealed marginal bone resorption (<0.5 mm), and just 1 implant (4.5%) showed a change of 2.12 mm from baseline to 36 months (mean $0.07{\pm}0.48mm$), while the crestal bone level decreased significantly, from $2.34{\pm}0.93mm$ at baseline to $1.70{\pm}1.10mm$ at 36 months. The facial gingival margin and papilla were stable and the esthetic scores indicated high patient and dentist satisfaction. Conclusions: Platform-switching bone-level implants placed in maxillary single-tooth gaps resulted in successful osseointegration with minimal marginal bone resorption. The peri-implant soft tissue was also esthetically satisfying and stable.

• 한국비블리아학회지
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• 제29권2호
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• pp.169-197
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• 2018

이 연구는 대학정보 사전공개서비스의 운영 현황을 대학기록물의 관리와 서비스라는 관점에서 분석하고 서비스의 안정적인 정착과 운영을 위한 개선방안을 제언하는 것을 목적으로 한다. 이를 위해 대학알리미 사이트와 대학정보공시 운영협력대학 40곳을 대상으로 각 대학 홈페이지에 공시된 대학정보를 중심으로 데이터를 수집하였다. 수집된 데이터를 분석한 결과, 첫째, 사전정보공개서비스를 통해 공시된 정보는 대학의 주요 기능인 연구나 교육에 관한 정보보다 대학행정 정보에 치우쳐 있었다. 둘째, 사전정보공개서비스를 통해 공개된 대학정보는 많은 오류와 잦은 수정으로 인해 신뢰성의 문제가 있었다. 끝으로, 각 대학 홈페이지의 정보공개 메뉴들은 형식적으로 기재되어 운영되고 있음이 밝혀졌다. 이상의 문제점을 해결하기 위한 운영방식의 개선을 제언하였다. 첫째, 공개된 대학정보의 신뢰성 확보를 위해 대학정보 공시방법의 개선을 위한 법적, 제도적 보완을, 둘째, 대학정보 사전공개서비스와 관련된 기관들간의 상호연계성 확보를 통한 운영의 일원화를, 셋째, 공개된 대학정보에 대한 메타데이터도 함께 공개할 것을, 마지막으로, 대학의 기본 기능에 충실한 정보들이 보유 관리되어 공개될 수 있도록 대학내 기록연구사를 배치할 것을 제언하였다.

• BMB Reports
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• 제32권4호
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• pp.331-338
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• 1999

Ethanol catabolism is thought to produce metabolic disorders resulting in alcoholic liver disease. To investigate the mutual effects of ethanol catabolism and cholestasis induced by common bile duct ligation on the activities of carboxylesterase, we have determined the enzyme activities in rat hepatic (cytosolic, mitochondrial, and microsomal) preparations as well as in rat serum using ten animal models: normal rats (group 1), sham-operated rats (group 2), common bile duct-ligated rats (group 3), ethanol-intoxicated rats (group 4), sham-operation plus chronic ethanol-intoxicated rats (group 5), common bile duct-ligated plus chronic ethanol-intoxicated rats at 1.5h and 24h (groups 7A and 7B), and duct-ligated and acute ethanol intoxicated rats at 1.5 h and 24 h (groups 8A and 8B). The $K_m$ and $V_{max}$ values of carboxylesterase from these hepatic preparations of cholestatic rat liver combined with chronic ethanol intoxication were also measured by using ethyl valerate as the substrate from the 14th day post-ligation. Carboxylesterase activities of all hepatic preparations and rat serum (group 3) showed significant decreases compared to the activities from the sham-operated control (group 2). Enzyme kinetic parameters indicated that $V_{max}$ of carboxylesterase from all the hepatic preparations in cholestatic rats (group 3) decreased significantly, although the $K_m$ values were about the same as in the sham-operated control (group 2). When cholestasis was combined with chronic ethanol intoxication (group 6), carboxylesterase activities showed further decrease in all the hepatic preparations and serum compared to the control activity (group 5). The $V_{max}$ also decreased significantly, although $K_m$ values did not change. When common bile duct ligation was combined with acute ethanol intoxication (group 8), the enzyme activities in the rat liver and serum showed significant decrease compared to the activity from acute ethanol-intoxicated rats (group 7). However, quite contrary to this, the activities of serum from acute ethanol intoxication 1.5 h (group 7A) increased significantly compared to the activities in the normal control (group 1). These results, therefore, suggest that the biosynthesis of hepatic carboxyl-esterase seems to decrease when cholestasis is combined with chronic and acute ethanol intoxication, and the decrease in activity is more significant than from cholestasis alone.

• 한국치위생학회지
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• 제4권2호
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• pp.277-291
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• 2004

The purpose of this study is to analyze the dental hygienists' overall performance in operative restoration and the clinical performance in operative restoration according to dental hygienists' career and to provide basic data for establishing the appropriate range of dental hygienists' work. Subjects of this study are 339 dental hygienists working at dental clinic and hospital nationwide, selected by their working place, career, type of clinic, and location of clinical institution. The distribution of people who responded to the survey shows that 81 belong to beginner level(less than 2 years since entering clinic), 115 intermediate level(2 to 3 years since entering clinic), 81 higher level(4 to 5 years since entering clinic) and 62 advanced level(more than 6 years since their entering clinic). In terms of the types of clinical institution, 178 belong to dental clinics and 161 belong to dental hospitals. The survey used in this study are focused on perception about clinical performance in operative dentistry and adequacy of the work. Operative dentistry consists of operative restoration and endodontic therapy. The operative restoration consists of 15 categories such as patient welcoming, examination and diagnosis, planning of treatment, anesthesia, control of moisture, cavity preparation, pulp protection, matrix band application, amalgam filling, resin filling, glass ionomer cement filling, abrasive strip removal, rubber dam removal, bite check and polishing, patient education, and arrangement. The reliability was Cronbach's Alpha .9453. SPSS 10.0 for Windows was used to analyze the responses. One way ANOVA was utilized to verify the differences in the dental hygienists' job performance in operative restoration and their job performance according to career. When significant difference was found. Duncan multi comparison post hoc was done. To sum up the results of this study, patient welcoming look the first place in the operative restoration. It was followed by patient education, examination and diagnosis, introducing treatment plan, resin filling, glass ionomer cement filling, amalgam filling, bite check and polishing, anesthesia, pulp protection, control of moisture, abrasive strip removal, cavity preparation, matrix band application, rubber dam removal, and anesthesia. In terms of the clinical performance by career, there were significant differences in 19 activities such as medical eraluation, oral examination, patient charting, intra oral readio graphs, firm developing fixing mounting, curing light gun, education of attention content after operation. Based on the results of this study, the specific range of operative restoration for dental hygienists should be focused on providing basic data for dentists' diagnosis, alleviation of fear and aching accompanied by injection and anesthesia, data providing for dentists' decision of anesthesia degree, and maximization of control of moisture.

• The Journal of Korean Physical Therapy
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• 제18권2호
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• pp.59-65
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• 2006

목적: 전침과 경피신경전기자극이 근육 손상에 미치는 차이와 효과에 대하여 알아보기 위하여 이 실험을 시행하였다. 방법: 8-10주령의 건강한 S-D계 흰쥐 18마리(250-300g)가 이 실험에 사용되었으며 각 실험은 수술을 통하여 장지신근을 30초간 수술용 겸좌로 압좌한 후 무작위로 세 그룹으로 나누었다. 아무런 처치를 하지 않은 그룹을 대조군(Con), TENS 적용 그룹을 실험군-1(Ex-1), 전참 적용군을 실험군-2(Ex-2)으로 정하여 전기 자극을 반도 2Hz, 강도 1mA, 통전시간 15분 씩 7일간 적용한 후 각 그룹에서 2마리씩 1, 3, 7일에 희생하여 척수의 요수부위를 적출하여 이를 NT-3 항체 처리하여 염색하였다. 결과: 실험군-1, 2는 대조군에 비하여 조금 더 많은 NT-3가 발현됨을 관찰 할 수 있었지만, 각 실험군 간의 큰 차이는 발견하지 못하였다. 결론: TENS와 전침적용의 분자수준에서의 큰 차이점은 없다고 사료된다.

• Journal of Chest Surgery
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• 제9권2호
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• pp.239-244
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• 1976

Alterations in the serum magnesium level were studied in twenty patients who had open-heart surgery during the period from August 1974 to May 1975. The patients were chosen at random. The operative procedures included repair for congenital heart diseases in fifteen patients and cardiac valve replacement for acquired valvular heart diseases in five patients. The age ranged from 8 to 46 years, with an average of 19 years. None of the patients had a history of gross neuromuscular abnormalities. Cardiopulmonary bypass was carried out using a roller pump and a disposable oxygenator. The prime solution consisted of 2 units of ACD banked blood and approximately an equal volume of non-blood additives in adults, while a relatively smaller volume was added in children. The average flow rate was 2,733 ml per minute. Blood samples for magnesium and arterial blood pH were obtained the day after admission 25 minutes after initiation of the bypass and on the morning the day after operation. Preoperative data were then compared with those obtained during the bypass and postoperatively by a paired test. During the bypass, the serum magnesium level decreased significantly from $1.425{\pm}0.029$ to $1.210{\pm}0.063mEq.$ liter (p<0.001). Also, there was a significant decrease in serum magnesium from $1.425{\pm}0.029$ preoperatively to $1.255{\pm}0.083mEq$. per liter (p<0.001). Also, there was a significant decrease in serum magnesium from $1.425{\pm}0.029$ preoperatively to $1.255{\pm}0.083mEq$. per liter postoperatively (p<0.01). The duration of bypass was less than 90 minutes in 10 patients (group A) and exceeded 90 minutes in the remaining 10 (group B). There was no statistical correlation between the groups A and B ($p{\gg}0.20$). Statistical analyses of the serum magnesium level and arterial blood pH showed no significant correlation with correlation coefficient; being -0.3485(pre-op), -0.2971(during bypass), and -0.1008(post-op), respectively. In all the patients, no gross neuromuscular abnormalities were found postoperatively. At present, the clinical significance of the serum magnesium level during and after bypass is controversial. In the near future, however, it is expected that improvements in prime solution and heart-lung machine will solve this problem.

• Journal of Nutrition and Health
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• 제18권4호
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• pp.283-292
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• 1985

대학 급식 시설의 위생 실태를 평가하기 위해서 오뎅국의 생산 과정을 통한 소요시간 및 온도상태 측정 pH 및 Aw측정, 미생물 검사를 실시하여 HACCP model에 의해 분석, 평가한 결과는 다음과 같다. 1 )소요시간 및 온도상태 측정 결과. 재료들의 조리후 실온방치 단계와 국물의 보온단계에서 철저한 관리가 요구된다. 2 ) pH및 Aw측정 결과, 대부분의 단계가 미생물 증식에 적합한 조건이었다. 3 )음식에 대한 미생물 분석 결과, 재료들의 미생물적 품질이 대체로 낮았다. 또한 조리후 급식전 보관단계에서 장시간 실온에 방치되므로 미생물의 오염 및 증식 기회가 많았다. 4 ) 오뎅국 생산에 사용되는 기구, 설비, 용품 및 용기에 대한 미생물 분석 결과 뚝배기, 장갑, 행주와 도마에 대한 즉각적인 시정이 요구된다. 5 ) 이상에서 오뎅국 생산 단계에서의 critical control points는 재료, 전처리, 후처리 및 급식전 보관단계로 지적되었다.

• Journal of Chest Surgery
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• 제29권8호
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• pp.897-904
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• 1996

폐절제술후 발생할 수 있는 호흡부전증을 예방하고 수술후 사망율을 줄이기 위해 수술범 위를 조정하 는 것이 필요하며 이를 위해서는 수술전에,수술후의 폐기능을 예측할 수 있어야 한다 술후 폐기능을 예측하는 방법은 여러 가지가 .있으나 폐관류주사법이 편리하고 환자에게도 위 험도가 작으며 또한 비교 적 정확하고 비용이 적게드는 방법으로 알려져 있다. 충남대 학교병 원 흉부외과에서 폐절제술을 시행한 34명을 대상으로 수술전 폐관류주사법을 이용하여 수술후 폐기능 예측치를 계산하고 수술후 평균20일에 폐기능검사를 실시하여 예측치와실측치의 관계 를 비교분석하였다. 폐엽절제술후 폐기능 예측치가 일측전폐절제술후 폐기능 예측치보다 훨신 더 좋은 상관관계를 보였으며 그 중에서도 1초내 강제호기량이 상관계수 R=0.693으로 가장 높은 상관관계를 나 타내었다. 폐실질의 손실없이 개흉술만 시 행한 대조군에서 수술전후의 상관관계는 1초내 강제호기 량이 상관계수 R=0.871 이 었으며 강제폐활량이 R=0.896으로 폐 절제수술을 시 행한군에 비해 매우 높은 상관 관계를 보이는 것으로보아 수술후 폐기능검사치는 개흉술 자체만으로도 영향을 받 嗤\ulcorner폐절제수술을 시행한군에서 휠신 더 영향을 받는것을 알수 있었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제31권5호
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• pp.390-398
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• 2005

Purpose: The aim of this study was to evaluate the skeletal and dentoalveolar dimensional changes following surgically-assisted rapid maxillary expansion (SARME). Patients & methods: Thirteen adults who had been treated by SARME for transverse maxillary deficiency from May 2000 to December 2003 were evaluated. The SARME procedure was the subtotal Le Fort I osteotomy combined with pterygomaxillary separation and anterior midpalatal osteotomy. Dental study casts and posteroanterior cephalometric radiographs were taken before operation, after removal of expansion device, and follow up period. Nasal cavity width, skeletal and dentoalveolar parameters were measured pre- and post-operatively. Results: 1. Mean nasal cavity width was increased 12%$(0{\sim}21%)$ of total expansion after retention. 2. Mean maxillary interdental width was increased 70%$(47{\sim}99%)$, 95%$(84{\sim}115%)$, and 77%$(57{\sim}94%)$ of total expansion in the canine, the first premolar, and the first molar region, respectively after retention. 3. Mean maxillary alveolar bone width was increased 66%$(42{\sim}84%)$, 74%$(42{\sim}94%)$, and 57%$(31{\sim}78%)$ of total expansion in the canine, the first premolar, and the first molar region, respectively after retention. 4. Mean palatal vault depth was decreased 1.3 mm ($0.5{\sim}2.0$ mm) after retention. 5. Mean interdental and alveolar bone width of the mandibular canine and intermolar width of mandible were slight increased as maxilla was expanded after retention. 6. There were statistical differences between preoperative and postoperative values of nasal cavity, all maxillary interdental and interalveolar widths, palatal vault depth, mandibular interdental and interalveolar width of canine(paired t-test, p<0.05). 7. The maxillary interdental and alveolar bone width were decreased approximately 25% of total expansion by relapse at follow up period. Conclusion: In conclusion, most amounts of maxillary interdental expansions were acquired with the expansion of the maxilla by SARME. For preventing the relapse, approximately 25% of the overexpansion was needed.