• Journal of the Korean Geographical Society
• /
• v.48 no.4
• /
• pp.509-532
• /
• 2013

Minimum Housing Standard is an instrument to cope with the problems of public health and community hygiene, deterioration of working class housing conditions appeared commonly in the process of capitalist industrialization and rapid rural-to-urban migration. This paper aims to examine the institutionalization of histories of minimum housing standard in the advanced countries, and analyze the spatio-temporal changes and characteristics of households failing to meet the New Minimum Housing Standard in Seoul Metropolitan since 1995. The analysis of this paper is based on the census data on population and housing. The results are as follows; Households failing to meet the New Minimum Housing Standard in Seoul are 501,000 households(1.368 million person, 14.4%). This means Seoul has overtaken the national average 11.8% for the first time and there are structurally marginal band of households who can not improve the housing conditions by themselves. In addition, the fact that the rate of Seoul households living in the marginal shelter including the basement and rooftop room is the highest in Korea means the housing quality issues of Seoul is serious. Spatial distribution of households failing to meet the standard is divided into the northeast area and the southwest area in Seoul. Main features of the households are female-headed families, middle and old-aged people, divorce families, lower educated people, under and graduate students, non-apartments, dweller in 15~20 year old houses.

• BMB Reports
• /
• v.53 no.10
• /
• pp.533-538
• /
• 2020

Notch signaling has been identified as a critical pathway in gastric cancer (GC) progression and metastasis, and inhibition of Delta-like ligand 4 (DLL4), a Notch ligand, is suggested as a potent therapeutic approach for GC. Expression of both DLL4 and vascular endothelial growth factor receptor 2 (VEGFR2) was similar in the malignant tissues of GC patients. We focused on vascular endothelial growth factor (VEGF), a known angiogenesis regulator and activator of DLL4. Here, we used ABL001, a DLL4/VEGF bispecific therapeutic antibody, and investigated its therapeutic effect in GC. Treatment with human DLL4 therapeutic antibody (anti-hDLL4) or ABL001 slightly reduced GC cell growth in monolayer culture; however, they significantly inhibited cell growth in 3D-culture, suggesting a reduction in the cancer stem cell population. Treatment with anti-hDLL4 or ABL001 also decreased GC cell migration and invasion. Moreover, the combined treatment of irinotecan with anti-hDLL4 or ABL001 showed synergistic antitumor activity. Both combination treatments further reduced cell growth in 3D-culture as well as cell invasion. Interestingly, the combination treatment of ABL001 with irinotecan synergistically reduced the GC burden in both xenograft and orthotopic mouse models. Collectively, DLL4 inhibition significantly decreased cell motility and stem-like phenotype and the combination treatment of DLL4/VEGF bispecific therapeutic antibody with irinotecan synergistically reduced the GC burden in mouse models. Our data suggest that ABL001 potentially represents a potent agent in GC therapy. Further biochemical and pre-clinical studies are needed for its application in the clinic.

• Korean Journal of Ecology and Environment
• /
• v.53 no.3
• /
• pp.255-264
• /
• 2020

The use of fishway has been investigated up to 2~9 years, continuously each month and over the long term that installed in 6 domestic rivers. The fish's use of fishway has been investigated as direct collection by trap in exit section of the fishway. The population structure of fish using 6 fishway and the fish that live in the river showed difference. About 2 to 7 species of fish took possession of more than 80% of total use of fish in fishways. This seems to be not the results of attraction flow in fishway but specialized result of physiology characteristic followed by species of fish. In addition, the distribution of fish species using fishway was different with the fishways installed in river. This difference seems to be consequence of the place that of the river and fishway types. Generally, the fish species were less and had high ratio of home migratory fish in vertical slot type fishway, which shows relatively fast velocity of water flow. This analysis result of major fish species using fishway can be used in planning fishway and to choose major targeted species for the planning.

• Information Systems Review
• /
• v.16 no.3
• /
• pp.135-160
• /
• 2014

Most Social Network Service (SNS) provide online chat, video and file sharing, blogging and others. Because of this advantage, people depend on SNS to communicate with others. However, recently SNS encourage people to reveal too much information broadly so SNS users are concerned about privacy invasion and data spill. They also feel fatigue in process of touching people they don't know while using SNSs. That is the reason why they attempt to switch from opened SNS to Closed SNS. Therefore, the purpose of this study is to empirically investigate and analyze the effect of the factors on the SNS users' switching behavior when using SNS. To accomplish this purpose, this research adopted "Push-Pull-Mooring (PPM)" framework. The PPM is proposed by population geologist, who used it to explain the incentives of demographic migration. Following PPM model, this research empirically examines the three categories of antecedents for SNS switching intention toward closed SNS: push (i.e., weak connection, privacy concern, relative complexity), pull (i.e., enjoyment, belongingness, peer influence), mooring (i.e., SNS fatigue, user resistance) factors. The survey was conducted for 285 users on SNS communities in Korea. The results of this study are as follows; First, wear connection and privacy concern are significantly related to SNS switching intention. Second, enjoyment and belongingness are significantly related to SNS switching intention. Finally, the results show that SNS fatigue has a moderating effect on the links between push factors and SNS switching Intention. Also, user resistance has a moderating effect on the links between pull factors and SNS switching Intention. These findings contribute to the SNS literature both theoretically and practically.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.35 no.2
• /
• pp.112-119
• /
• 2009

Extracellular matrix(ECM) is known to function as a reservoir of endogenous growth factors, can be an effective delivery system of growth factor that easily lost bioactivity in solution. Fibrillar collagens like type I collagen, are the major constituent of the ECM and structural protein of bone. Also, it can be a scaffold for osteoblast migration. The purpose of this study was to compare the effects of absorbable Atelo-collagen Sponge($Teruplug^{(R)}$) insertion in tooth extraction sites on periodontal healing of the mandibular second molar after the extraction of the impacted third molar. The study population comprised 31 cases who had been scheduled for surgical removal of impacted mandibular third molars. All patients were in good general health and were not using any medication that would influence wound healing after surgery. In 15 cases control group, none was inserted into the tooth extraction site. In 16 cases experimental groups, $Teruplug^{(R)}$ was inserted into the tooth extraction site. We evaluated tooth mobility, pocket depth, gingival margin level preoperatively and 1 week, 2 weeks, 4 weeks, and 3 months postoperatively. The change was compared with two groups using Mann-Whitney test. The results were as follows. 1. There was no significant change of tooth mobility on both groups. 2. There was tendency of decreasing of previous pocket depth causing tooth extraction on both groups. 3. On gingival margin level, there was various change according to initial swelling and loss of attachment on both groups. 4. There was tendency of decreasing of gingival margin level on both groups because of removal of inflammation and decreasing of previous pocket depth. 5. There was large change of pocket depth on buccal middle, distal, lingual distal area because of tooth extraction and bone reduction. Compared with the control group and experimental group, we observed significant difference during some periods. The results of this study suggest that absorbable atelo-collagen sponge($Teruplug^{(R)}$) is relatively favorable bone void filler with prevention of tissue collapse, food packing and enhance periodontal healing.

• Journal of Korean Society of Rural Planning
• /
• v.15 no.4
• /
• pp.75-87
• /
• 2009

This paper tries to explore the local uniqueness and evolutionary characteristics of the spatial structure of the rural dwelling houses of China's Korean Ethnic. For this purpose, the paper selected 51 typical samples in each district, analyzing their ancestral home, building age, size, construction method, family composition etc. Moreover, the paper classified the pattern of the samples and analyzed the characteristic and evolutionary process of each pattern. Conclusions based on the analysis of the ancestral homes are as follows: 1.The house pattern of these China's Korean ethnics who are originally from the Hamkyung province is mainly jeongji- access type (A-type). A-type is mainly distributed along the Tumen River and Yalu River, in the Sino-Russian borders and the inland areas of Heilongjiang province. With the migration of the China's Korean ethnics, in Sino-Russian borders and the inland areas of Heilongjiang province, A-type with the 'badang' space, vestibule-access type (C-type) and living-centered type (D-type) appeared. 2. House patterns of Korean ethnics who are originally from the Pyongan province include three types: A-type, kitchen type (B-type) and C-type. A-type is mainly distributed along the Yalu River while B-type and C-type are mainly in the inland areas of these three Northeast provinces. With the decrease of population, the merger of rooms happened in A-type; while in the B-type and C-type, bathroom and storage came to exist in the north of the room. 3. The house pattern of Korean ethnics who are originally from the Gyeongsang province is mainly B-type, which is distributed in the inland areas of Heilongjiang and Jilin provinces. Besides, C-type and D-type also exist. They are in Jilin and Liaoning provinces. In the process of evolution, storage was set in the north part of the room or the window was cancelled in order to defend the coldness in Heilongjiang area, while in Jilin and Liaoning provinces, living room came into existence, which is gradually developing to D-type.

• Korean Journal of Ecology and Environment
• /
• v.51 no.3
• /
• pp.234-244
• /
• 2018

The roadkill that animals die after bumping by vehicles on the roads is acting as a factor to decrease the size of various animal populations. It has also been known to be the biggest artificial causations of Vertebrata deaths not only in urban areas but also protected areas such as national parks. Nevertheless, in the national park areas which are major protected national areas for conservation of national biodiversity and ecological diversity, snake roadkills occur frequently. Up to date, related studies are rare. Therefore, in this study, we described snake roadkill patterns on the roads in six national parks between 2006 and 2015. We identified total 736 snake roadkills compromising 10 different species. Five species, Rhabdophis lateralis, Elaphe dione, Gloydius ussuriensis, Lycodon rufozonatus, Gloydius brevicaudus occupied more than 91.7% of total roadkill cases. Active forager snakes were killed by roadkills more than ambush foragers, and the snake roadkill frequency was the highest in September, a migration period and in August when the young individuals dispersed at between 100 and 799 m altitude areas. Roads where roadkills were frequent lie between forest and hydrosphere or between forest and crop field road sides. Our results could be used to identify the trend of snake roadkills on the roads in national parks, and to establish effective roadkill mitigation measures and policies.

• Korean Journal of Environment and Ecology
• /
• v.31 no.5
• /
• pp.472-478
• /
• 2017

The feeding habits of Coreoperca herzi were investigated from specimens collected in the Geum River, from March to December 2016. The specimens were separated into groups of 38~70 mm, 71~109 mm, and over 110 mm in total length. The live foods of C. herzi included Ephemeroptera, Odonata, Plecoptera, Coleoptera, Diptera, Trichoptera, and fishes. The Korean aucha perches fed mostly on aquatic insects which took up 98.8% of food regarding the number, 55.8% regarding the biomass, and 97.1% in terms of iregarding the index of relative importance. They were carnivorous in diet and predators (stalker) in food intake characteristics and forms when applying Keenleyside's classification. The main food sources of C. herzi were Ephemeroptera, Diptera, and Trichoptera while Odonata, Plecoptera, Coleoptera, and fishes were rare. A food migration was observed since less Ephemeroptera was found and more Trichoptera and fishes were found in the biomass of the feed consumed by larger species. The amount of Coleoptera and Diptera did not change much with the size of the species. The overall composition of live food was not seasonal. The result of the study indicates that, when restoring the streams to be the habitat for the natural population increase of Coreoperca herzi, the environment should be inhabitable to Ephemeroptera, Diptera, and Trichoptera which are the main foods.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.6
• /
• pp.1007-1021
• /
• 2018

Cancer represents one of the most significant threats to human health on a global scale. Hence, the development of effective cancer prevention strategies, as well as the discovery of novel therapeutic agents against cancer, is urgently required. In light of this challenge, this research aimed to evaluate the effects of several potent bioactive peptides and proteins contained in crocodile white blood cell extract (cWBC) against LU-1, LNCaP, PC-3, MCF-7, and CaCo-2 cancer cell lines. The results demonstrate that 25, 50, 100, and $200{\mu}g/ml$ cWBC exhibits a strong cytotoxic effect against all investigated cell lines ($IC_{50}$ $70.34-101.0{\mu}g/ml$), while showing no signs of cytotoxicity towards noncancerous Vero and HaCaT cells. Specifically, cWBC treatment caused a significant reduction in the cancerous cells' colony forming ability. A remarkable suppression of cancerous cell migration was observed after treatment with cWBC, indicating potent antimetastatic properties. The mechanism involved in the cancer cell cytotoxicity of cWBC may be related to apoptosis induction, as evidenced by typical apoptotic morphology features. Moreover, certain cWBC concentrations induced significant overproduction of ROS and significantly inhibited the $S-G_2/M$ transition in the cancer cell. The molecular mechanisms of cWBC in apoptosis induction were to decrease Bcl-2 and XIAP expression levels and increase the expression levels of caspase-3, caspase-8, and p53. These led to a decrease in the expression level of the cell cycle-associated gene cyclin-B1 and the arrest of cell population growth. Consequently, these findings demonstrate the prospect of the use of cWBC for cancer therapy.

• The Journal of the Convergence on Culture Technology
• /
• v.2 no.2
• /
• pp.45-49
• /
• 2016

It may be summarized to four kinds of innovation through global convergence, and the convergence of adjacent areas according to mega-trends in medical services market and actively introduced ICT technologies, public and private partnership. Health care is no longer a local industry, it is becoming Global Convergence. In the case of developed countries, it is increased to income levels, the development of new medical technologies, while the increase in specialized medical services and need of aging population. It increases migration of foreign medical personnel, geographical proximity and choice of the best medical technology, regardless of the cost. The increasing demand for high quality yet relatively low foreign prices of medical services. Hospitals are especially spread of international certification such as the US JCI standards. Hospital exports are being evaluated and opened the way for the export industrialization as ICT convergence hospital that can be exported to the fusion-related technologies more efficiently. Current local hospital has already reached saturation, globalization of Korean hospital is being the time necessary. Thus, unlike a strategy for each country, as well as technology transfer it is also possible, such as total exports provided the building, medical equipment procurement, local medical personnel (doctors and nurses) selection and training, PR and marketing. In the current medical law and need to be revised prospectively maintained for publicity and abroad, there is a need for further legal dragons and actively support a more flexible policy on the application of national law overseas medical services.