• Archives of Pharmacal Research
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• 제15권1호
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• pp.1-4
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• 1992

4-Acetylantipyrine 1 underwent condensation with 4-formyl-antipyrine 2 to give 3. Condensation of either 3 with 1 or 1 with 2 in a molar ratio of (2 :1) afforded 4. Cyclization of 4 in the presence of PPA and ammonium acetate or 4-aminoantipyrine in the presence of glacial acetic acid gave 5-6 respectively. Claisen condensation of 1 with ethyl acetate and diethyl oxalate afforded compounds 8-10. The reaction of 1 and 2 with indole in ethanol/conc. hyddrochloric acid was also investigated.